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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX3-1

Z-value: 1.03

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Transcription factors associated with NKX3-1

Gene Symbol Gene ID Gene Info
NKX3-1
ENSG00000167034.9 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX3-1hg19_v2_chr8_-_23540402_23540466-0.595.4e-04Click!

Activity profile of NKX3-1 motif

Sorted Z-values of NKX3-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_153113927 5.03 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr1_-_153066998 4.83 ENST00000368750.3
SPRR2E
small proline-rich protein 2E
chr10_+_118187379 4.41 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chrX_-_107681633 3.53 ENST00000394872.2
ENST00000334504.7
COL4A6
collagen, type IV, alpha 6
chr5_+_150404904 3.47 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr1_-_153085984 3.35 ENST00000468739.1
SPRR2F
small proline-rich protein 2F
chr6_+_24775641 3.22 ENST00000378054.2
ENST00000476555.1
GMNN
geminin, DNA replication inhibitor
chr18_+_61445007 3.20 ENST00000447428.1
ENST00000546027.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr5_+_68485433 3.17 ENST00000502689.1
CENPH
centromere protein H
chr19_+_16308711 3.15 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr6_-_39290316 3.09 ENST00000425054.2
ENST00000373227.4
ENST00000373229.5
ENST00000437525.2
KCNK16
potassium channel, subfamily K, member 16
chr19_-_14889349 2.85 ENST00000315576.3
ENST00000392967.2
ENST00000346057.1
ENST00000353876.1
ENST00000353005.1
EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
chr2_+_102456277 2.85 ENST00000421882.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr20_-_56285595 2.75 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr20_-_56286479 2.63 ENST00000265626.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr19_-_44174330 2.57 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr2_+_48541776 2.53 ENST00000413569.1
ENST00000340553.3
FOXN2
forkhead box N2
chr19_-_11266471 2.49 ENST00000592540.1
SPC24
SPC24, NDC80 kinetochore complex component
chr19_+_16308659 2.46 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr17_-_76870222 2.44 ENST00000585421.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_76870126 2.43 ENST00000586057.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr11_-_62323702 2.31 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr4_-_76928641 2.21 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chr5_+_96211643 2.17 ENST00000437043.3
ENST00000510373.1
ERAP2
endoplasmic reticulum aminopeptidase 2
chr2_-_36779411 2.16 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr2_-_102003987 2.15 ENST00000324768.5
CREG2
cellular repressor of E1A-stimulated genes 2
chr8_+_27168988 2.13 ENST00000397501.1
ENST00000338238.4
ENST00000544172.1
PTK2B
protein tyrosine kinase 2 beta
chr3_-_48632593 2.12 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr9_+_706842 2.10 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr17_-_39526052 2.05 ENST00000251646.3
KRT33B
keratin 33B
chr9_+_36572851 2.03 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
MELK
maternal embryonic leucine zipper kinase
chr10_-_103347883 1.98 ENST00000339310.3
ENST00000370158.3
ENST00000299206.4
ENST00000456836.2
ENST00000413344.1
ENST00000429502.1
ENST00000430045.1
ENST00000370172.1
ENST00000436284.2
ENST00000370162.3
POLL
polymerase (DNA directed), lambda
chr17_+_2699697 1.94 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr12_+_110011571 1.93 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
MVK
mevalonate kinase
chr6_-_144385698 1.84 ENST00000444202.1
ENST00000437412.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr1_-_208417620 1.74 ENST00000367033.3
PLXNA2
plexin A2
chr6_-_26124138 1.72 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chr17_+_33914460 1.64 ENST00000537622.2
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr5_+_68485363 1.56 ENST00000283006.2
ENST00000515001.1
CENPH
centromere protein H
chr1_-_6445809 1.55 ENST00000377855.2
ACOT7
acyl-CoA thioesterase 7
chr5_-_76788134 1.52 ENST00000507029.1
WDR41
WD repeat domain 41
chr9_+_116263639 1.49 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr3_+_26735991 1.47 ENST00000456208.2
LRRC3B
leucine rich repeat containing 3B
chr3_+_98482175 1.45 ENST00000485391.1
ENST00000492254.1
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr17_+_33914276 1.36 ENST00000592545.1
ENST00000538556.1
ENST00000312678.8
ENST00000589344.1
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr14_-_102829051 1.32 ENST00000536961.2
ENST00000541568.2
ENST00000216756.6
CINP
cyclin-dependent kinase 2 interacting protein
chr5_-_76788024 1.32 ENST00000515253.1
ENST00000414719.2
ENST00000507654.1
ENST00000514559.1
ENST00000511791.1
WDR41
WD repeat domain 41
chr8_-_49833978 1.31 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr19_-_44174305 1.28 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chrX_-_153637612 1.28 ENST00000369807.1
ENST00000369808.3
DNASE1L1
deoxyribonuclease I-like 1
chr10_+_91461337 1.25 ENST00000260753.4
ENST00000416354.1
ENST00000394289.2
ENST00000371728.3
KIF20B
kinesin family member 20B
chr17_-_55911970 1.24 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr3_-_81811312 1.24 ENST00000429644.2
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr3_+_156799587 1.21 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr1_-_32169920 1.21 ENST00000373672.3
ENST00000373668.3
COL16A1
collagen, type XVI, alpha 1
chr1_-_32169761 1.18 ENST00000271069.6
COL16A1
collagen, type XVI, alpha 1
chr6_+_26251835 1.18 ENST00000356350.2
HIST1H2BH
histone cluster 1, H2bh
chr12_-_4553385 1.17 ENST00000543077.1
FGF6
fibroblast growth factor 6
chr17_-_64187973 1.16 ENST00000583358.1
ENST00000392769.2
CEP112
centrosomal protein 112kDa
chr7_+_110731062 1.13 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chr8_-_49834299 1.13 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr3_+_160117418 1.10 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
SMC4
structural maintenance of chromosomes 4
chr7_+_141463897 1.10 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr11_-_101454658 1.06 ENST00000344327.3
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr12_+_6602517 1.04 ENST00000315579.5
ENST00000539714.1
NCAPD2
non-SMC condensin I complex, subunit D2
chr3_-_30936153 1.04 ENST00000454381.3
ENST00000282538.5
GADL1
glutamate decarboxylase-like 1
chr4_+_70916119 1.03 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr1_-_78444776 1.02 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr19_-_42931567 1.01 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr14_+_23654525 1.00 ENST00000399910.1
ENST00000492621.1
C14orf164
chromosome 14 open reading frame 164
chr22_-_50523760 1.00 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr21_-_46964306 0.98 ENST00000443742.1
ENST00000528477.1
ENST00000567670.1
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr17_-_37009882 0.96 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
RPL23
ribosomal protein L23
chr16_+_83986827 0.96 ENST00000393306.1
ENST00000565123.1
OSGIN1
oxidative stress induced growth inhibitor 1
chr1_-_120190396 0.93 ENST00000421812.2
ZNF697
zinc finger protein 697
chr1_-_173793458 0.93 ENST00000356198.2
CENPL
centromere protein L
chr4_+_37962018 0.93 ENST00000504686.1
PTTG2
pituitary tumor-transforming 2
chr8_-_101157680 0.89 ENST00000428847.2
FBXO43
F-box protein 43
chr4_-_90757364 0.88 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr14_-_47812321 0.86 ENST00000357362.3
ENST00000486952.2
ENST00000426342.1
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr12_-_54978086 0.86 ENST00000553113.1
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr15_-_55563072 0.85 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr2_+_201994569 0.83 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr11_+_60995849 0.82 ENST00000537932.1
PGA4
pepsinogen 4, group I (pepsinogen A)
chr5_+_149877334 0.81 ENST00000523767.1
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr1_+_158223923 0.81 ENST00000289429.5
CD1A
CD1a molecule
chr12_-_92536433 0.80 ENST00000551563.2
ENST00000546975.1
ENST00000549802.1
C12orf79
chromosome 12 open reading frame 79
chr17_-_2966901 0.80 ENST00000575751.1
OR1D5
olfactory receptor, family 1, subfamily D, member 5
chr1_-_173793246 0.79 ENST00000345664.6
ENST00000367710.3
CENPL
centromere protein L
chr15_-_33360342 0.79 ENST00000558197.1
FMN1
formin 1
chr4_-_90756769 0.78 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr17_-_7307358 0.77 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr12_-_127256772 0.77 ENST00000536517.1
LINC00944
long intergenic non-protein coding RNA 944
chr7_+_135242652 0.76 ENST00000285968.6
ENST00000440390.2
NUP205
nucleoporin 205kDa
chr1_+_46972668 0.76 ENST00000371956.4
ENST00000360032.3
DMBX1
diencephalon/mesencephalon homeobox 1
chr12_+_96252706 0.75 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr22_+_44577237 0.74 ENST00000415224.1
ENST00000417767.1
PARVG
parvin, gamma
chr3_+_158991025 0.73 ENST00000337808.6
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr16_+_3068393 0.73 ENST00000573001.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr17_+_80674559 0.71 ENST00000269373.6
ENST00000535965.1
ENST00000577128.1
ENST00000573158.1
FN3KRP
fructosamine 3 kinase related protein
chr8_+_30300119 0.70 ENST00000520191.1
RBPMS
RNA binding protein with multiple splicing
chr9_-_73477826 0.70 ENST00000396285.1
ENST00000396292.4
ENST00000396280.5
ENST00000358082.3
ENST00000408909.2
ENST00000377097.3
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr14_-_65409502 0.70 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr6_+_26124373 0.69 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr17_+_37824217 0.69 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr20_-_50722183 0.68 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr5_-_1799864 0.67 ENST00000510999.1
MRPL36
mitochondrial ribosomal protein L36
chr10_+_5406935 0.65 ENST00000380433.3
UCN3
urocortin 3
chr12_-_22063787 0.65 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr5_+_96038476 0.64 ENST00000511049.1
ENST00000309190.5
ENST00000510156.1
ENST00000509903.1
ENST00000511782.1
ENST00000504465.1
CAST
calpastatin
chr10_+_120116527 0.63 ENST00000445161.1
LINC00867
long intergenic non-protein coding RNA 867
chr16_-_3068171 0.62 ENST00000572154.1
ENST00000328796.4
CLDN6
claudin 6
chr9_-_104145795 0.62 ENST00000259407.2
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr1_-_160616804 0.59 ENST00000538290.1
SLAMF1
signaling lymphocytic activation molecule family member 1
chr12_+_113354341 0.59 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_+_8040739 0.58 ENST00000534099.1
TUB
tubby bipartite transcription factor
chr14_-_106805716 0.58 ENST00000438142.2
IGHV4-31
immunoglobulin heavy variable 4-31
chr3_+_39509070 0.57 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP
myelin-associated oligodendrocyte basic protein
chr17_+_37824411 0.57 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr4_+_88529681 0.57 ENST00000399271.1
DSPP
dentin sialophosphoprotein
chrX_+_13671225 0.57 ENST00000545566.1
ENST00000544987.1
ENST00000314720.4
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr17_-_295730 0.55 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr11_-_101454234 0.55 ENST00000348423.4
ENST00000360497.4
ENST00000532133.1
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr19_+_50433476 0.55 ENST00000596658.1
ATF5
activating transcription factor 5
chr4_+_15376165 0.54 ENST00000382383.3
ENST00000429690.1
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr11_+_60163918 0.54 ENST00000526375.1
ENST00000531783.1
ENST00000395001.1
MS4A14
membrane-spanning 4-domains, subfamily A, member 14
chr1_+_173793777 0.53 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr3_-_39196049 0.53 ENST00000514182.1
CSRNP1
cysteine-serine-rich nuclear protein 1
chr3_+_39509163 0.52 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
MOBP
myelin-associated oligodendrocyte basic protein
chr10_+_18629628 0.52 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr14_-_65409438 0.52 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr12_-_39300071 0.51 ENST00000550863.1
CPNE8
copine VIII
chr5_+_150051149 0.51 ENST00000523553.1
MYOZ3
myozenin 3
chr1_+_57320437 0.50 ENST00000361249.3
C8A
complement component 8, alpha polypeptide
chr16_+_33204156 0.50 ENST00000398667.4
TP53TG3C
TP53 target 3C
chr3_+_139062838 0.50 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
MRPS22
mitochondrial ribosomal protein S22
chr16_-_3074231 0.49 ENST00000572355.1
ENST00000248089.3
ENST00000574980.1
ENST00000354679.3
ENST00000396916.1
ENST00000573842.1
HCFC1R1
host cell factor C1 regulator 1 (XPO1 dependent)
chr1_-_193029192 0.49 ENST00000417752.1
ENST00000367452.4
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr19_+_17186577 0.48 ENST00000595618.1
ENST00000594824.1
MYO9B
myosin IXB
chr3_-_51813009 0.48 ENST00000398780.3
IQCF6
IQ motif containing F6
chr7_+_150147711 0.48 ENST00000307271.3
GIMAP8
GTPase, IMAP family member 8
chr1_-_216596738 0.47 ENST00000307340.3
ENST00000366943.2
ENST00000366942.3
USH2A
Usher syndrome 2A (autosomal recessive, mild)
chr6_-_123958141 0.47 ENST00000334268.4
TRDN
triadin
chr18_+_61144160 0.47 ENST00000489441.1
ENST00000424602.1
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr2_+_238877424 0.47 ENST00000434655.1
UBE2F
ubiquitin-conjugating enzyme E2F (putative)
chr4_+_159131630 0.46 ENST00000504569.1
ENST00000509278.1
ENST00000514558.1
ENST00000503200.1
TMEM144
transmembrane protein 144
chrX_-_24665353 0.45 ENST00000379144.2
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr16_-_20556492 0.45 ENST00000568098.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr5_-_9903938 0.45 ENST00000511616.1
CTD-2143L24.1
CTD-2143L24.1
chr12_-_53045948 0.43 ENST00000309680.3
KRT2
keratin 2
chr8_-_93029520 0.43 ENST00000521553.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr5_+_78407602 0.42 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr4_+_56719782 0.42 ENST00000381295.2
ENST00000346134.7
ENST00000349598.6
EXOC1
exocyst complex component 1
chr3_+_156807663 0.42 ENST00000467995.1
ENST00000474477.1
ENST00000471719.1
LINC00881
long intergenic non-protein coding RNA 881
chr16_+_1832902 0.41 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2
nucleotide binding protein 2
chr3_-_156840776 0.41 ENST00000471357.1
LINC00880
long intergenic non-protein coding RNA 880
chr15_-_50558223 0.40 ENST00000267845.3
HDC
histidine decarboxylase
chr7_+_50348268 0.40 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr6_+_37321823 0.40 ENST00000487950.1
ENST00000469731.1
RNF8
ring finger protein 8, E3 ubiquitin protein ligase
chr6_+_63921399 0.40 ENST00000356170.3
FKBP1C
FK506 binding protein 1C
chr15_+_58702742 0.39 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr6_-_26216872 0.39 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr17_-_39661849 0.39 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13
keratin 13
chr1_-_110155671 0.39 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr5_-_1799932 0.38 ENST00000382647.7
ENST00000505059.2
MRPL36
mitochondrial ribosomal protein L36
chr6_-_29324054 0.38 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr12_-_10562356 0.37 ENST00000309384.1
KLRC4
killer cell lectin-like receptor subfamily C, member 4
chr12_-_118628350 0.37 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr1_-_22109682 0.36 ENST00000400301.1
ENST00000532737.1
USP48
ubiquitin specific peptidase 48
chr19_-_42006539 0.36 ENST00000597702.1
ENST00000588495.1
ENST00000595837.1
ENST00000594315.1
AC011526.1
AC011526.1
chr3_+_100354442 0.36 ENST00000475887.1
GPR128
G protein-coupled receptor 128
chr10_+_32735030 0.36 ENST00000277657.6
ENST00000362006.5
CCDC7
coiled-coil domain containing 7
chr19_+_35396219 0.35 ENST00000595783.1
CTC-523E23.6
CTC-523E23.6
chr8_-_16035454 0.35 ENST00000355282.2
MSR1
macrophage scavenger receptor 1
chr1_-_31538517 0.34 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1
chr16_+_89628778 0.34 ENST00000472354.1
RPL13
ribosomal protein L13
chr2_+_132160448 0.34 ENST00000437751.1
AC073869.19
long intergenic non-protein coding RNA 1120
chr3_-_10334585 0.33 ENST00000430179.1
ENST00000449238.2
ENST00000437422.2
ENST00000287656.7
ENST00000457360.1
ENST00000439975.2
ENST00000446937.2
GHRL
ghrelin/obestatin prepropeptide
chr7_+_107301065 0.33 ENST00000265715.3
SLC26A4
solute carrier family 26 (anion exchanger), member 4
chr10_+_46994087 0.33 ENST00000374317.1
GPRIN2
G protein regulated inducer of neurite outgrowth 2
chr16_+_32264040 0.33 ENST00000398664.3
TP53TG3D
TP53 target 3D
chr20_+_123010 0.33 ENST00000382398.3
DEFB126
defensin, beta 126
chr16_-_32688053 0.33 ENST00000398682.4
TP53TG3
TP53 target 3
chr3_-_10334617 0.32 ENST00000429122.1
ENST00000425479.1
ENST00000335542.8
GHRL
ghrelin/obestatin prepropeptide
chr1_+_202431859 0.32 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr11_+_65337901 0.32 ENST00000309328.3
ENST00000531405.1
ENST00000527920.1
ENST00000526877.1
ENST00000533115.1
ENST00000526433.1
SSSCA1
Sjogren syndrome/scleroderma autoantigen 1
chr5_-_150138551 0.32 ENST00000446090.2
ENST00000447998.2
DCTN4
dynactin 4 (p62)
chr8_+_128426535 0.32 ENST00000465342.2
POU5F1B
POU class 5 homeobox 1B
chr6_-_57087042 0.30 ENST00000317483.3
RAB23
RAB23, member RAS oncogene family
chr1_+_84873913 0.30 ENST00000370662.3
DNASE2B
deoxyribonuclease II beta
chr4_-_10118469 0.30 ENST00000499869.2
WDR1
WD repeat domain 1
chr5_-_77072085 0.30 ENST00000518338.2
ENST00000520039.1
ENST00000306388.6
ENST00000520361.1
TBCA
tubulin folding cofactor A
chr6_-_135271219 0.30 ENST00000367847.2
ENST00000367845.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr7_-_6865826 0.30 ENST00000538180.1
CCZ1B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
chr12_+_60083118 0.29 ENST00000261187.4
ENST00000543448.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr17_-_29624343 0.29 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr3_+_100428188 0.29 ENST00000418917.2
ENST00000490574.1
TFG
TRK-fused gene
chr14_-_39417410 0.29 ENST00000557019.1
ENST00000556116.1
ENST00000554732.1
LINC00639
long intergenic non-protein coding RNA 639
chr8_+_87878640 0.29 ENST00000518476.1
CNBD1
cyclic nucleotide binding domain containing 1
chrX_-_102757802 0.28 ENST00000372633.1
RAB40A
RAB40A, member RAS oncogene family

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.9 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
1.0 3.9 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.8 2.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.8 3.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.7 2.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.6 1.9 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.6 3.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.6 3.5 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.5 3.2 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.5 2.1 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.4 5.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.4 1.6 GO:0036116 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.3 1.7 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.3 2.0 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.3 1.0 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.3 1.3 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.3 1.2 GO:1903436 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.3 4.7 GO:0051382 kinetochore assembly(GO:0051382)
0.3 2.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 5.6 GO:0048757 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.2 2.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.2 0.7 GO:1904344 positive regulation of growth rate(GO:0040010) regulation of gastric mucosal blood circulation(GO:1904344) positive regulation of gastric mucosal blood circulation(GO:1904346) gastric mucosal blood circulation(GO:1990768)
0.2 1.0 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 0.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.2 0.6 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.2 1.0 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.2 0.8 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 2.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 3.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 11.3 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.4 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.4 GO:0001694 histamine biosynthetic process(GO:0001694)
0.1 1.7 GO:0060174 branchiomotor neuron axon guidance(GO:0021785) limb bud formation(GO:0060174)
0.1 0.5 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 2.9 GO:0030033 microvillus assembly(GO:0030033)
0.1 0.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1 0.5 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 1.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 0.8 GO:1903943 negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.8 GO:0015014 protein sulfation(GO:0006477) heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 1.6 GO:0050774 manganese ion transport(GO:0006828) negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.8 GO:0008343 adult feeding behavior(GO:0008343)
0.1 0.3 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.1 1.1 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 0.6 GO:0019530 taurine metabolic process(GO:0019530)
0.1 0.5 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 0.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.2 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.1 1.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 1.1 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.1 0.2 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 5.3 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.6 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 1.7 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 2.4 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 0.4 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.2 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.9 GO:2000816 negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of chromosome segregation(GO:0051985) negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 0.3 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 2.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.6 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 1.5 GO:0097503 sialylation(GO:0097503)
0.0 0.5 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.5 GO:0070232 regulation of T cell apoptotic process(GO:0070232)
0.0 0.4 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.9 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.4 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.4 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.4 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.3 GO:0015705 iodide transport(GO:0015705)
0.0 0.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 1.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.8 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 1.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.4 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 2.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.5 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 1.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.6 GO:0051412 response to corticosterone(GO:0051412)
0.0 1.0 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.4 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.7 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 2.0 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 0.4 GO:0051601 exocyst localization(GO:0051601)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.5 GO:0045116 protein neddylation(GO:0045116)
0.0 0.3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.3 GO:0007097 nuclear migration(GO:0007097)
0.0 2.0 GO:0070268 cornification(GO:0070268)
0.0 2.5 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.4 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.0 GO:0006308 DNA catabolic process(GO:0006308)
0.0 1.2 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 2.2 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 1.4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.5 GO:0060325 face morphogenesis(GO:0060325)
0.0 1.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.5 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.4 3.5 GO:0005587 collagen type IV trimer(GO:0005587)
0.4 2.5 GO:0031262 Ndc80 complex(GO:0031262)
0.4 3.9 GO:0071438 invadopodium membrane(GO:0071438)
0.3 2.4 GO:0005593 FACIT collagen trimer(GO:0005593)
0.3 1.0 GO:0000799 nuclear condensin complex(GO:0000799)
0.2 2.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 13.7 GO:0001533 cornified envelope(GO:0001533)
0.2 0.8 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 1.1 GO:0000796 condensin complex(GO:0000796)
0.2 1.6 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.5 GO:0002139 stereocilia coupling link(GO:0002139)
0.2 8.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.5 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 2.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.2 GO:0070938 contractile ring(GO:0070938)
0.1 0.7 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 0.8 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 0.6 GO:0043196 varicosity(GO:0043196)
0.1 0.2 GO:0055028 cortical microtubule(GO:0055028)
0.1 6.5 GO:0035580 specific granule lumen(GO:0035580)
0.1 1.2 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.3 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 3.8 GO:0044815 DNA packaging complex(GO:0044815)
0.1 0.5 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.5 GO:0030314 junctional membrane complex(GO:0030314)
0.1 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 1.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.8 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.0 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 4.7 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 5.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.5 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.7 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.8 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 1.3 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.0 GO:0005901 caveola(GO:0005901)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0031904 endosome lumen(GO:0031904)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.3 GO:0044853 plasma membrane raft(GO:0044853)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.8 4.7 GO:0043515 kinetochore binding(GO:0043515)
0.7 2.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 2.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.4 1.3 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.4 1.5 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.4 2.8 GO:0004111 creatine kinase activity(GO:0004111)
0.4 5.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.3 1.0 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.3 1.7 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.3 1.0 GO:0008518 reduced folate carrier activity(GO:0008518)
0.3 2.9 GO:0008430 selenium binding(GO:0008430)
0.3 1.0 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.2 1.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 0.7 GO:0031768 ghrelin receptor binding(GO:0031768)
0.2 0.6 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.2 0.8 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.2 1.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 4.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 4.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.9 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.2 0.6 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 3.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.4 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 1.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 3.0 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.6 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 2.4 GO:0044548 S100 protein binding(GO:0044548)
0.1 6.6 GO:0050699 WW domain binding(GO:0050699)
0.1 0.6 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.3 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 0.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 2.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.4 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.5 GO:0051373 FATZ binding(GO:0051373)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.2 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 1.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 0.5 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.2 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.2 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.1 0.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 1.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.5 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.4 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 1.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 5.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 2.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 3.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 3.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.8 GO:0005123 death receptor binding(GO:0005123)
0.0 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 1.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 2.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0016301 kinase activity(GO:0016301)
0.0 2.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.5 GO:0005525 GTP binding(GO:0005525)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 1.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.5 GO:0001848 complement binding(GO:0001848)
0.0 1.3 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.0 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.1 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.0 NABA COLLAGENS Genes encoding collagen proteins
0.1 3.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 5.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 2.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 0.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 2.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.1 PID AURORA B PATHWAY Aurora B signaling
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 7.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.4 PID INSULIN PATHWAY Insulin Pathway
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID ATM PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 3.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 3.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 5.9 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 3.0 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 4.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 7.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 8.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 1.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.8 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 1.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 2.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 2.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 4.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.8 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 1.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation