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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX2-2

Z-value: 0.95

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
NKX2-2
ENSG00000125820.5 NK2 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-2hg19_v2_chr20_-_21494654_214946780.096.5e-01Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_61513146 3.95 ENST00000430431.1
LINC00948
long intergenic non-protein coding RNA 948
chr10_-_61513201 3.09 ENST00000414264.1
ENST00000594536.1
LINC00948
long intergenic non-protein coding RNA 948
chr1_+_104293028 3.02 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr2_+_228736321 2.59 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr1_+_54359854 2.50 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
DIO1
deiodinase, iodothyronine, type I
chr1_+_104159999 2.39 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr1_+_78769549 2.29 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr15_-_56757329 2.19 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr13_-_36429763 2.14 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr12_-_49582978 2.09 ENST00000301071.7
TUBA1A
tubulin, alpha 1a
chr1_-_26633067 1.93 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
UBXN11
UBX domain protein 11
chr13_+_31506818 1.79 ENST00000380473.3
TEX26
testis expressed 26
chr17_+_7591639 1.70 ENST00000396463.2
WRAP53
WD repeat containing, antisense to TP53
chr2_+_39103103 1.69 ENST00000340556.6
ENST00000410014.1
ENST00000409665.1
ENST00000409077.2
ENST00000409131.2
MORN2
MORN repeat containing 2
chr17_+_7591747 1.69 ENST00000534050.1
WRAP53
WD repeat containing, antisense to TP53
chr12_-_68696652 1.67 ENST00000539972.1
MDM1
Mdm1 nuclear protein homolog (mouse)
chr13_-_61989655 1.67 ENST00000409204.4
PCDH20
protocadherin 20
chr12_-_71551652 1.60 ENST00000546561.1
TSPAN8
tetraspanin 8
chr17_-_29641084 1.52 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr3_-_121379739 1.50 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_-_216978709 1.47 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr1_-_54405773 1.45 ENST00000371376.1
HSPB11
heat shock protein family B (small), member 11
chr5_+_140602904 1.42 ENST00000515856.2
ENST00000239449.4
PCDHB14
protocadherin beta 14
chr8_-_133637624 1.25 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr8_-_133772794 1.23 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71
transmembrane protein 71
chr16_+_30212378 1.21 ENST00000569485.1
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr7_-_102715263 1.21 ENST00000379305.3
FBXL13
F-box and leucine-rich repeat protein 13
chr11_+_93063137 1.16 ENST00000534747.1
CCDC67
coiled-coil domain containing 67
chr9_-_15510287 1.14 ENST00000397519.2
PSIP1
PC4 and SFRS1 interacting protein 1
chr6_-_110011704 1.13 ENST00000448084.2
AK9
adenylate kinase 9
chr7_+_23719749 1.11 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A
family with sequence similarity 221, member A
chr8_+_94767109 1.09 ENST00000409623.3
ENST00000453906.1
ENST00000521517.1
TMEM67
transmembrane protein 67
chr1_-_160231451 1.08 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr1_+_171217622 1.04 ENST00000433267.1
ENST00000367750.3
FMO1
flavin containing monooxygenase 1
chr7_-_102715172 1.03 ENST00000456695.1
ENST00000455112.2
ENST00000440067.1
FBXL13
F-box and leucine-rich repeat protein 13
chr6_-_110011718 1.03 ENST00000532976.1
AK9
adenylate kinase 9
chr4_+_36283213 0.99 ENST00000357504.3
DTHD1
death domain containing 1
chr3_-_150920979 0.97 ENST00000309180.5
ENST00000480322.1
GPR171
G protein-coupled receptor 171
chrX_-_154033661 0.95 ENST00000393531.1
MPP1
membrane protein, palmitoylated 1, 55kDa
chr2_+_120301997 0.92 ENST00000602047.1
PCDP1
Primary ciliary dyskinesia protein 1
chr3_-_170744498 0.92 ENST00000382808.4
ENST00000314251.3
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr10_-_112678692 0.91 ENST00000605742.1
BBIP1
BBSome interacting protein 1
chr2_+_170655322 0.89 ENST00000260956.4
ENST00000417292.1
SSB
Sjogren syndrome antigen B (autoantigen La)
chr7_-_130080977 0.85 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr6_-_80247105 0.84 ENST00000369846.4
LCA5
Leber congenital amaurosis 5
chr21_+_25801041 0.83 ENST00000453784.2
ENST00000423581.1
AP000476.1
AP000476.1
chr5_-_41261540 0.80 ENST00000263413.3
C6
complement component 6
chr1_+_211433275 0.79 ENST00000367005.4
RCOR3
REST corepressor 3
chr3_-_122134882 0.79 ENST00000330689.4
WDR5B
WD repeat domain 5B
chr6_+_159084188 0.79 ENST00000367081.3
SYTL3
synaptotagmin-like 3
chr13_-_20357110 0.76 ENST00000427943.1
PSPC1
paraspeckle component 1
chr4_+_128802016 0.76 ENST00000270861.5
ENST00000515069.1
ENST00000513090.1
ENST00000507249.1
PLK4
polo-like kinase 4
chr4_-_105416039 0.75 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr4_+_95679072 0.75 ENST00000515059.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr5_+_159656437 0.74 ENST00000402432.3
FABP6
fatty acid binding protein 6, ileal
chr6_-_80247140 0.73 ENST00000392959.1
ENST00000467898.3
LCA5
Leber congenital amaurosis 5
chr11_+_65266507 0.72 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr7_-_120497178 0.70 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr14_-_89878369 0.69 ENST00000553840.1
ENST00000556916.1
FOXN3
forkhead box N3
chr16_-_21289627 0.66 ENST00000396023.2
ENST00000415987.2
CRYM
crystallin, mu
chr11_-_72432950 0.66 ENST00000426523.1
ENST00000429686.1
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_-_150212029 0.66 ENST00000529948.1
ENST00000357183.4
ENST00000367363.3
RAET1E
retinoic acid early transcript 1E
chr9_-_20622478 0.62 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_-_110723335 0.62 ENST00000394634.2
CFI
complement factor I
chrX_+_47092314 0.60 ENST00000218348.3
USP11
ubiquitin specific peptidase 11
chr17_-_29641104 0.60 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr20_-_55841398 0.58 ENST00000395864.3
BMP7
bone morphogenetic protein 7
chr16_+_53241854 0.57 ENST00000565803.1
CHD9
chromodomain helicase DNA binding protein 9
chr8_+_76452097 0.57 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr3_+_158991025 0.55 ENST00000337808.6
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr16_+_30212050 0.55 ENST00000563322.1
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chrX_-_70474910 0.54 ENST00000373988.1
ENST00000373998.1
ZMYM3
zinc finger, MYM-type 3
chr6_+_140175987 0.53 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr11_+_94277017 0.52 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr9_-_99382065 0.50 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr1_-_207095324 0.50 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr1_+_84630367 0.49 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_41831485 0.48 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr2_+_162272605 0.48 ENST00000389554.3
TBR1
T-box, brain, 1
chr2_-_239198743 0.47 ENST00000440245.1
ENST00000431832.1
PER2
period circadian clock 2
chrX_-_70474499 0.47 ENST00000353904.2
ZMYM3
zinc finger, MYM-type 3
chr12_+_57998400 0.47 ENST00000548804.1
ENST00000550596.1
ENST00000551835.1
ENST00000549583.1
DTX3
deltex homolog 3 (Drosophila)
chr1_-_223308098 0.46 ENST00000342210.6
TLR5
toll-like receptor 5
chr7_+_114055052 0.44 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2
forkhead box P2
chr12_+_20963632 0.44 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr5_+_82767583 0.44 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr5_+_82767487 0.44 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr12_+_20963647 0.44 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr10_-_27529486 0.44 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr8_-_122653630 0.43 ENST00000303924.4
HAS2
hyaluronan synthase 2
chrX_+_11777671 0.43 ENST00000380693.3
ENST00000380692.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr9_-_39239171 0.40 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr1_+_61547894 0.39 ENST00000403491.3
NFIA
nuclear factor I/A
chr1_-_45253377 0.39 ENST00000372207.3
BEST4
bestrophin 4
chr1_-_227505289 0.38 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr3_-_114790179 0.38 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr2_-_163008903 0.37 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr3_+_108541545 0.36 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_-_197169672 0.36 ENST00000367405.4
ZBTB41
zinc finger and BTB domain containing 41
chr1_-_213188772 0.36 ENST00000544555.1
ANGEL2
angel homolog 2 (Drosophila)
chr3_-_69101461 0.36 ENST00000543976.1
TMF1
TATA element modulatory factor 1
chr7_-_99149715 0.36 ENST00000449309.1
FAM200A
family with sequence similarity 200, member A
chr1_+_43312258 0.35 ENST00000372508.3
ENST00000372507.1
ENST00000372506.1
ENST00000397044.3
ENST00000372504.1
ZNF691
zinc finger protein 691
chr8_+_71485681 0.35 ENST00000391684.1
AC120194.1
AC120194.1
chr1_-_115259337 0.35 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr14_-_24020858 0.34 ENST00000419474.3
ZFHX2
zinc finger homeobox 2
chr1_+_15272271 0.33 ENST00000400797.3
KAZN
kazrin, periplakin interacting protein
chr2_+_120436733 0.33 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
TMEM177
transmembrane protein 177
chr13_-_20357057 0.32 ENST00000338910.4
PSPC1
paraspeckle component 1
chr3_+_179280668 0.31 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr7_-_122339162 0.31 ENST00000340112.2
RNF133
ring finger protein 133
chr19_+_58193388 0.30 ENST00000596085.1
ENST00000594684.1
ZNF551
AC003006.7
zinc finger protein 551
Uncharacterized protein
chr19_-_14945933 0.30 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr14_-_100841930 0.30 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr17_+_53342311 0.29 ENST00000226067.5
HLF
hepatic leukemia factor
chr8_+_110552337 0.29 ENST00000337573.5
EBAG9
estrogen receptor binding site associated, antigen, 9
chr20_-_55841662 0.29 ENST00000395863.3
ENST00000450594.2
BMP7
bone morphogenetic protein 7
chrX_+_36053908 0.28 ENST00000378660.2
CHDC2
calponin homology domain containing 2
chrX_-_70474377 0.28 ENST00000373978.1
ENST00000373981.1
ZMYM3
zinc finger, MYM-type 3
chr14_-_44976474 0.28 ENST00000340446.4
FSCB
fibrous sheath CABYR binding protein
chr3_-_33686743 0.28 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr7_+_150065278 0.28 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1
replication initiator 1
chr9_-_85882145 0.28 ENST00000328788.1
FRMD3
FERM domain containing 3
chr12_+_510742 0.28 ENST00000239830.4
CCDC77
coiled-coil domain containing 77
chr18_+_29671812 0.27 ENST00000261593.3
ENST00000578914.1
RNF138
ring finger protein 138, E3 ubiquitin protein ligase
chr15_+_65843130 0.27 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr10_+_97759848 0.27 ENST00000424464.1
ENST00000410012.2
ENST00000344386.3
CC2D2B
coiled-coil and C2 domain containing 2B
chr8_+_110552831 0.26 ENST00000530629.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr12_+_510795 0.26 ENST00000412006.2
CCDC77
coiled-coil domain containing 77
chr5_+_167718604 0.26 ENST00000265293.4
WWC1
WW and C2 domain containing 1
chr2_+_113299990 0.26 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr1_-_246670519 0.26 ENST00000388985.4
ENST00000490107.1
SMYD3
SET and MYND domain containing 3
chr1_+_180601139 0.25 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr13_+_102104980 0.25 ENST00000545560.2
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr8_-_124279627 0.25 ENST00000357082.4
ZHX1-C8ORF76
ZHX1-C8ORF76 readthrough
chr14_-_100841670 0.25 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr12_-_58240470 0.24 ENST00000548823.1
ENST00000398073.2
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr12_-_42631529 0.24 ENST00000548917.1
YAF2
YY1 associated factor 2
chrX_+_105445717 0.24 ENST00000372552.1
MUM1L1
melanoma associated antigen (mutated) 1-like 1
chr1_-_207095212 0.24 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chrX_-_70473957 0.24 ENST00000373984.3
ENST00000314425.5
ENST00000373982.1
ZMYM3
zinc finger, MYM-type 3
chr17_-_67138015 0.24 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr16_-_20556492 0.23 ENST00000568098.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr1_+_241695424 0.23 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr18_-_52989217 0.23 ENST00000570287.2
TCF4
transcription factor 4
chr15_+_79165296 0.23 ENST00000558746.1
ENST00000558830.1
ENST00000559345.1
MORF4L1
mortality factor 4 like 1
chr5_-_58652788 0.23 ENST00000405755.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_+_79165372 0.23 ENST00000558502.1
MORF4L1
mortality factor 4 like 1
chrX_+_83116142 0.23 ENST00000329312.4
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr17_-_43339474 0.23 ENST00000331780.4
SPATA32
spermatogenesis associated 32
chr1_-_226926864 0.22 ENST00000429204.1
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr3_+_88188254 0.22 ENST00000309495.5
ZNF654
zinc finger protein 654
chr3_+_23847432 0.22 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr15_+_42841008 0.22 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr14_+_39703112 0.22 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr11_-_72433346 0.22 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chrX_+_152953505 0.22 ENST00000253122.5
SLC6A8
solute carrier family 6 (neurotransmitter transporter), member 8
chr2_+_202937972 0.21 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr9_-_95166841 0.21 ENST00000262551.4
OGN
osteoglycin
chr15_+_79165151 0.21 ENST00000331268.5
MORF4L1
mortality factor 4 like 1
chr22_-_24093267 0.21 ENST00000341976.3
ZNF70
zinc finger protein 70
chr3_-_123339418 0.21 ENST00000583087.1
MYLK
myosin light chain kinase
chr3_-_123339343 0.21 ENST00000578202.1
MYLK
myosin light chain kinase
chr17_+_48823975 0.21 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr16_+_22501658 0.21 ENST00000415833.2
NPIPB5
nuclear pore complex interacting protein family, member B5
chr17_+_39261584 0.20 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr3_-_33686925 0.20 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr9_-_95166884 0.20 ENST00000375561.5
OGN
osteoglycin
chr13_-_36944307 0.20 ENST00000355182.4
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr15_-_60690163 0.19 ENST00000558998.1
ENST00000560165.1
ENST00000557986.1
ENST00000559780.1
ENST00000559467.1
ENST00000559956.1
ENST00000332680.4
ENST00000396024.3
ENST00000421017.2
ENST00000560466.1
ENST00000558132.1
ENST00000559113.1
ENST00000557906.1
ENST00000558558.1
ENST00000560468.1
ENST00000559370.1
ENST00000558169.1
ENST00000559725.1
ENST00000558985.1
ENST00000451270.2
ANXA2
annexin A2
chr3_+_23847394 0.19 ENST00000306627.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr20_-_13765526 0.19 ENST00000202816.1
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr9_+_71944241 0.19 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr17_+_52978107 0.18 ENST00000445275.2
TOM1L1
target of myb1 (chicken)-like 1
chr8_-_134072593 0.18 ENST00000427060.2
SLA
Src-like-adaptor
chr15_+_79165222 0.18 ENST00000559930.1
MORF4L1
mortality factor 4 like 1
chr17_-_15469590 0.18 ENST00000312127.2
CDRT1
CMT duplicated region transcript 1; Uncharacterized protein
chrX_-_130037198 0.18 ENST00000370935.1
ENST00000338144.3
ENST00000394363.1
ENOX2
ecto-NOX disulfide-thiol exchanger 2
chr3_-_69101413 0.18 ENST00000398559.2
TMF1
TATA element modulatory factor 1
chr2_-_25565377 0.17 ENST00000264709.3
ENST00000406659.3
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr6_+_45296391 0.16 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr13_+_50656307 0.16 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr16_+_10837643 0.16 ENST00000574334.1
ENST00000283027.5
ENST00000433392.2
NUBP1
nucleotide binding protein 1
chr9_+_92219919 0.16 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr14_+_22948510 0.16 ENST00000390483.1
TRAJ56
T cell receptor alpha joining 56
chr5_+_125758813 0.16 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr5_-_58571935 0.16 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr8_-_18666360 0.16 ENST00000286485.8
PSD3
pleckstrin and Sec7 domain containing 3
chr2_-_75938115 0.15 ENST00000321027.3
GCFC2
GC-rich sequence DNA-binding factor 2
chr1_+_110577229 0.15 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr5_+_125758865 0.15 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr9_-_97356075 0.15 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr11_-_77850629 0.15 ENST00000376156.3
ENST00000525870.1
ENST00000530454.1
ENST00000525755.1
ENST00000527099.1
ENST00000525761.1
ENST00000299626.5
ALG8
ALG8, alpha-1,3-glucosyltransferase
chr12_-_371994 0.15 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr15_+_54305101 0.14 ENST00000260323.11
ENST00000545554.1
ENST00000537900.1
UNC13C
unc-13 homolog C (C. elegans)
chr2_+_103035102 0.14 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chrX_+_108779004 0.14 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chrX_+_100743031 0.14 ENST00000423738.3
ARMCX4
armadillo repeat containing, X-linked 4
chr11_+_93479588 0.13 ENST00000526335.1
C11orf54
chromosome 11 open reading frame 54
chr12_+_52056548 0.13 ENST00000545061.1
ENST00000355133.3
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0032203 telomere formation via telomerase(GO:0032203)
0.7 2.2 GO:0061566 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.3 2.4 GO:0044245 polysaccharide digestion(GO:0044245)
0.3 2.3 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.3 1.8 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.2 0.9 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.2 0.9 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.2 0.9 GO:1905069 allantois development(GO:1905069)
0.2 0.8 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 3.6 GO:0070986 left/right axis specification(GO:0070986)
0.2 1.0 GO:0070995 NADPH oxidation(GO:0070995)
0.2 2.9 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.2 0.5 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.2 0.8 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.1 0.7 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.4 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.1 GO:0009405 pathogenesis(GO:0009405)
0.1 1.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.2 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 0.9 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 0.5 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.5 GO:2000845 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.1 0.5 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 0.4 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 1.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.9 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 3.2 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 0.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.5 GO:0021764 amygdala development(GO:0021764)
0.1 0.2 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 2.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 1.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 1.0 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.5 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.0 0.1 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.9 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.1 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.1 GO:0032268 regulation of cellular protein metabolic process(GO:0032268)
0.0 0.7 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.9 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.3 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 0.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 2.6 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 1.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.0 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.7 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.0 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.3 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.0 0.0 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 2.1 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0098536 deuterosome(GO:0098536)
0.1 1.1 GO:0042382 paraspeckles(GO:0042382)
0.1 3.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.2 GO:0043159 cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.1 0.9 GO:0034464 BBSome(GO:0034464)
0.1 0.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 1.1 GO:0036038 MKS complex(GO:0036038)
0.1 0.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.4 GO:0072487 MSL complex(GO:0072487)
0.1 0.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.2 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.5 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 1.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 2.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.6 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.0 1.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.6 2.4 GO:0016160 amylase activity(GO:0016160)
0.4 2.5 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 1.8 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.2 0.9 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.2 2.2 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.2 1.5 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 0.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 1.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.5 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.1 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 3.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 0.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.3 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.9 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.1 GO:0031005 filamin binding(GO:0031005)
0.0 0.7 GO:0032052 bile acid binding(GO:0032052)
0.0 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 1.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.6 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.0 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.9 PID ALK2 PATHWAY ALK2 signaling events
0.0 2.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 2.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 3.5 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 2.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.7 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.9 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism