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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MESP1
Z-value: 1.10
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Transcription factors associated with MESP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MESP1 | hg19_v2_chr15_-_90294523_90294541 | -0.20 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MESP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 13.5 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 1.3 | 6.7 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.5 | 6.0 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.5 | 5.2 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 4.1 | GO:0007602 | phototransduction(GO:0007602) |
| 0.3 | 3.8 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.5 | 3.7 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.1 | 3.7 | GO:0060972 | left/right pattern formation(GO:0060972) |
| 0.3 | 3.6 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.2 | 3.0 | GO:0070327 | thyroid hormone transport(GO:0070327) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 13.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 5.3 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.1 | 4.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 4.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.7 | 3.7 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 3.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 3.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 2.3 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 2.2 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 2.1 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.4 | GO:0042805 | actinin binding(GO:0042805) |
| 1.5 | 6.0 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 4.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 3.5 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.7 | 3.0 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.0 | 2.9 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.4 | 2.7 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 0.2 | 2.6 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 2.6 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 2.4 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 2.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 1.2 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 1.2 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.1 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 1.0 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 2.7 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 2.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 2.3 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 2.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.1 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 2.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.9 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 1.8 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 1.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |