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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX2-5

Z-value: 0.45

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Transcription factors associated with NKX2-5

Gene Symbol Gene ID Gene Info
NKX2-5
ENSG00000183072.9 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-5hg19_v2_chr5_-_172662303_172662360-0.096.3e-01Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_29641084 0.57 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr3_-_111314230 0.52 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr4_+_81118647 0.52 ENST00000415738.2
PRDM8
PR domain containing 8
chr11_+_76813886 0.45 ENST00000529803.1
OMP
olfactory marker protein
chr9_+_118950325 0.43 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr4_-_153700864 0.40 ENST00000304337.2
TIGD4
tigger transposable element derived 4
chr17_-_8059638 0.39 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr7_-_122339162 0.37 ENST00000340112.2
RNF133
ring finger protein 133
chr14_+_21467414 0.37 ENST00000554422.1
ENST00000298681.4
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr6_-_39290316 0.36 ENST00000425054.2
ENST00000373227.4
ENST00000373229.5
ENST00000437525.2
KCNK16
potassium channel, subfamily K, member 16
chr14_-_106830057 0.36 ENST00000390616.2
IGHV4-34
immunoglobulin heavy variable 4-34
chr9_+_116263778 0.34 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr14_+_78227105 0.33 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
C14orf178
chromosome 14 open reading frame 178
chr17_-_29624343 0.32 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr12_+_123717967 0.31 ENST00000536130.1
ENST00000546132.1
C12orf65
chromosome 12 open reading frame 65
chr1_-_113498943 0.29 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr17_-_55911970 0.29 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr14_-_106963409 0.29 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr16_+_31483451 0.29 ENST00000565360.1
ENST00000361773.3
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr3_-_149095652 0.29 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr16_+_8814563 0.28 ENST00000425191.2
ENST00000569156.1
ABAT
4-aminobutyrate aminotransferase
chr7_-_37488834 0.27 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr17_+_40811283 0.27 ENST00000251412.7
TUBG2
tubulin, gamma 2
chr17_-_29641104 0.27 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr10_-_7513904 0.27 ENST00000420395.1
RP5-1031D4.2
RP5-1031D4.2
chr7_+_142919130 0.26 ENST00000408947.3
TAS2R40
taste receptor, type 2, member 40
chr18_-_13915530 0.25 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr2_-_187713891 0.25 ENST00000295131.2
ZSWIM2
zinc finger, SWIM-type containing 2
chr3_-_47950745 0.25 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr10_-_101841588 0.24 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr9_+_116263639 0.24 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr7_-_94953878 0.24 ENST00000222381.3
PON1
paraoxonase 1
chr17_-_7493390 0.23 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SOX15
SRY (sex determining region Y)-box 15
chrX_-_30326445 0.23 ENST00000378963.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr1_+_150254936 0.23 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
C1orf51
chromosome 1 open reading frame 51
chr1_+_154300217 0.21 ENST00000368489.3
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr6_-_94129244 0.21 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr7_+_142457315 0.21 ENST00000486171.1
ENST00000311737.7
PRSS1
protease, serine, 1 (trypsin 1)
chr17_-_10452929 0.21 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr17_+_29421987 0.21 ENST00000431387.4
NF1
neurofibromin 1
chr20_-_41818373 0.20 ENST00000373187.1
ENST00000356100.2
ENST00000373184.1
ENST00000373190.1
PTPRT
protein tyrosine phosphatase, receptor type, T
chr12_+_123717458 0.20 ENST00000253233.1
C12orf65
chromosome 12 open reading frame 65
chr18_+_42260861 0.20 ENST00000282030.5
SETBP1
SET binding protein 1
chr3_+_45984947 0.20 ENST00000304552.4
CXCR6
chemokine (C-X-C motif) receptor 6
chr16_+_3194211 0.20 ENST00000428155.1
CASP16
caspase 16, apoptosis-related cysteine peptidase (putative)
chr14_+_23654525 0.20 ENST00000399910.1
ENST00000492621.1
C14orf164
chromosome 14 open reading frame 164
chr1_-_160616804 0.19 ENST00000538290.1
SLAMF1
signaling lymphocytic activation molecule family member 1
chr2_+_113403434 0.19 ENST00000272542.3
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr12_-_4553385 0.19 ENST00000543077.1
FGF6
fibroblast growth factor 6
chr17_-_19771216 0.19 ENST00000395544.4
ULK2
unc-51 like autophagy activating kinase 2
chr5_+_78407602 0.19 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr8_-_10588010 0.18 ENST00000304501.1
SOX7
SRY (sex determining region Y)-box 7
chr1_+_159796534 0.18 ENST00000289707.5
SLAMF8
SLAM family member 8
chr6_+_109169591 0.18 ENST00000368972.3
ENST00000392644.4
ARMC2
armadillo repeat containing 2
chr12_+_4918342 0.17 ENST00000280684.3
ENST00000433855.1
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr2_+_48541776 0.17 ENST00000413569.1
ENST00000340553.3
FOXN2
forkhead box N2
chr7_-_81399329 0.17 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_87342564 0.17 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr22_+_40322623 0.17 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr22_+_40322595 0.17 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr10_+_75504105 0.16 ENST00000535742.1
ENST00000546025.1
ENST00000345254.4
ENST00000540668.1
ENST00000339365.2
ENST00000411652.2
SEC24C
SEC24 family member C
chr2_+_136289030 0.16 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chr15_+_78799948 0.16 ENST00000566332.1
HYKK
hydroxylysine kinase
chr16_-_30134524 0.16 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
MAPK3
mitogen-activated protein kinase 3
chr10_+_73156664 0.16 ENST00000398809.4
ENST00000398842.3
ENST00000461841.3
ENST00000299366.7
CDH23
cadherin-related 23
chr4_+_144354644 0.16 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr8_-_120651020 0.16 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr12_-_53097247 0.16 ENST00000341809.3
ENST00000537195.1
KRT77
keratin 77
chr9_+_35906176 0.16 ENST00000354323.2
HRCT1
histidine rich carboxyl terminus 1
chr14_+_22356029 0.15 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr13_+_109248500 0.15 ENST00000356711.2
MYO16
myosin XVI
chr15_+_78799895 0.15 ENST00000408962.2
ENST00000388988.4
ENST00000360519.3
HYKK
hydroxylysine kinase
chr1_-_160040038 0.14 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chrX_-_154299501 0.14 ENST00000369476.3
ENST00000369484.3
MTCP1
CMC4
mature T-cell proliferation 1
C-x(9)-C motif containing 4
chr14_+_81421355 0.14 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr8_+_133879193 0.14 ENST00000377869.1
ENST00000220616.4
TG
thyroglobulin
chr1_-_102312517 0.14 ENST00000338858.5
OLFM3
olfactomedin 3
chr2_+_219646462 0.13 ENST00000258415.4
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr17_+_53342311 0.13 ENST00000226067.5
HLF
hepatic leukemia factor
chr5_+_75699040 0.13 ENST00000274364.6
IQGAP2
IQ motif containing GTPase activating protein 2
chr2_+_152214098 0.13 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_+_124223586 0.13 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chr17_-_79623597 0.13 ENST00000574024.1
ENST00000331056.5
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr21_+_17791838 0.13 ENST00000453910.1
LINC00478
long intergenic non-protein coding RNA 478
chr6_-_112115074 0.13 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr3_-_194072019 0.13 ENST00000429275.1
ENST00000323830.3
CPN2
carboxypeptidase N, polypeptide 2
chr22_-_29137771 0.13 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr7_-_44229022 0.12 ENST00000403799.3
GCK
glucokinase (hexokinase 4)
chr1_+_26606608 0.12 ENST00000319041.6
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr4_-_74853897 0.12 ENST00000296028.3
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr14_+_81421861 0.12 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr2_-_162931052 0.12 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr20_-_271304 0.12 ENST00000400269.3
ENST00000360321.2
C20orf96
chromosome 20 open reading frame 96
chr1_-_22109682 0.12 ENST00000400301.1
ENST00000532737.1
USP48
ubiquitin specific peptidase 48
chr4_+_156680518 0.11 ENST00000513437.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr11_-_19223523 0.11 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr6_+_33378738 0.11 ENST00000374512.3
ENST00000374516.3
PHF1
PHD finger protein 1
chr12_-_371994 0.11 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr7_-_28220354 0.11 ENST00000283928.5
JAZF1
JAZF zinc finger 1
chr1_+_32671236 0.11 ENST00000537469.1
ENST00000291358.6
IQCC
IQ motif containing C
chr18_+_61575200 0.11 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr7_+_130020180 0.11 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
CPA1
carboxypeptidase A1 (pancreatic)
chr17_+_54230819 0.10 ENST00000318698.2
ENST00000566473.2
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chrX_+_86772787 0.10 ENST00000373114.4
KLHL4
kelch-like family member 4
chr15_-_42840961 0.10 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chr20_-_271009 0.10 ENST00000382369.5
C20orf96
chromosome 20 open reading frame 96
chr17_-_3500392 0.10 ENST00000571088.1
ENST00000174621.6
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr2_-_175499294 0.10 ENST00000392547.2
WIPF1
WAS/WASL interacting protein family, member 1
chr1_-_23520755 0.10 ENST00000314113.3
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr10_-_128359074 0.10 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr5_-_76788317 0.10 ENST00000296679.4
WDR41
WD repeat domain 41
chr16_-_30134266 0.10 ENST00000484663.1
ENST00000478356.1
MAPK3
mitogen-activated protein kinase 3
chr21_+_17791648 0.10 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
LINC00478
long intergenic non-protein coding RNA 478
chr11_-_116663127 0.10 ENST00000433069.1
ENST00000542499.1
APOA5
apolipoprotein A-V
chr15_+_81589254 0.09 ENST00000394652.2
IL16
interleukin 16
chr19_+_5681011 0.09 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr7_-_99774945 0.09 ENST00000292377.2
GPC2
glypican 2
chr5_-_171615315 0.09 ENST00000176763.5
STK10
serine/threonine kinase 10
chr5_-_74062930 0.09 ENST00000509430.1
ENST00000345239.2
ENST00000427854.2
ENST00000506778.1
GFM2
G elongation factor, mitochondrial 2
chr2_-_85895295 0.09 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr19_-_5680499 0.09 ENST00000587589.1
C19orf70
chromosome 19 open reading frame 70
chr12_-_123717643 0.09 ENST00000541437.1
ENST00000606320.1
MPHOSPH9
M-phase phosphoprotein 9
chr6_-_134373732 0.08 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chrX_-_49041242 0.08 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chrX_-_49965663 0.08 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
AKAP4
A kinase (PRKA) anchor protein 4
chrX_+_86772707 0.08 ENST00000373119.4
KLHL4
kelch-like family member 4
chr19_-_5680891 0.08 ENST00000309324.4
C19orf70
chromosome 19 open reading frame 70
chr14_+_94393605 0.08 ENST00000556222.1
ENST00000554404.1
ENST00000557000.2
FAM181A
family with sequence similarity 181, member A
chr11_+_60102304 0.08 ENST00000300182.4
MS4A6E
membrane-spanning 4-domains, subfamily A, member 6E
chr8_+_48873453 0.08 ENST00000523944.1
MCM4
minichromosome maintenance complex component 4
chr15_-_74726283 0.08 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr8_+_87878640 0.07 ENST00000518476.1
CNBD1
cyclic nucleotide binding domain containing 1
chr3_+_108321623 0.07 ENST00000497905.1
ENST00000463306.1
DZIP3
DAZ interacting zinc finger protein 3
chr2_+_201997492 0.07 ENST00000494258.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr4_+_153701081 0.07 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
ARFIP1
ADP-ribosylation factor interacting protein 1
chr19_+_5681153 0.07 ENST00000579559.1
ENST00000577222.1
HSD11B1L
RPL36
hydroxysteroid (11-beta) dehydrogenase 1-like
ribosomal protein L36
chr1_-_214638146 0.07 ENST00000543945.1
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr5_+_74062806 0.07 ENST00000296802.5
NSA2
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr5_+_147258266 0.07 ENST00000296694.4
SCGB3A2
secretoglobin, family 3A, member 2
chr1_+_161676983 0.07 ENST00000367957.2
FCRLA
Fc receptor-like A
chr8_-_72459885 0.07 ENST00000523987.1
RP11-1102P16.1
Uncharacterized protein
chr8_+_48873479 0.07 ENST00000262105.2
MCM4
minichromosome maintenance complex component 4
chr1_+_161676739 0.06 ENST00000236938.6
ENST00000367959.2
ENST00000546024.1
ENST00000540521.1
ENST00000367949.2
ENST00000350710.3
ENST00000540926.1
FCRLA
Fc receptor-like A
chr8_+_9009296 0.06 ENST00000521718.1
RP11-10A14.4
Uncharacterized protein
chrY_+_16634483 0.06 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr11_-_18813110 0.06 ENST00000396168.1
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr11_-_18813353 0.06 ENST00000358540.2
ENST00000396171.4
ENST00000396167.2
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr20_+_55841819 0.06 ENST00000412321.1
ENST00000426580.1
RP4-813D12.3
RP4-813D12.3
chr16_-_57809015 0.06 ENST00000540079.2
ENST00000569222.1
KIFC3
kinesin family member C3
chr10_+_133753533 0.06 ENST00000422256.2
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta
chr1_-_207143802 0.06 ENST00000324852.4
ENST00000400962.3
FCAMR
Fc receptor, IgA, IgM, high affinity
chr1_-_26232951 0.06 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr15_-_81282133 0.06 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr17_+_38333263 0.06 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr12_+_113354341 0.06 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_166958346 0.06 ENST00000367872.4
MAEL
maelstrom spermatogenic transposon silencer
chr3_-_112356944 0.05 ENST00000461431.1
CCDC80
coiled-coil domain containing 80
chr12_+_56360550 0.05 ENST00000266970.4
CDK2
cyclin-dependent kinase 2
chr9_-_34048873 0.05 ENST00000449054.1
ENST00000379239.4
ENST00000539807.1
ENST00000379238.1
ENST00000418786.2
ENST00000360802.1
ENST00000412543.1
UBAP2
ubiquitin associated protein 2
chr1_-_102462565 0.05 ENST00000370103.4
OLFM3
olfactomedin 3
chr1_-_149982624 0.05 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr3_-_15374659 0.05 ENST00000426925.1
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr15_+_42841008 0.05 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr1_-_11907829 0.05 ENST00000376480.3
NPPA
natriuretic peptide A
chr17_-_56621665 0.05 ENST00000321691.3
C17orf47
chromosome 17 open reading frame 47
chr17_-_13505219 0.05 ENST00000284110.1
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr8_-_49833978 0.05 ENST00000020945.1
SNAI2
snail family zinc finger 2
chrX_+_14547632 0.05 ENST00000218075.4
GLRA2
glycine receptor, alpha 2
chr3_-_123710893 0.04 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1
rhophilin associated tail protein 1
chr1_+_161677034 0.04 ENST00000349527.4
ENST00000309691.6
ENST00000294796.4
ENST00000367953.3
ENST00000367950.1
FCRLA
Fc receptor-like A
chr17_-_46667594 0.04 ENST00000476342.1
ENST00000460160.1
ENST00000472863.1
HOXB3
homeobox B3
chr16_-_3149278 0.04 ENST00000575108.1
ENST00000576483.1
ENST00000538082.2
ENST00000576985.1
ZSCAN10
zinc finger and SCAN domain containing 10
chr5_-_134788086 0.04 ENST00000537858.1
TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B
chr9_+_33265011 0.04 ENST00000419016.2
CHMP5
charged multivesicular body protein 5
chr3_+_46283863 0.04 ENST00000545097.1
ENST00000541018.1
CCR3
chemokine (C-C motif) receptor 3
chr1_+_76540386 0.04 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr7_+_99775366 0.04 ENST00000394018.2
ENST00000416412.1
STAG3
stromal antigen 3
chr9_+_33264861 0.04 ENST00000223500.8
CHMP5
charged multivesicular body protein 5
chr13_-_53422640 0.04 ENST00000338862.4
ENST00000377942.3
PCDH8
protocadherin 8
chr3_+_46283916 0.04 ENST00000395940.2
CCR3
chemokine (C-C motif) receptor 3
chr16_+_765092 0.03 ENST00000568223.2
METRN
meteorin, glial cell differentiation regulator
chr10_-_99531709 0.03 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr7_+_129906660 0.03 ENST00000222481.4
CPA2
carboxypeptidase A2 (pancreatic)
chr17_-_40169659 0.03 ENST00000457167.4
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr11_+_64879317 0.03 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
TM7SF2
transmembrane 7 superfamily member 2
chr14_+_81421921 0.03 ENST00000554263.1
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chr7_+_99775520 0.03 ENST00000317296.5
ENST00000422690.1
ENST00000439782.1
STAG3
stromal antigen 3
chr12_+_14518598 0.03 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
ATF7IP
activating transcription factor 7 interacting protein
chr1_+_27153173 0.03 ENST00000374142.4
ZDHHC18
zinc finger, DHHC-type containing 18
chr7_-_81399438 0.03 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr14_+_81421710 0.03 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr17_-_40169429 0.02 ENST00000316603.7
ENST00000588641.1
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr7_-_27224795 0.02 ENST00000006015.3
HOXA11
homeobox A11
chr11_-_47616210 0.02 ENST00000302514.3
C1QTNF4
C1q and tumor necrosis factor related protein 4
chrX_-_142722897 0.02 ENST00000338017.4
SLITRK4
SLIT and NTRK-like family, member 4
chr11_+_18417813 0.02 ENST00000540430.1
ENST00000379412.5
LDHA
lactate dehydrogenase A
chr6_-_27279949 0.02 ENST00000444565.1
ENST00000377451.2
POM121L2
POM121 transmembrane nucleoporin-like 2
chr7_-_150675372 0.02 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chrX_-_55057403 0.02 ENST00000396198.3
ENST00000335854.4
ENST00000455688.1
ENST00000330807.5
ALAS2
aminolevulinate, delta-, synthase 2
chr3_-_56717246 0.02 ENST00000355628.5
FAM208A
family with sequence similarity 208, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.3 GO:0015728 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.3 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.1 0.2 GO:0048627 myoblast development(GO:0048627)
0.1 0.3 GO:1904450 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 0.2 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.1 0.2 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.1 0.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.2 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.1 0.4 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.2 GO:0030070 insulin processing(GO:0030070)
0.0 0.3 GO:0000189 MAPK import into nucleus(GO:0000189) regulation of Golgi inheritance(GO:0090170)
0.0 0.1 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.3 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.4 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.1 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.2 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 0.1 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.0 0.1 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.0 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.3 GO:0006554 lysine catabolic process(GO:0006554)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.4 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.2 GO:0030238 male sex determination(GO:0030238) Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.0 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0000806 Y chromosome(GO:0000806)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0030849 autosome(GO:0030849)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581) invadopodium membrane(GO:0071438)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 0.5 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 0.3 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 0.2 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.3 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.3 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0060230 lipase binding(GO:0035473) lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1