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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX1-1

Z-value: 0.36

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
ENSG00000235608.1 NK1 homeobox 1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_8822113 2.85 ENST00000396290.1
ENST00000331129.3
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr12_+_7013897 1.88 ENST00000007969.8
ENST00000323702.5
leucine rich repeat containing 23
chr12_+_7014064 1.87 ENST00000443597.2
leucine rich repeat containing 23
chr12_+_7014126 1.55 ENST00000415834.1
ENST00000436789.1
leucine rich repeat containing 23
chr13_+_36050881 1.33 ENST00000537702.1
neurobeachin
chr19_+_32897009 1.05 ENST00000342179.5
ENST00000586427.1
dpy-19-like 3 (C. elegans)
chr19_+_32896697 1.02 ENST00000586987.1
dpy-19-like 3 (C. elegans)
chr6_-_80247105 0.67 ENST00000369846.4
Leber congenital amaurosis 5
chr10_+_120789223 0.60 ENST00000425699.1
nanos homolog 1 (Drosophila)
chr1_+_100818156 0.46 ENST00000336454.3
cell division cycle 14A
chr11_-_105892937 0.40 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr4_-_103682145 0.39 ENST00000226578.4
mannosidase, beta A, lysosomal
chr6_+_26501449 0.36 ENST00000244513.6
butyrophilin, subfamily 1, member A1
chr2_+_217524323 0.31 ENST00000456764.1
insulin-like growth factor binding protein 2, 36kDa
chr7_+_99717230 0.30 ENST00000262932.3
canopy FGF signaling regulator 4
chr6_-_167040731 0.30 ENST00000265678.4
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_+_186560462 0.30 ENST00000412955.2
adiponectin, C1Q and collagen domain containing
chr3_+_186560476 0.30 ENST00000320741.2
ENST00000444204.2
adiponectin, C1Q and collagen domain containing
chr7_-_86849883 0.28 ENST00000433078.1
transmembrane protein 243, mitochondrial
chr11_-_4629388 0.28 ENST00000526337.1
ENST00000300747.5
tripartite motif containing 68
chr1_+_174843548 0.27 ENST00000478442.1
ENST00000465412.1
RAB GTPase activating protein 1-like
chr1_-_108507631 0.26 ENST00000527011.1
ENST00000370056.4
vav 3 guanine nucleotide exchange factor
chr16_+_640055 0.25 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C, member RAS oncogene family
chr1_+_100818009 0.25 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
cell division cycle 14A
chr2_-_239197201 0.22 ENST00000254658.3
period circadian clock 2
chr4_-_66536196 0.21 ENST00000511294.1
EPH receptor A5
chr8_+_26371763 0.20 ENST00000521913.1
dihydropyrimidinase-like 2
chr7_+_2559399 0.20 ENST00000222725.5
ENST00000359574.3
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_-_239197238 0.20 ENST00000254657.3
period circadian clock 2
chr15_-_78526855 0.18 ENST00000541759.1
ENST00000558130.1
acyl-CoA synthetase bubblegum family member 1
chr13_+_78315295 0.18 ENST00000351546.3
SLAIN motif family, member 1
chr19_+_45504688 0.18 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr11_-_62521614 0.16 ENST00000527994.1
ENST00000394807.3
zinc finger and BTB domain containing 3
chr7_+_70597109 0.15 ENST00000333538.5
Williams-Beuren syndrome chromosome region 17
chr12_+_28410128 0.15 ENST00000381259.1
ENST00000381256.1
coiled-coil domain containing 91
chr15_-_64386120 0.15 ENST00000300030.3
family with sequence similarity 96, member A
chr7_+_99647389 0.15 ENST00000543588.1
ENST00000292450.4
ENST00000456748.2
zinc finger and SCAN domain containing 21
chr7_-_73256838 0.14 ENST00000297873.4
Williams Beuren syndrome chromosome region 27
chr12_+_16500037 0.14 ENST00000536371.1
ENST00000010404.2
microsomal glutathione S-transferase 1
chr3_+_23851928 0.14 ENST00000467766.1
ENST00000424381.1
ubiquitin-conjugating enzyme E2E 1
chr12_+_16500571 0.14 ENST00000543076.1
ENST00000396210.3
microsomal glutathione S-transferase 1
chr12_+_16500599 0.13 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
microsomal glutathione S-transferase 1
chr5_-_159546396 0.13 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP domain containing 2A
chr15_-_64385981 0.12 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
family with sequence similarity 96, member A
chr7_-_99717463 0.12 ENST00000437822.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chrX_+_72783026 0.11 ENST00000373504.6
ENST00000373502.5
cysteine-rich hydrophobic domain 1
chr9_+_116225999 0.10 ENST00000317613.6
regulator of G-protein signaling 3
chr10_-_1095050 0.09 ENST00000381344.3
isopentenyl-diphosphate delta isomerase 1
chr10_-_56561022 0.09 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
protocadherin-related 15
chr12_-_23737534 0.09 ENST00000396007.2
SRY (sex determining region Y)-box 5
chr2_-_97405775 0.09 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
lectin, mannose-binding 2-like
chrX_+_19362011 0.08 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
pyruvate dehydrogenase (lipoamide) alpha 1
chr16_-_2318373 0.08 ENST00000566458.1
ENST00000320225.5
RNA binding protein S1, serine-rich domain
chr4_-_66536057 0.08 ENST00000273854.3
EPH receptor A5
chr1_-_190446759 0.07 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr17_-_44439084 0.07 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ADP-ribosylation factor-like 17B
chr5_+_63802109 0.07 ENST00000334025.2
regulator of G-protein signaling 7 binding protein
chr3_-_105587879 0.07 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr1_-_151762943 0.07 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
tudor and KH domain containing
chr4_+_128554081 0.06 ENST00000335251.6
ENST00000296461.5
inturned planar cell polarity protein
chr7_-_99716952 0.06 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr10_+_1095416 0.06 ENST00000358220.1
WD repeat domain 37
chr9_+_34646651 0.06 ENST00000378842.3
galactose-1-phosphate uridylyltransferase
chr12_+_2921788 0.05 ENST00000228799.2
ENST00000419778.2
ENST00000542548.1
integrin alpha FG-GAP repeat containing 2
chr17_-_44657017 0.05 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ADP-ribosylation factor-like 17A
chr9_+_34646624 0.05 ENST00000450095.2
ENST00000556278.1
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr19_+_54641444 0.05 ENST00000221232.5
ENST00000358389.3
CCR4-NOT transcription complex, subunit 3
chr11_-_124981475 0.05 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
transmembrane protein 218
chr3_+_158519654 0.05 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
major facilitator superfamily domain containing 1
chr1_+_161691353 0.04 ENST00000367948.2
Fc receptor-like B
chr17_+_45286387 0.04 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
myosin, light chain 4, alkali; atrial, embryonic
chr8_+_98656336 0.04 ENST00000336273.3
metadherin
chr7_-_6048650 0.04 ENST00000382321.4
ENST00000406569.3
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr11_+_134201768 0.04 ENST00000535456.2
ENST00000339772.7
galactosidase, beta 1-like 2
chr1_-_51796987 0.04 ENST00000262676.5
tetratricopeptide repeat domain 39A
chr7_-_6048702 0.03 ENST00000265849.7
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr17_+_57232690 0.03 ENST00000262293.4
proline rich 11
chr11_-_47198380 0.03 ENST00000419701.2
ENST00000526342.1
ENST00000528444.1
ENST00000530596.1
ENST00000525398.1
ENST00000319543.6
ENST00000426335.2
ENST00000527927.1
ENST00000525314.1
ADP-ribosylation factor GTPase activating protein 2
chr16_-_2318055 0.03 ENST00000561518.1
ENST00000561718.1
ENST00000567147.1
ENST00000562690.1
ENST00000569598.2
RNA binding protein S1, serine-rich domain
chr17_-_10372875 0.03 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr3_+_57261743 0.03 ENST00000288266.3
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr1_-_231004220 0.02 ENST00000366663.5
chromosome 1 open reading frame 198
chr11_-_62494821 0.02 ENST00000301785.5
heterogeneous nuclear ribonucleoprotein U-like 2
chr10_-_56560939 0.02 ENST00000373955.1
protocadherin-related 15
chrX_-_153363188 0.01 ENST00000303391.6
methyl CpG binding protein 2 (Rett syndrome)
chr8_+_94929077 0.01 ENST00000297598.4
ENST00000520614.1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr19_-_6424783 0.01 ENST00000398148.3
KH-type splicing regulatory protein
chr8_+_98656693 0.01 ENST00000519934.1
metadherin
chr8_+_94929168 0.00 ENST00000518107.1
ENST00000396200.3
pyruvate dehyrogenase phosphatase catalytic subunit 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.3 2.1 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.2 0.6 GO:2000532 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.4 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.4 GO:0051946 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.7 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.1 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.4 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.6 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.1 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.3 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0032688 negative regulation of interferon-beta production(GO:0032688)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0060091 kinocilium(GO:0060091)
0.0 2.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0071547 piP-body(GO:0071547)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.6 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.5 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.4 GO:0043295 glutathione binding(GO:0043295)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.6 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID EPHA FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)