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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX6-2

Z-value: 0.69

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Transcription factors associated with NKX6-2

Gene Symbol Gene ID Gene Info
NKX6-2
ENSG00000148826.6 NK6 homeobox 2

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_7921090 2.85 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_-_23891658 1.50 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr7_+_123241908 1.33 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15
ankyrin repeat and SOCS box containing 15
chr1_+_244515930 1.31 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr4_+_169013666 1.26 ENST00000359299.3
ANXA10
annexin A10
chr14_-_98444461 1.21 ENST00000499006.2
C14orf64
chromosome 14 open reading frame 64
chr12_+_4385230 1.20 ENST00000536537.1
CCND2
cyclin D2
chr2_+_210444142 1.18 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chrX_+_135230712 1.13 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr4_+_88896819 1.09 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr3_-_141747950 1.00 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_-_208030647 0.91 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_+_31193847 0.87 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr4_+_41258786 0.82 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr3_+_39509163 0.76 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
MOBP
myelin-associated oligodendrocyte basic protein
chr2_+_11864458 0.75 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr1_+_209878182 0.73 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr17_-_60885700 0.72 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885659 0.71 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr10_+_32873190 0.67 ENST00000375025.4
C10orf68
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr18_-_19994830 0.66 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr1_-_110933611 0.63 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr17_-_7307358 0.62 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr12_+_32655110 0.62 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_-_110933663 0.62 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4
solute carrier family 16, member 4
chr10_-_100995540 0.61 ENST00000370546.1
ENST00000404542.1
HPSE2
heparanase 2
chr6_+_26199737 0.60 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr22_-_29137771 0.54 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr3_+_39509070 0.53 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP
myelin-associated oligodendrocyte basic protein
chr1_-_114696472 0.51 ENST00000393296.1
ENST00000369547.1
ENST00000610222.1
SYT6
synaptotagmin VI
chr13_-_33760216 0.50 ENST00000255486.4
STARD13
StAR-related lipid transfer (START) domain containing 13
chr12_-_28124903 0.49 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr6_-_26199471 0.45 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr17_-_57232525 0.45 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr1_+_145477060 0.45 ENST00000369308.3
LIX1L
Lix1 homolog (mouse)-like
chr3_-_74570291 0.43 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr6_-_131277510 0.41 ENST00000525193.1
ENST00000527659.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr7_+_77469439 0.41 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr3_-_141747439 0.41 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_40787194 0.40 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr18_-_12656715 0.39 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
SPIRE1
spire-type actin nucleation factor 1
chr4_+_169418195 0.39 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr17_-_41836153 0.38 ENST00000301691.2
SOST
sclerostin
chr3_+_130650738 0.38 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr6_-_26199499 0.37 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr6_+_47666275 0.37 ENST00000327753.3
ENST00000283303.2
GPR115
G protein-coupled receptor 115
chr3_+_159557637 0.36 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr14_-_75530693 0.35 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr9_-_23826298 0.34 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr8_-_91095099 0.34 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr1_-_49242553 0.33 ENST00000371833.3
BEND5
BEN domain containing 5
chr4_+_169418255 0.33 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr10_+_50887683 0.33 ENST00000374113.3
ENST00000374111.3
ENST00000374112.3
ENST00000535836.1
C10orf53
chromosome 10 open reading frame 53
chr10_-_71169031 0.33 ENST00000373307.1
TACR2
tachykinin receptor 2
chr1_-_109935819 0.33 ENST00000538502.1
SORT1
sortilin 1
chr1_-_221915418 0.32 ENST00000323825.3
ENST00000366899.3
DUSP10
dual specificity phosphatase 10
chr12_-_53045948 0.32 ENST00000309680.3
KRT2
keratin 2
chr10_-_115904361 0.32 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr2_+_211342432 0.32 ENST00000430249.2
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr15_+_93443419 0.31 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr17_-_40828969 0.30 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr3_+_68053359 0.30 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr2_-_136873735 0.29 ENST00000409817.1
CXCR4
chemokine (C-X-C motif) receptor 4
chr17_-_40829026 0.29 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr2_-_238322800 0.29 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
COL6A3
collagen, type VI, alpha 3
chr17_-_39306054 0.29 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chr14_+_76776957 0.29 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr3_+_137490748 0.29 ENST00000478772.1
RP11-2A4.3
RP11-2A4.3
chrX_+_82763265 0.28 ENST00000373200.2
POU3F4
POU class 3 homeobox 4
chr6_-_33864684 0.28 ENST00000506222.2
ENST00000533304.1
LINC01016
long intergenic non-protein coding RNA 1016
chr9_+_116263778 0.28 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr7_-_37024665 0.28 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr10_+_6625605 0.28 ENST00000414894.1
ENST00000449648.1
PRKCQ-AS1
PRKCQ antisense RNA 1
chr5_+_161274940 0.27 ENST00000393943.4
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_57232596 0.27 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr14_+_52164820 0.26 ENST00000554167.1
FRMD6
FERM domain containing 6
chr1_+_100810575 0.26 ENST00000542213.1
CDC14A
cell division cycle 14A
chr1_+_32379174 0.26 ENST00000391369.1
AL136115.1
HCG2032337; PRO1848; Uncharacterized protein
chr2_-_238323007 0.26 ENST00000295550.4
COL6A3
collagen, type VI, alpha 3
chr5_-_16916624 0.25 ENST00000513882.1
MYO10
myosin X
chr5_+_161275320 0.25 ENST00000437025.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_+_114178512 0.25 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr6_-_87804815 0.24 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr10_+_90346519 0.24 ENST00000371939.3
LIPJ
lipase, family member J
chr17_+_72581057 0.23 ENST00000392620.1
C17orf77
chromosome 17 open reading frame 77
chr5_-_78365437 0.23 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
DMGDH
dimethylglycine dehydrogenase
chr6_+_41021027 0.22 ENST00000244669.2
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr3_-_147124547 0.22 ENST00000491672.1
ENST00000383075.3
ZIC4
Zic family member 4
chr6_+_31582961 0.22 ENST00000376059.3
ENST00000337917.7
AIF1
allograft inflammatory factor 1
chr9_+_88556036 0.21 ENST00000361671.5
ENST00000416045.1
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr11_-_62521614 0.21 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr5_+_155753745 0.21 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr7_+_16828866 0.21 ENST00000597084.1
AC073333.1
Uncharacterized protein
chr4_+_55095264 0.21 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr12_+_105380073 0.21 ENST00000552951.1
ENST00000280749.5
C12orf45
chromosome 12 open reading frame 45
chr12_-_122241812 0.21 ENST00000538335.1
AC084018.1
AC084018.1
chr6_+_116850174 0.20 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
FAM26D
family with sequence similarity 26, member D
chr13_-_103719196 0.20 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr12_+_9980069 0.20 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr5_+_161495038 0.19 ENST00000393933.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr1_-_243326612 0.19 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr22_-_40929812 0.19 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr1_-_150849174 0.19 ENST00000515192.1
ARNT
aryl hydrocarbon receptor nuclear translocator
chr5_+_161274685 0.19 ENST00000428797.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr8_+_97597148 0.19 ENST00000521590.1
SDC2
syndecan 2
chr14_-_27066636 0.18 ENST00000267422.7
ENST00000344429.5
ENST00000574031.1
ENST00000465357.2
ENST00000547619.1
NOVA1
neuro-oncological ventral antigen 1
chr1_+_156095951 0.18 ENST00000448611.2
ENST00000368297.1
LMNA
lamin A/C
chr7_-_22233442 0.18 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr14_+_73706308 0.18 ENST00000554301.1
ENST00000555445.1
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr5_-_88119580 0.18 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chr21_-_27462351 0.17 ENST00000448850.1
APP
amyloid beta (A4) precursor protein
chr18_-_3220106 0.17 ENST00000356443.4
ENST00000400569.3
MYOM1
myomesin 1
chr14_+_72399833 0.17 ENST00000553530.1
ENST00000556437.1
RGS6
regulator of G-protein signaling 6
chr14_-_60097524 0.17 ENST00000342503.4
RTN1
reticulon 1
chr3_+_156799587 0.17 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr6_+_12290586 0.16 ENST00000379375.5
EDN1
endothelin 1
chr17_-_56494713 0.16 ENST00000407977.2
RNF43
ring finger protein 43
chr9_-_23825956 0.16 ENST00000397312.2
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr8_-_15095832 0.15 ENST00000382080.1
SGCZ
sarcoglycan, zeta
chr8_+_79428539 0.15 ENST00000352966.5
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr4_+_71337834 0.15 ENST00000304887.5
MUC7
mucin 7, secreted
chr17_-_56494882 0.15 ENST00000584437.1
RNF43
ring finger protein 43
chr4_+_188916918 0.14 ENST00000509524.1
ENST00000326866.4
ZFP42
ZFP42 zinc finger protein
chr12_+_32655048 0.14 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr10_-_48055018 0.14 ENST00000426610.2
ASAH2C
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C
chr3_-_141747459 0.14 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr21_+_47706239 0.14 ENST00000397701.4
ENST00000397694.1
ENST00000329319.3
ENST00000339195.6
ENST00000397692.1
YBEY
ybeY metallopeptidase (putative)
chr10_-_100995603 0.14 ENST00000370552.3
ENST00000370549.1
HPSE2
heparanase 2
chrX_+_105937068 0.14 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr17_-_56494908 0.14 ENST00000577716.1
RNF43
ring finger protein 43
chr11_-_11374904 0.13 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr19_+_852291 0.13 ENST00000263621.1
ELANE
elastase, neutrophil expressed
chr2_+_218990727 0.13 ENST00000318507.2
ENST00000454148.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr2_+_179149636 0.13 ENST00000409631.1
OSBPL6
oxysterol binding protein-like 6
chr19_-_49220084 0.13 ENST00000595591.1
ENST00000356751.4
ENST00000594582.1
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_-_150849208 0.13 ENST00000358595.5
ARNT
aryl hydrocarbon receptor nuclear translocator
chr7_-_107880508 0.13 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr1_-_21377447 0.12 ENST00000374937.3
ENST00000264211.8
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr14_-_60097297 0.12 ENST00000395090.1
RTN1
reticulon 1
chr3_-_98241358 0.12 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chr19_+_4402659 0.12 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr3_-_71294304 0.12 ENST00000498215.1
FOXP1
forkhead box P1
chr16_+_89228757 0.12 ENST00000565008.1
LINC00304
long intergenic non-protein coding RNA 304
chr9_+_34652164 0.12 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr1_-_186430222 0.12 ENST00000391997.2
PDC
phosducin
chr4_+_74269956 0.11 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr5_-_58295712 0.11 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_65593784 0.11 ENST00000443619.2
SPRED2
sprouty-related, EVH1 domain containing 2
chr3_+_51575596 0.11 ENST00000409535.2
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr3_+_178276488 0.11 ENST00000432997.1
ENST00000455865.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_-_200379180 0.11 ENST00000294740.3
ZNF281
zinc finger protein 281
chr2_+_207024306 0.11 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr11_-_13517565 0.10 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr14_-_98444438 0.10 ENST00000512901.2
C14orf64
chromosome 14 open reading frame 64
chr17_-_67057203 0.10 ENST00000340001.4
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr10_+_26505179 0.10 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr9_-_4666421 0.10 ENST00000381895.5
SPATA6L
spermatogenesis associated 6-like
chr12_+_54422142 0.10 ENST00000243108.4
HOXC6
homeobox C6
chr6_-_26043885 0.09 ENST00000357905.2
HIST1H2BB
histone cluster 1, H2bb
chr15_+_49715293 0.09 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr7_+_138943265 0.09 ENST00000483726.1
UBN2
ubinuclein 2
chr12_+_28410128 0.09 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr6_+_12007963 0.09 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chr6_-_116833500 0.08 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr10_+_133753533 0.08 ENST00000422256.2
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta
chr7_-_20256965 0.08 ENST00000400331.5
ENST00000332878.4
MACC1
metastasis associated in colon cancer 1
chr7_-_102184083 0.08 ENST00000379357.5
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr15_+_69857515 0.08 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr15_+_80364901 0.08 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
ZFAND6
zinc finger, AN1-type domain 6
chr1_-_110155671 0.08 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr1_+_201617450 0.07 ENST00000295624.6
ENST00000367297.4
ENST00000367300.3
NAV1
neuron navigator 1
chr7_+_107224364 0.07 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr4_+_55095428 0.07 ENST00000508170.1
ENST00000512143.1
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr5_-_159546396 0.07 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr1_-_200379129 0.07 ENST00000367353.1
ZNF281
zinc finger protein 281
chr12_-_76462713 0.07 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr11_+_57529234 0.07 ENST00000360682.6
ENST00000361796.4
ENST00000529526.1
ENST00000426142.2
ENST00000399050.4
ENST00000361391.6
ENST00000361332.4
ENST00000532463.1
ENST00000529986.1
ENST00000358694.6
ENST00000532787.1
ENST00000533667.1
ENST00000532649.1
ENST00000528621.1
ENST00000530748.1
ENST00000428599.2
ENST00000527467.1
ENST00000528232.1
ENST00000531014.1
ENST00000526772.1
ENST00000529873.1
ENST00000525902.1
ENST00000532844.1
ENST00000526357.1
ENST00000530094.1
ENST00000415361.2
ENST00000532245.1
ENST00000534579.1
ENST00000526938.1
CTNND1
catenin (cadherin-associated protein), delta 1
chrX_+_102840408 0.07 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4
transcription elongation factor A (SII)-like 4
chr1_+_78383813 0.07 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr7_-_102283238 0.07 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr1_+_244624678 0.06 ENST00000366534.4
ENST00000366533.4
ENST00000428042.1
ENST00000366531.3
C1orf101
chromosome 1 open reading frame 101
chr9_-_4666337 0.06 ENST00000381890.5
SPATA6L
spermatogenesis associated 6-like
chr14_-_64804814 0.06 ENST00000554572.1
ENST00000358599.5
ESR2
estrogen receptor 2 (ER beta)
chrX_+_68835911 0.06 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr4_+_183370146 0.06 ENST00000510504.1
TENM3
teneurin transmembrane protein 3
chr9_-_77643307 0.06 ENST00000376834.3
ENST00000376830.3
C9orf41
chromosome 9 open reading frame 41
chr18_-_10701979 0.06 ENST00000538948.1
ENST00000285141.4
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr12_+_122241928 0.06 ENST00000604567.1
ENST00000542440.1
SETD1B
SET domain containing 1B
chr2_-_207024134 0.05 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr10_-_73848531 0.05 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr1_+_174933899 0.05 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr18_-_30716038 0.05 ENST00000581852.1
CCDC178
coiled-coil domain containing 178
chr17_+_73663470 0.05 ENST00000583536.1
SAP30BP
SAP30 binding protein
chr2_+_108994633 0.04 ENST00000409309.3
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr8_+_26150628 0.04 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr6_-_64029879 0.04 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr1_+_174670143 0.04 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr7_-_140482926 0.04 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr3_+_140981456 0.04 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr18_+_32290218 0.04 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.4 2.9 GO:0009441 glycolate metabolic process(GO:0009441)
0.3 0.8 GO:0007412 axon target recognition(GO:0007412)
0.2 0.5 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.4 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.1 0.3 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 0.8 GO:0006642 triglyceride mobilization(GO:0006642)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 1.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 0.5 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.5 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.3 GO:0071400 cellular response to oleic acid(GO:0071400)
0.1 0.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.3 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.4 GO:0070649 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.1 0.2 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 1.2 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.1 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.0 0.2 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.3 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.1 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.3 GO:0003383 apical constriction(GO:0003383)
0.0 0.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 1.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.7 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.3 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.4 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.1 GO:1903238 neutrophil mediated killing of gram-negative bacterium(GO:0070945) positive regulation of leukocyte tethering or rolling(GO:1903238)
0.0 0.3 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 1.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.0 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 2.1 GO:0048813 dendrite morphogenesis(GO:0048813)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.2 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 2.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.8 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 0.7 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 0.8 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.2 0.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 0.7 GO:0030305 heparanase activity(GO:0030305)
0.1 0.3 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.3 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.4 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.2 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 1.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0019959 interleukin-8 binding(GO:0019959)
0.0 0.0 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.4 GO:0042731 PH domain binding(GO:0042731)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.3 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 1.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.6 PID E2F PATHWAY E2F transcription factor network
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK