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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MAZ_ZNF281_GTF2F1
Z-value: 1.55
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Transcription factors associated with MAZ_ZNF281_GTF2F1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000103495.9 | MYC associated zinc finger protein | |
| ENSG00000162702.7 | zinc finger protein 281 | |
| ENSG00000125651.9 | general transcription factor IIF subunit 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2F1 | hg19_v2_chr19_-_6393216_6393229 | 0.22 | 2.4e-01 | Click! |
| MAZ | hg19_v2_chr16_+_29819096_29819250 | -0.18 | 3.5e-01 | Click! |
| ZNF281 | hg19_v2_chr1_-_200379104_200379128, hg19_v2_chr1_-_200379129_200379174 | 0.11 | 5.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 17.2 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.7 | 15.6 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 11.2 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.4 | 10.2 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 2.8 | 8.4 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.2 | 8.1 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.8 | 7.6 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.1 | 7.6 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 6.3 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 1.1 | 5.5 | GO:0021773 | striatal medium spiny neuron differentiation(GO:0021773) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.7 | GO:0005615 | extracellular space(GO:0005615) |
| 2.5 | 17.7 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 15.5 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 11.6 | GO:0005912 | adherens junction(GO:0005912) |
| 0.2 | 10.2 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.1 | 8.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 7.9 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 7.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.3 | 7.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 7.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 30.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 11.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.6 | 8.3 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 8.3 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 8.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 8.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 7.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 6.1 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.1 | 6.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 21.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 12.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 12.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 12.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 11.2 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 6.6 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 6.3 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 6.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 5.3 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 14.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 13.4 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.2 | 11.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.4 | 9.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 8.3 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 7.9 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.3 | 7.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 6.4 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 6.0 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |