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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for MECOM

Z-value: 0.98

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Transcription factors associated with MECOM

Gene Symbol Gene ID Gene Info
MECOM
ENSG00000085276.13 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MECOMhg19_v2_chr3_-_168864427_168864464,
hg19_v2_chr3_-_169381183_169381258		0.451.3e-02Click!

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_6797288 6.14 ENST00000433859.2
ENST00000359718.3
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr18_-_24722995 5.80 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr7_+_6796986 5.71 ENST00000297186.3
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr7_-_6007070 5.70 ENST00000337579.3
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr3_-_145968923 5.51 ENST00000493382.1
ENST00000354952.2
ENST00000383083.2
PLSCR4
phospholipid scramblase 4
chr7_-_6006768 5.16 ENST00000441023.2
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr3_-_145968857 5.05 ENST00000433593.2
ENST00000476202.1
ENST00000460885.1
PLSCR4
phospholipid scramblase 4
chr9_-_112970436 4.75 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr8_-_133637624 3.95 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr5_+_121465207 3.69 ENST00000296600.4
ZNF474
zinc finger protein 474
chr19_-_41388657 3.48 ENST00000301146.4
ENST00000291764.3
CYP2A7
cytochrome P450, family 2, subfamily A, polypeptide 7
chr11_+_17316870 3.41 ENST00000458064.2
NUCB2
nucleobindin 2
chr1_-_146696901 3.31 ENST00000369272.3
ENST00000441068.2
FMO5
flavin containing monooxygenase 5
chr22_-_30866564 3.21 ENST00000435069.1
ENST00000415957.2
ENST00000540910.1
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr3_-_167371740 2.63 ENST00000466760.1
ENST00000479765.1
WDR49
WD repeat domain 49
chr17_+_53344945 2.53 ENST00000575345.1
HLF
hepatic leukemia factor
chr10_-_50122277 2.53 ENST00000374160.3
LRRC18
leucine rich repeat containing 18
chr6_-_87804815 2.37 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr15_+_71185148 2.31 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr12_+_12202774 2.30 ENST00000589718.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr12_+_12202785 2.28 ENST00000586576.1
ENST00000464885.2
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr15_-_48470544 2.18 ENST00000267836.6
MYEF2
myelin expression factor 2
chr3_-_45883558 1.99 ENST00000445698.1
ENST00000296135.6
LZTFL1
leucine zipper transcription factor-like 1
chr5_+_140165876 1.87 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
PCDHA1
protocadherin alpha 1
chr2_-_237416181 1.86 ENST00000409907.3
IQCA1
IQ motif containing with AAA domain 1
chr2_-_237416071 1.85 ENST00000309507.5
ENST00000431676.2
IQCA1
IQ motif containing with AAA domain 1
chr1_+_171060018 1.82 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
FMO3
flavin containing monooxygenase 3
chr11_-_33891362 1.82 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr15_-_40401062 1.82 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
BMF
Bcl2 modifying factor
chr11_-_73689037 1.76 ENST00000544615.1
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr14_-_76447494 1.67 ENST00000238682.3
TGFB3
transforming growth factor, beta 3
chr4_+_189060573 1.55 ENST00000332517.3
TRIML1
tripartite motif family-like 1
chr8_-_38008783 1.43 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr17_-_40346477 1.37 ENST00000593209.1
ENST00000587427.1
ENST00000588352.1
ENST00000414034.3
ENST00000590249.1
GHDC
GH3 domain containing
chr19_-_14316980 1.34 ENST00000361434.3
ENST00000340736.6
LPHN1
latrophilin 1
chr9_-_13175823 1.32 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr9_-_139293249 1.31 ENST00000298532.2
SNAPC4
small nuclear RNA activating complex, polypeptide 4, 190kDa
chr1_+_109102652 1.27 ENST00000370035.3
ENST00000405454.1
FAM102B
family with sequence similarity 102, member B
chr15_-_48470558 1.26 ENST00000324324.7
MYEF2
myelin expression factor 2
chr7_+_17338239 1.25 ENST00000242057.4
AHR
aryl hydrocarbon receptor
chr12_+_55248289 1.23 ENST00000308796.6
MUCL1
mucin-like 1
chr14_-_102701740 1.21 ENST00000561150.1
ENST00000522867.1
MOK
MOK protein kinase
chr3_+_108541545 1.19 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr15_+_41057818 1.17 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr2_+_27805880 1.16 ENST00000379717.1
ENST00000355467.4
ENST00000556601.1
ENST00000416005.2
ZNF512
zinc finger protein 512
chr7_-_25702669 1.16 ENST00000446840.1
AC003090.1
AC003090.1
chr12_-_12837423 1.16 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr7_+_35756186 1.15 ENST00000430518.1
AC018647.3
AC018647.3
chrX_-_101694853 1.14 ENST00000372749.1
NXF2B
nuclear RNA export factor 2B
chr2_-_157189180 1.14 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr3_+_108541608 1.13 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr6_+_44310421 1.13 ENST00000288390.2
SPATS1
spermatogenesis associated, serine-rich 1
chr6_+_44310376 1.13 ENST00000515220.1
ENST00000323108.8
SPATS1
spermatogenesis associated, serine-rich 1
chrX_+_101502170 1.12 ENST00000372757.1
NXF2
nuclear RNA export factor 2
chrX_+_129473916 1.10 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr15_-_37391507 1.07 ENST00000557796.2
ENST00000397620.2
MEIS2
Meis homeobox 2
chr8_+_42552533 1.06 ENST00000289957.2
CHRNB3
cholinergic receptor, nicotinic, beta 3 (neuronal)
chr15_-_37392086 1.05 ENST00000561208.1
MEIS2
Meis homeobox 2
chr2_+_97779233 1.04 ENST00000461153.2
ENST00000420699.2
ANKRD36
ankyrin repeat domain 36
chr2_+_55746722 1.01 ENST00000339012.3
CCDC104
coiled-coil domain containing 104
chr1_+_172422026 1.01 ENST00000367725.4
C1orf105
chromosome 1 open reading frame 105
chr12_+_124457746 1.00 ENST00000392404.3
ENST00000538932.2
ENST00000337815.4
ENST00000540762.2
ZNF664
FAM101A
zinc finger protein 664
family with sequence similarity 101, member A
chr2_+_55746746 0.97 ENST00000406691.3
ENST00000349456.4
ENST00000407816.3
ENST00000403007.3
CCDC104
coiled-coil domain containing 104
chr12_+_41831485 0.93 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr14_-_25479811 0.92 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr6_-_154831779 0.86 ENST00000607772.1
CNKSR3
CNKSR family member 3
chr12_-_8218997 0.81 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr11_+_65266507 0.81 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr12_-_39734783 0.80 ENST00000552961.1
KIF21A
kinesin family member 21A
chrX_-_10588459 0.74 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr12_+_7169887 0.74 ENST00000542978.1
C1S
complement component 1, s subcomponent
chr12_-_81763127 0.73 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chrX_-_10588595 0.71 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr12_-_86650045 0.70 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr9_+_82186872 0.70 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_248031277 0.65 ENST00000537741.1
OR2W3
olfactory receptor, family 2, subfamily W, member 3
chr19_+_17403413 0.64 ENST00000595444.1
ENST00000600434.1
MRPL34
mitochondrial ribosomal protein L34
chrX_+_102883620 0.64 ENST00000372626.3
TCEAL1
transcription elongation factor A (SII)-like 1
chr12_-_15038779 0.64 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr1_-_98386543 0.63 ENST00000423006.2
ENST00000370192.3
ENST00000306031.5
DPYD
dihydropyrimidine dehydrogenase
chr3_-_119379427 0.63 ENST00000264231.3
ENST00000468801.1
ENST00000538678.1
POPDC2
popeye domain containing 2
chr10_-_49459800 0.61 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr12_-_81763184 0.59 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr16_-_3930724 0.59 ENST00000262367.5
CREBBP
CREB binding protein
chr20_+_15177480 0.58 ENST00000402914.1
MACROD2
MACRO domain containing 2
chr5_+_102201509 0.57 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr8_-_114449112 0.57 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chr3_-_193272874 0.57 ENST00000342695.4
ATP13A4
ATPase type 13A4
chr5_+_64920543 0.57 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr17_-_37308824 0.56 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
PLXDC1
plexin domain containing 1
chr16_+_71879861 0.55 ENST00000427980.2
ENST00000568581.1
ATXN1L
IST1
ataxin 1-like
increased sodium tolerance 1 homolog (yeast)
chr9_+_134378289 0.54 ENST00000423007.1
ENST00000404875.2
ENST00000441334.1
ENST00000341012.7
ENST00000372228.3
ENST00000402686.3
ENST00000419118.2
ENST00000541219.1
ENST00000354713.4
ENST00000418774.1
ENST00000415075.1
ENST00000448212.1
ENST00000430619.1
POMT1
protein-O-mannosyltransferase 1
chrX_+_15525426 0.54 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr16_-_73093597 0.52 ENST00000397992.5
ZFHX3
zinc finger homeobox 3
chr7_-_112726393 0.51 ENST00000449591.1
ENST00000449735.1
ENST00000438062.1
ENST00000424100.1
GPR85
G protein-coupled receptor 85
chr14_-_76447336 0.51 ENST00000556285.1
TGFB3
transforming growth factor, beta 3
chr5_+_102201722 0.50 ENST00000274392.9
ENST00000455264.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr5_+_56471592 0.50 ENST00000511209.1
GPBP1
GC-rich promoter binding protein 1
chr19_-_47735918 0.49 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr14_+_64680854 0.48 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chr17_-_43138357 0.48 ENST00000342350.5
DCAKD
dephospho-CoA kinase domain containing
chr5_-_158526693 0.48 ENST00000380654.4
EBF1
early B-cell factor 1
chr5_-_115910091 0.46 ENST00000257414.8
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr11_+_60989688 0.46 ENST00000378149.3
ENST00000422676.2
PGA4
pepsinogen 4, group I (pepsinogen A)
chr22_+_29138013 0.45 ENST00000216027.3
ENST00000398941.2
HSCB
HscB mitochondrial iron-sulfur cluster co-chaperone
chr4_+_129349188 0.45 ENST00000511497.1
RP11-420A23.1
RP11-420A23.1
chr8_-_27115931 0.45 ENST00000523048.1
STMN4
stathmin-like 4
chr5_+_125695805 0.45 ENST00000513040.1
GRAMD3
GRAM domain containing 3
chr12_-_371994 0.44 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr14_+_24584508 0.44 ENST00000559354.1
ENST00000560459.1
ENST00000559593.1
ENST00000396941.4
ENST00000396936.1
DCAF11
DDB1 and CUL4 associated factor 11
chr3_+_4344988 0.44 ENST00000358065.4
SETMAR
SET domain and mariner transposase fusion gene
chr19_-_35981358 0.44 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr3_-_193272741 0.42 ENST00000392443.3
ATP13A4
ATPase type 13A4
chr14_-_24551195 0.42 ENST00000560550.1
NRL
neural retina leucine zipper
chr6_+_27215494 0.42 ENST00000230582.3
PRSS16
protease, serine, 16 (thymus)
chr6_-_22297730 0.42 ENST00000306482.1
PRL
prolactin
chr6_+_69942298 0.41 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr12_-_16758059 0.41 ENST00000261169.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_27215471 0.41 ENST00000421826.2
PRSS16
protease, serine, 16 (thymus)
chr22_-_31688381 0.41 ENST00000487265.2
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr14_+_73563735 0.40 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr5_-_160973649 0.40 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr14_+_22458631 0.40 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr2_-_56150910 0.40 ENST00000424836.2
ENST00000438672.1
ENST00000440439.1
ENST00000429909.1
ENST00000424207.1
ENST00000452337.1
ENST00000355426.3
ENST00000439193.1
ENST00000421664.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr1_-_92949505 0.40 ENST00000370332.1
GFI1
growth factor independent 1 transcription repressor
chr6_+_89674246 0.39 ENST00000369474.1
AL079342.1
Uncharacterized protein; cDNA FLJ27030 fis, clone SLV07741
chr19_-_17014408 0.39 ENST00000594249.1
CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr20_+_32782375 0.38 ENST00000568305.1
ASIP
agouti signaling protein
chr12_-_16758304 0.38 ENST00000320122.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_53836339 0.38 ENST00000549135.1
PRR13
proline rich 13
chr5_+_102201430 0.38 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr14_-_24551137 0.36 ENST00000396995.1
NRL
neural retina leucine zipper
chr19_+_15121532 0.36 ENST00000292574.3
CCDC105
coiled-coil domain containing 105
chrX_+_66764375 0.36 ENST00000374690.3
AR
androgen receptor
chr6_-_31514516 0.36 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr13_+_60971080 0.35 ENST00000377894.2
TDRD3
tudor domain containing 3
chr7_+_44040488 0.34 ENST00000258704.3
SPDYE1
speedy/RINGO cell cycle regulator family member E1
chr13_+_108870714 0.34 ENST00000375898.3
ABHD13
abhydrolase domain containing 13
chr8_+_134203303 0.33 ENST00000519433.1
ENST00000517423.1
ENST00000377863.2
ENST00000220856.6
WISP1
WNT1 inducible signaling pathway protein 1
chr16_-_50402836 0.33 ENST00000394688.3
BRD7
bromodomain containing 7
chr3_-_112738565 0.32 ENST00000383675.2
ENST00000314400.5
C3orf17
chromosome 3 open reading frame 17
chr9_+_39355699 0.32 ENST00000377647.3
SPATA31A1
SPATA31 subfamily A, member 1
chr3_+_148583043 0.32 ENST00000296046.3
CPA3
carboxypeptidase A3 (mast cell)
chr17_+_56160768 0.31 ENST00000579991.2
DYNLL2
dynein, light chain, LC8-type 2
chr12_+_53835539 0.31 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13
proline rich 13
chr6_-_52859968 0.30 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr16_-_90096309 0.30 ENST00000408886.2
C16orf3
chromosome 16 open reading frame 3
chr3_+_152552685 0.30 ENST00000305097.3
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr1_+_47901689 0.30 ENST00000334793.5
FOXD2
forkhead box D2
chr8_-_17942432 0.30 ENST00000381733.4
ENST00000314146.10
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr22_-_31688431 0.30 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr20_-_30310336 0.29 ENST00000434194.1
ENST00000376062.2
BCL2L1
BCL2-like 1
chr7_+_97361388 0.29 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr11_-_5207612 0.27 ENST00000380367.1
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr3_-_38992052 0.27 ENST00000302328.3
ENST00000450244.1
ENST00000444237.2
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr19_+_22235310 0.27 ENST00000600162.1
ZNF257
zinc finger protein 257
chr16_-_71758602 0.27 ENST00000568954.1
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr7_-_8302164 0.26 ENST00000447326.1
ENST00000406470.2
ICA1
islet cell autoantigen 1, 69kDa
chr13_+_27844464 0.25 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr11_+_47586982 0.25 ENST00000426530.2
ENST00000534775.1
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr12_-_57522813 0.24 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr16_+_31225337 0.24 ENST00000322122.3
TRIM72
tripartite motif containing 72
chrX_-_62974941 0.24 ENST00000374872.1
ENST00000253401.6
ENST00000374870.4
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr6_-_52860171 0.23 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chr11_+_22696314 0.23 ENST00000532398.1
ENST00000433790.1
GAS2
growth arrest-specific 2
chr2_-_231989808 0.23 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chrX_+_67718863 0.22 ENST00000374622.2
YIPF6
Yip1 domain family, member 6
chr3_-_184971853 0.22 ENST00000231887.3
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
chr9_+_82186682 0.22 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr15_-_79103757 0.21 ENST00000388820.4
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr16_+_10837643 0.21 ENST00000574334.1
ENST00000283027.5
ENST00000433392.2
NUBP1
nucleotide binding protein 1
chr3_-_194393206 0.20 ENST00000265245.5
LSG1
large 60S subunit nuclear export GTPase 1
chr15_-_51535208 0.20 ENST00000405913.3
ENST00000559878.1
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr4_-_99851766 0.20 ENST00000450253.2
EIF4E
eukaryotic translation initiation factor 4E
chr11_+_47587129 0.19 ENST00000326656.8
ENST00000326674.9
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr8_+_11351494 0.18 ENST00000259089.4
BLK
B lymphoid tyrosine kinase
chr14_-_75179774 0.18 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr5_+_140787600 0.17 ENST00000520790.1
PCDHGB6
protocadherin gamma subfamily B, 6
chr13_+_111855414 0.17 ENST00000375737.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr8_-_6420930 0.16 ENST00000325203.5
ANGPT2
angiopoietin 2
chr12_-_129570545 0.15 ENST00000389441.4
TMEM132D
transmembrane protein 132D
chr16_+_5083950 0.15 ENST00000588623.1
ALG1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr12_+_27863706 0.15 ENST00000081029.3
ENST00000538315.1
ENST00000542791.1
MRPS35
mitochondrial ribosomal protein S35
chr17_-_37309480 0.15 ENST00000539608.1
PLXDC1
plexin domain containing 1
chr12_+_57522439 0.15 ENST00000338962.4
LRP1
low density lipoprotein receptor-related protein 1
chr10_+_57358750 0.14 ENST00000512524.2
MTRNR2L5
MT-RNR2-like 5
chr1_-_208084729 0.13 ENST00000310833.7
ENST00000356522.4
CD34
CD34 molecule
chr12_-_95945246 0.13 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr17_+_55173933 0.13 ENST00000539273.1
AKAP1
A kinase (PRKA) anchor protein 1
chr5_+_118965244 0.13 ENST00000515256.1
ENST00000509264.1
FAM170A
family with sequence similarity 170, member A
chr19_-_36391434 0.12 ENST00000396901.1
ENST00000585925.1
NFKBID
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr16_-_27899478 0.12 ENST00000380897.3
GSG1L
GSG1-like
chr1_+_160160283 0.12 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_-_1629176 0.11 ENST00000366424.2
AC144450.2
AC144450.2
chr19_-_53324884 0.11 ENST00000457749.2
ENST00000414252.2
ENST00000391783.2
ZNF28
zinc finger protein 28
chr11_-_18656028 0.10 ENST00000336349.5
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr12_-_76879852 0.10 ENST00000548341.1
OSBPL8
oxysterol binding protein-like 8
chr19_+_36630454 0.10 ENST00000246533.3
CAPNS1
calpain, small subunit 1
chr10_+_106034884 0.09 ENST00000369707.2
ENST00000429569.2
GSTO2
glutathione S-transferase omega 2
chr2_+_36923830 0.09 ENST00000379242.3
ENST00000389975.3
VIT
vitrin

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0042704 detection of oxygen(GO:0003032) uterine wall breakdown(GO:0042704)
0.7 2.0 GO:1903565 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.5 10.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.5 1.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.4 1.2 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.4 1.1 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.4 1.5 GO:0018032 protein amidation(GO:0018032)
0.4 4.0 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.3 1.3 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.3 2.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 0.6 GO:0046104 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) beta-alanine metabolic process(GO:0019482) thymine metabolic process(GO:0019859) uracil metabolic process(GO:0019860) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 0.4 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 0.6 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 3.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.4 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 5.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 1.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 0.4 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599)
0.1 0.5 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.1 0.5 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.1 1.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.3 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.1 0.6 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 1.8 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 0.5 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.9 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 1.8 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.6 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 0.2 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.1 0.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.2 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 0.3 GO:0060406 positive regulation of penile erection(GO:0060406)
0.1 0.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.5 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 1.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 2.4 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.3 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.4 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.4 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0071655 glial cell-derived neurotrophic factor secretion(GO:0044467) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.1 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.1 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.4 GO:0008343 adult feeding behavior(GO:0008343)
0.0 2.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.9 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.1 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 1.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 1.3 GO:0014047 glutamate secretion(GO:0014047)
0.0 2.8 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.4 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.5 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.6 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 1.6 GO:0031016 pancreas development(GO:0031016)
0.0 0.4 GO:0001502 cartilage condensation(GO:0001502)
0.0 1.9 GO:0014902 myotube differentiation(GO:0014902)
0.0 1.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.0 GO:0045796 negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.0 0.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.0 GO:0009060 aerobic respiration(GO:0009060)
0.0 1.2 GO:0007631 feeding behavior(GO:0007631)
0.0 0.0 GO:1903517 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.0 0.0 GO:2000360 negative regulation of binding of sperm to zona pellucida(GO:2000360)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.2 1.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 2.3 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.4 GO:0031904 endosome lumen(GO:0031904)
0.0 2.4 GO:0030315 T-tubule(GO:0030315)
0.0 0.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.2 GO:0097546 ciliary base(GO:0097546)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.4 GO:0042599 lamellar body(GO:0042599)
0.0 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 0.4 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 2.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332) chromatoid body(GO:0033391)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.8 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.6 5.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.6 10.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.5 2.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.4 1.2 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.4 1.5 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.3 1.2 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.3 1.8 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 0.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 0.6 GO:0090541 MIT domain binding(GO:0090541)
0.2 3.5 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.4 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 0.5 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.1 2.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.3 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 0.6 GO:0043426 MRF binding(GO:0043426)
0.1 0.4 GO:0004882 androgen receptor activity(GO:0004882)
0.1 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.8 GO:0004875 complement receptor activity(GO:0004875)
0.1 0.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 0.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.4 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 1.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 3.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 1.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) aromatase activity(GO:0070330)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0043199 sulfate binding(GO:0043199)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 1.5 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 2.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 2.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 4.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.4 ST ADRENERGIC Adrenergic Pathway
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 2.4 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 2.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 2.3 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.8 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.2 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling