Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for MXI1_MYC_MYCN
Z-value: 1.87
Motif logo
Transcription factors associated with MXI1_MYC_MYCN
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000119950.16 | MAX interactor 1, dimerization protein | |
| ENSG00000136997.10 | MYC proto-oncogene, bHLH transcription factor | |
| ENSG00000134323.10 | MYCN proto-oncogene, bHLH transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MXI1 | hg19_v2_chr10_+_111985713_111985774, hg19_v2_chr10_+_111967345_111967442 | -0.80 | 1.5e-07 | Click! |
| MYCN | hg19_v2_chr2_+_16080659_16080686 | 0.19 | 3.2e-01 | Click! |
| MYC | hg19_v2_chr8_+_128748308_128748330, hg19_v2_chr8_+_128748466_128748487 | 0.09 | 6.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.3 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 1.6 | 9.9 | GO:0046985 | positive regulation of hemoglobin biosynthetic process(GO:0046985) |
| 1.5 | 9.0 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 1.1 | 8.9 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.2 | 8.6 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 1.0 | 8.3 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.1 | 8.1 | GO:0045815 | positive regulation of gene expression, epigenetic(GO:0045815) |
| 0.0 | 8.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.4 | 7.6 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 1.8 | 7.4 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 13.4 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.7 | 12.9 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 10.6 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.4 | 10.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 1.6 | 9.6 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.7 | 8.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 1.3 | 8.1 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.3 | 8.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 7.7 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 58.8 | GO:0003723 | RNA binding(GO:0003723) |
| 0.3 | 15.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.4 | 9.6 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.3 | 9.3 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.1 | 8.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.4 | 7.5 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.4 | 7.2 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.4 | 7.1 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 6.9 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 2.2 | 6.7 | GO:0004766 | spermidine synthase activity(GO:0004766) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 33.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 15.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 9.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 8.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 5.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 5.6 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 4.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 3.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 3.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.5 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.5 | 14.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 13.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 12.0 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.1 | 9.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 9.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 9.1 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.2 | 8.2 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.3 | 7.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.3 | 6.7 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |