ISMARA results: NFIA

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NFIA

Z-value: 0.96

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Transcription factors associated with NFIA

Gene Symbol	Gene ID	Gene Info
NFIA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000162599.11	nuclear factor I A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIA	hg19_v2_chr1_+_61869748_61869782	-0.64	1.3e-04	Click!

Activity profile of NFIA motif

Sorted Z-values of NFIA motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_41742697 Show fit	5.98	ENST00000242208.4	INHBA Ensembl NCBI GeneCards UniProt NextProt Show fit	inhibin, beta A
chr2_-_31637560 Show fit	5.61	ENST00000379416.3	XDH Ensembl NCBI GeneCards UniProt NextProt Show fit	xanthine dehydrogenase
chr13_-_20805109 Show fit	3.82	ENST00000241124.6	GJB6 Ensembl NCBI GeneCards UniProt NextProt Show fit	gap junction protein, beta 6, 30kDa
chr4_-_57547454 Show fit	2.54	ENST00000556376.2	HOPX Ensembl NCBI GeneCards UniProt NextProt Show fit	HOP homeobox
chr4_-_57547870 Show fit	2.53	ENST00000381260.3 ENST00000420433.1 ENST00000554144.1 ENST00000557328.1	HOPX Ensembl NCBI GeneCards UniProt NextProt Show fit	HOP homeobox
chr2_-_113542063 Show fit	2.30	ENST00000263339.3	IL1A Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1, alpha
chrX_+_135251783 Show fit	2.28	ENST00000394153.2	FHL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	four and a half LIM domains 1
chr10_+_102106829 Show fit	2.27	ENST00000370355.2	SCD Ensembl NCBI GeneCards UniProt NextProt Show fit	stearoyl-CoA desaturase (delta-9-desaturase)
chrX_+_135252050 Show fit	2.19	ENST00000449474.1 ENST00000345434.3	FHL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	four and a half LIM domains 1
chr7_-_27135591 Show fit	2.13	ENST00000343060.4 ENST00000355633.5	HOXA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeobox A1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.7	GO:0030216	keratinocyte differentiation(GO:0030216)
0.1	6.6	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
2.0	6.0	GO:0060278	regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.4	5.6	GO:0046110	xanthine metabolic process(GO:0046110)
0.2	5.1	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.0	4.5	GO:0006501	C-terminal protein lipidation(GO:0006501)
1.0	4.2	GO:0090119	vesicle-mediated cholesterol transport(GO:0090119)
0.1	3.8	GO:0051602	response to electrical stimulus(GO:0051602)
0.5	3.2	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.3	3.2	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)

Showing 1 to 10 of 222 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.6	GO:0005925	focal adhesion(GO:0005925)
0.1	7.3	GO:0001533	cornified envelope(GO:0001533)
2.0	6.0	GO:0043512	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0	5.9	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.2	3.8	GO:0005922	connexon complex(GO:0005922)
0.0	3.3	GO:0002102	podosome(GO:0002102)
0.1	3.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	3.0	GO:0043202	lysosomal lumen(GO:0043202)
0.3	2.8	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.0	2.8	GO:0016529	sarcoplasmic reticulum(GO:0016529)

Showing 1 to 10 of 87 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	6.0	GO:0070699	type II activin receptor binding(GO:0070699)
0.6	5.6	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	4.9	GO:0044325	ion channel binding(GO:0044325)
0.0	4.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.8	4.1	GO:0047374	methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1	3.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	2.9	GO:0050840	extracellular matrix binding(GO:0050840)
0.6	2.8	GO:0031962	mineralocorticoid receptor binding(GO:0031962)
0.3	2.7	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1	2.7	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)

Showing 1 to 10 of 156 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	5.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	5.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	4.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	3.8	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	3.4	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	3.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	2.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	2.7	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	2.7	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	7.5	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.4	5.6	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	3.8	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	3.2	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.1	3.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	2.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	2.6	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	2.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	2.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	2.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis

Showing 1 to 10 of 49 entries

Results for NFIA

Z-value: 0.96

Motif logo

Transcription factors associated with NFIA

Activity-expression correlation:

Activity profile of NFIA motif

Sorted Z-values of NFIA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: