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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MAFK
Z-value: 1.13
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Transcription factors associated with MAFK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFK | hg19_v2_chr7_+_1570322_1570360 | -0.39 | 3.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_70861647 Show fit | 11.15 |
ENST00000246895.4
ENST00000381060.2 |
statherin |
|
| chr7_-_16921601 Show fit | 10.82 |
ENST00000402239.3
ENST00000310398.2 ENST00000414935.1 |
anterior gradient 3 |
|
| chr4_+_69962185 Show fit | 9.42 |
ENST00000305231.7
|
UDP glucuronosyltransferase 2 family, polypeptide B7 |
|
| chr4_+_69962212 Show fit | 9.07 |
ENST00000508661.1
|
UDP glucuronosyltransferase 2 family, polypeptide B7 |
|
| chr11_+_61976137 Show fit | 5.66 |
ENST00000244930.4
|
secretoglobin, family 2A, member 1 |
|
| chr12_-_71533055 Show fit | 5.60 |
ENST00000552128.1
|
tetraspanin 8 |
|
| chr1_-_109655355 Show fit | 4.99 |
ENST00000369945.3
|
chromosome 1 open reading frame 194 |
|
| chr1_-_109655377 Show fit | 4.92 |
ENST00000369948.3
|
chromosome 1 open reading frame 194 |
|
| chr4_-_110723134 Show fit | 4.51 |
ENST00000510800.1
ENST00000512148.1 |
complement factor I |
|
| chr1_-_161337662 Show fit | 3.93 |
ENST00000367974.1
|
chromosome 1 open reading frame 192 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFK
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 20.0 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.7 | 11.2 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.1 | 9.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.4 | 8.7 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.0 | 7.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 6.3 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.5 | 5.4 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 4.7 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 1.4 | 4.3 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.0 | 4.1 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 12.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 3.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 3.6 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 2.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 2.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.2 | 2.3 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 2.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 2.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 2.1 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 23.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 3.7 | 11.2 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.4 | 10.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.3 | 7.8 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 7.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 6.8 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 1.2 | 5.0 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 1.1 | 4.3 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.1 | 3.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 3.9 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 4.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 4.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 24.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.4 | 10.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 7.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.4 | 5.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 3.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 2.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 2.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 2.5 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.1 | 2.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 2.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |