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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX6-3

Z-value: 0.25

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.11 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-3hg19_v2_chr8_-_41504878_41504878-0.202.9e-01Click!

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_125133315 0.69 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr5_-_139726181 0.50 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chr3_-_141747950 0.48 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_130339710 0.46 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr9_+_125132803 0.46 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chrX_+_43515467 0.42 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chrX_+_107288239 0.28 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr6_+_114178512 0.27 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr9_+_124329336 0.26 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chrX_+_107288197 0.23 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr1_-_208417620 0.23 ENST00000367033.3
PLXNA2
plexin A2
chr11_-_13517565 0.19 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr19_+_4402659 0.18 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr17_-_64225508 0.16 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr16_-_67517716 0.15 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr15_+_93443419 0.14 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr1_-_204183071 0.13 ENST00000308302.3
GOLT1A
golgi transport 1A
chr12_-_52761262 0.12 ENST00000257901.3
KRT85
keratin 85
chr6_-_9933500 0.11 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr15_+_92006567 0.10 ENST00000554333.1
RP11-661P17.1
RP11-661P17.1
chr14_-_51027838 0.10 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr7_+_129984630 0.09 ENST00000355388.3
ENST00000497503.1
ENST00000463587.1
ENST00000461828.1
ENST00000494311.1
ENST00000466363.2
ENST00000485477.1
ENST00000431780.2
ENST00000474905.1
CPA5
carboxypeptidase A5
chr20_+_30697298 0.09 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr17_-_10372875 0.08 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr3_-_141719195 0.08 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr3_+_121902511 0.07 ENST00000490131.1
CASR
calcium-sensing receptor
chr3_+_136649311 0.07 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr20_-_33735070 0.06 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr10_+_18549645 0.05 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr8_+_77593448 0.04 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr8_+_77593474 0.04 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr13_-_81801115 0.04 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr4_+_80584903 0.03 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr4_+_76481258 0.03 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr20_-_29978286 0.01 ENST00000376315.2
DEFB119
defensin, beta 119
chrX_-_130423200 0.00 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chrX_+_47696337 0.00 ENST00000334937.4
ENST00000376950.4
ZNF81
zinc finger protein 81

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0051541 elastin metabolic process(GO:0051541)
0.1 1.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.2 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.3 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0034392 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990032 parallel fiber(GO:1990032)
0.1 0.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion