ISMARA results: NFIX

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NFIX_NFIB

Z-value: 1.08

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Transcription factors associated with NFIX_NFIB

Gene Symbol	Gene ID	Gene Info
NFIX Ensembl NCBI GeneCards UniProt NextProt	ENSG00000008441.12	nuclear factor I X
NFIB Ensembl NCBI GeneCards UniProt NextProt	ENSG00000147862.10	nuclear factor I B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIB	hg19_v2_chr9_-_14180778_14180808	0.58	8.1e-04	Click!
NFIX	hg19_v2_chr19_+_13135386_13135435	0.37	4.4e-02	Click!

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_100354442 Show fit	3.51	ENST00000475887.1	GPR128 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 128
chr4_-_16077741 Show fit	3.05	ENST00000447510.2 ENST00000540805.1 ENST00000539194.1	PROM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	prominin 1
chr17_+_1633755 Show fit	2.94	ENST00000545662.1	WDR81 Ensembl NCBI GeneCards UniProt NextProt Show fit	WD repeat domain 81
chr20_+_31749574 Show fit	2.64	ENST00000253362.2	BPIFA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	BPI fold containing family A, member 2
chr5_-_180018540 Show fit	2.54	ENST00000292641.3	SCGB3A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	secretoglobin, family 3A, member 1
chr6_+_43612750 Show fit	2.32	ENST00000372165.4 ENST00000372163.4	RSPH9 Ensembl NCBI GeneCards UniProt NextProt Show fit	radial spoke head 9 homolog (Chlamydomonas)
chr16_-_28621353 Show fit	2.32	ENST00000567512.1	SULT1A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr20_+_31870927 Show fit	2.18	ENST00000253354.1	BPIFB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	BPI fold containing family B, member 1
chr4_+_15480828 Show fit	2.08	ENST00000389652.5	CC2D2A Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil and C2 domain containing 2A
chr3_+_100328433 Show fit	2.02	ENST00000273352.3	GPR128 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 128

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.8	GO:0035082	axoneme assembly(GO:0035082)
0.1	8.2	GO:0001895	retina homeostasis(GO:0001895)
0.4	7.5	GO:0036158	outer dynein arm assembly(GO:0036158)
0.2	4.9	GO:0015671	oxygen transport(GO:0015671)
0.2	4.7	GO:0006068	ethanol catabolic process(GO:0006068)
0.7	3.6	GO:1904158	axonemal central apparatus assembly(GO:1904158)
0.8	3.1	GO:0072139	glomerular parietal epithelial cell differentiation(GO:0072139)
0.1	2.9	GO:0010107	potassium ion import(GO:0010107)
0.1	2.7	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.4	2.6	GO:1904491	protein localization to ciliary transition zone(GO:1904491)

Showing 1 to 10 of 774 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.8	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.3	5.1	GO:0036038	MKS complex(GO:0036038)
0.0	4.4	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.5	3.5	GO:0002177	manchette(GO:0002177)
0.3	3.5	GO:0036157	outer dynein arm(GO:0036157)
0.1	3.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.2	2.8	GO:0005833	hemoglobin complex(GO:0005833)
0.1	2.8	GO:0034451	centriolar satellite(GO:0034451)
0.2	2.7	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	2.6	GO:0005844	polysome(GO:0005844)

Showing 1 to 10 of 221 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.1	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.2	5.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.3	4.9	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	4.8	GO:0030246	carbohydrate binding(GO:0030246)
0.3	4.4	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2	4.3	GO:0070330	aromatase activity(GO:0070330)
0.2	4.2	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	4.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.6	4.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.1	3.9	GO:0030544	Hsp70 protein binding(GO:0030544)

Showing 1 to 10 of 437 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	PID NOTCH PATHWAY	Notch signaling pathway
0.0	2.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	2.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	1.8	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	1.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	1.0	ST ADRENERGIC	Adrenergic Pathway
0.0	1.0	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.8	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.8	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.8	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events

Showing 1 to 10 of 38 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	4.4	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1	3.9	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	3.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	2.6	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	2.4	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	2.2	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	2.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	2.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	1.9	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation

Showing 1 to 10 of 81 entries

Results for NFIX_NFIB

Z-value: 1.08

Motif logo

Transcription factors associated with NFIX_NFIB

Activity-expression correlation:

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: