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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MAF_NRL
Z-value: 0.97
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Transcription factors associated with MAF_NRL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAF | hg19_v2_chr16_-_79634595_79634620 | 0.44 | 1.5e-02 | Click! |
| NRL | hg19_v2_chr14_-_24551137_24551178, hg19_v2_chr14_-_24551195_24551214 | -0.36 | 5.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_152386732 Show fit | 4.62 |
ENST00000271835.3
|
cornulin |
|
| chr17_-_38859996 Show fit | 3.87 |
ENST00000264651.2
|
keratin 24 |
|
| chr1_+_24645807 Show fit | 3.50 |
ENST00000361548.4
|
grainyhead-like 3 (Drosophila) |
|
| chr1_+_24645865 Show fit | 3.48 |
ENST00000342072.4
|
grainyhead-like 3 (Drosophila) |
|
| chr1_+_24646002 Show fit | 3.41 |
ENST00000356046.2
|
grainyhead-like 3 (Drosophila) |
|
| chr19_-_51471362 Show fit | 2.62 |
ENST00000376853.4
ENST00000424910.2 |
kallikrein-related peptidase 6 |
|
| chr17_-_39769005 Show fit | 2.58 |
ENST00000301653.4
ENST00000593067.1 |
keratin 16 |
|
| chr4_-_57547454 Show fit | 2.30 |
ENST00000556376.2
|
HOP homeobox |
|
| chr11_-_2924720 Show fit | 2.06 |
ENST00000455942.2
|
solute carrier family 22 (organic cation transporter), member 18 antisense |
|
| chr2_+_113885138 Show fit | 1.91 |
ENST00000409930.3
|
interleukin 1 receptor antagonist |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAF_NRL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | GO:0070268 | cornification(GO:0070268) |
| 0.5 | 10.4 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.0 | 4.9 | GO:0009408 | response to heat(GO:0009408) |
| 0.1 | 3.9 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.1 | 3.8 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.0 | 3.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.5 | 3.0 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.0 | 2.7 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.1 | 2.6 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.8 | 2.4 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.4 | 3.0 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 2.9 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.2 | 2.4 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.1 | 2.1 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 2.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.6 | 1.9 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.5 | 1.9 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 1.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 1.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 10.8 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 4.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 3.5 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 3.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 2.6 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 2.0 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 2.0 | GO:0019841 | retinol binding(GO:0019841) |
| 0.1 | 2.0 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 2.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 2.6 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 2.4 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 3.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 2.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 2.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 2.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.3 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.3 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 1.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |