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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX6-2

Z-value: 0.69

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Transcription factors associated with NKX6-2

Gene Symbol Gene ID Gene Info
ENSG00000148826.6 NK6 homeobox 2

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_7921090 2.85 ENST00000378789.3
hydroxyacid oxidase (glycolate oxidase) 1
chr4_-_23891658 1.50 ENST00000507380.1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr7_+_123241908 1.33 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ankyrin repeat and SOCS box containing 15
chr1_+_244515930 1.31 ENST00000366537.1
ENST00000308105.4
chromosome 1 open reading frame 100
chr4_+_169013666 1.26 ENST00000359299.3
annexin A10
chr14_-_98444461 1.21 ENST00000499006.2
chromosome 14 open reading frame 64
chr12_+_4385230 1.20 ENST00000536537.1
cyclin D2
chr2_+_210444142 1.18 ENST00000360351.4
ENST00000361559.4
microtubule-associated protein 2
chrX_+_135230712 1.13 ENST00000535737.1
four and a half LIM domains 1
chr4_+_88896819 1.09 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
secreted phosphoprotein 1
chr3_-_141747950 1.00 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_-_208030647 0.91 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr5_+_31193847 0.87 ENST00000514738.1
ENST00000265071.2
cadherin 6, type 2, K-cadherin (fetal kidney)
chr4_+_41258786 0.82 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr3_+_39509163 0.76 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
myelin-associated oligodendrocyte basic protein
chr2_+_11864458 0.75 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
lipin 1
chr1_+_209878182 0.73 ENST00000367027.3
hydroxysteroid (11-beta) dehydrogenase 1
chr17_-_60885700 0.72 ENST00000583600.1
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885659 0.71 ENST00000311269.5
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr10_+_32873190 0.67 ENST00000375025.4
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr18_-_19994830 0.66 ENST00000525417.1
cutaneous T-cell lymphoma-associated antigen 1
chr1_-_110933611 0.63 ENST00000472422.2
ENST00000437429.2
solute carrier family 16, member 4
chr17_-_7307358 0.62 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr12_+_32655110 0.62 ENST00000546442.1
ENST00000583694.1
FYVE, RhoGEF and PH domain containing 4
chr1_-_110933663 0.62 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
solute carrier family 16, member 4
chr10_-_100995540 0.61 ENST00000370546.1
ENST00000404542.1
heparanase 2
chr6_+_26199737 0.60 ENST00000359985.1
histone cluster 1, H2bf
chr22_-_29137771 0.54 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
checkpoint kinase 2
chr3_+_39509070 0.53 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
myelin-associated oligodendrocyte basic protein
chr1_-_114696472 0.51 ENST00000393296.1
ENST00000369547.1
ENST00000610222.1
synaptotagmin VI
chr13_-_33760216 0.50 ENST00000255486.4
StAR-related lipid transfer (START) domain containing 13
chr12_-_28124903 0.49 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
parathyroid hormone-like hormone
chr6_-_26199471 0.45 ENST00000341023.1
histone cluster 1, H2ad
chr17_-_57232525 0.45 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
spindle and kinetochore associated complex subunit 2
chr1_+_145477060 0.45 ENST00000369308.3
Lix1 homolog (mouse)-like
chr3_-_74570291 0.43 ENST00000263665.6
contactin 3 (plasmacytoma associated)
chr6_-_131277510 0.41 ENST00000525193.1
ENST00000527659.1
erythrocyte membrane protein band 4.1-like 2
chr7_+_77469439 0.41 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
putative homeodomain transcription factor 2
chr3_-_141747439 0.41 ENST00000467667.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_40787194 0.40 ENST00000425730.2
ENST00000454784.4
mucin 19, oligomeric
chr18_-_12656715 0.39 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
spire-type actin nucleation factor 1
chr4_+_169418195 0.39 ENST00000261509.6
ENST00000335742.7
palladin, cytoskeletal associated protein
chr17_-_41836153 0.38 ENST00000301691.2
sclerostin
chr3_+_130650738 0.38 ENST00000504612.1
ATPase, Ca++ transporting, type 2C, member 1
chr6_-_26199499 0.37 ENST00000377831.5
histone cluster 1, H3d
chr6_+_47666275 0.37 ENST00000327753.3
ENST00000283303.2
G protein-coupled receptor 115
chr3_+_159557637 0.36 ENST00000445224.2
schwannomin interacting protein 1
chr14_-_75530693 0.35 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
acylphosphatase 1, erythrocyte (common) type
chr9_-_23826298 0.34 ENST00000380117.1
ELAV like neuron-specific RNA binding protein 2
chr8_-_91095099 0.34 ENST00000265431.3
calbindin 1, 28kDa
chr1_-_49242553 0.33 ENST00000371833.3
BEN domain containing 5
chr4_+_169418255 0.33 ENST00000505667.1
ENST00000511948.1
palladin, cytoskeletal associated protein
chr10_+_50887683 0.33 ENST00000374113.3
ENST00000374111.3
ENST00000374112.3
ENST00000535836.1
chromosome 10 open reading frame 53
chr10_-_71169031 0.33 ENST00000373307.1
tachykinin receptor 2
chr1_-_109935819 0.33 ENST00000538502.1
sortilin 1
chr1_-_221915418 0.32 ENST00000323825.3
ENST00000366899.3
dual specificity phosphatase 10
chr12_-_53045948 0.32 ENST00000309680.3
keratin 2
chr10_-_115904361 0.32 ENST00000428953.1
ENST00000543782.1
chromosome 10 open reading frame 118
chr2_+_211342432 0.32 ENST00000430249.2
carbamoyl-phosphate synthase 1, mitochondrial
chr15_+_93443419 0.31 ENST00000557381.1
ENST00000420239.2
chromodomain helicase DNA binding protein 2
chr17_-_40828969 0.30 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr3_+_68053359 0.30 ENST00000478136.1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr2_-_136873735 0.29 ENST00000409817.1
chemokine (C-X-C motif) receptor 4
chr17_-_40829026 0.29 ENST00000412503.1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr2_-_238322800 0.29 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
collagen, type VI, alpha 3
chr17_-_39306054 0.29 ENST00000343246.4
keratin associated protein 4-5
chr14_+_76776957 0.29 ENST00000512784.1
estrogen-related receptor beta
chr3_+_137490748 0.29 ENST00000478772.1
RP11-2A4.3
chrX_+_82763265 0.28 ENST00000373200.2
POU class 3 homeobox 4
chr6_-_33864684 0.28 ENST00000506222.2
ENST00000533304.1
long intergenic non-protein coding RNA 1016
chr9_+_116263778 0.28 ENST00000394646.3
regulator of G-protein signaling 3
chr7_-_37024665 0.28 ENST00000396040.2
engulfment and cell motility 1
chr10_+_6625605 0.28 ENST00000414894.1
ENST00000449648.1
PRKCQ antisense RNA 1
chr5_+_161274940 0.27 ENST00000393943.4
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_57232596 0.27 ENST00000581068.1
ENST00000330137.7
spindle and kinetochore associated complex subunit 2
chr14_+_52164820 0.26 ENST00000554167.1
FERM domain containing 6
chr1_+_100810575 0.26 ENST00000542213.1
cell division cycle 14A
chr1_+_32379174 0.26 ENST00000391369.1
HCG2032337; PRO1848; Uncharacterized protein
chr2_-_238323007 0.26 ENST00000295550.4
collagen, type VI, alpha 3
chr5_-_16916624 0.25 ENST00000513882.1
myosin X
chr5_+_161275320 0.25 ENST00000437025.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_+_114178512 0.25 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr6_-_87804815 0.24 ENST00000369582.2
glycoprotein hormones, alpha polypeptide
chr10_+_90346519 0.24 ENST00000371939.3
lipase, family member J
chr17_+_72581057 0.23 ENST00000392620.1
chromosome 17 open reading frame 77
chr5_-_78365437 0.23 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
dimethylglycine dehydrogenase
chr6_+_41021027 0.22 ENST00000244669.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr3_-_147124547 0.22 ENST00000491672.1
ENST00000383075.3
Zic family member 4
chr6_+_31582961 0.22 ENST00000376059.3
ENST00000337917.7
allograft inflammatory factor 1
chr9_+_88556036 0.21 ENST00000361671.5
ENST00000416045.1
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr11_-_62521614 0.21 ENST00000527994.1
ENST00000394807.3
zinc finger and BTB domain containing 3
chr5_+_155753745 0.21 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr7_+_16828866 0.21 ENST00000597084.1
Uncharacterized protein
chr4_+_55095264 0.21 ENST00000257290.5
platelet-derived growth factor receptor, alpha polypeptide
chr12_+_105380073 0.21 ENST00000552951.1
ENST00000280749.5
chromosome 12 open reading frame 45
chr12_-_122241812 0.21 ENST00000538335.1
AC084018.1
chr6_+_116850174 0.20 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
family with sequence similarity 26, member D
chr13_-_103719196 0.20 ENST00000245312.3
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr12_+_9980069 0.20 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
killer cell lectin-like receptor subfamily F, member 1
chr5_+_161495038 0.19 ENST00000393933.4
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr1_-_243326612 0.19 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
centrosomal protein 170kDa
chr22_-_40929812 0.19 ENST00000422851.1
megakaryoblastic leukemia (translocation) 1
chr1_-_150849174 0.19 ENST00000515192.1
aryl hydrocarbon receptor nuclear translocator
chr5_+_161274685 0.19 ENST00000428797.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr8_+_97597148 0.19 ENST00000521590.1
syndecan 2
chr14_-_27066636 0.18 ENST00000267422.7
ENST00000344429.5
ENST00000574031.1
ENST00000465357.2
ENST00000547619.1
neuro-oncological ventral antigen 1
chr1_+_156095951 0.18 ENST00000448611.2
ENST00000368297.1
lamin A/C
chr7_-_22233442 0.18 ENST00000401957.2
Rap guanine nucleotide exchange factor (GEF) 5
chr14_+_73706308 0.18 ENST00000554301.1
ENST00000555445.1
papilin, proteoglycan-like sulfated glycoprotein
chr5_-_88119580 0.18 ENST00000539796.1
myocyte enhancer factor 2C
chr21_-_27462351 0.17 ENST00000448850.1
amyloid beta (A4) precursor protein
chr18_-_3220106 0.17 ENST00000356443.4
ENST00000400569.3
myomesin 1
chr14_+_72399833 0.17 ENST00000553530.1
ENST00000556437.1
regulator of G-protein signaling 6
chr14_-_60097524 0.17 ENST00000342503.4
reticulon 1
chr3_+_156799587 0.17 ENST00000469196.1
RP11-6F2.5
chr6_+_12290586 0.16 ENST00000379375.5
endothelin 1
chr17_-_56494713 0.16 ENST00000407977.2
ring finger protein 43
chr9_-_23825956 0.16 ENST00000397312.2
ELAV like neuron-specific RNA binding protein 2
chr8_-_15095832 0.15 ENST00000382080.1
sarcoglycan, zeta
chr8_+_79428539 0.15 ENST00000352966.5
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr4_+_71337834 0.15 ENST00000304887.5
mucin 7, secreted
chr17_-_56494882 0.15 ENST00000584437.1
ring finger protein 43
chr4_+_188916918 0.14 ENST00000509524.1
ENST00000326866.4
ZFP42 zinc finger protein
chr12_+_32655048 0.14 ENST00000427716.2
ENST00000266482.3
FYVE, RhoGEF and PH domain containing 4
chr10_-_48055018 0.14 ENST00000426610.2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C
chr3_-_141747459 0.14 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr21_+_47706239 0.14 ENST00000397701.4
ENST00000397694.1
ENST00000329319.3
ENST00000339195.6
ENST00000397692.1
ybeY metallopeptidase (putative)
chr10_-_100995603 0.14 ENST00000370552.3
ENST00000370549.1
heparanase 2
chrX_+_105937068 0.14 ENST00000324342.3
ring finger protein 128, E3 ubiquitin protein ligase
chr17_-_56494908 0.14 ENST00000577716.1
ring finger protein 43
chr11_-_11374904 0.13 ENST00000528848.2
casein kinase 2, alpha 3 polypeptide
chr19_+_852291 0.13 ENST00000263621.1
elastase, neutrophil expressed
chr2_+_218990727 0.13 ENST00000318507.2
ENST00000454148.1
chemokine (C-X-C motif) receptor 2
chr2_+_179149636 0.13 ENST00000409631.1
oxysterol binding protein-like 6
chr19_-_49220084 0.13 ENST00000595591.1
ENST00000356751.4
ENST00000594582.1
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_-_150849208 0.13 ENST00000358595.5
aryl hydrocarbon receptor nuclear translocator
chr7_-_107880508 0.13 ENST00000425651.2
neuronal cell adhesion molecule
chr1_-_21377447 0.12 ENST00000374937.3
ENST00000264211.8
eukaryotic translation initiation factor 4 gamma, 3
chr14_-_60097297 0.12 ENST00000395090.1
reticulon 1
chr3_-_98241358 0.12 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
claudin domain containing 1
chr19_+_4402659 0.12 ENST00000301280.5
ENST00000585854.1
chromatin assembly factor 1, subunit A (p150)
chr3_-_71294304 0.12 ENST00000498215.1
forkhead box P1
chr16_+_89228757 0.12 ENST00000565008.1
long intergenic non-protein coding RNA 304
chr9_+_34652164 0.12 ENST00000441545.2
ENST00000553620.1
interleukin 11 receptor, alpha
chr1_-_186430222 0.12 ENST00000391997.2
phosducin
chr4_+_74269956 0.11 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
albumin
chr5_-_58295712 0.11 ENST00000317118.8
phosphodiesterase 4D, cAMP-specific
chr2_-_65593784 0.11 ENST00000443619.2
sprouty-related, EVH1 domain containing 2
chr3_+_51575596 0.11 ENST00000409535.2
RAD54-like 2 (S. cerevisiae)
chr3_+_178276488 0.11 ENST00000432997.1
ENST00000455865.1
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_-_200379180 0.11 ENST00000294740.3
zinc finger protein 281
chr2_+_207024306 0.11 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
eukaryotic translation elongation factor 1 beta 2
chr11_-_13517565 0.10 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr14_-_98444438 0.10 ENST00000512901.2
chromosome 14 open reading frame 64
chr17_-_67057203 0.10 ENST00000340001.4
ATP-binding cassette, sub-family A (ABC1), member 9
chr10_+_26505179 0.10 ENST00000376261.3
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr9_-_4666421 0.10 ENST00000381895.5
spermatogenesis associated 6-like
chr12_+_54422142 0.10 ENST00000243108.4
homeobox C6
chr6_-_26043885 0.09 ENST00000357905.2
histone cluster 1, H2bb
chr15_+_49715293 0.09 ENST00000267843.4
ENST00000560270.1
fibroblast growth factor 7
chr7_+_138943265 0.09 ENST00000483726.1
ubinuclein 2
chr12_+_28410128 0.09 ENST00000381259.1
ENST00000381256.1
coiled-coil domain containing 91
chr6_+_12007963 0.09 ENST00000607445.1
RP11-456H18.2
chr6_-_116833500 0.08 ENST00000356128.4
trafficking protein particle complex 3-like
chr10_+_133753533 0.08 ENST00000422256.2
protein phosphatase 2, regulatory subunit B, delta
chr7_-_20256965 0.08 ENST00000400331.5
ENST00000332878.4
metastasis associated in colon cancer 1
chr7_-_102184083 0.08 ENST00000379357.5
polymerase (RNA) II (DNA directed) polypeptide J3
chr15_+_69857515 0.08 ENST00000559477.1
RP11-279F6.1
chr15_+_80364901 0.08 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
zinc finger, AN1-type domain 6
chr1_-_110155671 0.08 ENST00000351050.3
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr1_+_201617450 0.07 ENST00000295624.6
ENST00000367297.4
ENST00000367300.3
neuron navigator 1
chr7_+_107224364 0.07 ENST00000491150.1
B-cell receptor-associated protein 29
chr4_+_55095428 0.07 ENST00000508170.1
ENST00000512143.1
platelet-derived growth factor receptor, alpha polypeptide
chr5_-_159546396 0.07 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP domain containing 2A
chr1_-_200379129 0.07 ENST00000367353.1
zinc finger protein 281
chr12_-_76462713 0.07 ENST00000552056.1
nucleosome assembly protein 1-like 1
chr11_+_57529234 0.07 ENST00000360682.6
ENST00000361796.4
ENST00000529526.1
ENST00000426142.2
ENST00000399050.4
ENST00000361391.6
ENST00000361332.4
ENST00000532463.1
ENST00000529986.1
ENST00000358694.6
ENST00000532787.1
ENST00000533667.1
ENST00000532649.1
ENST00000528621.1
ENST00000530748.1
ENST00000428599.2
ENST00000527467.1
ENST00000528232.1
ENST00000531014.1
ENST00000526772.1
ENST00000529873.1
ENST00000525902.1
ENST00000532844.1
ENST00000526357.1
ENST00000530094.1
ENST00000415361.2
ENST00000532245.1
ENST00000534579.1
ENST00000526938.1
catenin (cadherin-associated protein), delta 1
chrX_+_102840408 0.07 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
transcription elongation factor A (SII)-like 4
chr1_+_78383813 0.07 ENST00000342754.5
nexilin (F actin binding protein)
chr7_-_102283238 0.07 ENST00000340457.8
uroplakin 3B-like
chr1_+_244624678 0.06 ENST00000366534.4
ENST00000366533.4
ENST00000428042.1
ENST00000366531.3
chromosome 1 open reading frame 101
chr9_-_4666337 0.06 ENST00000381890.5
spermatogenesis associated 6-like
chr14_-_64804814 0.06 ENST00000554572.1
ENST00000358599.5
estrogen receptor 2 (ER beta)
chrX_+_68835911 0.06 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
ectodysplasin A
chr4_+_183370146 0.06 ENST00000510504.1
teneurin transmembrane protein 3
chr9_-_77643307 0.06 ENST00000376834.3
ENST00000376830.3
chromosome 9 open reading frame 41
chr18_-_10701979 0.06 ENST00000538948.1
ENST00000285141.4
piezo-type mechanosensitive ion channel component 2
chr12_+_122241928 0.06 ENST00000604567.1
ENST00000542440.1
SET domain containing 1B
chr2_-_207024134 0.05 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr10_-_73848531 0.05 ENST00000373109.2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr1_+_174933899 0.05 ENST00000367688.3
RAB GTPase activating protein 1-like
chr18_-_30716038 0.05 ENST00000581852.1
coiled-coil domain containing 178
chr17_+_73663470 0.05 ENST00000583536.1
SAP30 binding protein
chr2_+_108994633 0.04 ENST00000409309.3
sulfotransferase family, cytosolic, 1C, member 4
chr8_+_26150628 0.04 ENST00000523925.1
ENST00000315985.7
protein phosphatase 2, regulatory subunit B, alpha
chr6_-_64029879 0.04 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
lengsin, lens protein with glutamine synthetase domain
chr1_+_174670143 0.04 ENST00000367687.1
ENST00000347255.2
RAB GTPase activating protein 1-like
chr7_-_140482926 0.04 ENST00000496384.2
v-raf murine sarcoma viral oncogene homolog B
chr3_+_140981456 0.04 ENST00000504264.1
acid phosphatase-like 2
chr18_+_32290218 0.04 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
dystrobrevin, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.4 2.9 GO:0009441 glycolate metabolic process(GO:0009441)
0.3 0.8 GO:0007412 axon target recognition(GO:0007412)
0.2 0.5 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.4 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.1 0.3 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 0.8 GO:0006642 triglyceride mobilization(GO:0006642)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 1.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 0.5 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.5 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.3 GO:0071400 cellular response to oleic acid(GO:0071400)
0.1 0.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.3 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.4 GO:0070649 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.1 0.2 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 1.2 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.1 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.0 0.2 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.3 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.1 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.3 GO:0003383 apical constriction(GO:0003383)
0.0 0.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 1.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.7 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.3 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.4 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.1 GO:1903238 neutrophil mediated killing of gram-negative bacterium(GO:0070945) positive regulation of leukocyte tethering or rolling(GO:1903238)
0.0 0.3 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 1.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.0 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 2.1 GO:0048813 dendrite morphogenesis(GO:0048813)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.2 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 2.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.8 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 0.7 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 0.8 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.2 0.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 0.7 GO:0030305 heparanase activity(GO:0030305)
0.1 0.3 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.3 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.4 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.2 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 1.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0019959 interleukin-8 binding(GO:0019959)
0.0 0.0 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.4 GO:0042731 PH domain binding(GO:0042731)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.3 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 1.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.6 PID E2F PATHWAY E2F transcription factor network
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK