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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NFAT5

Z-value: 0.75

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Transcription factors associated with NFAT5

Gene Symbol Gene ID Gene Info
NFAT5
ENSG00000102908.16 nuclear factor of activated T cells 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFAT5hg19_v2_chr16_+_69599861_69599887,
hg19_v2_chr16_+_69600058_69600111		0.532.5e-03Click!

Activity profile of NFAT5 motif

Sorted Z-values of NFAT5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_111888890 3.99 ENST00000369738.4
PIFO
primary cilia formation
chr1_+_111889212 3.88 ENST00000369737.4
PIFO
primary cilia formation
chr18_-_24765248 3.86 ENST00000580774.1
ENST00000284224.8
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr9_-_80263220 3.34 ENST00000341700.6
GNA14
guanine nucleotide binding protein (G protein), alpha 14
chr20_-_44176391 2.72 ENST00000409554.1
EPPIN
epididymal peptidase inhibitor
chr17_+_45908974 2.62 ENST00000269025.4
LRRC46
leucine rich repeat containing 46
chr20_-_44176060 2.53 ENST00000354280.4
ENST00000504988.1
EPPIN
EPPIN-WFDC6
epididymal peptidase inhibitor
EPPIN-WFDC6 readthrough
chr17_+_68071458 2.53 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 2.51 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_+_156712372 2.26 ENST00000541131.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_-_60539405 2.24 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 2.20 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr8_-_133772794 2.05 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71
transmembrane protein 71
chr5_+_140186647 1.83 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr12_+_69742121 1.82 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr1_+_54359854 1.80 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
DIO1
deiodinase, iodothyronine, type I
chr20_-_44176013 1.77 ENST00000555685.1
EPPIN
epididymal peptidase inhibitor
chr16_+_2079637 1.64 ENST00000561844.1
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr12_+_119772502 1.57 ENST00000536742.1
ENST00000327554.2
CCDC60
coiled-coil domain containing 60
chr1_+_95975672 1.40 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
RP11-286B14.1
chr3_+_49027308 1.40 ENST00000383729.4
ENST00000343546.4
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr14_+_91580777 1.36 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
C14orf159
chromosome 14 open reading frame 159
chr14_+_91580708 1.35 ENST00000518868.1
C14orf159
chromosome 14 open reading frame 159
chr14_+_91581011 1.34 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
C14orf159
chromosome 14 open reading frame 159
chr11_-_75062829 1.29 ENST00000393505.4
ARRB1
arrestin, beta 1
chr5_+_140261703 1.24 ENST00000409494.1
ENST00000289272.2
PCDHA13
protocadherin alpha 13
chr16_+_2079501 1.23 ENST00000563587.1
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr5_-_41261540 1.19 ENST00000263413.3
C6
complement component 6
chr4_-_83483395 1.17 ENST00000515780.2
TMEM150C
transmembrane protein 150C
chr19_+_14142535 1.14 ENST00000263379.2
IL27RA
interleukin 27 receptor, alpha
chr13_-_24463530 1.12 ENST00000382172.3
MIPEP
mitochondrial intermediate peptidase
chr4_+_74718906 1.09 ENST00000226524.3
PF4V1
platelet factor 4 variant 1
chr6_+_153552455 1.08 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr4_+_17579110 1.06 ENST00000606142.1
LAP3
leucine aminopeptidase 3
chr14_+_100848311 1.06 ENST00000542471.2
WDR25
WD repeat domain 25
chr14_-_102706934 1.06 ENST00000523231.1
ENST00000524370.1
ENST00000517966.1
MOK
MOK protein kinase
chr1_-_57045228 1.05 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr7_-_47579188 1.01 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr6_-_134495992 0.97 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_55375622 0.88 ENST00000316577.8
TESPA1
thymocyte expressed, positive selection associated 1
chr9_+_139921916 0.86 ENST00000314330.2
C9orf139
chromosome 9 open reading frame 139
chr19_+_859425 0.85 ENST00000327726.6
CFD
complement factor D (adipsin)
chr18_-_52989525 0.84 ENST00000457482.3
TCF4
transcription factor 4
chr11_-_75062730 0.77 ENST00000420843.2
ENST00000360025.3
ARRB1
arrestin, beta 1
chr16_+_30968615 0.76 ENST00000262519.8
SETD1A
SET domain containing 1A
chr8_-_27469196 0.75 ENST00000546343.1
ENST00000560566.1
CLU
clusterin
chr14_+_91580732 0.75 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
C14orf159
chromosome 14 open reading frame 159
chr3_+_69812877 0.73 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr2_+_56179262 0.70 ENST00000606639.1
RP11-481J13.1
RP11-481J13.1
chr4_+_17578815 0.68 ENST00000226299.4
LAP3
leucine aminopeptidase 3
chr1_-_246670519 0.66 ENST00000388985.4
ENST00000490107.1
SMYD3
SET and MYND domain containing 3
chr11_+_103907308 0.64 ENST00000302259.3
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr2_-_20101385 0.62 ENST00000431392.1
TTC32
tetratricopeptide repeat domain 32
chr1_-_145470383 0.61 ENST00000369314.1
ENST00000369313.3
POLR3GL
polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like
chr17_-_38083843 0.61 ENST00000304046.2
ENST00000579695.1
ORMDL3
ORM1-like 3 (S. cerevisiae)
chr14_+_91580357 0.61 ENST00000298858.4
ENST00000521081.1
ENST00000520328.1
ENST00000256324.10
ENST00000524232.1
ENST00000522170.1
ENST00000519950.1
ENST00000523879.1
ENST00000521077.2
ENST00000518665.2
C14orf159
chromosome 14 open reading frame 159
chr9_-_13175823 0.59 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr15_+_45028753 0.57 ENST00000338264.4
TRIM69
tripartite motif containing 69
chr1_+_1115056 0.57 ENST00000379288.3
TTLL10
tubulin tyrosine ligase-like family, member 10
chr14_+_95078714 0.55 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr2_+_198570081 0.55 ENST00000282276.6
MARS2
methionyl-tRNA synthetase 2, mitochondrial
chr9_-_124989804 0.54 ENST00000373755.2
ENST00000373754.2
LHX6
LIM homeobox 6
chr18_-_52989217 0.52 ENST00000570287.2
TCF4
transcription factor 4
chr3_-_42003479 0.51 ENST00000420927.1
ULK4
unc-51 like kinase 4
chr1_-_85870177 0.50 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr22_-_44208070 0.49 ENST00000396231.2
EFCAB6
EF-hand calcium binding domain 6
chr15_+_49170281 0.49 ENST00000560490.1
EID1
EP300 interacting inhibitor of differentiation 1
chr3_-_9834375 0.49 ENST00000343450.2
ENST00000301964.2
TADA3
transcriptional adaptor 3
chr14_-_25479811 0.47 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chrX_+_70752917 0.46 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr15_+_43885252 0.45 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr17_-_202579 0.45 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL
rabphilin 3A-like (without C2 domains)
chr17_+_32646055 0.42 ENST00000394620.1
CCL8
chemokine (C-C motif) ligand 8
chr3_+_8543533 0.41 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr15_+_45028520 0.40 ENST00000329464.4
TRIM69
tripartite motif containing 69
chr3_+_185000729 0.40 ENST00000448876.1
ENST00000446828.1
ENST00000447637.1
ENST00000424227.1
ENST00000454237.1
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr15_+_43985084 0.40 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr10_-_118928543 0.39 ENST00000419373.2
RP11-501J20.2
RP11-501J20.2
chr20_+_33104199 0.39 ENST00000357156.2
ENST00000417166.2
ENST00000300469.9
ENST00000374846.3
DYNLRB1
dynein, light chain, roadblock-type 1
chr13_-_67804445 0.39 ENST00000456367.1
ENST00000377861.3
ENST00000544246.1
PCDH9
protocadherin 9
chr10_+_111967345 0.39 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr15_+_49170083 0.39 ENST00000530028.2
EID1
EP300 interacting inhibitor of differentiation 1
chr15_+_45028719 0.38 ENST00000560442.1
ENST00000558329.1
ENST00000561043.1
TRIM69
tripartite motif containing 69
chr14_+_103589789 0.38 ENST00000558056.1
ENST00000560869.1
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr10_+_89419370 0.38 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr5_-_35230434 0.37 ENST00000504500.1
PRLR
prolactin receptor
chr12_+_53848505 0.36 ENST00000552819.1
ENST00000455667.3
PCBP2
poly(rC) binding protein 2
chr2_-_68479614 0.36 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr11_+_65190245 0.36 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr15_+_43985725 0.35 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chr4_+_26322185 0.33 ENST00000361572.6
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr19_+_15852203 0.31 ENST00000305892.1
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr7_-_92157760 0.30 ENST00000248633.4
PEX1
peroxisomal biogenesis factor 1
chr7_-_92157747 0.30 ENST00000428214.1
ENST00000438045.1
PEX1
peroxisomal biogenesis factor 1
chr4_+_26322409 0.30 ENST00000514807.1
ENST00000348160.4
ENST00000509158.1
ENST00000355476.3
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr12_+_120502441 0.29 ENST00000446727.2
CCDC64
coiled-coil domain containing 64
chr7_+_149570049 0.29 ENST00000421974.2
ENST00000456496.2
ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr7_-_92855762 0.28 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr3_+_120461484 0.28 ENST00000484715.1
ENST00000469772.1
ENST00000283875.5
ENST00000492959.1
GTF2E1
general transcription factor IIE, polypeptide 1, alpha 56kDa
chr12_+_10365404 0.28 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr9_-_14314518 0.27 ENST00000397581.2
NFIB
nuclear factor I/B
chr3_+_63805017 0.26 ENST00000295896.8
C3orf49
chromosome 3 open reading frame 49
chr12_-_122018859 0.25 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
KDM2B
lysine (K)-specific demethylase 2B
chr3_+_47866490 0.25 ENST00000457607.1
DHX30
DEAH (Asp-Glu-Ala-His) box helicase 30
chr3_-_49131013 0.24 ENST00000424300.1
QRICH1
glutamine-rich 1
chr12_-_323689 0.24 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr16_-_51185172 0.21 ENST00000251020.4
SALL1
spalt-like transcription factor 1
chr16_+_68573116 0.21 ENST00000570495.1
ENST00000563169.2
ENST00000564323.1
ENST00000562156.1
ENST00000573685.1
ZFP90
ZFP90 zinc finger protein
chr9_-_6015607 0.20 ENST00000259569.5
RANBP6
RAN binding protein 6
chr16_-_75498553 0.20 ENST00000569276.1
ENST00000357613.4
ENST00000561878.1
ENST00000566980.1
ENST00000567194.1
TMEM170A
RP11-77K12.1
transmembrane protein 170A
Uncharacterized protein
chr7_+_95401851 0.19 ENST00000447467.2
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
chr1_+_36789335 0.19 ENST00000373137.2
RP11-268J15.5
RP11-268J15.5
chr13_+_45694583 0.19 ENST00000340473.6
GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chrX_-_45060135 0.19 ENST00000398000.2
ENST00000377934.4
CXorf36
chromosome X open reading frame 36
chr22_+_24551765 0.18 ENST00000337989.7
CABIN1
calcineurin binding protein 1
chrX_+_83116142 0.18 ENST00000329312.4
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr6_+_138188551 0.18 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr17_-_15466742 0.18 ENST00000584811.1
ENST00000419890.2
TVP23C
trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)
chr8_+_96037205 0.18 ENST00000396124.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr20_-_23807358 0.17 ENST00000304725.2
CST2
cystatin SA
chr1_+_34632484 0.17 ENST00000373374.3
C1orf94
chromosome 1 open reading frame 94
chr17_-_15466850 0.16 ENST00000438826.3
ENST00000225576.3
ENST00000519970.1
ENST00000518321.1
ENST00000428082.2
ENST00000522212.2
TVP23C
TVP23C-CDRT4
trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)
TVP23C-CDRT4 readthrough
chr16_-_67514982 0.16 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr7_+_95401877 0.16 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
chr2_-_162931052 0.14 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr1_-_36945097 0.14 ENST00000331941.5
ENST00000418048.2
ENST00000338937.5
ENST00000440588.2
CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr11_+_19798964 0.13 ENST00000527559.2
NAV2
neuron navigator 2
chr11_+_22696314 0.13 ENST00000532398.1
ENST00000433790.1
GAS2
growth arrest-specific 2
chr11_+_19799327 0.13 ENST00000540292.1
NAV2
neuron navigator 2
chr3_-_44552094 0.13 ENST00000436261.1
ZNF852
zinc finger protein 852
chr17_+_40950797 0.12 ENST00000588408.1
ENST00000585355.1
CNTD1
cyclin N-terminal domain containing 1
chr17_+_4853442 0.12 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chr20_-_62103862 0.12 ENST00000344462.4
ENST00000357249.2
ENST00000359125.2
ENST00000360480.3
ENST00000370224.1
ENST00000344425.5
ENST00000354587.3
ENST00000359689.1
KCNQ2
potassium voltage-gated channel, KQT-like subfamily, member 2
chr4_+_122685691 0.11 ENST00000424958.1
AC079341.1
Uncharacterized protein
chr1_+_18958008 0.11 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chrX_+_12993202 0.11 ENST00000451311.2
ENST00000380636.1
TMSB4X
thymosin beta 4, X-linked
chr2_+_47799601 0.11 ENST00000601243.1
AC138655.1
CDNA: FLJ23120 fis, clone LNG07989; HCG1987724; Uncharacterized protein
chr12_+_69139886 0.11 ENST00000398004.2
SLC35E3
solute carrier family 35, member E3
chr12_+_99038998 0.10 ENST00000359972.2
ENST00000357310.1
ENST00000339433.3
ENST00000333991.1
APAF1
apoptotic peptidase activating factor 1
chr6_+_89790459 0.10 ENST00000369472.1
PNRC1
proline-rich nuclear receptor coactivator 1
chr8_-_99954788 0.09 ENST00000523601.1
STK3
serine/threonine kinase 3
chr4_-_76861392 0.09 ENST00000505594.1
NAAA
N-acylethanolamine acid amidase
chr6_+_109416684 0.09 ENST00000521522.1
ENST00000524064.1
ENST00000522608.1
ENST00000521503.1
ENST00000519407.1
ENST00000519095.1
ENST00000368968.2
ENST00000522490.1
ENST00000523209.1
ENST00000368970.2
ENST00000520883.1
ENST00000523787.1
CEP57L1
centrosomal protein 57kDa-like 1
chr12_-_11214893 0.08 ENST00000533467.1
TAS2R46
taste receptor, type 2, member 46
chr18_-_74839891 0.08 ENST00000581878.1
MBP
myelin basic protein
chr10_-_135122603 0.07 ENST00000368563.2
TUBGCP2
tubulin, gamma complex associated protein 2
chr5_-_137090028 0.07 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr7_-_102119342 0.07 ENST00000393794.3
ENST00000292614.5
POLR2J
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
chr12_-_75603482 0.07 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr12_-_75603643 0.06 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr7_-_19184929 0.06 ENST00000275461.3
FERD3L
Fer3-like bHLH transcription factor
chr6_+_160327974 0.05 ENST00000252660.4
MAS1
MAS1 oncogene
chr17_+_18684563 0.05 ENST00000476139.1
TVP23B
trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
chr7_+_65670186 0.05 ENST00000304842.5
ENST00000442120.1
TPST1
tyrosylprotein sulfotransferase 1
chr3_-_149293990 0.04 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr8_+_96037255 0.04 ENST00000286687.4
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr5_-_133747589 0.04 ENST00000458198.2
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr17_+_40950900 0.04 ENST00000588527.1
CNTD1
cyclin N-terminal domain containing 1
chr19_-_46285736 0.04 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chr6_+_44094627 0.03 ENST00000259746.9
TMEM63B
transmembrane protein 63B
chr15_-_102285007 0.02 ENST00000560292.2
RP11-89K11.1
Uncharacterized protein
chr3_-_156878540 0.02 ENST00000461804.1
CCNL1
cyclin L1
chr1_-_153517473 0.02 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr13_-_50265570 0.02 ENST00000378270.5
ENST00000378284.2
ENST00000378272.5
ENST00000378268.1
ENST00000242827.6
ENST00000378282.5
EBPL
emopamil binding protein-like
chr7_-_100888313 0.02 ENST00000442303.1
FIS1
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
chrX_+_18725758 0.02 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1
protein phosphatase, EF-hand calcium binding domain 1
chr11_+_56949221 0.01 ENST00000497933.1
LRRC55
leucine rich repeat containing 55
chr7_-_100888337 0.01 ENST00000223136.4
FIS1
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
chr4_-_74847800 0.00 ENST00000296029.3
PF4
platelet factor 4

Network of associatons between targets according to the STRING database.

First level regulatory network of NFAT5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.0 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.3 3.3 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.3 1.2 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 2.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 0.9 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.2 0.6 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.2 0.6 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.2 0.6 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2 2.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 1.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.8 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 0.5 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 1.0 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1 5.0 GO:0010107 potassium ion import(GO:0010107)
0.1 5.4 GO:0006536 glutamate metabolic process(GO:0006536)
0.1 0.4 GO:0000103 sulfate assimilation(GO:0000103)
0.1 3.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 1.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.5 GO:0018094 protein polyglycylation(GO:0018094)
0.1 1.1 GO:0002829 negative regulation of type 2 immune response(GO:0002829)
0.1 0.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 1.8 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 0.3 GO:0021592 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592)
0.1 0.5 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.2 GO:0071947 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) negative regulation of osteoclast proliferation(GO:0090291)
0.1 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.4 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.3 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.9 GO:0051601 exocyst localization(GO:0051601)
0.0 0.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 1.1 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.5 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.3 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 1.4 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:2001171 positive regulation of ATP biosynthetic process(GO:2001171)
0.0 1.0 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 2.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.1 GO:1904685 positive regulation of metalloendopeptidase activity(GO:1904685)
0.0 0.0 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.1 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.5 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.7 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.7 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.4 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.2 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.8 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 8.0 GO:0033674 positive regulation of kinase activity(GO:0033674)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 0.6 GO:0035339 SPOTS complex(GO:0035339)
0.1 1.2 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 5.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.2 GO:0043159 cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.1 7.9 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.8 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 4.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.5 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.6 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 1.1 GO:0097546 ciliary base(GO:0097546)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 1.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581) invadopodium membrane(GO:0071438)
0.0 1.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 7.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.4 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.7 2.1 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.6 3.9 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.3 1.8 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 0.9 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.3 5.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 8.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.4 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.1 1.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 3.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.7 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.5 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.1 1.2 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.7 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 0.5 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.4 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.6 GO:0000150 recombinase activity(GO:0000150)
0.1 0.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 6.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.4 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 1.0 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.8 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 2.9 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 1.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.4 GO:0008009 chemokine activity(GO:0008009)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 2.1 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 2.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.6 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 1.1 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.0 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 5.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 3.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.1 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 1.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 2.0 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 1.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins