Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MYB
Z-value: 1.87
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Transcription factors associated with MYB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYB | hg19_v2_chr6_+_135502466_135502489, hg19_v2_chr6_+_135502408_135502459 | 0.85 | 4.0e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.2 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.7 | 12.6 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.1 | 10.9 | GO:0007286 | spermatid development(GO:0007286) |
| 0.4 | 8.9 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.2 | 8.1 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.2 | 8.1 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 1.5 | 7.3 | GO:0071733 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.1 | 6.8 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 6.8 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 1.6 | 6.6 | GO:0032053 | ciliary basal body organization(GO:0032053) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.4 | 13.0 | GO:0034451 | centriolar satellite(GO:0034451) |
| 1.0 | 10.7 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 10.0 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 9.5 | GO:0005813 | centrosome(GO:0005813) |
| 0.7 | 7.3 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.4 | 7.0 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.3 | 6.2 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 5.9 | GO:0000922 | spindle pole(GO:0000922) |
| 0.6 | 5.8 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 1.9 | 7.7 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.9 | 7.3 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.2 | 4.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 4.7 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 4.3 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 4.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.4 | 3.6 | GO:0050145 | nucleoside phosphate kinase activity(GO:0050145) |
| 1.2 | 3.5 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.1 | 3.5 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 4.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 3.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 1.9 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.2 | 7.3 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 5.2 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 3.8 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.1 | 3.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 3.7 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.3 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 2.4 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 2.4 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 2.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |