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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX2-4

Z-value: 0.73

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Transcription factors associated with NKX2-4

Gene Symbol Gene ID Gene Info
NKX2-4
ENSG00000125816.4 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-4hg19_v2_chr20_-_21378666_213786660.365.2e-02Click!

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_41620335 6.71 ENST00000331105.2
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr11_+_73675873 5.37 ENST00000537753.1
ENST00000542350.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr2_+_228736321 4.46 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr11_+_61976137 4.07 ENST00000244930.4
SCGB2A1
secretoglobin, family 2A, member 1
chr2_+_228736335 3.99 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr5_+_140186647 3.80 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr12_-_71533055 3.54 ENST00000552128.1
TSPAN8
tetraspanin 8
chr12_-_58329819 2.96 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr4_+_72204755 2.76 ENST00000512686.1
ENST00000340595.3
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr17_-_34329084 2.56 ENST00000354059.4
ENST00000536149.1
CCL15
CCL14
chemokine (C-C motif) ligand 15
chemokine (C-C motif) ligand 14
chr19_-_40440533 2.02 ENST00000221347.6
FCGBP
Fc fragment of IgG binding protein
chr21_-_35884573 2.00 ENST00000399286.2
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr12_+_109826524 1.92 ENST00000431443.2
MYO1H
myosin IH
chr12_-_58329888 1.88 ENST00000546580.1
RP11-620J15.3
RP11-620J15.3
chr13_-_36429763 1.86 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr5_-_160279207 1.85 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr2_-_27712583 1.70 ENST00000260570.3
ENST00000359466.6
ENST00000416524.2
IFT172
intraflagellar transport 172 homolog (Chlamydomonas)
chr6_+_159071015 1.69 ENST00000360448.3
SYTL3
synaptotagmin-like 3
chr4_-_70518941 1.64 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr5_-_13944652 1.53 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr11_+_6897856 1.50 ENST00000379829.2
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr1_+_110036699 1.47 ENST00000496961.1
ENST00000533024.1
ENST00000310611.4
ENST00000527072.1
ENST00000420578.2
ENST00000528785.1
CYB561D1
cytochrome b561 family, member D1
chr1_+_161136180 1.46 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
PPOX
protoporphyrinogen oxidase
chr1_+_110036728 1.44 ENST00000369868.3
ENST00000430195.2
CYB561D1
cytochrome b561 family, member D1
chr1_-_57285038 1.44 ENST00000343433.6
C1orf168
chromosome 1 open reading frame 168
chr20_-_21494654 1.37 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr1_+_87794150 1.37 ENST00000370544.5
LMO4
LIM domain only 4
chr12_-_113658892 1.33 ENST00000299732.2
ENST00000416617.2
IQCD
IQ motif containing D
chr1_-_217250231 1.33 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr8_+_136469684 1.30 ENST00000355849.5
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr19_-_49843539 1.28 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4
CTC-301O7.4
chr16_+_78056412 1.27 ENST00000299642.4
ENST00000575655.1
CLEC3A
C-type lectin domain family 3, member A
chr5_+_140227048 1.25 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr17_+_42977122 1.23 ENST00000412523.2
ENST00000331733.4
ENST00000417826.2
FAM187A
CCDC103
family with sequence similarity 187, member A
coiled-coil domain containing 103
chr12_+_50451462 1.16 ENST00000447966.2
ASIC1
acid-sensing (proton-gated) ion channel 1
chr17_-_38074842 1.15 ENST00000309481.7
GSDMB
gasdermin B
chr1_+_61869748 1.06 ENST00000357977.5
NFIA
nuclear factor I/A
chr11_-_105892937 1.04 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr12_+_50451331 1.03 ENST00000228468.4
ASIC1
acid-sensing (proton-gated) ion channel 1
chr1_-_160231451 1.02 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr11_-_44972476 1.00 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr1_-_223308098 0.99 ENST00000342210.6
TLR5
toll-like receptor 5
chr11_+_63137251 0.96 ENST00000310969.4
ENST00000279178.3
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr5_-_42811986 0.96 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr11_-_44972418 0.95 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chr7_+_133812052 0.93 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr12_+_133757995 0.91 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr19_+_36235964 0.91 ENST00000587708.2
PSENEN
presenilin enhancer gamma secretase subunit
chr1_+_226013047 0.89 ENST00000366837.4
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr14_+_45431379 0.89 ENST00000361577.3
ENST00000361462.2
ENST00000382233.2
FAM179B
family with sequence similarity 179, member B
chr11_-_106889157 0.87 ENST00000282249.2
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr17_-_56406117 0.85 ENST00000268893.6
ENST00000355701.3
BZRAP1
benzodiazepine receptor (peripheral) associated protein 1
chr5_-_42812143 0.85 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr1_-_89591749 0.84 ENST00000370466.3
GBP2
guanylate binding protein 2, interferon-inducible
chr1_+_26146397 0.84 ENST00000374303.2
ENST00000533762.1
ENST00000529116.1
ENST00000474295.1
ENST00000488327.2
ENST00000472643.1
ENST00000526894.1
ENST00000524618.1
ENST00000374307.5
MTFR1L
mitochondrial fission regulator 1-like
chr11_-_44972390 0.83 ENST00000395648.3
ENST00000531928.2
TP53I11
tumor protein p53 inducible protein 11
chr9_-_86432547 0.82 ENST00000376365.3
ENST00000376371.2
GKAP1
G kinase anchoring protein 1
chr3_+_32737027 0.81 ENST00000454516.2
CNOT10
CCR4-NOT transcription complex, subunit 10
chr19_+_50706866 0.81 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14
myosin, heavy chain 14, non-muscle
chr19_+_45504688 0.80 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr11_-_5255861 0.80 ENST00000380299.3
HBD
hemoglobin, delta
chr22_+_25465786 0.80 ENST00000401395.1
KIAA1671
KIAA1671
chr17_-_40264692 0.80 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_+_179184955 0.77 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr12_+_133758115 0.76 ENST00000541009.2
ENST00000592241.1
ZNF268
zinc finger protein 268
chr1_+_95975672 0.76 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
RP11-286B14.1
chr6_-_39282221 0.74 ENST00000453413.2
KCNK17
potassium channel, subfamily K, member 17
chr4_-_75695366 0.74 ENST00000512743.1
BTC
betacellulin
chr7_-_47579188 0.73 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr6_-_39282329 0.72 ENST00000373231.4
KCNK17
potassium channel, subfamily K, member 17
chr15_-_78526855 0.72 ENST00000541759.1
ENST00000558130.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr4_-_168155169 0.72 ENST00000534949.1
ENST00000535728.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr1_-_85870177 0.70 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_-_87028478 0.69 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr10_-_61900762 0.69 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr21_+_40823753 0.67 ENST00000333634.4
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr7_+_117120017 0.67 ENST00000003084.6
ENST00000454343.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr4_+_130017268 0.67 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr9_-_140082983 0.66 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr5_+_43602750 0.66 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT
nicotinamide nucleotide transhydrogenase
chr4_-_168155300 0.66 ENST00000541637.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_-_62493131 0.65 ENST00000539111.2
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr14_-_105708942 0.65 ENST00000549655.1
BRF1
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
chr14_-_81408093 0.64 ENST00000555265.1
CEP128
centrosomal protein 128kDa
chr12_-_39837192 0.64 ENST00000361961.3
ENST00000395670.3
KIF21A
kinesin family member 21A
chr10_-_28571015 0.63 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr15_-_82338460 0.61 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr11_-_111383064 0.59 ENST00000525791.1
ENST00000456861.2
ENST00000356018.2
BTG4
B-cell translocation gene 4
chr10_-_13544945 0.58 ENST00000378605.3
ENST00000341083.3
BEND7
BEN domain containing 7
chr19_+_13135386 0.57 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_+_8234807 0.57 ENST00000339754.5
NECAP1
NECAP endocytosis associated 1
chr8_+_74206829 0.56 ENST00000240285.5
RDH10
retinol dehydrogenase 10 (all-trans)
chr5_+_139505520 0.56 ENST00000333305.3
IGIP
IgA-inducing protein
chr2_+_38177575 0.56 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr2_+_54951679 0.56 ENST00000356458.6
EML6
echinoderm microtubule associated protein like 6
chr11_-_119252425 0.55 ENST00000260187.2
USP2
ubiquitin specific peptidase 2
chr17_-_43339453 0.54 ENST00000543122.1
SPATA32
spermatogenesis associated 32
chr2_+_46524537 0.53 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr15_-_86338100 0.52 ENST00000536947.1
KLHL25
kelch-like family member 25
chr14_+_22962898 0.52 ENST00000390492.1
TRAJ45
T cell receptor alpha joining 45
chr3_+_184056614 0.51 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr12_+_58176525 0.50 ENST00000543727.1
ENST00000540550.1
ENST00000323833.8
ENST00000350762.5
ENST00000550559.1
ENST00000548851.1
ENST00000434359.1
ENST00000457189.1
TSFM
Ts translation elongation factor, mitochondrial
chr19_-_50316423 0.48 ENST00000528094.1
ENST00000526575.1
FUZ
fuzzy planar cell polarity protein
chr12_+_124155652 0.48 ENST00000426174.2
ENST00000303372.5
TCTN2
tectonic family member 2
chr10_-_32667660 0.47 ENST00000375110.2
EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr1_+_107599267 0.47 ENST00000361318.5
ENST00000370078.1
PRMT6
protein arginine methyltransferase 6
chr2_-_179315786 0.47 ENST00000457633.1
ENST00000438687.3
ENST00000325748.4
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr16_+_524850 0.47 ENST00000450428.1
ENST00000452814.1
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr5_-_61031495 0.47 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
CTD-2170G1.2
chr2_+_179316163 0.46 ENST00000409117.3
DFNB59
deafness, autosomal recessive 59
chr4_+_86748898 0.45 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr2_-_242556900 0.45 ENST00000402545.1
ENST00000402136.1
THAP4
THAP domain containing 4
chr19_-_50316489 0.45 ENST00000533418.1
FUZ
fuzzy planar cell polarity protein
chr6_-_152639479 0.45 ENST00000356820.4
SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_-_125802765 0.44 ENST00000514891.1
ENST00000512470.1
ENST00000504035.1
ENST00000360370.4
ENST00000513723.1
ENST00000510651.1
ENST00000514333.1
SLC41A3
solute carrier family 41, member 3
chr2_-_118943930 0.43 ENST00000449075.1
ENST00000414886.1
ENST00000449819.1
AC093901.1
AC093901.1
chr6_+_153552455 0.43 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr5_+_140235469 0.43 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chr19_-_50316517 0.42 ENST00000313777.4
ENST00000445575.2
FUZ
fuzzy planar cell polarity protein
chr13_-_41240717 0.42 ENST00000379561.5
FOXO1
forkhead box O1
chr14_-_88459182 0.42 ENST00000544807.2
GALC
galactosylceramidase
chr16_+_8736232 0.42 ENST00000562973.1
METTL22
methyltransferase like 22
chr18_+_9136758 0.42 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr14_+_75988851 0.41 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr17_-_47723943 0.41 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr20_+_4702548 0.41 ENST00000305817.2
PRND
prion protein 2 (dublet)
chr6_+_126240442 0.41 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr12_-_7261772 0.40 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
C1RL
complement component 1, r subcomponent-like
chr3_+_137906109 0.39 ENST00000481646.1
ENST00000469044.1
ENST00000491704.1
ENST00000461600.1
ARMC8
armadillo repeat containing 8
chr11_+_19138670 0.39 ENST00000446113.2
ENST00000399351.3
ZDHHC13
zinc finger, DHHC-type containing 13
chr12_-_104532062 0.38 ENST00000240055.3
NFYB
nuclear transcription factor Y, beta
chr1_+_158323755 0.38 ENST00000368157.1
ENST00000368156.1
ENST00000368155.3
ENST00000368154.1
ENST00000368160.3
ENST00000368161.3
CD1E
CD1e molecule
chr3_+_173116225 0.38 ENST00000457714.1
NLGN1
neuroligin 1
chr13_+_111365602 0.37 ENST00000333219.7
ING1
inhibitor of growth family, member 1
chrX_+_102883620 0.37 ENST00000372626.3
TCEAL1
transcription elongation factor A (SII)-like 1
chr3_-_88108192 0.37 ENST00000309534.6
CGGBP1
CGG triplet repeat binding protein 1
chr14_-_96830207 0.37 ENST00000359933.4
ATG2B
autophagy related 2B
chr1_+_205225319 0.37 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr11_+_103907308 0.37 ENST00000302259.3
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr2_+_220071490 0.36 ENST00000409206.1
ENST00000409594.1
ENST00000289528.5
ENST00000422255.1
ENST00000409412.1
ENST00000409097.1
ENST00000409336.1
ENST00000409217.1
ENST00000409319.1
ENST00000444522.2
ZFAND2B
zinc finger, AN1-type domain 2B
chr19_+_44100632 0.36 ENST00000533118.1
ZNF576
zinc finger protein 576
chr2_+_183982238 0.35 ENST00000442895.2
ENST00000446612.1
ENST00000409798.1
NUP35
nucleoporin 35kDa
chr8_-_6914251 0.35 ENST00000330590.2
DEFA5
defensin, alpha 5, Paneth cell-specific
chr8_+_37594103 0.35 ENST00000397228.2
ERLIN2
ER lipid raft associated 2
chrX_+_144908928 0.35 ENST00000408967.2
TMEM257
transmembrane protein 257
chr17_-_63822563 0.35 ENST00000317442.8
CEP112
centrosomal protein 112kDa
chr4_+_129349188 0.35 ENST00000511497.1
RP11-420A23.1
RP11-420A23.1
chr22_-_19974616 0.35 ENST00000344269.3
ENST00000401994.1
ENST00000406522.1
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr12_-_122710556 0.35 ENST00000446652.1
ENST00000541273.1
ENST00000353548.6
ENST00000267169.6
ENST00000464942.2
DIABLO
diablo, IAP-binding mitochondrial protein
chr2_+_36923830 0.34 ENST00000379242.3
ENST00000389975.3
VIT
vitrin
chr17_+_28804380 0.34 ENST00000225724.5
ENST00000451249.2
ENST00000467337.2
ENST00000581721.1
ENST00000414833.2
GOSR1
golgi SNAP receptor complex member 1
chr7_-_86849025 0.34 ENST00000257637.3
TMEM243
transmembrane protein 243, mitochondrial
chr7_-_152373216 0.34 ENST00000359321.1
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr8_+_42396712 0.34 ENST00000518574.1
ENST00000417410.2
ENST00000414154.2
SMIM19
small integral membrane protein 19
chr9_-_32573130 0.34 ENST00000350021.2
ENST00000379847.3
NDUFB6
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
chr14_-_104028595 0.34 ENST00000337322.4
ENST00000445922.2
BAG5
BCL2-associated athanogene 5
chr17_-_41050716 0.33 ENST00000417193.1
ENST00000301683.3
ENST00000436546.1
ENST00000431109.2
LINC00671
long intergenic non-protein coding RNA 671
chr14_+_65381079 0.33 ENST00000549115.1
ENST00000607599.1
ENST00000548752.2
ENST00000359118.2
ENST00000552002.2
ENST00000551947.1
ENST00000551093.1
ENST00000542227.1
ENST00000447296.2
ENST00000549987.1
CHURC1
FNTB
CHURC1-FNTB
churchill domain containing 1
farnesyltransferase, CAAX box, beta
CHURC1-FNTB readthrough
chr8_+_42396936 0.33 ENST00000416469.2
SMIM19
small integral membrane protein 19
chr16_+_77822427 0.33 ENST00000302536.2
VAT1L
vesicle amine transport 1-like
chr20_+_43991668 0.33 ENST00000243918.5
ENST00000426004.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr2_-_55920952 0.33 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr19_-_20748541 0.33 ENST00000427401.4
ENST00000594419.1
ZNF737
zinc finger protein 737
chr4_+_86749045 0.33 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr1_+_152850787 0.33 ENST00000368765.3
SMCP
sperm mitochondria-associated cysteine-rich protein
chr11_+_34642656 0.33 ENST00000257831.3
ENST00000450654.2
EHF
ets homologous factor
chr10_-_49482907 0.32 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr7_-_99332719 0.32 ENST00000336374.2
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
chrX_-_154563889 0.32 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chrX_+_49020882 0.32 ENST00000454342.1
MAGIX
MAGI family member, X-linked
chr7_-_86849883 0.32 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr1_-_95391315 0.32 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chrX_+_105445717 0.31 ENST00000372552.1
MUM1L1
melanoma associated antigen (mutated) 1-like 1
chr17_+_4634705 0.31 ENST00000575284.1
ENST00000573708.1
ENST00000293777.5
MED11
mediator complex subunit 11
chr1_+_160097462 0.31 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr13_-_36944307 0.31 ENST00000355182.4
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr14_+_64680854 0.31 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chr17_-_56606664 0.31 ENST00000580844.1
SEPT4
septin 4
chr1_-_85040090 0.30 ENST00000370630.5
CTBS
chitobiase, di-N-acetyl-
chr15_+_74466744 0.30 ENST00000560862.1
ENST00000395118.1
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr9_-_85678043 0.30 ENST00000376447.3
ENST00000340717.4
RASEF
RAS and EF-hand domain containing
chr17_+_26684604 0.29 ENST00000292114.3
ENST00000509083.1
TMEM199
transmembrane protein 199
chr19_-_42348692 0.29 ENST00000330743.3
ENST00000601246.1
LYPD4
LY6/PLAUR domain containing 4
chr19_+_44100544 0.29 ENST00000391965.2
ENST00000525771.1
ZNF576
zinc finger protein 576
chr7_+_151038850 0.29 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
NUB1
negative regulator of ubiquitin-like proteins 1
chr6_+_37225540 0.29 ENST00000373491.3
TBC1D22B
TBC1 domain family, member 22B
chr17_-_37844267 0.29 ENST00000579146.1
ENST00000378011.4
ENST00000429199.2
ENST00000300658.4
PGAP3
post-GPI attachment to proteins 3
chr17_-_42295870 0.28 ENST00000526094.1
ENST00000529383.1
ENST00000530828.1
UBTF
upstream binding transcription factor, RNA polymerase I
chr6_-_149969871 0.28 ENST00000335643.8
ENST00000444282.1
KATNA1
katanin p60 (ATPase containing) subunit A 1
chr1_+_174846570 0.27 ENST00000392064.2
RABGAP1L
RAB GTPase activating protein 1-like
chr4_+_102734967 0.27 ENST00000444316.2
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr18_+_11851383 0.27 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr1_-_47407097 0.27 ENST00000457840.2
CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr20_-_23402028 0.27 ENST00000398425.3
ENST00000432543.2
ENST00000377026.4
NAPB
N-ethylmaleimide-sensitive factor attachment protein, beta
chr11_+_34645791 0.27 ENST00000529527.1
ENST00000531728.1
ENST00000525253.1
EHF
ets homologous factor
chr3_-_88108212 0.26 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chr10_+_98592674 0.26 ENST00000356016.3
ENST00000371097.4
LCOR
ligand dependent nuclear receptor corepressor
chr10_+_22605374 0.26 ENST00000448361.1
COMMD3
COMM domain containing 3
chr20_-_43729750 0.26 ENST00000537075.1
ENST00000306117.1
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr5_+_175298674 0.25 ENST00000514150.1
CPLX2
complexin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.6 1.7 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.5 1.4 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3 1.4 GO:2000314 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.3 1.0 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.3 2.2 GO:0050915 sensory perception of sour taste(GO:0050915)
0.3 0.9 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.3 6.9 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.2 0.8 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.2 0.7 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 0.5 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.2 0.3 GO:0030473 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear migration along microfilament(GO:0031022)
0.2 2.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 1.2 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.1 1.7 GO:0061525 hindgut development(GO:0061525)
0.1 0.7 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 1.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.1 0.3 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.1 0.3 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.1 1.4 GO:0021527 ventral spinal cord interneuron differentiation(GO:0021514) spinal cord association neuron differentiation(GO:0021527)
0.1 1.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.3 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.7 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.4 GO:1902617 response to fluoride(GO:1902617)
0.1 0.6 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.3 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 0.2 GO:0036309 protein localization to M-band(GO:0036309)
0.1 1.0 GO:0015747 urate transport(GO:0015747)
0.1 1.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.6 GO:0060431 primary lung bud formation(GO:0060431)
0.1 0.6 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 1.6 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.4 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.5 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 0.5 GO:0043129 surfactant homeostasis(GO:0043129)
0.1 0.6 GO:0009304 tRNA transcription(GO:0009304)
0.1 0.3 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 0.2 GO:0051598 meiotic recombination checkpoint(GO:0051598)
0.1 0.2 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
0.1 0.2 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.1 0.3 GO:0051946 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 0.3 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.2 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 1.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.9 GO:0007220 Notch receptor processing(GO:0007220)
0.1 1.6 GO:0045332 phospholipid translocation(GO:0045332)
0.1 6.9 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 0.3 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.1 0.3 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.6 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.3 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.6 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.4 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 1.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.8 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.7 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 2.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.8 GO:0015671 oxygen transport(GO:0015671)
0.0 1.1 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0051013 microtubule severing(GO:0051013)
0.0 1.1 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.0 0.4 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.9 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.1 GO:0016139 glycoside catabolic process(GO:0016139)
0.0 0.2 GO:0021764 amygdala development(GO:0021764)
0.0 0.3 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.7 GO:0035810 positive regulation of urine volume(GO:0035810)
0.0 0.1 GO:0045634 regulation of melanocyte differentiation(GO:0045634) positive regulation of melanocyte differentiation(GO:0045636) regulation of pigment cell differentiation(GO:0050932) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.3 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 2.6 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.1 GO:1900111 positive regulation of histone H3-K9 dimethylation(GO:1900111)
0.0 0.5 GO:0045475 locomotor rhythm(GO:0045475)
0.0 4.1 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.3 GO:0044211 CTP salvage(GO:0044211)
0.0 0.5 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 2.7 GO:0050918 positive chemotaxis(GO:0050918)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0 0.3 GO:1905146 lysosomal protein catabolic process(GO:1905146)
0.0 0.9 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.5 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.5 GO:0035886 vascular smooth muscle cell differentiation(GO:0035886)
0.0 0.1 GO:0001999 renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.0 0.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.3 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.0 1.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 1.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.4 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.4 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.7 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.2 GO:1901374 acetate ester transport(GO:1901374)
0.0 0.1 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.3 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.1 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
0.0 0.3 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.0 0.8 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0034959 neuropeptide catabolic process(GO:0010813) substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.4 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.7 GO:0007050 cell cycle arrest(GO:0007050)
0.0 3.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.3 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.2 GO:0001763 morphogenesis of a branching structure(GO:0001763)
0.0 0.4 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.1 GO:2001214 arterial endothelial cell differentiation(GO:0060842) positive regulation of vasculogenesis(GO:2001214)
0.0 0.3 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0048538 thymus development(GO:0048538)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.4 GO:0044804 nucleophagy(GO:0044804)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.2 GO:0071888 macrophage apoptotic process(GO:0071888)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.4 GO:0006999 nuclear pore organization(GO:0006999)
0.0 1.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.4 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.1 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.2 0.6 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.2 0.6 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.2 0.9 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.2 1.5 GO:0036157 outer dynein arm(GO:0036157)
0.2 0.8 GO:0097513 myosin II filament(GO:0097513)
0.1 0.9 GO:0002177 manchette(GO:0002177)
0.1 0.3 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.9 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.2 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.1 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 6.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 0.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.9 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.5 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.3 GO:0031105 septin complex(GO:0031105)
0.0 0.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.4 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.2 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 7.2 GO:0005929 cilium(GO:0005929)
0.0 0.4 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.6 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.3 6.9 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.3 0.9 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.2 0.7 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.2 0.6 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.2 1.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 2.0 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 2.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.9 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.5 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.1 0.7 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.7 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 2.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.3 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 0.3 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 1.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.0 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.2 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 1.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.6 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 1.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.2 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.5 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 1.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.3 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.1 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 1.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.3 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 4.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.1 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) aromatase activity(GO:0070330)
0.0 0.3 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.1 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.8 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 2.6 GO:0003774 motor activity(GO:0003774)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 1.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.3 GO:0016788 hydrolase activity, acting on ester bonds(GO:0016788)
0.0 0.1 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.1 ST ADRENERGIC Adrenergic Pathway
0.0 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 0.9 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 1.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 2.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.8 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.4 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination