Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for MIXL1_GSX1_BSX_MEOX2_LHX4
Z-value: 0.67
Motif logo
Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000185155.7 | Mix paired-like homeobox | |
| ENSG00000169840.4 | GS homeobox 1 | |
| ENSG00000188909.4 | brain specific homeobox | |
| ENSG00000106511.5 | mesenchyme homeobox 2 | |
| ENSG00000121454.4 | LIM homeobox 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX4 | hg19_v2_chr1_+_180199393_180199426 | 0.39 | 3.3e-02 | Click! |
| MEOX2 | hg19_v2_chr7_-_15726296_15726437 | 0.15 | 4.1e-01 | Click! |
| MIXL1 | hg19_v2_chr1_+_226411319_226411366 | 0.02 | 9.1e-01 | Click! |
| GSX1 | hg19_v2_chr13_+_28366780_28366780 | -0.02 | 9.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_152386732 Show fit | 5.99 |
ENST00000271835.3
|
cornulin |
|
| chr4_+_69313145 Show fit | 3.75 |
ENST00000305363.4
|
transmembrane protease, serine 11E |
|
| chr4_-_69111401 Show fit | 2.17 |
ENST00000332644.5
|
transmembrane protease, serine 11B |
|
| chr10_+_17270214 Show fit | 2.09 |
ENST00000544301.1
|
vimentin |
|
| chr17_-_38859996 Show fit | 2.04 |
ENST00000264651.2
|
keratin 24 |
|
| chr1_+_62439037 Show fit | 1.81 |
ENST00000545929.1
|
InaD-like (Drosophila) |
|
| chr12_+_107712173 Show fit | 1.62 |
ENST00000280758.5
ENST00000420571.2 |
BTB (POZ) domain containing 11 |
|
| chr16_-_30122717 Show fit | 1.58 |
ENST00000566613.1
|
glycerophosphodiester phosphodiesterase domain containing 3 |
|
| chr11_+_33061543 Show fit | 1.45 |
ENST00000432887.1
ENST00000528898.1 ENST00000531632.2 |
t-complex 11, testis-specific-like 1 |
|
| chr11_-_121986923 Show fit | 1.39 |
ENST00000560104.1
|
BH3-like motif containing, cell death inducer |
Network of associatons between targets according to the STRING database.
First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 5.2 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 4.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 2.1 | GO:0060020 | Bergmann glial cell differentiation(GO:0060020) |
| 0.1 | 1.7 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.3 | 1.6 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.0 | 1.6 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.1 | 1.5 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.2 | 1.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 1.4 | GO:0003334 | keratinocyte development(GO:0003334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 3.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 2.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 1.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 1.6 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.0 | 1.5 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 1.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 1.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 1.2 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 1.1 | GO:0005828 | kinetochore microtubule(GO:0005828) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 3.0 | GO:0005549 | odorant binding(GO:0005549) |
| 0.3 | 2.3 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 2.2 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 2.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 2.0 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 2.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.8 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 1.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 1.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 3.0 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 2.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.2 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 3.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 1.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 1.5 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 1.3 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 1.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |