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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX2-3

Z-value: 0.65

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Transcription factors associated with NKX2-3

Gene Symbol Gene ID Gene Info
NKX2-3
ENSG00000119919.9 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v2_chr10_+_101292684_101292706-0.251.7e-01Click!

Activity profile of NKX2-3 motif

Sorted Z-values of NKX2-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_150404904 4.30 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr19_-_51504852 2.15 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
KLK8
kallikrein-related peptidase 8
chr1_-_205391178 2.10 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chr19_-_19051993 1.80 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
HOMER3
homer homolog 3 (Drosophila)
chrX_+_37865804 1.70 ENST00000297875.2
ENST00000357972.5
SYTL5
synaptotagmin-like 5
chr3_+_101818088 1.64 ENST00000491959.1
ZPLD1
zona pellucida-like domain containing 1
chr3_+_98482175 1.56 ENST00000485391.1
ENST00000492254.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr5_-_110848189 1.50 ENST00000296632.3
ENST00000512160.1
ENST00000509887.1
STARD4
StAR-related lipid transfer (START) domain containing 4
chr2_-_31440377 1.32 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr6_-_11382478 1.31 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr4_-_57524061 1.30 ENST00000508121.1
HOPX
HOP homeobox
chr11_+_35211429 1.19 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44
CD44 molecule (Indian blood group)
chr19_+_45409011 1.17 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
APOE
apolipoprotein E
chr17_-_76870126 1.08 ENST00000586057.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_76870222 1.07 ENST00000585421.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_79472365 1.02 ENST00000370742.3
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chrX_+_41548220 1.02 ENST00000378142.4
GPR34
G protein-coupled receptor 34
chr18_+_61445007 1.00 ENST00000447428.1
ENST00000546027.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chrX_+_41548259 0.99 ENST00000378138.5
GPR34
G protein-coupled receptor 34
chr6_+_31126291 0.98 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr5_-_39270725 0.96 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr19_-_44174330 0.95 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr1_+_43824669 0.92 ENST00000372462.1
CDC20
cell division cycle 20
chr1_-_68962805 0.92 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr12_-_120315074 0.90 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr11_+_35211511 0.89 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr15_+_40674920 0.88 ENST00000416151.2
ENST00000249776.8
KNSTRN
kinetochore-localized astrin/SPAG5 binding protein
chr3_-_123512688 0.87 ENST00000475616.1
MYLK
myosin light chain kinase
chr2_+_173420697 0.87 ENST00000282077.3
ENST00000392571.2
ENST00000410055.1
PDK1
pyruvate dehydrogenase kinase, isozyme 1
chr3_-_47950745 0.86 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr17_-_15469590 0.85 ENST00000312127.2
CDRT1
CMT duplicated region transcript 1; Uncharacterized protein
chr17_-_8055747 0.84 ENST00000317276.4
ENST00000581703.1
PER1
period circadian clock 1
chr13_-_30881134 0.83 ENST00000380617.3
ENST00000441394.1
KATNAL1
katanin p60 subunit A-like 1
chr15_+_40674963 0.81 ENST00000448395.2
KNSTRN
kinetochore-localized astrin/SPAG5 binding protein
chr7_-_84569561 0.81 ENST00000439105.1
AC074183.4
AC074183.4
chr9_+_75229616 0.79 ENST00000340019.3
TMC1
transmembrane channel-like 1
chr7_+_141463897 0.78 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr14_-_91720224 0.77 ENST00000238699.3
ENST00000531499.2
GPR68
G protein-coupled receptor 68
chr14_-_50154921 0.72 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr4_-_39033963 0.71 ENST00000381938.3
TMEM156
transmembrane protein 156
chr6_+_32121789 0.70 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr17_-_34808047 0.69 ENST00000592614.1
ENST00000591542.1
ENST00000330458.7
ENST00000341264.6
ENST00000592987.1
ENST00000400684.4
TBC1D3G
TBC1D3H
TBC1 domain family, member 3G
TBC1 domain family, member 3H
chr10_+_101419187 0.68 ENST00000370489.4
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr12_-_123187890 0.66 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr6_+_69942298 0.65 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr12_-_52604607 0.65 ENST00000551894.1
ENST00000553017.1
C12orf80
chromosome 12 open reading frame 80
chr12_-_123201337 0.64 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr14_-_69263043 0.64 ENST00000408913.2
ZFP36L1
ZFP36 ring finger protein-like 1
chr1_-_197036364 0.62 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr16_+_68877496 0.61 ENST00000261778.1
TANGO6
transport and golgi organization 6 homolog (Drosophila)
chr10_+_13203543 0.61 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
MCM10
minichromosome maintenance complex component 10
chr2_+_191002486 0.60 ENST00000396974.2
C2orf88
chromosome 2 open reading frame 88
chr1_-_162381907 0.59 ENST00000367929.2
ENST00000359567.3
SH2D1B
SH2 domain containing 1B
chr1_+_65613340 0.59 ENST00000546702.1
AK4
adenylate kinase 4
chr9_+_118950325 0.59 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr6_-_111927062 0.57 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr4_-_39034542 0.57 ENST00000344606.6
TMEM156
transmembrane protein 156
chr18_-_64271316 0.56 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr1_+_230193521 0.56 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr6_+_32121218 0.55 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
PPT2
palmitoyl-protein thioesterase 2
chr14_-_72458326 0.55 ENST00000542853.1
AC005477.1
AC005477.1
chr17_+_26662597 0.55 ENST00000544907.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr13_-_46756351 0.54 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_+_36283971 0.54 ENST00000327454.6
ENST00000378174.5
TBC1D3F
TBC1 domain family, member 3F
chr7_+_134430212 0.54 ENST00000436461.2
CALD1
caldesmon 1
chr9_-_39239171 0.53 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr19_-_46288917 0.53 ENST00000537879.1
ENST00000596586.1
ENST00000595946.1
DMWD
AC011530.4
dystrophia myotonica, WD repeat containing
Uncharacterized protein
chr1_-_114696472 0.53 ENST00000393296.1
ENST00000369547.1
ENST00000610222.1
SYT6
synaptotagmin VI
chr17_-_36348610 0.53 ENST00000339023.4
ENST00000354664.4
TBC1D3
TBC1 domain family, member 3
chr19_-_18433910 0.53 ENST00000594828.3
ENST00000593829.1
LSM4
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr17_-_8059638 0.53 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr22_-_37584321 0.52 ENST00000397110.2
ENST00000337843.2
C1QTNF6
C1q and tumor necrosis factor related protein 6
chr20_-_23969416 0.50 ENST00000335694.4
GGTLC1
gamma-glutamyltransferase light chain 1
chr9_+_116263778 0.50 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr3_+_149191723 0.50 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr6_-_144329531 0.50 ENST00000429150.1
ENST00000392309.1
ENST00000416623.1
ENST00000392307.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr11_+_124735282 0.49 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr19_+_39616410 0.48 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr17_+_26662730 0.48 ENST00000226225.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr1_+_155278625 0.47 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr1_+_155278539 0.46 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr4_-_90757364 0.46 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr10_-_104262460 0.46 ENST00000446605.2
ENST00000369905.4
ENST00000545684.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr5_+_150051149 0.46 ENST00000523553.1
MYOZ3
myozenin 3
chr17_+_75401152 0.46 ENST00000585930.1
SEPT9
septin 9
chr7_-_29186008 0.45 ENST00000396276.3
ENST00000265394.5
CPVL
carboxypeptidase, vitellogenic-like
chr2_+_191045173 0.44 ENST00000409870.1
C2orf88
chromosome 2 open reading frame 88
chr11_+_6226782 0.42 ENST00000316375.2
C11orf42
chromosome 11 open reading frame 42
chr15_+_91411810 0.41 ENST00000268171.3
FURIN
furin (paired basic amino acid cleaving enzyme)
chr8_-_49833978 0.41 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr19_+_56187987 0.41 ENST00000411543.2
EPN1
epsin 1
chr18_+_43684298 0.41 ENST00000282058.6
HAUS1
HAUS augmin-like complex, subunit 1
chr12_+_93963590 0.41 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr8_+_41386761 0.39 ENST00000523277.2
GINS4
GINS complex subunit 4 (Sld5 homolog)
chr3_+_63428982 0.39 ENST00000479198.1
ENST00000460711.1
ENST00000465156.1
SYNPR
synaptoporin
chr11_+_33902189 0.38 ENST00000330381.2
AC132216.1
HCG1785179; PRO1787; Uncharacterized protein
chr9_+_131644398 0.38 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr16_-_32688053 0.38 ENST00000398682.4
TP53TG3
TP53 target 3
chr16_+_32264040 0.38 ENST00000398664.3
TP53TG3D
TP53 target 3D
chr1_+_43803475 0.37 ENST00000372470.3
ENST00000413998.2
MPL
myeloproliferative leukemia virus oncogene
chr3_+_113775576 0.37 ENST00000485050.1
ENST00000281273.4
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr17_-_41132410 0.37 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr1_+_202431859 0.37 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr2_+_201170596 0.37 ENST00000439084.1
ENST00000409718.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr2_-_188419078 0.36 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_+_113217043 0.36 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr9_+_131644388 0.35 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr18_+_43684310 0.35 ENST00000592471.1
ENST00000585518.1
HAUS1
HAUS augmin-like complex, subunit 1
chr2_-_188419200 0.35 ENST00000233156.3
ENST00000426055.1
ENST00000453013.1
ENST00000417013.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_+_65613217 0.34 ENST00000545314.1
AK4
adenylate kinase 4
chr8_-_49834299 0.34 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr8_+_7801144 0.34 ENST00000443676.1
ZNF705B
zinc finger protein 705B
chr5_+_108083517 0.34 ENST00000281092.4
ENST00000536402.1
FER
fer (fps/fes related) tyrosine kinase
chr8_+_11961898 0.33 ENST00000400085.3
ZNF705D
zinc finger protein 705D
chr10_-_36813162 0.32 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr9_-_137809718 0.31 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr4_+_88754069 0.31 ENST00000395102.4
ENST00000497649.2
MEPE
matrix extracellular phosphoglycoprotein
chr1_+_113217073 0.31 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_+_205682497 0.31 ENST00000598338.1
AC119673.1
AC119673.1
chr11_+_10326612 0.30 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr7_+_142880512 0.30 ENST00000446620.1
TAS2R39
taste receptor, type 2, member 39
chr4_+_95376396 0.30 ENST00000508216.1
ENST00000514743.1
PDLIM5
PDZ and LIM domain 5
chr1_-_155880672 0.30 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chrX_-_134049233 0.29 ENST00000370779.4
MOSPD1
motile sperm domain containing 1
chr12_+_123464607 0.29 ENST00000543566.1
ENST00000315580.5
ENST00000542099.1
ENST00000392435.2
ENST00000413381.2
ENST00000426960.2
ENST00000453766.2
ARL6IP4
ADP-ribosylation-like factor 6 interacting protein 4
chr2_+_90458201 0.29 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chr13_+_32313658 0.29 ENST00000380314.1
ENST00000298386.2
RXFP2
relaxin/insulin-like family peptide receptor 2
chr4_-_120550146 0.29 ENST00000354960.3
PDE5A
phosphodiesterase 5A, cGMP-specific
chr1_+_110091189 0.29 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr1_-_28559502 0.28 ENST00000263697.4
DNAJC8
DnaJ (Hsp40) homolog, subfamily C, member 8
chr3_-_160167301 0.28 ENST00000494486.1
TRIM59
tripartite motif containing 59
chr1_+_202317815 0.28 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr4_+_88754113 0.28 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr19_-_10341948 0.28 ENST00000590320.1
ENST00000592342.1
ENST00000588952.1
S1PR2
DNMT1
sphingosine-1-phosphate receptor 2
DNA (cytosine-5-)-methyltransferase 1
chr12_+_82347498 0.28 ENST00000550506.1
RP11-362A1.1
RP11-362A1.1
chr18_+_22040620 0.28 ENST00000426880.2
HRH4
histamine receptor H4
chr2_+_114163945 0.28 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr10_+_99332529 0.28 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr6_-_26216872 0.27 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr10_+_99332198 0.27 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr14_-_75643296 0.27 ENST00000303575.4
TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chrX_-_118284542 0.27 ENST00000402510.2
KIAA1210
KIAA1210
chr17_-_29641084 0.27 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr22_+_38453207 0.27 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr6_+_144185573 0.27 ENST00000237275.6
ENST00000539295.1
ZC2HC1B
zinc finger, C2HC-type containing 1B
chr19_+_41882466 0.27 ENST00000436170.2
TMEM91
transmembrane protein 91
chr18_-_64271363 0.27 ENST00000262150.2
CDH19
cadherin 19, type 2
chr3_+_124223586 0.27 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chr8_-_93029520 0.26 ENST00000521553.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_-_109541539 0.26 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr21_+_33671264 0.26 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chrX_-_55057403 0.26 ENST00000396198.3
ENST00000335854.4
ENST00000455688.1
ENST00000330807.5
ALAS2
aminolevulinate, delta-, synthase 2
chr2_+_219110149 0.26 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr4_+_144303093 0.26 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr5_-_151784838 0.26 ENST00000255262.3
NMUR2
neuromedin U receptor 2
chr4_+_158142750 0.25 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr19_-_3772209 0.25 ENST00000555978.1
ENST00000555633.1
RAX2
retina and anterior neural fold homeobox 2
chr3_-_122233723 0.25 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr18_+_22040593 0.25 ENST00000256906.4
HRH4
histamine receptor H4
chr11_+_120195992 0.24 ENST00000314475.2
ENST00000529187.1
TMEM136
transmembrane protein 136
chr14_+_94547628 0.24 ENST00000555523.1
IFI27L1
interferon, alpha-inducible protein 27-like 1
chr12_+_10124001 0.24 ENST00000396507.3
ENST00000304361.4
ENST00000434319.2
CLEC12A
C-type lectin domain family 12, member A
chr10_-_104262426 0.24 ENST00000487599.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr12_+_123465033 0.24 ENST00000454885.2
ARL6IP4
ADP-ribosylation-like factor 6 interacting protein 4
chr3_+_182971018 0.24 ENST00000326505.3
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr18_-_33702078 0.24 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chrX_-_106362013 0.23 ENST00000372487.1
ENST00000372479.3
ENST00000203616.8
RBM41
RNA binding motif protein 41
chr1_-_182573514 0.23 ENST00000367558.5
RGS16
regulator of G-protein signaling 16
chr10_-_76868931 0.23 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr7_-_87342564 0.23 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr13_-_50018241 0.23 ENST00000409308.1
CAB39L
calcium binding protein 39-like
chr8_-_101719159 0.23 ENST00000520868.1
ENST00000522658.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr1_-_232598163 0.23 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr18_-_60986613 0.23 ENST00000444484.1
BCL2
B-cell CLL/lymphoma 2
chr12_-_120632505 0.23 ENST00000300648.6
GCN1L1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr11_-_27384737 0.23 ENST00000317945.6
CCDC34
coiled-coil domain containing 34
chr16_-_11363178 0.22 ENST00000312693.3
TNP2
transition protein 2 (during histone to protamine replacement)
chr15_+_43477455 0.22 ENST00000300213.4
CCNDBP1
cyclin D-type binding-protein 1
chr10_+_44340748 0.22 ENST00000374432.3
LINC00619
long intergenic non-protein coding RNA 619
chr21_-_46131470 0.22 ENST00000323084.4
TSPEAR
thrombospondin-type laminin G domain and EAR repeats
chr19_+_33865218 0.21 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr17_+_66521936 0.21 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr12_+_49761147 0.21 ENST00000549298.1
SPATS2
spermatogenesis associated, serine-rich 2
chr12_+_10460417 0.21 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr6_+_134758827 0.21 ENST00000431422.1
LINC01010
long intergenic non-protein coding RNA 1010
chr14_+_21387508 0.21 ENST00000555624.1
RP11-84C10.2
RP11-84C10.2
chrX_-_69509738 0.21 ENST00000374454.1
ENST00000239666.4
PDZD11
PDZ domain containing 11
chr12_+_49761224 0.21 ENST00000553127.1
ENST00000321898.6
SPATS2
spermatogenesis associated, serine-rich 2
chr1_-_29508499 0.20 ENST00000373795.4
SRSF4
serine/arginine-rich splicing factor 4
chr18_-_60985914 0.20 ENST00000589955.1
BCL2
B-cell CLL/lymphoma 2
chr3_-_52002403 0.20 ENST00000490063.1
ENST00000468324.1
ENST00000497653.1
ENST00000484633.1
PCBP4
poly(rC) binding protein 4
chr11_+_12399071 0.20 ENST00000539723.1
ENST00000550549.1
PARVA
parvin, alpha
chr15_-_50558223 0.20 ENST00000267845.3
HDC
histidine decarboxylase
chr17_+_58227287 0.20 ENST00000300900.4
ENST00000591725.1
CA4
carbonic anhydrase IV
chr3_+_57094469 0.20 ENST00000334325.1
SPATA12
spermatogenesis associated 12
chr16_+_69458537 0.20 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
CYB5B
cytochrome b5 type B (outer mitochondrial membrane)
chr6_-_26027480 0.20 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr12_+_104982622 0.20 ENST00000549016.1
CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr19_-_38743878 0.20 ENST00000587515.1
PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr12_+_10460549 0.19 ENST00000543420.1
ENST00000543777.1
KLRD1
killer cell lectin-like receptor subfamily D, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.3 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.5 1.5 GO:1904253 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.4 2.2 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.4 1.2 GO:2000646 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of receptor catabolic process(GO:2000646)
0.3 2.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.3 2.1 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 0.8 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3 1.0 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.2 0.9 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.2 0.6 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.2 1.4 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.2 0.9 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.2 0.8 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.9 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.6 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 0.4 GO:0032900 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) negative regulation of neurotrophin production(GO:0032900) negative regulation of transforming growth factor beta1 production(GO:0032911) negative regulation of receptor catabolic process(GO:2000645)
0.1 0.5 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 1.3 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 0.4 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.1 0.9 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.1 0.6 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1 0.3 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.1 0.7 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.4 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.3 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.8 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.9 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 0.8 GO:0051013 microtubule severing(GO:0051013)
0.1 1.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.7 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.5 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.3 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.1 0.7 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 1.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 1.8 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.2 GO:0001694 histamine biosynthetic process(GO:0001694)
0.1 0.2 GO:0035690 cellular response to drug(GO:0035690)
0.1 0.7 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.1 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.1 0.3 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.5 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.2 GO:0071879 UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 1.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 1.6 GO:0097503 sialylation(GO:0097503)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
0.0 0.7 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.9 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.1 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.1 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.4 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 1.0 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.3 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.3 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.3 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.7 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.1 GO:1903939 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.0 0.5 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.2 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.1 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.0 0.2 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 1.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.5 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 1.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.7 GO:0002717 positive regulation of natural killer cell mediated immunity(GO:0002717)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 1.3 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.8 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.3 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:2001027 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.6 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.0 GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.0 0.4 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.6 GO:0001783 B cell apoptotic process(GO:0001783)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.5 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0051552 flavone metabolic process(GO:0051552)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.0 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.3 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.3 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.2 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.1 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.3 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.3 2.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 0.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.1 0.4 GO:0000811 GINS complex(GO:0000811)
0.1 0.3 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.9 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.6 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.1 0.8 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.5 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.5 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.6 GO:0042588 zymogen granule(GO:0042588)
0.0 0.2 GO:0036021 endolysosome lumen(GO:0036021)
0.0 2.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 1.8 GO:0045178 basal part of cell(GO:0045178)
0.0 0.5 GO:0031105 septin complex(GO:0031105)
0.0 0.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.4 GO:0046930 pore complex(GO:0046930)
0.0 0.1 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0036020 endolysosome membrane(GO:0036020)
0.0 1.5 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.5 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.7 GO:0031672 A band(GO:0031672)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.3 0.9 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.3 1.2 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.2 0.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 2.3 GO:0008430 selenium binding(GO:0008430)
0.2 0.9 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 0.9 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.2 0.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 1.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.6 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.6 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.4 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.3 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 2.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.4 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 1.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.5 GO:0051373 FATZ binding(GO:0051373)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.2 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 1.5 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 0.5 GO:0042731 PH domain binding(GO:0042731)
0.1 0.8 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.5 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 1.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0001003 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.7 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 1.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.2 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 2.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.4 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.4 GO:0070888 E-box binding(GO:0070888)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 1.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.9 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.2 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.4 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 3.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.7 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.7 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.7 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 1.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.7 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.9 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 1.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.7 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 2.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events