Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MYBL2
Z-value: 1.89
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Transcription factors associated with MYBL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYBL2 | hg19_v2_chr20_+_42295745_42295797 | 0.28 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYBL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.6 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.5 | 9.5 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 1.0 | 7.9 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.2 | 7.5 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 7.5 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.4 | 7.4 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 2.2 | 6.5 | GO:1903567 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 1.2 | 4.8 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.4 | 4.8 | GO:0061525 | hindgut development(GO:0061525) |
| 0.4 | 4.7 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 10.0 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.2 | 9.6 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 8.2 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.2 | 7.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 6.8 | GO:0030286 | dynein complex(GO:0030286) |
| 0.1 | 6.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 6.7 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 6.2 | GO:0005874 | microtubule(GO:0005874) |
| 0.7 | 5.6 | GO:0032133 | chromosome passenger complex(GO:0032133) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.1 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 1.1 | 6.6 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 4.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 4.5 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.6 | 4.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.2 | 4.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 3.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.4 | 3.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.4 | 3.2 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.1 | 3.1 | GO:0008536 | Ran GTPase binding(GO:0008536) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 8.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.3 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 3.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 11.2 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 4.4 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 3.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.2 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 2.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.7 | 2.2 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.1 | 2.1 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 2.1 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 1.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |