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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MECP2
Z-value: 1.83
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Transcription factors associated with MECP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECP2 | hg19_v2_chrX_-_153363125_153363182 | 0.24 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_33877654 Show fit | 7.12 |
ENST00000257209.4
ENST00000445677.1 ENST00000590592.1 ENST00000359247.4 |
formin homology 2 domain containing 3 |
|
| chr19_-_51471362 Show fit | 7.12 |
ENST00000376853.4
ENST00000424910.2 |
kallikrein-related peptidase 6 |
|
| chr19_-_51471381 Show fit | 6.84 |
ENST00000594641.1
|
kallikrein-related peptidase 6 |
|
| chr13_-_20806440 Show fit | 5.77 |
ENST00000400066.3
ENST00000400065.3 ENST00000356192.6 |
gap junction protein, beta 6, 30kDa |
|
| chr19_-_51472222 Show fit | 5.64 |
ENST00000376851.3
|
kallikrein-related peptidase 6 |
|
| chr1_-_17307173 Show fit | 5.48 |
ENST00000438542.1
ENST00000375535.3 |
microfibrillar-associated protein 2 |
|
| chr19_-_51472031 Show fit | 5.26 |
ENST00000391808.1
|
kallikrein-related peptidase 6 |
|
| chr17_+_70117153 Show fit | 5.16 |
ENST00000245479.2
|
SRY (sex determining region Y)-box 9 |
|
| chr21_-_44496441 Show fit | 5.10 |
ENST00000359624.3
ENST00000352178.5 |
cystathionine-beta-synthase |
|
| chr1_+_150522222 Show fit | 4.89 |
ENST00000369039.5
|
ADAMTS-like 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 29.7 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 11.7 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.4 | 11.4 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.2 | 11.1 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 3.2 | 9.6 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.2 | 9.4 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 8.4 | GO:0007264 | small GTPase mediated signal transduction(GO:0007264) |
| 0.5 | 8.2 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.3 | 8.1 | GO:0034380 | high-density lipoprotein particle assembly(GO:0034380) |
| 1.3 | 7.9 | GO:0030421 | defecation(GO:0030421) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 63.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 49.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 17.4 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 16.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 14.8 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.6 | 14.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.7 | 12.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 10.8 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.1 | 10.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 10.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 48.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 18.4 | GO:0002020 | protease binding(GO:0002020) |
| 0.2 | 15.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 15.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 14.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 13.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 12.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 11.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.7 | 11.7 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.2 | 10.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 47.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 32.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 18.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 18.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 14.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 12.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.4 | 10.8 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 10.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 10.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 10.2 | PID CDC42 PATHWAY | CDC42 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 24.2 | REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | Genes involved in Class I MHC mediated antigen processing & presentation |
| 0.3 | 17.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 16.8 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.2 | 16.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.7 | 11.7 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.3 | 11.1 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.3 | 9.5 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.2 | 9.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.4 | 8.7 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |