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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX2-1

Z-value: 0.54

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Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
NKX2-1
ENSG00000136352.13 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36990354_36990397,
hg19_v2_chr14_-_36989427_36989442,
hg19_v2_chr14_-_36988882_36988898		0.356.0e-02Click!

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_31360887 1.51 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr15_+_40453204 1.34 ENST00000287598.6
ENST00000412359.3
BUB1B
BUB1 mitotic checkpoint serine/threonine kinase B
chr18_+_33877654 1.18 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr16_+_66638003 1.13 ENST00000562357.1
ENST00000360086.4
ENST00000562707.1
ENST00000361909.4
ENST00000460097.1
ENST00000565666.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr20_-_36793663 1.11 ENST00000536701.1
ENST00000536724.1
TGM2
transglutaminase 2
chr6_+_32121789 1.09 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr11_-_62313090 0.99 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr20_-_56285595 0.96 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr1_+_15736359 0.91 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr11_+_35160709 0.90 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
CD44
CD44 molecule (Indian blood group)
chr5_-_146889619 0.88 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chr6_+_32121218 0.87 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
PPT2
palmitoyl-protein thioesterase 2
chr19_+_39903185 0.84 ENST00000409794.3
PLEKHG2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr3_-_16524357 0.83 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr17_+_76210267 0.82 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
BIRC5
baculoviral IAP repeat containing 5
chr17_+_40610862 0.78 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr16_+_66638616 0.78 ENST00000564060.1
ENST00000565922.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr4_+_144354644 0.78 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr8_+_70404996 0.71 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr17_+_76210367 0.70 ENST00000592734.1
ENST00000587746.1
BIRC5
baculoviral IAP repeat containing 5
chr2_-_187713891 0.68 ENST00000295131.2
ZSWIM2
zinc finger, SWIM-type containing 2
chr16_+_66638567 0.67 ENST00000567572.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr1_-_17338386 0.66 ENST00000341676.5
ENST00000452699.1
ATP13A2
ATPase type 13A2
chr5_-_171615315 0.64 ENST00000176763.5
STK10
serine/threonine kinase 10
chr12_-_10978957 0.64 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr15_+_89182178 0.59 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr8_-_62602327 0.59 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr18_+_42260861 0.57 ENST00000282030.5
SETBP1
SET binding protein 1
chrX_-_30326445 0.57 ENST00000378963.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr3_-_42744312 0.56 ENST00000416756.1
ENST00000441594.1
HHATL
hedgehog acyltransferase-like
chr17_+_61086917 0.56 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr2_+_136289030 0.54 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chr11_-_105948040 0.54 ENST00000534815.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr19_-_10679644 0.54 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr10_-_129691195 0.54 ENST00000368671.3
CLRN3
clarin 3
chr8_-_16859690 0.54 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr11_-_105948129 0.53 ENST00000526793.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr2_+_101591314 0.52 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr19_+_38924316 0.51 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chr16_+_58533951 0.51 ENST00000566192.1
ENST00000565088.1
ENST00000568640.1
ENST00000563978.1
ENST00000569923.1
ENST00000356752.4
ENST00000563799.1
ENST00000562999.1
ENST00000570248.1
ENST00000562731.1
ENST00000568424.1
NDRG4
NDRG family member 4
chr11_+_66512089 0.50 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
C11orf80
chromosome 11 open reading frame 80
chr1_+_178694300 0.50 ENST00000367635.3
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr11_+_66512303 0.50 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr22_+_24999114 0.49 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1
gamma-glutamyltransferase 1
chr2_+_119699864 0.45 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr2_+_119699742 0.44 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr4_-_123377880 0.44 ENST00000226730.4
IL2
interleukin 2
chr19_+_39390320 0.43 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr11_-_65325203 0.43 ENST00000526927.1
ENST00000536982.1
LTBP3
latent transforming growth factor beta binding protein 3
chr11_-_104827425 0.42 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr6_-_117747015 0.42 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr19_-_46234119 0.42 ENST00000317683.3
FBXO46
F-box protein 46
chr15_+_89181974 0.41 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr19_+_48972265 0.41 ENST00000452733.2
CYTH2
cytohesin 2
chr14_+_94393605 0.41 ENST00000556222.1
ENST00000554404.1
ENST00000557000.2
FAM181A
family with sequence similarity 181, member A
chr12_+_60058458 0.41 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr20_+_825275 0.41 ENST00000541082.1
FAM110A
family with sequence similarity 110, member A
chr11_-_73472096 0.40 ENST00000541588.1
ENST00000336083.3
ENST00000540771.1
ENST00000310653.6
RAB6A
RAB6A, member RAS oncogene family
chr18_+_29171689 0.40 ENST00000237014.3
TTR
transthyretin
chr8_-_141810634 0.39 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr11_-_88796803 0.38 ENST00000418177.2
ENST00000455756.2
GRM5
glutamate receptor, metabotropic 5
chr15_+_89182156 0.37 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chrX_+_136648297 0.37 ENST00000287538.5
ZIC3
Zic family member 3
chr7_-_121944491 0.36 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr11_+_55594695 0.36 ENST00000378397.1
OR5L2
olfactory receptor, family 5, subfamily L, member 2
chr16_+_640201 0.35 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr16_-_67190152 0.34 ENST00000486556.1
TRADD
TNFRSF1A-associated via death domain
chrX_+_131157290 0.34 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chrX_+_131157322 0.33 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr1_+_228337553 0.32 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr16_-_29757272 0.31 ENST00000329410.3
C16orf54
chromosome 16 open reading frame 54
chr1_-_228604328 0.31 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
TRIM17
tripartite motif containing 17
chr2_+_99797636 0.31 ENST00000409145.1
MRPL30
mitochondrial ribosomal protein L30
chr22_+_50986462 0.31 ENST00000395676.2
KLHDC7B
kelch domain containing 7B
chr11_-_65325430 0.30 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr20_-_22565101 0.30 ENST00000419308.2
FOXA2
forkhead box A2
chr1_+_214163033 0.30 ENST00000607425.1
PROX1
prospero homeobox 1
chr12_+_121416489 0.29 ENST00000541395.1
ENST00000544413.1
HNF1A
HNF1 homeobox A
chr10_-_98031265 0.29 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr14_+_81421355 0.29 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr17_-_40169429 0.28 ENST00000316603.7
ENST00000588641.1
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr14_-_58893832 0.28 ENST00000556007.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr22_-_30925150 0.27 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr14_+_81421861 0.27 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr1_-_15735925 0.27 ENST00000427824.1
RP3-467K16.4
RP3-467K16.4
chr16_+_2022036 0.27 ENST00000568546.1
TBL3
transducin (beta)-like 3
chr18_-_58040000 0.27 ENST00000299766.3
MC4R
melanocortin 4 receptor
chr1_+_151512775 0.26 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1
tuftelin 1
chr19_+_751122 0.26 ENST00000215582.6
MISP
mitotic spindle positioning
chr14_-_106068065 0.25 ENST00000390541.2
IGHE
immunoglobulin heavy constant epsilon
chr1_-_153599426 0.24 ENST00000392622.1
S100A13
S100 calcium binding protein A13
chr14_+_74353320 0.24 ENST00000540593.1
ENST00000555730.1
ZNF410
zinc finger protein 410
chr12_+_18414446 0.24 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chrX_+_86772787 0.24 ENST00000373114.4
KLHL4
kelch-like family member 4
chr14_+_67707826 0.23 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr19_-_39390350 0.23 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr18_+_54814288 0.23 ENST00000585477.1
BOD1L2
biorientation of chromosomes in cell division 1-like 2
chr3_-_52029830 0.23 ENST00000492277.1
ENST00000475248.1
ENST00000479017.1
ENST00000495383.1
ENST00000466397.1
ENST00000481629.1
RPL29
ribosomal protein L29
chr17_-_49198216 0.22 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr6_-_71012773 0.22 ENST00000370496.3
ENST00000357250.6
COL9A1
collagen, type IX, alpha 1
chr19_+_48972459 0.22 ENST00000427476.1
CYTH2
cytohesin 2
chr6_+_43968306 0.21 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr19_-_51336443 0.21 ENST00000598673.1
KLK15
kallikrein-related peptidase 15
chr1_-_62190793 0.19 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr18_-_24283586 0.19 ENST00000579458.1
U3
Small nucleolar RNA U3
chr7_+_65338230 0.19 ENST00000360768.3
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr19_-_54804173 0.19 ENST00000391744.3
ENST00000251390.3
LILRA3
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
chr3_-_52029958 0.19 ENST00000294189.6
RPL29
ribosomal protein L29
chr2_+_168043793 0.18 ENST00000409273.1
ENST00000409605.1
XIRP2
xin actin-binding repeat containing 2
chrX_+_86772707 0.18 ENST00000373119.4
KLHL4
kelch-like family member 4
chr1_+_180165672 0.18 ENST00000443059.1
QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr7_-_27224842 0.18 ENST00000517402.1
HOXA11
homeobox A11
chr15_-_42448788 0.17 ENST00000382396.4
ENST00000397272.3
PLA2G4F
phospholipase A2, group IVF
chr2_+_99797542 0.17 ENST00000338148.3
ENST00000512183.2
MRPL30
C2orf15
mitochondrial ribosomal protein L30
chromosome 2 open reading frame 15
chr10_+_111967345 0.17 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr7_-_27224795 0.17 ENST00000006015.3
HOXA11
homeobox A11
chr5_-_172662303 0.17 ENST00000517440.1
ENST00000329198.4
NKX2-5
NK2 homeobox 5
chr22_+_35653445 0.16 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr10_+_63808970 0.16 ENST00000309334.5
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr5_+_140430979 0.15 ENST00000306549.3
PCDHB1
protocadherin beta 1
chr17_+_66521936 0.15 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr6_+_25652501 0.15 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr14_+_74815116 0.15 ENST00000256362.4
VRTN
vertebrae development associated
chr1_-_25291475 0.15 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr1_-_68698222 0.15 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr17_-_3499125 0.14 ENST00000399759.3
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr1_-_156051789 0.14 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr9_-_128246769 0.14 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr10_-_98031310 0.14 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr3_+_121311966 0.13 ENST00000338040.4
FBXO40
F-box protein 40
chr17_-_10452929 0.13 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr16_-_28223166 0.13 ENST00000304658.5
XPO6
exportin 6
chr17_+_73642315 0.13 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr12_-_719573 0.13 ENST00000397265.3
NINJ2
ninjurin 2
chr3_-_113464906 0.12 ENST00000477813.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr3_-_139195350 0.12 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr7_-_142583506 0.12 ENST00000359396.3
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr2_+_85646054 0.12 ENST00000389938.2
SH2D6
SH2 domain containing 6
chrX_+_153170455 0.12 ENST00000430697.1
ENST00000337474.5
ENST00000370049.1
AVPR2
arginine vasopressin receptor 2
chr7_+_127881325 0.11 ENST00000308868.4
LEP
leptin
chr17_+_73642486 0.11 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr1_-_115259337 0.11 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr12_-_21810765 0.11 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr14_+_67708137 0.11 ENST00000556345.1
ENST00000555925.1
ENST00000557783.1
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr16_+_12995614 0.10 ENST00000423335.2
SHISA9
shisa family member 9
chrX_+_134478706 0.10 ENST00000370761.3
ENST00000339249.4
ENST00000370760.3
ZNF449
zinc finger protein 449
chr8_+_22019168 0.10 ENST00000318561.3
ENST00000521315.1
ENST00000437090.2
ENST00000520605.1
ENST00000522109.1
ENST00000524255.1
ENST00000523296.1
ENST00000518615.1
SFTPC
surfactant protein C
chr6_+_31674639 0.10 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr18_-_13915530 0.10 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr6_-_42858534 0.10 ENST00000408925.2
C6orf226
chromosome 6 open reading frame 226
chr12_+_50478977 0.10 ENST00000381513.4
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr14_-_74892805 0.09 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr16_-_20556492 0.09 ENST00000568098.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr1_+_150266256 0.09 ENST00000309092.7
ENST00000369084.5
MRPS21
mitochondrial ribosomal protein S21
chr12_-_21810726 0.09 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr17_+_26646175 0.08 ENST00000583381.1
ENST00000582113.1
ENST00000582384.1
TMEM97
transmembrane protein 97
chr1_-_41487415 0.08 ENST00000372611.1
SLFNL1
schlafen-like 1
chr20_-_45142154 0.08 ENST00000347606.4
ENST00000457685.2
ZNF334
zinc finger protein 334
chr21_-_35016231 0.08 ENST00000438788.1
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr1_-_41487383 0.07 ENST00000302946.8
ENST00000372613.2
ENST00000439569.2
ENST00000397197.2
SLFNL1
schlafen-like 1
chr1_-_10003372 0.07 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr11_-_18813353 0.07 ENST00000358540.2
ENST00000396171.4
ENST00000396167.2
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr11_+_46193466 0.07 ENST00000533793.1
RP11-702F3.3
RP11-702F3.3
chr8_-_67341208 0.07 ENST00000499642.1
RP11-346I3.4
RP11-346I3.4
chr7_+_150782945 0.06 ENST00000463381.1
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chrX_+_153170189 0.05 ENST00000358927.2
AVPR2
arginine vasopressin receptor 2
chr20_+_30407105 0.05 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr16_+_1359138 0.05 ENST00000325437.5
UBE2I
ubiquitin-conjugating enzyme E2I
chr20_+_30407151 0.05 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chr1_+_24019099 0.05 ENST00000443624.1
ENST00000458455.1
RPL11
ribosomal protein L11
chr1_-_17380630 0.05 ENST00000375499.3
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr6_-_27841289 0.05 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr12_+_7941989 0.04 ENST00000229307.4
NANOG
Nanog homeobox
chr11_-_18813110 0.04 ENST00000396168.1
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr5_-_134783038 0.04 ENST00000503143.2
C5orf20
chromosome 5 open reading frame 20
chr12_-_102591604 0.03 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr8_-_144679296 0.03 ENST00000317198.6
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr3_+_4535155 0.03 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr1_-_153538292 0.03 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr2_-_85895295 0.03 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chrX_-_70474377 0.03 ENST00000373978.1
ENST00000373981.1
ZMYM3
zinc finger, MYM-type 3
chr6_-_137113604 0.03 ENST00000359015.4
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr3_+_4535025 0.03 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr10_+_102222798 0.02 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr20_+_59654146 0.01 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr5_-_137548997 0.01 ENST00000505120.1
ENST00000394886.2
ENST00000394884.3
CDC23
cell division cycle 23
chr2_-_121223697 0.01 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr12_+_121837905 0.01 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
RNF34
ring finger protein 34, E3 ubiquitin protein ligase
chr5_-_58335281 0.01 ENST00000358923.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_42466864 0.01 ENST00000353281.4
ENST00000262407.5
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr3_+_32726774 0.00 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr9_-_72374848 0.00 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr17_+_59489112 0.00 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr19_+_24009879 0.00 ENST00000354585.4
RPSAP58
ribosomal protein SA pseudogene 58
chr21_+_45773515 0.00 ENST00000397932.2
ENST00000300481.9
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chrY_-_25345070 0.00 ENST00000382510.4
ENST00000426000.2
ENST00000540248.1
ENST00000405239.1
DAZ1
deleted in azoospermia 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.3 1.3 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.3 1.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 0.7 GO:1904351 negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.2 2.0 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.2 0.6 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.2 0.7 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 0.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 2.6 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.6 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.4 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.5 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.1 0.9 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.4 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.8 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 0.3 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.3 GO:0035623 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.1 0.4 GO:0010966 regulation of phosphate transport(GO:0010966)
0.1 0.4 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.2 GO:2000777 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 1.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.2 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.5 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 1.5 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 0.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.8 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.2 GO:0003162 atrioventricular node development(GO:0003162) right ventricular cardiac muscle tissue morphogenesis(GO:0003221) septum secundum development(GO:0003285)
0.1 0.4 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.5 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.1 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.5 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.5 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.1 GO:2000364 negative regulation of glucagon secretion(GO:0070093) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.0 0.6 GO:0030238 male sex determination(GO:0030238) Leydig cell differentiation(GO:0033327)
0.0 0.5 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.3 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.3 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.5 GO:0051775 response to redox state(GO:0051775)
0.0 0.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992) negative regulation of urine volume(GO:0035811)
0.0 0.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.7 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.2 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.3 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.8 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.3 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 1.0 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.9 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 1.5 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.6 GO:2000401 regulation of lymphocyte migration(GO:2000401)
0.0 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.0 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 0.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.1 0.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.5 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 1.3 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.6 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.3 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.6 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.6 GO:0043219 lateral loop(GO:0043219)
0.0 0.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.3 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 1.1 GO:0015030 Cajal body(GO:0015030)
0.0 0.3 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 2.0 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.0 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 2.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 0.6 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.5 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.7 GO:1903135 cupric ion binding(GO:1903135)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.2 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.3 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208)
0.0 0.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 1.0 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.3 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 1.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.9 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.6 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.3 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0070513 death domain binding(GO:0070513)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.6 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.0 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.5 PID AURORA A PATHWAY Aurora A signaling
0.0 1.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 PID ARF 3PATHWAY Arf1 pathway
0.0 1.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.3 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.9 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.4 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.2 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.9 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation