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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX2-6

Z-value: 0.95

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
ENSG00000180053.6 NK2 homeobox 6

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_56757329 7.11 ENST00000260453.3
meiosis-specific nuclear structural 1
chr8_+_99076750 3.92 ENST00000545282.1
chromosome 8 open reading frame 47
chr3_-_121379739 3.69 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr11_+_27062860 3.64 ENST00000528583.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr8_+_99076509 3.63 ENST00000318528.3
chromosome 8 open reading frame 47
chr11_+_27062502 3.57 ENST00000263182.3
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr8_-_133637624 3.49 ENST00000522789.1
leucine rich repeat containing 6
chr11_+_27062272 3.46 ENST00000529202.1
ENST00000533566.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr5_-_43412418 3.42 ENST00000537013.1
ENST00000361115.4
chemokine (C-C motif) ligand 28
chr6_+_33043703 3.04 ENST00000418931.2
ENST00000535465.1
major histocompatibility complex, class II, DP beta 1
chr3_-_120365866 3.04 ENST00000475447.2
homogentisate 1,2-dioxygenase
chr6_-_110012380 2.95 ENST00000424296.2
ENST00000341338.6
ENST00000368948.2
ENST00000285397.5
adenylate kinase 9
chr16_+_78056412 2.88 ENST00000299642.4
ENST00000575655.1
C-type lectin domain family 3, member A
chr16_-_23724518 2.87 ENST00000457008.2
endoplasmic reticulum to nucleus signaling 2
chr3_+_42544084 2.75 ENST00000543411.1
ENST00000438259.2
ENST00000439731.1
ENST00000325123.4
vasoactive intestinal peptide receptor 1
chr21_-_43735628 2.70 ENST00000291525.10
ENST00000518498.1
trefoil factor 3 (intestinal)
chr7_+_121513143 2.57 ENST00000393386.2
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr1_+_20512568 2.48 ENST00000375099.3
UBX domain protein 10
chr17_-_34329084 2.46 ENST00000354059.4
ENST00000536149.1
chemokine (C-C motif) ligand 15
chemokine (C-C motif) ligand 14
chr12_-_89920030 2.37 ENST00000413530.1
ENST00000547474.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr11_+_65265141 2.27 ENST00000534336.1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr1_+_64936428 2.27 ENST00000371073.2
ENST00000290039.5
cache domain containing 1
chr19_-_14992264 2.25 ENST00000327462.2
olfactory receptor, family 7, subfamily A, member 17
chr1_-_227505289 2.22 ENST00000366765.3
CDC42 binding protein kinase alpha (DMPK-like)
chr12_-_89919965 2.20 ENST00000548729.1
POC1B-GALNT4 readthrough
chr5_-_42825983 2.19 ENST00000506577.1
selenoprotein P, plasma, 1
chr19_-_49843539 2.11 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4
chr8_+_136469684 2.03 ENST00000355849.5
KH domain containing, RNA binding, signal transduction associated 3
chr4_-_156875003 1.88 ENST00000433477.3
cathepsin O
chr7_+_23719749 1.82 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
family with sequence similarity 221, member A
chr6_+_109169591 1.81 ENST00000368972.3
ENST00000392644.4
armadillo repeat containing 2
chr4_-_186317034 1.77 ENST00000505916.1
LRP2 binding protein
chr4_+_17579110 1.75 ENST00000606142.1
leucine aminopeptidase 3
chr7_+_101917407 1.64 ENST00000487284.1
cut-like homeobox 1
chr7_+_133812052 1.62 ENST00000285928.2
leucine-rich repeats and guanylate kinase domain containing
chr12_+_56075330 1.61 ENST00000394252.3
methyltransferase like 7B
chr1_+_171217622 1.57 ENST00000433267.1
ENST00000367750.3
flavin containing monooxygenase 1
chr12_-_86230315 1.52 ENST00000361228.3
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr20_-_21494654 1.51 ENST00000377142.4
NK2 homeobox 2
chr3_-_114790179 1.46 ENST00000462705.1
zinc finger and BTB domain containing 20
chr6_-_80247105 1.42 ENST00000369846.4
Leber congenital amaurosis 5
chr17_+_58755184 1.42 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
breast carcinoma amplified sequence 3
chr3_+_171561127 1.36 ENST00000334567.5
ENST00000450693.1
transmembrane protein 212
chr15_-_28344439 1.35 ENST00000431101.1
ENST00000445578.1
ENST00000353809.5
ENST00000382996.2
ENST00000354638.3
oculocutaneous albinism II
chr10_-_6019455 1.34 ENST00000530685.1
ENST00000397255.3
ENST00000379971.1
ENST00000528354.1
ENST00000397250.2
ENST00000429135.2
interleukin 15 receptor, alpha
chr1_-_48866517 1.30 ENST00000371841.1
spermatogenesis associated 6
chr12_-_15103621 1.26 ENST00000536592.1
Rho GDP dissociation inhibitor (GDI) beta
chr1_+_156338993 1.25 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
Rh family, B glycoprotein (gene/pseudogene)
chr17_-_7216939 1.20 ENST00000573684.1
G protein pathway suppressor 2
chr12_-_50294033 1.20 ENST00000552669.1
Fas apoptotic inhibitory molecule 2
chr1_-_175712665 1.15 ENST00000263525.2
tenascin R
chr1_-_108231101 1.08 ENST00000544443.1
ENST00000415432.2
vav 3 guanine nucleotide exchange factor
chr11_-_105892937 1.08 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr7_-_150777874 1.05 ENST00000540185.1
Fas-activated serine/threonine kinase
chr19_+_10563567 1.05 ENST00000344979.3
phosphodiesterase 4A, cAMP-specific
chr19_+_52076425 1.05 ENST00000436511.2
zinc finger protein 175
chr1_-_169337176 1.04 ENST00000472647.1
ENST00000367811.3
NME/NM23 family member 7
chr7_+_75544466 1.03 ENST00000421059.1
ENST00000394893.1
ENST00000412521.1
ENST00000414186.1
P450 (cytochrome) oxidoreductase
chr11_-_104480019 1.03 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
chr16_+_69796209 1.03 ENST00000359154.2
ENST00000561780.1
ENST00000563659.1
ENST00000448661.1
WW domain containing E3 ubiquitin protein ligase 2
chr10_+_135204338 1.02 ENST00000468317.2
Mitochondrial GTPase 1
chr12_-_56236690 1.00 ENST00000322569.4
matrix metallopeptidase 19
chr10_-_27529486 0.99 ENST00000375888.1
acyl-CoA binding domain containing 5
chr1_+_158259558 0.99 ENST00000368170.3
CD1c molecule
chr1_-_160001737 0.98 ENST00000368090.2
phosphatidylinositol glycan anchor biosynthesis, class M
chr11_-_111383064 0.97 ENST00000525791.1
ENST00000456861.2
ENST00000356018.2
B-cell translocation gene 4
chr22_+_31160239 0.97 ENST00000445781.1
ENST00000401475.1
oxysterol binding protein 2
chr9_-_215744 0.97 ENST00000382387.2
chromosome 9 open reading frame 66
chr3_+_132316081 0.96 ENST00000249887.2
atypical chemokine receptor 4
chr4_-_1685718 0.96 ENST00000472884.2
ENST00000489363.1
ENST00000308132.6
ENST00000463238.1
family with sequence similarity 53, member A
chr11_+_93063878 0.94 ENST00000298050.3
coiled-coil domain containing 67
chr3_-_42003479 0.93 ENST00000420927.1
unc-51 like kinase 4
chr11_+_94277017 0.93 ENST00000358752.2
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr12_-_109531264 0.93 ENST00000429722.2
ENST00000536242.1
ENST00000343075.3
ENST00000536358.1
alkB, alkylation repair homolog 2 (E. coli)
chr15_+_65843130 0.92 ENST00000569894.1
protein tyrosine phosphatase-like A domain containing 1
chr4_+_89299885 0.91 ENST00000380265.5
ENST00000273960.3
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr17_-_47723943 0.91 ENST00000510476.1
ENST00000503676.1
speckle-type POZ protein
chr3_+_32726620 0.87 ENST00000331889.6
ENST00000328834.5
CCR4-NOT transcription complex, subunit 10
chr11_-_118901559 0.87 ENST00000330775.7
ENST00000545985.1
ENST00000357590.5
ENST00000538950.1
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr11_+_98891797 0.85 ENST00000527185.1
ENST00000528682.1
ENST00000524871.1
contactin 5
chr6_+_126102292 0.84 ENST00000368357.3
nuclear receptor coactivator 7
chr12_-_89919765 0.84 ENST00000541909.1
ENST00000313546.3
POC1 centriolar protein B
chr20_-_271009 0.83 ENST00000382369.5
chromosome 20 open reading frame 96
chr20_-_32262165 0.81 ENST00000606690.1
ENST00000246190.6
ENST00000439478.1
ENST00000375238.4
N-terminal EF-hand calcium binding protein 3
chr10_+_121652204 0.80 ENST00000369075.3
ENST00000543134.1
SEC23 interacting protein
chr17_-_56606705 0.79 ENST00000317268.3
septin 4
chr11_-_6640585 0.78 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
tripeptidyl peptidase I
chr7_-_150777949 0.78 ENST00000482571.1
Fas-activated serine/threonine kinase
chr7_-_150777920 0.76 ENST00000353841.2
ENST00000297532.6
Fas-activated serine/threonine kinase
chr19_-_6459746 0.73 ENST00000301454.4
ENST00000334510.5
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr11_-_62521614 0.72 ENST00000527994.1
ENST00000394807.3
zinc finger and BTB domain containing 3
chr17_-_56606664 0.71 ENST00000580844.1
septin 4
chr1_-_200638964 0.71 ENST00000367348.3
ENST00000447706.2
ENST00000331314.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr6_-_15586238 0.70 ENST00000462989.2
dystrobrevin binding protein 1
chr3_-_15106747 0.69 ENST00000449354.2
ENST00000444840.2
ENST00000253686.2
mitochondrial ribosomal protein S25
chr17_-_62493131 0.69 ENST00000539111.2
polymerase (DNA directed), gamma 2, accessory subunit
chr20_+_32254286 0.67 ENST00000330271.4
actin-like 10
chr7_-_112430647 0.66 ENST00000312814.6
transmembrane protein 168
chr13_-_48669232 0.66 ENST00000258648.2
ENST00000378586.1
mediator complex subunit 4
chr9_+_134065506 0.66 ENST00000483497.2
nucleoporin 214kDa
chr5_-_111091948 0.65 ENST00000447165.2
neuronal regeneration related protein
chr8_-_95220775 0.63 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
cadherin 17, LI cadherin (liver-intestine)
chr17_-_56606639 0.63 ENST00000579371.1
septin 4
chr8_-_17942432 0.62 ENST00000381733.4
ENST00000314146.10
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chrX_-_132231123 0.60 ENST00000511190.1
ubiquitin specific peptidase 26
chr3_+_37034823 0.57 ENST00000231790.2
ENST00000456676.2
mutL homolog 1
chr14_+_50779071 0.57 ENST00000426751.2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr1_+_205225319 0.56 ENST00000329800.7
transmembrane and coiled-coil domain family 2
chr1_+_19578033 0.55 ENST00000330263.4
mRNA turnover 4 homolog (S. cerevisiae)
chr9_+_71944241 0.54 ENST00000257515.8
family with sequence similarity 189, member A2
chr2_+_109335929 0.54 ENST00000283195.6
RAN binding protein 2
chr10_-_13342097 0.53 ENST00000263038.4
phytanoyl-CoA 2-hydroxylase
chr8_+_42396936 0.52 ENST00000416469.2
small integral membrane protein 19
chr3_-_39234074 0.51 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
xin actin-binding repeat containing 1
chrX_+_51149767 0.51 ENST00000342995.2
chromosome X open reading frame 67
chr3_+_37035289 0.50 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
mutL homolog 1
chr4_-_79860506 0.50 ENST00000295462.3
ENST00000380645.4
ENST00000512733.1
progestin and adipoQ receptor family member III
chr9_-_33402506 0.50 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
aquaporin 7
chr7_+_128116783 0.50 ENST00000262432.8
ENST00000480046.1
methyltransferase like 2B
chr8_-_101571933 0.48 ENST00000520311.1
ankyrin repeat domain 46
chr7_+_142498725 0.46 ENST00000466254.1
T cell receptor beta constant 2
chr12_-_44152551 0.45 ENST00000416848.2
ENST00000550784.1
ENST00000547156.1
ENST00000549868.1
ENST00000553166.1
ENST00000551923.1
ENST00000431332.3
ENST00000344862.5
pseudouridylate synthase 7 homolog (S. cerevisiae)-like
chr1_-_175712829 0.44 ENST00000367674.2
tenascin R
chr17_+_44370099 0.44 ENST00000496930.1
leucine rich repeat containing 37A
chr1_-_203144941 0.44 ENST00000255416.4
myosin binding protein H
chr17_+_60501228 0.44 ENST00000311506.5
methyltransferase like 2A
chr8_+_42396712 0.44 ENST00000518574.1
ENST00000417410.2
ENST00000414154.2
small integral membrane protein 19
chr7_-_91509986 0.44 ENST00000456229.1
ENST00000442961.1
ENST00000406735.2
ENST00000419292.1
ENST00000351870.3
mitochondrial transcription termination factor
chr11_-_61687739 0.43 ENST00000531922.1
ENST00000301773.5
RAB3A interacting protein (rabin3)-like 1
chr12_-_371994 0.43 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
solute carrier family 6 (neurotransmitter transporter), member 13
chr17_-_49337392 0.43 ENST00000376381.2
ENST00000586178.1
mbt domain containing 1
chr12_-_50290839 0.41 ENST00000552863.1
Fas apoptotic inhibitory molecule 2
chr7_+_123241908 0.41 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ankyrin repeat and SOCS box containing 15
chr4_-_170924888 0.41 ENST00000502832.1
ENST00000393704.3
microfibrillar-associated protein 3-like
chr17_-_34890732 0.40 ENST00000268852.9
myosin XIX
chr10_-_6019984 0.39 ENST00000525219.2
interleukin 15 receptor, alpha
chr12_-_71182695 0.39 ENST00000342084.4
protein tyrosine phosphatase, receptor type, R
chr17_+_49337881 0.37 ENST00000225298.7
UTP18 small subunit (SSU) processome component homolog (yeast)
chr9_-_70465758 0.37 ENST00000489273.1
COBW domain containing 5
chr17_-_72527605 0.37 ENST00000392621.1
ENST00000314401.3
CD300 molecule-like family member b
chr5_+_173763250 0.36 ENST00000515513.1
ENST00000507361.1
ENST00000510234.1
RP11-267A15.1
chr19_-_56110859 0.35 ENST00000221665.3
ENST00000592585.1
FLT3-interacting zinc finger 1
chr8_-_101571964 0.34 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ankyrin repeat domain 46
chr1_+_158969752 0.34 ENST00000566111.1
interferon, gamma-inducible protein 16
chr8_-_42397037 0.34 ENST00000342228.3
solute carrier family 20 (phosphate transporter), member 2
chr2_+_203776937 0.33 ENST00000402905.3
ENST00000414490.1
ENST00000431787.1
ENST00000444724.1
ENST00000414857.1
ENST00000430899.1
ENST00000445120.1
ENST00000441569.1
ENST00000432024.1
ENST00000443740.1
ENST00000414439.1
ENST00000428585.1
ENST00000545253.1
ENST00000545262.1
ENST00000447539.1
ENST00000456821.2
ENST00000434998.1
ENST00000320443.8
calcium responsive transcription factor
chr10_-_6019552 0.33 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
interleukin 15 receptor, alpha
chr4_+_37003420 0.32 ENST00000562049.1
RP11-103J17.2
chr2_-_100721178 0.31 ENST00000409236.2
AF4/FMR2 family, member 3
chr13_+_115000521 0.31 ENST00000252457.5
ENST00000375308.1
cell division cycle 16
chr17_-_34890759 0.30 ENST00000431794.3
myosin XIX
chr5_+_175487692 0.30 ENST00000510151.1
family with sequence similarity 153, member B
chr13_+_115000556 0.29 ENST00000252458.6
cell division cycle 16
chr7_+_75511362 0.29 ENST00000428119.1
rhomboid domain containing 2
chr1_-_36863481 0.28 ENST00000315732.2
LSM10, U7 small nuclear RNA associated
chr5_-_177210399 0.28 ENST00000510276.1
family with sequence similarity 153, member A
chr3_+_140981456 0.28 ENST00000504264.1
acid phosphatase-like 2
chr19_+_58144529 0.26 ENST00000347302.3
ENST00000254182.7
ENST00000391703.3
ENST00000541801.1
ENST00000299871.5
ENST00000544273.1
zinc finger protein 211
chr18_+_7754957 0.26 ENST00000400053.4
protein tyrosine phosphatase, receptor type, M
chr11_+_118958689 0.24 ENST00000535253.1
ENST00000392841.1
hydroxymethylbilane synthase
chr1_-_21377383 0.24 ENST00000374935.3
eukaryotic translation initiation factor 4 gamma, 3
chr2_-_69180012 0.23 ENST00000481498.1
gastrokine 2
chr2_-_179567206 0.23 ENST00000414766.1
titin
chr16_-_69373396 0.23 ENST00000562595.1
ENST00000562081.1
ENST00000306875.4
component of oligomeric golgi complex 8
chr17_-_29624343 0.22 ENST00000247271.4
oligodendrocyte myelin glycoprotein
chr12_-_57039739 0.21 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr11_-_129817356 0.21 ENST00000526082.1
PR domain containing 10
chr14_+_64680854 0.20 ENST00000458046.2
spectrin repeat containing, nuclear envelope 2
chr2_-_69180083 0.20 ENST00000328895.4
gastrokine 2
chr17_+_41150479 0.19 ENST00000589913.1
ribosomal protein L27
chr20_-_5100591 0.19 ENST00000379143.5
proliferating cell nuclear antigen
chr1_+_173793641 0.19 ENST00000361951.4
aspartyl-tRNA synthetase 2, mitochondrial
chr5_-_169725231 0.18 ENST00000046794.5
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr2_+_86426478 0.17 ENST00000254644.8
ENST00000605125.1
ENST00000337109.4
ENST00000409180.1
mitochondrial ribosomal protein L35
chr2_-_25565377 0.17 ENST00000264709.3
ENST00000406659.3
DNA (cytosine-5-)-methyltransferase 3 alpha
chr14_+_50779029 0.16 ENST00000245448.6
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chrX_-_47341928 0.16 ENST00000313116.7
zinc finger protein 41
chr8_-_120651020 0.16 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr19_+_7694623 0.15 ENST00000594797.1
ENST00000456958.3
ENST00000601406.1
PET100 homolog (S. cerevisiae)
chr6_-_159466042 0.15 ENST00000338313.5
T-cell activation RhoGTPase activating protein
chrX_+_151081351 0.15 ENST00000276344.2
melanoma antigen family A, 4
chr19_+_496454 0.14 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
mucosal vascular addressin cell adhesion molecule 1
chr19_-_37663332 0.13 ENST00000392157.2
zinc finger protein 585A
chr9_-_134406611 0.13 ENST00000372208.3
ENST00000372215.4
uridine-cytidine kinase 1
chr4_+_113739244 0.13 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ankyrin 2, neuronal
chr19_+_52074502 0.13 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
zinc finger protein 175
chr22_+_42017987 0.13 ENST00000405506.1
X-ray repair complementing defective repair in Chinese hamster cells 6
chr3_-_157824292 0.13 ENST00000483851.2
short stature homeobox 2
chr6_+_10528560 0.13 ENST00000379597.3
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_+_1417228 0.12 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
thyroid peroxidase
chr1_-_21377447 0.12 ENST00000374937.3
ENST00000264211.8
eukaryotic translation initiation factor 4 gamma, 3
chr11_-_64684672 0.12 ENST00000377264.3
ENST00000421419.2
autophagy related 2A
chr17_-_39341594 0.12 ENST00000398472.1
keratin associated protein 4-1
chr1_+_233086326 0.11 ENST00000366628.5
ENST00000366627.4
nucleoside-triphosphatase, cancer-related
chr14_+_31494841 0.11 ENST00000556232.1
ENST00000216366.4
ENST00000334725.4
ENST00000554609.1
ENST00000554345.1
adaptor-related protein complex 4, sigma 1 subunit
chr5_-_133510456 0.11 ENST00000520417.1
S-phase kinase-associated protein 1
chr17_+_41150793 0.10 ENST00000586277.1
ribosomal protein L27
chr17_-_34890709 0.10 ENST00000544606.1
myosin XIX
chr17_+_41150290 0.09 ENST00000589037.1
ENST00000253788.5
ribosomal protein L27
chr2_-_175462934 0.08 ENST00000392546.2
ENST00000436221.1
WAS/WASL interacting protein family, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0006186 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
1.0 10.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.6 3.4 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.5 1.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.4 2.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.4 1.3 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.4 3.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.4 1.1 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.4 7.1 GO:0070986 left/right axis specification(GO:0070986)
0.3 1.0 GO:0043602 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210)
0.3 1.4 GO:0006726 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.3 2.6 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.3 1.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 3.5 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.3 2.9 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.3 5.1 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 1.6 GO:0070995 NADPH oxidation(GO:0070995)
0.2 1.3 GO:0071461 cellular response to redox state(GO:0071461)
0.2 0.6 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 0.9 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 1.0 GO:0030242 pexophagy(GO:0030242)
0.1 0.5 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.9 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.1 0.5 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 0.9 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 1.0 GO:0001554 luteolysis(GO:0001554)
0.1 1.6 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.7 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 1.0 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 0.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.9 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 0.7 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.8 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 0.4 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.3 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.5 GO:0015793 glycerol transport(GO:0015793)
0.1 1.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.2 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0 0.7 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.2 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116) hindlimb morphogenesis(GO:0035137)
0.0 0.8 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309) regulation of SA node cell action potential(GO:0098907)
0.0 1.6 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 1.0 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 2.5 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.9 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 1.1 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 1.6 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.3 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 1.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.6 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.9 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 2.6 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 1.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 5.5 GO:0007586 digestion(GO:0007586)
0.0 0.9 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.4 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 1.2 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 4.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 1.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.8 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.1 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.7 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 0.8 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.8 GO:0060271 cilium morphogenesis(GO:0060271)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0072534 perineuronal net(GO:0072534)
0.6 2.9 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.4 1.1 GO:0005715 late recombination nodule(GO:0005715)
0.3 1.3 GO:0097224 sperm connecting piece(GO:0097224)
0.2 1.6 GO:0002177 manchette(GO:0002177)
0.2 0.7 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.2 0.7 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.1 2.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.1 GO:0097227 sperm annulus(GO:0097227)
0.1 0.7 GO:0070847 core mediator complex(GO:0070847)
0.1 0.5 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 1.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 2.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 7.1 GO:0036126 sperm flagellum(GO:0036126)
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.4 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 1.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.0 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.0 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.7 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 3.5 GO:0005929 cilium(GO:0005929)
0.0 0.7 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 4.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.5 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.7 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.9 2.6 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.5 2.7 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.5 1.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.5 1.4 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.3 1.0 GO:0047726 iron-cytochrome-c reductase activity(GO:0047726)
0.3 0.9 GO:0035514 DNA demethylase activity(GO:0035514)
0.3 2.9 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.2 1.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 2.1 GO:0032027 myosin light chain binding(GO:0032027)
0.2 0.6 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.8 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 1.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.9 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 0.6 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.9 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1 3.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 5.9 GO:0008009 chemokine activity(GO:0008009)
0.1 1.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.2 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.1 0.9 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 3.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 3.0 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.3 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.7 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.7 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0 1.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.7 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.7 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 1.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.0 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 5.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.7 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.5 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 5.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.4 GO:0000339 RNA cap binding(GO:0000339)
0.0 1.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 0.6 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 2.5 ST ADRENERGIC Adrenergic Pathway
0.0 0.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 3.7 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.6 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 2.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 2.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 2.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.0 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 11.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.2 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism