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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX3-2

Z-value: 1.29

Motif logo

Transcription factors associated with NKX3-2

Gene Symbol Gene ID Gene Info
ENSG00000109705.7 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX3-2hg19_v2_chr4_-_13546632_13546674-0.212.6e-01Click!

Activity profile of NKX3-2 motif

Sorted Z-values of NKX3-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_112970436 12.16 ENST00000400613.4
chromosome 9 open reading frame 152
chr1_-_161337662 11.59 ENST00000367974.1
chromosome 1 open reading frame 192
chr9_-_34397800 10.71 ENST00000297623.2
chromosome 9 open reading frame 24
chr5_-_149792295 7.94 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_32557610 7.62 ENST00000360004.5
major histocompatibility complex, class II, DR beta 1
chr7_-_99573677 7.37 ENST00000292401.4
alpha-2-glycoprotein 1, zinc-binding
chr17_-_74137374 7.26 ENST00000322957.6
forkhead box J1
chr13_+_43355683 6.96 ENST00000537894.1
family with sequence similarity 216, member B
chr13_+_43355732 6.94 ENST00000313851.1
family with sequence similarity 216, member B
chr9_+_34458771 6.94 ENST00000437363.1
ENST00000242317.4
dynein, axonemal, intermediate chain 1
chr11_-_111175739 5.61 ENST00000532918.1
colorectal cancer associated 1
chr5_+_156696362 4.72 ENST00000377576.3
cytoplasmic FMR1 interacting protein 2
chr1_-_183622442 4.70 ENST00000308641.4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr6_+_32821924 4.53 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr16_-_21289627 4.52 ENST00000396023.2
ENST00000415987.2
crystallin, mu
chr2_+_98703643 4.40 ENST00000477737.1
von Willebrand factor A domain containing 3B
chr16_+_57406368 4.24 ENST00000006053.6
ENST00000563383.1
chemokine (C-X3-C motif) ligand 1
chr17_+_68071389 4.21 ENST00000283936.1
ENST00000392671.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr11_-_26593649 4.21 ENST00000455601.2
mucin 15, cell surface associated
chr19_+_41497178 4.10 ENST00000324071.4
cytochrome P450, family 2, subfamily B, polypeptide 6
chr11_-_26593779 3.90 ENST00000529533.1
mucin 15, cell surface associated
chr9_-_75567962 3.83 ENST00000297785.3
ENST00000376939.1
aldehyde dehydrogenase 1 family, member A1
chr7_-_99573640 3.73 ENST00000411734.1
alpha-2-glycoprotein 1, zinc-binding
chr1_+_162351503 3.72 ENST00000458626.2
chromosome 1 open reading frame 226
chr4_-_168155730 3.68 ENST00000502330.1
ENST00000357154.3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr3_+_125694347 3.61 ENST00000505382.1
ENST00000511082.1
rhophilin associated tail protein 1B
chr4_-_141348789 3.49 ENST00000414773.1
calmegin
chr4_-_141348999 3.43 ENST00000325617.5
calmegin
chr9_-_124976185 3.41 ENST00000464484.2
LIM homeobox 6
chr9_-_124976154 3.34 ENST00000482062.1
LIM homeobox 6
chr5_+_156712372 3.24 ENST00000541131.1
cytoplasmic FMR1 interacting protein 2
chr3_-_112693865 3.09 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200 receptor 1
chr11_-_26593677 3.03 ENST00000527569.1
mucin 15, cell surface associated
chr12_-_113658892 2.94 ENST00000299732.2
ENST00000416617.2
IQ motif containing D
chr19_-_6720686 2.86 ENST00000245907.6
complement component 3
chr6_-_32731299 2.77 ENST00000435145.2
ENST00000437316.2
major histocompatibility complex, class II, DQ beta 2
chr7_-_120498357 2.71 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
tetraspanin 12
chr15_-_40401062 2.71 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
Bcl2 modifying factor
chr4_-_168155417 2.70 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr5_-_54468974 2.63 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
cell division cycle 20B
chr3_-_112693759 2.62 ENST00000440122.2
ENST00000490004.1
CD200 receptor 1
chr1_-_217262933 2.62 ENST00000359162.2
estrogen-related receptor gamma
chr4_-_168155700 2.60 ENST00000357545.4
ENST00000512648.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr10_+_7745232 2.56 ENST00000358415.4
inter-alpha-trypsin inhibitor heavy chain 2
chr17_+_68071458 2.55 ENST00000589377.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr1_-_217262969 2.49 ENST00000361525.3
estrogen-related receptor gamma
chr5_-_160279207 2.47 ENST00000327245.5
ATPase, class V, type 10B
chr12_+_56075330 2.38 ENST00000394252.3
methyltransferase like 7B
chr3_+_169629354 2.36 ENST00000428432.2
ENST00000335556.3
sterile alpha motif domain containing 7
chr15_-_43513187 2.23 ENST00000540029.1
ENST00000441366.2
erythrocyte membrane protein band 4.2
chr17_+_58755184 2.22 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
breast carcinoma amplified sequence 3
chr7_+_90338712 2.22 ENST00000265741.3
ENST00000406263.1
cyclin-dependent kinase 14
chr6_+_159084188 2.19 ENST00000367081.3
synaptotagmin-like 3
chr1_-_216978709 2.12 ENST00000360012.3
estrogen-related receptor gamma
chr10_-_46168156 2.08 ENST00000374371.2
ENST00000335258.7
zinc finger, AN1-type domain 4
chr2_-_220435963 2.08 ENST00000373876.1
ENST00000404537.1
ENST00000603926.1
ENST00000373873.4
ENST00000289656.3
obscurin-like 1
chr19_-_3028354 2.03 ENST00000586422.1
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr5_-_176326333 1.92 ENST00000292432.5
hexokinase 3 (white cell)
chr11_-_106889157 1.87 ENST00000282249.2
guanylate cyclase 1, soluble, alpha 2
chr4_-_168155577 1.75 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr15_+_89402148 1.74 ENST00000560601.1
aggrecan
chr11_+_66045634 1.74 ENST00000528852.1
ENST00000311445.6
cornichon family AMPA receptor auxiliary protein 2
chr1_+_211433275 1.70 ENST00000367005.4
REST corepressor 3
chr14_-_23770683 1.70 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
protein phosphatase 1, regulatory subunit 3E
chr6_+_18155560 1.70 ENST00000546309.2
ENST00000388870.2
ENST00000397244.1
lysine (K)-specific demethylase 1B
chr11_-_59633951 1.67 ENST00000257264.3
transcobalamin I (vitamin B12 binding protein, R binder family)
chr16_-_3350614 1.65 ENST00000268674.2
tigger transposable element derived 7
chr3_-_112218378 1.63 ENST00000334529.5
B and T lymphocyte associated
chr10_+_35415851 1.62 ENST00000374726.3
cAMP responsive element modulator
chr4_+_17579110 1.60 ENST00000606142.1
leucine aminopeptidase 3
chrX_+_48660287 1.59 ENST00000444343.2
ENST00000376610.2
ENST00000334136.5
ENST00000376619.2
histone deacetylase 6
chr1_-_217250231 1.57 ENST00000493748.1
ENST00000463665.1
estrogen-related receptor gamma
chr3_+_132316081 1.56 ENST00000249887.2
atypical chemokine receptor 4
chr19_+_17337473 1.54 ENST00000598068.1
occludin/ELL domain containing 1
chr2_-_220436248 1.53 ENST00000265318.4
obscurin-like 1
chr2_-_25194963 1.53 ENST00000264711.2
DnaJ (Hsp40) homolog, subfamily C, member 27
chr12_-_10151773 1.52 ENST00000298527.6
ENST00000348658.4
C-type lectin domain family 1, member B
chr1_+_60280458 1.52 ENST00000455990.1
ENST00000371208.3
hook microtubule-tethering protein 1
chr7_+_90339169 1.50 ENST00000436577.2
cyclin-dependent kinase 14
chr19_-_51412584 1.48 ENST00000431178.2
kallikrein-related peptidase 4
chr12_-_42983478 1.46 ENST00000345127.3
ENST00000547113.1
prickle homolog 1 (Drosophila)
chr1_-_48866517 1.40 ENST00000371841.1
spermatogenesis associated 6
chrX_+_95939711 1.40 ENST00000373049.4
ENST00000324765.8
diaphanous-related formin 2
chr11_+_36317830 1.33 ENST00000530639.1
proline rich 5 like
chr12_+_56473939 1.32 ENST00000450146.2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr17_+_18380051 1.30 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
lectin, galactoside-binding, soluble, 9C
chr6_+_29910301 1.30 ENST00000376809.5
ENST00000376802.2
major histocompatibility complex, class I, A
chr11_-_63381823 1.29 ENST00000323646.5
phospholipase A2, group XVI
chr14_+_21156915 1.27 ENST00000397990.4
ENST00000555597.1
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr3_-_112218205 1.26 ENST00000383680.4
B and T lymphocyte associated
chr2_-_188312971 1.25 ENST00000410068.1
ENST00000447403.1
ENST00000410102.1
calcitonin receptor-like
chr8_+_67624653 1.24 ENST00000521198.2
serum/glucocorticoid regulated kinase family, member 3
chr4_+_159727272 1.23 ENST00000379346.3
folliculin interacting protein 2
chr16_+_3019552 1.23 ENST00000572687.1
progestin and adipoQ receptor family member IV
chr3_-_160117301 1.22 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
intraflagellar transport 80 homolog (Chlamydomonas)
chr14_+_104604916 1.21 ENST00000423312.2
kinesin family member 26A
chr1_-_156399184 1.19 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
chromosome 1 open reading frame 61
chr11_+_60970852 1.19 ENST00000325558.6
pepsinogen 3, group I (pepsinogen A)
chr11_+_118978045 1.19 ENST00000336702.3
C2CD2-like
chr2_-_208489707 1.18 ENST00000448007.2
ENST00000432416.1
ENST00000411432.1
methyltransferase like 21A
chr7_-_50628745 1.17 ENST00000380984.4
ENST00000357936.5
ENST00000426377.1
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr6_-_116381918 1.16 ENST00000606080.1
fyn-related kinase
chr21_-_43816052 1.14 ENST00000398405.1
transmembrane protease, serine 3
chr2_+_186603545 1.13 ENST00000424728.1
fibrous sheath interacting protein 2
chr11_-_22851367 1.13 ENST00000354193.4
small VCP/p97-interacting protein
chr6_+_29274403 1.10 ENST00000377160.2
olfactory receptor, family 14, subfamily J, member 1
chr6_-_27279949 1.07 ENST00000444565.1
ENST00000377451.2
POM121 transmembrane nucleoporin-like 2
chr11_-_77531752 1.04 ENST00000440064.2
ENST00000528095.1
remodeling and spacing factor 1
chr20_+_53092123 1.03 ENST00000262593.5
docking protein 5
chr5_-_36152031 1.02 ENST00000296603.4
LMBR1 domain containing 2
chr17_-_9929581 1.02 ENST00000437099.2
ENST00000396115.2
growth arrest-specific 7
chr6_-_31697255 1.01 ENST00000436437.1
dimethylarginine dimethylaminohydrolase 2
chr10_+_16478942 1.01 ENST00000535784.2
ENST00000423462.2
ENST00000378000.1
phosphotriesterase related
chr20_-_2821271 1.00 ENST00000448755.1
ENST00000360652.2
PC-esterase domain containing 1A
chr15_+_90895471 0.99 ENST00000354377.3
ENST00000379090.5
zinc finger protein 774
chr19_-_7764281 0.98 ENST00000360067.4
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr12_+_6309517 0.96 ENST00000382519.4
ENST00000009180.4
CD9 molecule
chr8_+_144295067 0.96 ENST00000330824.2
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr1_+_160097462 0.96 ENST00000447527.1
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_+_48507210 0.95 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
three prime repair exonuclease 1
chr14_+_50779071 0.94 ENST00000426751.2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr10_-_27529486 0.94 ENST00000375888.1
acyl-CoA binding domain containing 5
chr11_-_102401469 0.94 ENST00000260227.4
matrix metallopeptidase 7 (matrilysin, uterine)
chr3_-_52443799 0.94 ENST00000470173.1
ENST00000296288.5
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr1_+_158259558 0.94 ENST00000368170.3
CD1c molecule
chr19_+_54609230 0.94 ENST00000420296.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr12_-_122712038 0.94 ENST00000413918.1
ENST00000443649.3
diablo, IAP-binding mitochondrial protein
chr14_-_68066849 0.92 ENST00000558493.1
ENST00000561272.1
phosphatidylinositol glycan anchor biosynthesis, class H
chr2_-_25016251 0.92 ENST00000328379.5
peptidyl-tRNA hydrolase domain containing 1
chr5_+_56111361 0.92 ENST00000399503.3
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr20_+_53092232 0.92 ENST00000395939.1
docking protein 5
chrX_+_76709648 0.92 ENST00000439435.1
fibroblast growth factor 16
chr20_-_2821756 0.91 ENST00000356872.3
ENST00000439542.1
PC-esterase domain containing 1A
chr14_-_92506371 0.91 ENST00000267622.4
thyroid hormone receptor interactor 11
chr15_+_88120158 0.88 ENST00000560153.1
long intergenic non-protein coding RNA 52
chr20_+_2276639 0.88 ENST00000381458.5
transglutaminase 3
chr1_-_202858227 0.87 ENST00000367262.3
RAB interacting factor
chr10_-_127505167 0.85 ENST00000368786.1
uroporphyrinogen III synthase
chr7_-_56160666 0.84 ENST00000297373.2
phosphorylase kinase, gamma 1 (muscle)
chr12_+_56473910 0.84 ENST00000411731.2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr1_-_165324983 0.84 ENST00000367893.4
LIM homeobox transcription factor 1, alpha
chr16_-_86532148 0.84 ENST00000594398.1
FOXF1 adjacent non-coding developmental regulatory RNA
chr14_-_68000442 0.83 ENST00000554278.1
transmembrane protein 229B
chr20_+_15177480 0.81 ENST00000402914.1
MACRO domain containing 2
chr3_+_52454971 0.81 ENST00000465863.1
PHD finger protein 7
chr20_+_55966444 0.81 ENST00000356208.5
ENST00000440234.2
RNA binding motif protein 38
chr1_+_210001309 0.79 ENST00000491415.2
digestive organ expansion factor homolog (zebrafish)
chr20_-_34330129 0.79 ENST00000397370.3
ENST00000528062.3
ENST00000407261.4
ENST00000374038.3
ENST00000361162.6
RNA binding motif protein 39
chr4_-_11430221 0.78 ENST00000514690.1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr1_+_22307592 0.77 ENST00000400277.2
chymotrypsin-like elastase family, member 3B
chr5_+_64859066 0.77 ENST00000261308.5
ENST00000535264.1
ENST00000538977.1
peptidylprolyl isomerase domain and WD repeat containing 1
chr10_+_35416223 0.77 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
cAMP responsive element modulator
chr22_-_21356375 0.77 ENST00000215742.4
ENST00000399133.2
THAP domain containing 7
chr10_-_27529716 0.75 ENST00000375897.3
ENST00000396271.3
acyl-CoA binding domain containing 5
chrX_-_15332665 0.75 ENST00000537676.1
ENST00000344384.4
ankyrin repeat and SOCS box containing 11
chr11_-_116662593 0.75 ENST00000227665.4
apolipoprotein A-V
chr1_-_91487013 0.74 ENST00000347275.5
ENST00000370440.1
zinc finger protein 644
chr20_-_61557821 0.74 ENST00000354665.4
ENST00000370368.1
ENST00000395343.1
ENST00000395340.1
death inducer-obliterator 1
chr3_-_146262293 0.74 ENST00000448205.1
phospholipid scramblase 1
chr1_+_6845497 0.73 ENST00000473578.1
ENST00000557126.1
calmodulin binding transcription activator 1
chr16_+_5121814 0.73 ENST00000262374.5
ENST00000586840.1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr15_-_43559055 0.71 ENST00000220420.5
ENST00000349114.4
transglutaminase 5
chr17_-_7145475 0.71 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABA(A) receptor-associated protein
chr19_+_16999654 0.71 ENST00000248076.3
coagulation factor II (thrombin) receptor-like 3
chr3_-_52008016 0.70 ENST00000489595.2
ENST00000461108.1
ENST00000395008.2
ENST00000525795.1
ENST00000361143.5
Poly(rC)-binding protein 4
abhydrolase domain containing 14B
chr21_-_33984888 0.70 ENST00000382549.4
ENST00000540881.1
chromosome 21 open reading frame 59
chr2_-_24270217 0.70 ENST00000295148.4
ENST00000406895.3
chromosome 2 open reading frame 44
chr17_-_79623597 0.70 ENST00000574024.1
ENST00000331056.5
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr1_+_35734562 0.69 ENST00000314607.6
ENST00000373297.2
zinc finger, MYM-type 4
chr7_-_56160625 0.69 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
phosphorylase kinase, gamma 1 (muscle)
chr7_-_79082867 0.68 ENST00000419488.1
ENST00000354212.4
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_+_23847432 0.68 ENST00000346855.3
ubiquitin-conjugating enzyme E2E 1
chr15_-_37393406 0.68 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr11_-_77531858 0.68 ENST00000360355.2
remodeling and spacing factor 1
chr9_+_134065506 0.67 ENST00000483497.2
nucleoporin 214kDa
chr9_+_35161998 0.66 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
unc-13 homolog B (C. elegans)
chr8_-_27115931 0.66 ENST00000523048.1
stathmin-like 4
chr17_-_42295870 0.66 ENST00000526094.1
ENST00000529383.1
ENST00000530828.1
upstream binding transcription factor, RNA polymerase I
chr5_+_68710906 0.65 ENST00000325631.5
ENST00000454295.2
MARVEL domain containing 2
chr21_-_33984865 0.64 ENST00000458138.1
chromosome 21 open reading frame 59
chr10_-_49459800 0.64 ENST00000305531.3
FERM and PDZ domain containing 2
chr9_+_5890802 0.63 ENST00000381477.3
ENST00000381476.1
ENST00000381471.1
melan-A
chrX_-_71526813 0.63 ENST00000246139.5
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr2_+_232572361 0.62 ENST00000409321.1
prothymosin, alpha
chr18_-_6414884 0.61 ENST00000317931.7
ENST00000284898.6
ENST00000400104.3
l(3)mbt-like 4 (Drosophila)
chr19_-_10444188 0.61 ENST00000293677.6
ribonucleoprotein, PTB-binding 1
chr17_-_60883993 0.60 ENST00000583803.1
ENST00000456609.2
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr19_-_3061397 0.60 ENST00000586839.1
amino-terminal enhancer of split
chr5_+_169780485 0.60 ENST00000377360.4
Kv channel interacting protein 1
chr11_+_77532155 0.60 ENST00000532481.1
ENST00000526415.1
ENST00000393427.2
ENST00000527134.1
ENST00000304716.8
adipogenesis associated, Mth938 domain containing
chr19_-_36545649 0.59 ENST00000292894.1
THAP domain containing 8
chr6_-_30080876 0.59 ENST00000376734.3
tripartite motif containing 31
chr1_+_156756667 0.59 ENST00000526188.1
ENST00000454659.1
papillary renal cell carcinoma (translocation-associated)
chr1_-_154164534 0.58 ENST00000271850.7
ENST00000368530.2
tropomyosin 3
chr6_-_47010061 0.57 ENST00000371253.2
G protein-coupled receptor 110
chr19_+_18544045 0.56 ENST00000599699.2
single stranded DNA binding protein 4
chr11_-_77532050 0.56 ENST00000308488.6
remodeling and spacing factor 1
chr5_+_68711209 0.56 ENST00000512803.1
MARVEL domain containing 2
chr9_-_32526184 0.56 ENST00000545044.1
ENST00000379868.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr7_+_73106926 0.55 ENST00000453316.1
Williams Beuren syndrome chromosome region 22

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
1.6 7.9 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.5 7.6 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.4 4.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
1.0 3.8 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
1.0 2.9 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.8 8.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.6 1.7 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.5 6.8 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.4 10.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 1.2 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.4 1.6 GO:0090034 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.4 1.2 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.4 1.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.4 1.5 GO:2000691 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.3 6.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.3 4.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.3 1.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.3 0.9 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.3 0.9 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.3 0.8 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.2 2.0 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 1.7 GO:0030242 pexophagy(GO:0030242)
0.2 0.9 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2 9.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.4 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of phospholipid metabolic process(GO:1903726)
0.2 4.6 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.2 1.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.2 2.9 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.2 2.6 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 2.0 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.0 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.2 1.0 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 1.0 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.2 1.7 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.2 0.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.2 2.1 GO:0016584 nucleosome positioning(GO:0016584)
0.2 1.6 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.2 11.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 0.7 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.2 0.5 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.2 3.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 7.6 GO:0010107 potassium ion import(GO:0010107)
0.2 6.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 0.7 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.1 0.3 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 0.4 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.1 0.4 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.7 GO:2000302 regulation of synaptic vesicle priming(GO:0010807) positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.1 0.9 GO:0070346 positive regulation of fat cell proliferation(GO:0070346) positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 10.5 GO:0016266 O-glycan processing(GO:0016266)
0.1 1.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 1.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.5 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.1 1.3 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 2.7 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 0.4 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.8 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 2.0 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.5 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 2.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.6 GO:0071105 response to interleukin-11(GO:0071105)
0.1 1.3 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 1.7 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 2.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 2.4 GO:0045332 phospholipid translocation(GO:0045332)
0.1 2.7 GO:0010842 retina layer formation(GO:0010842)
0.1 0.9 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413)
0.1 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.1 0.3 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.1 0.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.3 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1 1.0 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.7 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.1 0.5 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.1 0.1 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.7 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.8 GO:0042048 olfactory behavior(GO:0042048)
0.1 0.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 0.9 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 1.5 GO:0097186 amelogenesis(GO:0097186)
0.1 1.9 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 0.7 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 0.2 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.3 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 7.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 1.0 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.6 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 1.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.5 GO:1901374 acetate ester transport(GO:1901374)
0.0 0.2 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 1.1 GO:0044849 estrous cycle(GO:0044849)
0.0 1.2 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.0 0.5 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.5 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 2.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 4.6 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.2 GO:0035900 response to isolation stress(GO:0035900)
0.0 0.9 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.6 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 2.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.2 GO:0044026 DNA hypermethylation(GO:0044026)
0.0 1.4 GO:0032259 methylation(GO:0032259)
0.0 0.3 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 1.3 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 1.5 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 0.8 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 1.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 1.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.8 GO:0016246 RNA interference(GO:0016246)
0.0 1.7 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 0.1 GO:0097327 response to antineoplastic agent(GO:0097327)
0.0 0.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.1 GO:0060701 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 1.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.9 GO:0006298 mismatch repair(GO:0006298)
0.0 0.3 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 0.1 GO:0042100 B cell proliferation(GO:0042100)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.2 GO:0016139 glycoside catabolic process(GO:0016139)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.2 GO:0001505 regulation of neurotransmitter levels(GO:0001505)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.3 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.1 GO:0001828 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.2 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.0 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 0.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.7 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.7 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.6 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 1.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.0 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.7 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.0 GO:2000864 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) positive regulation of estrogen secretion(GO:2000863) regulation of estradiol secretion(GO:2000864) positive regulation of estradiol secretion(GO:2000866)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.2 GO:0051934 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.1 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.7 GO:0008542 visual learning(GO:0008542)
0.0 0.3 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.1 GO:0008037 cell recognition(GO:0008037)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.7 3.7 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.6 6.9 GO:0036157 outer dynein arm(GO:0036157)
0.6 2.3 GO:0031213 RSF complex(GO:0031213)
0.5 3.6 GO:1990393 3M complex(GO:1990393)
0.5 4.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.5 10.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.4 1.4 GO:0097224 sperm connecting piece(GO:0097224)
0.3 1.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 0.7 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.2 1.5 GO:0070695 FHF complex(GO:0070695)
0.2 1.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 0.9 GO:0002079 inner acrosomal membrane(GO:0002079) outer acrosomal membrane(GO:0002081)
0.2 1.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 0.5 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.4 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 1.4 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 1.2 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.7 GO:0044305 calyx of Held(GO:0044305)
0.1 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.7 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.3 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 13.6 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.7 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.1 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 2.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 4.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.9 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 1.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 1.3 GO:0031932 TORC2 complex(GO:0031932)
0.1 8.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 1.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.7 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.5 GO:0031010 ISWI-type complex(GO:0031010)
0.0 1.2 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 3.0 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.7 GO:0042627 chylomicron(GO:0042627)
0.0 4.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0030897 HOPS complex(GO:0030897)
0.0 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.6 GO:0030286 dynein complex(GO:0030286)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.7 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 1.6 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 9.2 GO:0043235 receptor complex(GO:0043235)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.6 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 1.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0001741 XY body(GO:0001741)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.4 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.7 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 7.9 GO:0042289 MHC class II protein binding(GO:0042289)
1.3 8.8 GO:0050682 AF-2 domain binding(GO:0050682)
1.1 4.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.8 3.8 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.7 2.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.6 11.8 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.4 1.6 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.4 10.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 3.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.4 6.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 0.4 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.3 2.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.3 6.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.3 1.3 GO:0004948 calcitonin receptor activity(GO:0004948)
0.3 3.0 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 0.9 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.3 1.7 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.3 2.0 GO:0016403 dimethylargininase activity(GO:0016403)
0.3 1.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 1.9 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 7.1 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 0.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 1.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 4.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.2 1.3 GO:0004522 ribonuclease A activity(GO:0004522)
0.2 2.0 GO:0031419 cobalamin binding(GO:0031419)
0.2 3.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 1.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.2 6.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 0.5 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.2 2.2 GO:0038132 neuregulin binding(GO:0038132)
0.2 0.5 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.2 0.9 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 0.9 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 1.2 GO:0043559 insulin binding(GO:0043559)
0.1 4.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.4 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 0.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.7 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.1 0.8 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 3.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.7 GO:0035473 lipase binding(GO:0035473)
0.1 1.0 GO:0019863 IgE binding(GO:0019863)
0.1 2.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 3.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.4 GO:0032027 myosin light chain binding(GO:0032027)
0.1 0.3 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 3.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 2.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.7 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 2.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.6 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 1.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.8 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.7 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.2 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.1 3.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 4.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 0.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 3.7 GO:0030332 cyclin binding(GO:0030332)
0.1 0.4 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.2 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 1.0 GO:1990239 steroid hormone binding(GO:1990239)
0.1 1.1 GO:0005549 odorant binding(GO:0005549)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.8 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.2 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.1 0.1 GO:0030226 apolipoprotein receptor activity(GO:0030226)
0.1 0.5 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 1.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.0 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.6 GO:0019956 chemokine binding(GO:0019956)
0.0 0.7 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.6 GO:0050693 LBD domain binding(GO:0050693)
0.0 2.0 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.4 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 1.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 5.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 1.1 GO:0043621 protein self-association(GO:0043621)
0.0 1.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.6 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 5.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.9 GO:0002039 p53 binding(GO:0002039)
0.0 1.2 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 0.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.3 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 6.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 6.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 2.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 9.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 3.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 11.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 7.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 3.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 4.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 6.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.0 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 2.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 7.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 4.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 4.5 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 8.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 5.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 2.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.4 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.5 REACTOME OPSINS Genes involved in Opsins
0.0 0.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.9 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 2.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.7 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.7 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.7 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0