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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MEIS2
Z-value: 1.18
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Transcription factors associated with MEIS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEIS2 | hg19_v2_chr15_-_37391614_37391683 | -0.05 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_65769392 Show fit | 6.60 |
ENST00000555736.1
|
CTD-2509G16.5 |
|
| chr1_+_78956651 Show fit | 5.26 |
ENST00000370757.3
ENST00000370756.3 |
prostaglandin F receptor (FP) |
|
| chr19_-_9092018 Show fit | 5.07 |
ENST00000397910.4
|
mucin 16, cell surface associated |
|
| chr6_+_32407619 Show fit | 4.85 |
ENST00000395388.2
ENST00000374982.5 |
major histocompatibility complex, class II, DR alpha |
|
| chr1_-_152131703 Show fit | 4.77 |
ENST00000316073.3
|
repetin |
|
| chr3_+_13610216 Show fit | 4.75 |
ENST00000492059.1
|
fibulin 2 |
|
| chr3_+_63638339 Show fit | 4.60 |
ENST00000343837.3
ENST00000469440.1 |
sentan, cilia apical structure protein |
|
| chr6_-_32498046 Show fit | 4.29 |
ENST00000374975.3
|
major histocompatibility complex, class II, DR beta 5 |
|
| chr5_-_35938674 Show fit | 4.27 |
ENST00000397366.1
ENST00000513623.1 ENST00000514524.1 ENST00000397367.2 |
calcyphosine-like |
|
| chr4_+_69962185 Show fit | 4.10 |
ENST00000305231.7
|
UDP glucuronosyltransferase 2 family, polypeptide B7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.1 | 10.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 10.1 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.8 | 9.2 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.4 | 8.7 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 8.1 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.2 | 6.6 | GO:0090383 | phagosome acidification(GO:0090383) |
| 1.6 | 6.3 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.1 | 6.1 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.1 | 5.5 | GO:0050912 | detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 23.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 16.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 15.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 6.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 5.1 | GO:0030286 | dynein complex(GO:0030286) |
| 0.3 | 4.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.4 | 4.6 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.3 | 4.1 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 4.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 3.8 | GO:0036126 | sperm flagellum(GO:0036126) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 10.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.3 | 10.0 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 2.3 | 9.0 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.2 | 8.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.3 | 7.0 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 6.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 5.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 5.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.3 | 5.4 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 1.7 | 5.2 | GO:0004958 | prostaglandin F receptor activity(GO:0004958) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.5 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.1 | 5.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 4.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 2.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 2.0 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 2.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 16.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 14.1 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 9.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.4 | 9.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 6.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 6.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.5 | 5.7 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.2 | 5.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 5.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |