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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MLXIPL
Z-value: 1.28
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Transcription factors associated with MLXIPL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLXIPL | hg19_v2_chr7_-_73038822_73038862, hg19_v2_chr7_-_73038867_73038878 | 0.24 | 2.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLXIPL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.5 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.2 | 5.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 4.2 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.1 | 4.0 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.1 | 3.4 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 3.3 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 2.9 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.7 | 2.8 | GO:0003095 | pressure natriuresis(GO:0003095) |
| 0.5 | 2.8 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.2 | 2.8 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.9 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 4.5 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 4.5 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.0 | 4.3 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 3.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.2 | 3.2 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 3.2 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 2.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 2.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.4 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 3.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 3.6 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.0 | 3.5 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 3.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 3.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.2 | 3.0 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 2.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 2.9 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 8.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 5.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 4.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 3.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 3.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.2 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 3.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 3.0 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 5.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 4.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 4.4 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 3.5 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 3.2 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 3.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.0 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 3.0 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.2 | 2.9 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |