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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for MSX2

Z-value: 0.36

Motif logo

Transcription factors associated with MSX2

Gene Symbol Gene ID Gene Info
ENSG00000120149.7 msh homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX2hg19_v2_chr5_+_174151536_1741516100.096.4e-01Click!

Activity profile of MSX2 motif

Sorted Z-values of MSX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_120315074 0.84 ENST00000261833.7
ENST00000392521.2
citron (rho-interacting, serine/threonine kinase 21)
chr20_-_54967187 0.75 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
aurora kinase A
chr12_+_53662073 0.54 ENST00000553219.1
ENST00000257934.4
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr8_+_1993173 0.43 ENST00000523438.1
myomesin 2
chr8_+_1993152 0.43 ENST00000262113.4
myomesin 2
chr12_+_53662110 0.42 ENST00000552462.1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr17_-_38574169 0.39 ENST00000423485.1
topoisomerase (DNA) II alpha 170kDa
chr6_+_130339710 0.37 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr10_-_99447024 0.36 ENST00000370626.3
arginine vasopressin-induced 1
chr11_+_33061543 0.30 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
t-complex 11, testis-specific-like 1
chr1_-_197115818 0.30 ENST00000367409.4
ENST00000294732.7
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr2_-_55646957 0.25 ENST00000263630.8
coiled-coil domain containing 88A
chr19_-_47137942 0.25 ENST00000300873.4
guanine nucleotide binding protein (G protein), gamma 8
chr2_-_55647057 0.24 ENST00000436346.1
coiled-coil domain containing 88A
chr10_-_105110831 0.24 ENST00000337211.4
polycomb group ring finger 6
chr6_+_53948328 0.24 ENST00000370876.2
muscular LMNA-interacting protein
chr16_+_58783542 0.23 ENST00000500117.1
ENST00000565722.1
RP11-410D17.2
chr10_-_105110890 0.22 ENST00000369847.3
polycomb group ring finger 6
chr6_-_111927062 0.22 ENST00000359831.4
TRAF3 interacting protein 2
chr1_-_232651312 0.22 ENST00000262861.4
signal-induced proliferation-associated 1 like 2
chr12_+_9102632 0.22 ENST00000539240.1
killer cell lectin-like receptor subfamily G, member 1
chr2_-_89292422 0.20 ENST00000495489.1
immunoglobulin kappa variable 1-8
chr14_+_32798547 0.19 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr6_+_34204642 0.18 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr14_+_32798462 0.18 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr3_-_48672859 0.18 ENST00000395550.2
ENST00000455886.2
ENST00000431739.1
ENST00000426599.1
ENST00000383733.3
ENST00000420764.2
ENST00000337000.8
solute carrier family 26 (anion exchanger), member 6
chr9_+_80912059 0.18 ENST00000347159.2
ENST00000376588.3
phosphoserine aminotransferase 1
chr19_+_4007644 0.17 ENST00000262971.2
protein inhibitor of activated STAT, 4
chr3_-_120003941 0.16 ENST00000464295.1
G protein-coupled receptor 156
chr12_-_10022735 0.15 ENST00000228438.2
C-type lectin domain family 2, member B
chr1_-_47779762 0.15 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
SCL/TAL1 interrupting locus
chr1_-_68698222 0.15 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
wntless Wnt ligand secretion mediator
chr19_+_42817450 0.15 ENST00000301204.3
transmembrane protein 145
chr9_+_124329336 0.15 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2 interacting protein
chr19_+_41869894 0.14 ENST00000413014.2
transmembrane protein 91
chr6_-_111927449 0.14 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3 interacting protein 2
chr9_+_34646624 0.13 ENST00000450095.2
ENST00000556278.1
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr3_-_151034734 0.12 ENST00000260843.4
G protein-coupled receptor 87
chr15_-_37393406 0.12 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr8_-_12612962 0.12 ENST00000398246.3
LON peptidase N-terminal domain and ring finger 1
chr5_+_95998070 0.12 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
calpastatin
chr4_-_69536346 0.12 ENST00000338206.5
UDP glucuronosyltransferase 2 family, polypeptide B15
chr17_+_74261277 0.11 ENST00000327490.6
UBA-like domain containing 2
chr10_-_99205607 0.11 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
exosome component 1
chr20_+_54967409 0.11 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr19_-_19249255 0.11 ENST00000587583.2
ENST00000450333.2
ENST00000587096.1
ENST00000162044.9
ENST00000592369.1
ENST00000587915.1
transmembrane protein 161A
chr1_-_94050668 0.11 ENST00000539242.1
breast cancer anti-estrogen resistance 3
chr1_-_68698197 0.10 ENST00000370973.2
ENST00000370971.1
wntless Wnt ligand secretion mediator
chr7_+_99717230 0.10 ENST00000262932.3
canopy FGF signaling regulator 4
chr19_-_41985048 0.10 ENST00000599801.1
ENST00000595063.1
ENST00000598215.1
AC011526.1
chr6_+_25652432 0.10 ENST00000377961.2
secretagogin, EF-hand calcium binding protein
chr12_+_28410128 0.09 ENST00000381259.1
ENST00000381256.1
coiled-coil domain containing 91
chr9_+_34646651 0.09 ENST00000378842.3
galactose-1-phosphate uridylyltransferase
chr16_-_29934558 0.09 ENST00000568995.1
ENST00000566413.1
potassium channel tetramerization domain containing 13
chr6_+_160183492 0.09 ENST00000541436.1
acetyl-CoA acetyltransferase 2
chr15_+_41245160 0.09 ENST00000444189.2
ENST00000446533.3
ChaC, cation transport regulator homolog 1 (E. coli)
chr8_+_38831683 0.09 ENST00000302495.4
HtrA serine peptidase 4
chrX_+_89176881 0.09 ENST00000283891.5
ENST00000561129.2
TGFB-induced factor homeobox 2-like, X-linked
chr2_+_187371440 0.08 ENST00000445547.1
zinc finger CCCH-type containing 15
chr7_+_134331550 0.08 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
2,3-bisphosphoglycerate mutase
chr4_+_71587669 0.07 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr5_+_150639360 0.07 ENST00000523004.1
GM2 ganglioside activator
chr12_-_9102549 0.07 ENST00000000412.3
mannose-6-phosphate receptor (cation dependent)
chr6_+_25652501 0.07 ENST00000334979.6
secretagogin, EF-hand calcium binding protein
chr1_-_228613026 0.07 ENST00000366696.1
histone cluster 3, H3
chr1_+_151735431 0.07 ENST00000321531.5
ENST00000315067.8
ornithine decarboxylase antizyme 3
chr10_-_56560939 0.07 ENST00000373955.1
protocadherin-related 15
chr3_+_140396881 0.07 ENST00000286349.3
tripartite motif containing 42
chr3_-_112127981 0.06 ENST00000486726.2
RP11-231E6.1
chr11_-_13517565 0.06 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr21_-_32253874 0.06 ENST00000332378.4
keratin associated protein 11-1
chr3_+_113251143 0.06 ENST00000264852.4
ENST00000393830.3
SID1 transmembrane family, member 1
chr1_-_190446759 0.06 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr10_-_56561022 0.06 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
protocadherin-related 15
chr2_+_90248739 0.06 ENST00000468879.1
immunoglobulin kappa variable 1D-43
chr17_-_48785216 0.06 ENST00000285243.6
ankyrin repeat domain 40
chr18_-_48346298 0.06 ENST00000398439.3
maestro
chr5_+_140797296 0.05 ENST00000398594.2
protocadherin gamma subfamily B, 7
chr3_+_147795932 0.05 ENST00000490465.1
RP11-639B1.1
chr8_+_9413410 0.05 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr5_-_31532160 0.05 ENST00000511367.2
ENST00000513349.1
drosha, ribonuclease type III
chr4_-_46126093 0.05 ENST00000295452.4
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr17_+_74261413 0.05 ENST00000587913.1
UBA-like domain containing 2
chr7_-_100183742 0.05 ENST00000310300.6
leucine-rich repeats and calponin homology (CH) domain containing 4
chr21_-_22175341 0.05 ENST00000416768.1
ENST00000452561.1
ENST00000419299.1
ENST00000437238.1
long intergenic non-protein coding RNA 320
chr17_-_10372875 0.04 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr4_-_69434245 0.04 ENST00000317746.2
UDP glucuronosyltransferase 2 family, polypeptide B17
chr1_-_151431909 0.04 ENST00000361398.3
ENST00000271715.2
pogo transposable element with ZNF domain
chr20_+_56964169 0.04 ENST00000475243.1
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr10_+_85954377 0.04 ENST00000332904.3
ENST00000372117.3
cadherin-related family member 1
chr5_-_148758839 0.04 ENST00000261796.3
interleukin 17B
chrX_+_113818545 0.04 ENST00000371951.1
ENST00000276198.1
ENST00000371950.3
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
chr22_-_30960876 0.04 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
galactose-3-O-sulfotransferase 1
chr12_-_95397442 0.04 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr10_+_99205894 0.03 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
zinc finger, DHHC-type containing 16
chr14_+_22670455 0.03 ENST00000390460.1
T cell receptor alpha variable 26-2
chr3_-_141747950 0.03 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_-_99716952 0.03 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr16_+_69345243 0.03 ENST00000254950.11
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr1_-_151965048 0.03 ENST00000368809.1
S100 calcium binding protein A10
chr7_-_56174161 0.03 ENST00000395422.3
coiled-coil-helix-coiled-coil-helix domain containing 2
chr10_+_99205959 0.03 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
zinc finger, DHHC-type containing 16
chr18_-_44181442 0.03 ENST00000398722.4
lipoxygenase homology domains 1
chr22_+_17956618 0.03 ENST00000262608.8
cat eye syndrome chromosome region, candidate 2
chr20_-_50418947 0.03 ENST00000371539.3
spalt-like transcription factor 4
chr11_-_71823266 0.02 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
anaphase promoting complex subunit 15
chr5_+_66254698 0.02 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
microtubule associated serine/threonine kinase family member 4
chr5_+_95997918 0.02 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
calpastatin
chr14_-_23504337 0.02 ENST00000361611.6
proteasome (prosome, macropain) subunit, beta type, 5
chr18_+_5748793 0.02 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1
chr1_-_151431647 0.02 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
pogo transposable element with ZNF domain
chr5_+_31532373 0.02 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
chromosome 5 open reading frame 22
chr11_-_102323740 0.02 ENST00000398136.2
transmembrane protein 123
chr1_-_21377383 0.02 ENST00000374935.3
eukaryotic translation initiation factor 4 gamma, 3
chr14_-_23504432 0.02 ENST00000425762.2
proteasome (prosome, macropain) subunit, beta type, 5
chr20_-_50418972 0.02 ENST00000395997.3
spalt-like transcription factor 4
chr10_-_28571015 0.02 ENST00000375719.3
ENST00000375732.1
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr19_+_17378159 0.02 ENST00000598188.1
ENST00000359435.4
ENST00000599474.1
ENST00000599057.1
ENST00000601043.1
ENST00000447614.2
BRISC and BRCA1 A complex member 1
chr14_+_39736582 0.02 ENST00000556148.1
ENST00000348007.3
CTAGE family, member 5
chr9_-_95056010 0.01 ENST00000443024.2
isoleucyl-tRNA synthetase
chr10_-_72142345 0.01 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
leucine rich repeat containing 20
chr11_+_67250490 0.01 ENST00000528641.2
ENST00000279146.3
aryl hydrocarbon receptor interacting protein
chr7_+_100183927 0.01 ENST00000241071.6
ENST00000360609.2
F-box protein 24
chr9_-_4666421 0.01 ENST00000381895.5
spermatogenesis associated 6-like
chr19_-_46088068 0.01 ENST00000263275.4
ENST00000323060.3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr12_+_52695617 0.01 ENST00000293525.5
keratin 86
chr7_-_25268104 0.01 ENST00000222674.2
neuropeptide VF precursor
chr19_+_17378278 0.01 ENST00000596335.1
ENST00000601436.1
ENST00000595632.1
BRISC and BRCA1 A complex member 1
chr5_+_140557371 0.01 ENST00000239444.2
protocadherin beta 8
chr11_-_71823796 0.00 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
anaphase promoting complex subunit 15
chr19_-_10121144 0.00 ENST00000264828.3
collagen, type V, alpha 3
chr2_+_172864490 0.00 ENST00000315796.4
methionyl aminopeptidase type 1D (mitochondrial)
chr11_-_71823715 0.00 ENST00000545944.1
ENST00000502597.2
anaphase promoting complex subunit 15
chr11_+_108535752 0.00 ENST00000322536.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr12_-_57039739 0.00 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr20_+_56964253 0.00 ENST00000395802.3
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_-_151762943 0.00 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
tudor and KH domain containing
chr12_-_10955226 0.00 ENST00000240687.2
taste receptor, type 2, member 7
chr3_-_164796269 0.00 ENST00000264382.3
sucrase-isomaltase (alpha-glucosidase)

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.2 0.7 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.1 0.5 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.9 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.2 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.1 0.3 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.2 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.2 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:1902231 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.2 GO:0033504 floor plate development(GO:0033504)
0.0 0.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.0 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.0 0.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.4 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.9 GO:0032982 myosin filament(GO:0032982)
0.0 0.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.5 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.7 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.2 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.9 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.5 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.1 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.1 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.0 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID AURORA A PATHWAY Aurora A signaling
0.0 0.8 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection