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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MAFB
Z-value: 1.72
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Transcription factors associated with MAFB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFB | hg19_v2_chr20_-_39317868_39317884 | -0.79 | 1.6e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_53491220 Show fit | 5.40 |
ENST00000548547.1
ENST00000301464.3 |
insulin-like growth factor binding protein 6 |
|
| chr17_+_7942424 Show fit | 5.39 |
ENST00000573359.1
|
arachidonate 15-lipoxygenase, type B |
|
| chr12_-_76425368 Show fit | 5.07 |
ENST00000602540.1
|
pleckstrin homology-like domain, family A, member 1 |
|
| chr17_+_7942335 Show fit | 4.49 |
ENST00000380183.4
ENST00000572022.1 ENST00000380173.2 |
arachidonate 15-lipoxygenase, type B |
|
| chr4_-_57547454 Show fit | 4.42 |
ENST00000556376.2
|
HOP homeobox |
|
| chr4_-_57547870 Show fit | 4.39 |
ENST00000381260.3
ENST00000420433.1 ENST00000554144.1 ENST00000557328.1 |
HOP homeobox |
|
| chr10_+_120967072 Show fit | 4.34 |
ENST00000392870.2
|
G protein-coupled receptor kinase 5 |
|
| chr2_+_191745560 Show fit | 4.20 |
ENST00000338435.4
|
glutaminase |
|
| chr2_+_238536207 Show fit | 3.90 |
ENST00000308482.9
|
leucine rich repeat (in FLII) interacting protein 1 |
|
| chr16_-_85784557 Show fit | 3.82 |
ENST00000602675.1
|
chromosome 16 open reading frame 74 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.2 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 1.4 | 9.9 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.1 | 8.8 | GO:1901998 | toxin transport(GO:1901998) |
| 1.6 | 7.8 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.0 | 6.8 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.1 | 6.7 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.3 | 6.4 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 1.0 | 6.0 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.1 | 6.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 1.8 | 5.5 | GO:0045210 | FasL biosynthetic process(GO:0045210) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 13.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 9.4 | GO:0045095 | keratin filament(GO:0045095) |
| 0.4 | 7.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 6.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.6 | 6.0 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.2 | 5.8 | GO:1990752 | microtubule end(GO:1990752) |
| 0.1 | 5.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 5.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.3 | 4.8 | GO:0034709 | methylosome(GO:0034709) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 13.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 3.3 | 9.9 | GO:0016165 | linoleate 13S-lipoxygenase activity(GO:0016165) |
| 0.1 | 9.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.6 | 7.8 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.4 | 6.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 6.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.5 | 6.0 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.2 | 5.9 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 5.5 | GO:0005126 | cytokine receptor binding(GO:0005126) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 13.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 8.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 7.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.2 | 7.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 6.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 5.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 5.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 10.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 10.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 7.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 7.2 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.3 | 6.5 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 5.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 5.7 | REACTOME PLATELET AGGREGATION PLUG FORMATION | Genes involved in Platelet Aggregation (Plug Formation) |
| 0.1 | 5.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 5.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |