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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MLX_USF2_USF1_PAX2
Z-value: 0.79
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Transcription factors associated with MLX_USF2_USF1_PAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000108788.7 | MAX dimerization protein MLX | |
| ENSG00000105698.11 | upstream transcription factor 2, c-fos interacting | |
| ENSG00000158773.10 | upstream transcription factor 1 | |
| ENSG00000075891.17 | paired box 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLX | hg19_v2_chr17_+_40719073_40719092 | -0.45 | 1.3e-02 | Click! |
| USF1 | hg19_v2_chr1_-_161014731_161014788, hg19_v2_chr1_-_161015752_161015778 | 0.09 | 6.3e-01 | Click! |
| PAX2 | hg19_v2_chr10_+_102505468_102505546 | -0.08 | 6.9e-01 | Click! |
| USF2 | hg19_v2_chr19_+_35759824_35759891 | -0.05 | 8.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.1 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 1.5 | 7.5 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.7 | 6.5 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.5 | 4.6 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.2 | 4.1 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
| 0.1 | 4.0 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.7 | 3.7 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.2 | 3.4 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.8 | 2.4 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.0 | 2.2 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.0 | GO:0036157 | outer dynein arm(GO:0036157) |
| 1.0 | 5.9 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 4.8 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.7 | 4.7 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 3.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 3.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 3.3 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.1 | 3.1 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 3.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 3.1 | GO:0005929 | cilium(GO:0005929) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.3 | 6.0 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 5.2 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.6 | 4.6 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.4 | 4.6 | GO:0031419 | cobalamin binding(GO:0031419) |
| 1.4 | 4.1 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.2 | 3.9 | GO:0015250 | water channel activity(GO:0015250) |
| 0.2 | 3.2 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 3.2 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 3.1 | GO:0070840 | dynein complex binding(GO:0070840) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 5.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 4.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 4.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 3.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.9 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 1.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 3.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 3.0 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 2.9 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 2.5 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.2 | 2.3 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 2.0 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.9 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |