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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1

Z-value: 0.64

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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1

Gene Symbol Gene ID Gene Info
NOTO
ENSG00000214513.3 notochord homeobox
VSX2
ENSG00000119614.2 visual system homeobox 2
DLX2
ENSG00000115844.6 distal-less homeobox 2
DLX6
ENSG00000006377.9 distal-less homeobox 6
NKX6-1
ENSG00000163623.5 NK6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX2hg19_v2_chr2_-_172967621_1729676370.542.2e-03Click!
DLX6hg19_v2_chr7_+_96634850_96634874,
hg19_v2_chr7_+_96635277_96635301		-0.291.2e-01Click!
NKX6-1hg19_v2_chr4_-_85418103_854181030.154.3e-01Click!

Activity profile of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Sorted Z-values of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_36050881 4.03 ENST00000537702.1
NBEA
neurobeachin
chr17_-_39203519 3.46 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr6_-_87804815 2.99 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr7_-_25268104 2.49 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr1_-_183622442 2.09 ENST00000308641.4
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr8_-_10512569 1.92 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr20_-_7921090 1.61 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_-_138453606 1.57 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr2_-_68052694 1.48 ENST00000457448.1
AC010987.6
AC010987.6
chr6_-_76203345 1.47 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr6_-_76203454 1.42 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chr20_-_50419055 1.34 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr11_-_31531121 1.33 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr4_+_71108300 1.28 ENST00000304954.3
CSN3
casein kappa
chr1_+_183774240 1.23 ENST00000360851.3
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr16_-_28621353 1.21 ENST00000567512.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr2_-_145278475 1.20 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr14_-_92413727 1.18 ENST00000267620.10
FBLN5
fibulin 5
chr1_-_150738261 1.15 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr12_-_16761007 1.14 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr16_+_53133070 1.14 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr14_-_54423529 1.09 ENST00000245451.4
ENST00000559087.1
BMP4
bone morphogenetic protein 4
chr4_-_25865159 1.06 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr9_-_215744 1.03 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr8_-_72268968 1.00 ENST00000388740.3
EYA1
eyes absent homolog 1 (Drosophila)
chr14_-_92413353 0.99 ENST00000556154.1
FBLN5
fibulin 5
chrX_-_73512411 0.97 ENST00000602576.1
ENST00000429124.1
FTX
FTX transcript, XIST regulator (non-protein coding)
chr8_-_72268889 0.97 ENST00000388742.4
EYA1
eyes absent homolog 1 (Drosophila)
chrX_-_44202857 0.94 ENST00000420999.1
EFHC2
EF-hand domain (C-terminal) containing 2
chr1_+_244515930 0.92 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr9_+_12693336 0.89 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr5_-_137475071 0.82 ENST00000265191.2
NME5
NME/NM23 family member 5
chr3_+_111717600 0.78 ENST00000273368.4
TAGLN3
transgelin 3
chr1_+_61548374 0.78 ENST00000485903.2
ENST00000371185.2
ENST00000371184.2
NFIA
nuclear factor I/A
chr11_-_40315640 0.78 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr3_+_111718036 0.77 ENST00000455401.2
TAGLN3
transgelin 3
chr17_-_10421853 0.77 ENST00000226207.5
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr18_+_32173276 0.76 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr15_-_37393406 0.76 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr12_+_54378923 0.76 ENST00000303460.4
HOXC10
homeobox C10
chr7_-_130080977 0.75 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr4_+_77356248 0.74 ENST00000296043.6
SHROOM3
shroom family member 3
chr12_-_68696652 0.73 ENST00000539972.1
MDM1
Mdm1 nuclear protein homolog (mouse)
chr12_+_26348582 0.73 ENST00000535504.1
SSPN
sarcospan
chr20_-_50418947 0.73 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr5_-_24645078 0.73 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr3_+_111718173 0.72 ENST00000494932.1
TAGLN3
transgelin 3
chr5_-_96478466 0.71 ENST00000274382.4
LIX1
Lix1 homolog (chicken)
chr3_+_111717511 0.70 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr5_+_156696362 0.68 ENST00000377576.3
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr19_-_7698599 0.68 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr3_+_2933893 0.67 ENST00000397459.2
CNTN4
contactin 4
chr19_-_56110859 0.66 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr6_-_161695042 0.65 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr20_-_50418972 0.64 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr20_-_21494654 0.62 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr17_-_39165366 0.61 ENST00000391588.1
KRTAP3-1
keratin associated protein 3-1
chr8_-_133637624 0.61 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr13_-_70682590 0.59 ENST00000377844.4
KLHL1
kelch-like family member 1
chr4_-_177116772 0.58 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr17_-_39280419 0.58 ENST00000394014.1
KRTAP4-12
keratin associated protein 4-12
chr6_+_135502501 0.58 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr11_-_33913708 0.56 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_+_68071389 0.54 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_+_53751445 0.54 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr2_+_128403439 0.54 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr7_+_99717230 0.54 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr11_-_129062093 0.53 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr5_-_13944652 0.53 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr6_-_161695074 0.52 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr2_+_128403720 0.52 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr17_-_77924627 0.52 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr1_+_61548225 0.52 ENST00000371187.3
NFIA
nuclear factor I/A
chr3_-_114477787 0.52 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_76072719 0.51 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr6_-_22297730 0.50 ENST00000306482.1
PRL
prolactin
chr3_+_69928256 0.50 ENST00000394355.2
MITF
microphthalmia-associated transcription factor
chr8_-_109799793 0.49 ENST00000297459.3
TMEM74
transmembrane protein 74
chr8_+_50824233 0.49 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr10_-_102989551 0.49 ENST00000370193.2
LBX1
ladybird homeobox 1
chr7_+_23286182 0.49 ENST00000258733.4
ENST00000381990.2
ENST00000409458.3
ENST00000539136.1
ENST00000453162.2
GPNMB
glycoprotein (transmembrane) nmb
chr18_-_53089723 0.49 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr3_-_141747950 0.48 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_94586651 0.48 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr1_+_180601139 0.48 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr13_-_84456527 0.47 ENST00000377084.2
SLITRK1
SLIT and NTRK-like family, member 1
chr11_+_71900703 0.47 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chrX_-_46187069 0.47 ENST00000446884.1
RP1-30G7.2
RP1-30G7.2
chr4_-_123542224 0.47 ENST00000264497.3
IL21
interleukin 21
chr11_+_71900572 0.46 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr12_-_52946923 0.46 ENST00000267119.5
KRT71
keratin 71
chr6_+_39760129 0.46 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr3_-_114477962 0.45 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr13_-_36050819 0.45 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr7_+_73442487 0.45 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
ELN
elastin
chr11_+_124481361 0.44 ENST00000284288.2
PANX3
pannexin 3
chr18_-_47792851 0.44 ENST00000398545.4
CCDC11
coiled-coil domain containing 11
chrX_-_117119243 0.44 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr4_-_138453559 0.44 ENST00000511115.1
PCDH18
protocadherin 18
chr7_+_116660246 0.44 ENST00000434836.1
ENST00000393443.1
ENST00000465133.1
ENST00000477742.1
ENST00000393447.4
ENST00000393444.3
ST7
suppression of tumorigenicity 7
chr2_-_203735586 0.43 ENST00000454326.1
ENST00000432273.1
ENST00000450143.1
ENST00000411681.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr4_-_74486109 0.43 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr11_-_124190184 0.43 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr13_-_46716969 0.42 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_16759711 0.42 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr19_-_7697857 0.41 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr1_+_61547405 0.40 ENST00000371189.4
NFIA
nuclear factor I/A
chr21_+_17442799 0.40 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
LINC00478
long intergenic non-protein coding RNA 478
chr4_-_41884582 0.39 ENST00000499082.2
LINC00682
long intergenic non-protein coding RNA 682
chr11_-_26593779 0.39 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr4_+_71494461 0.39 ENST00000396073.3
ENAM
enamelin
chr13_-_41593425 0.38 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_61547894 0.38 ENST00000403491.3
NFIA
nuclear factor I/A
chr21_-_32253874 0.38 ENST00000332378.4
KRTAP11-1
keratin associated protein 11-1
chr3_+_173116225 0.38 ENST00000457714.1
NLGN1
neuroligin 1
chr4_+_41614909 0.37 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIMCH1
LIM and calponin homology domains 1
chrX_-_10851762 0.36 ENST00000380785.1
ENST00000380787.1
MID1
midline 1 (Opitz/BBB syndrome)
chr4_+_71458012 0.36 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr7_+_73442422 0.35 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
ELN
elastin
chr2_+_162272605 0.35 ENST00000389554.3
TBR1
T-box, brain, 1
chr3_+_113616317 0.35 ENST00000440446.2
ENST00000488680.1
GRAMD1C
GRAM domain containing 1C
chr15_+_76352178 0.34 ENST00000388942.3
C15orf27
chromosome 15 open reading frame 27
chr19_+_50016411 0.34 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr17_-_40337470 0.34 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr12_+_41831485 0.33 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr4_+_66536248 0.33 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr1_-_48937838 0.33 ENST00000371847.3
SPATA6
spermatogenesis associated 6
chr9_+_2159850 0.32 ENST00000416751.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr11_-_121986923 0.32 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr12_-_86650045 0.32 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr6_-_76782371 0.32 ENST00000369950.3
ENST00000369963.3
IMPG1
interphotoreceptor matrix proteoglycan 1
chr2_+_216946589 0.32 ENST00000433112.1
ENST00000454545.1
ENST00000437356.2
ENST00000295658.4
ENST00000455479.1
ENST00000406027.2
TMEM169
transmembrane protein 169
chr9_+_130026756 0.31 ENST00000314904.5
ENST00000373387.4
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr4_+_159727272 0.31 ENST00000379346.3
FNIP2
folliculin interacting protein 2
chr12_+_20963647 0.31 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr6_-_111804905 0.31 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chrX_+_72783026 0.31 ENST00000373504.6
ENST00000373502.5
CHIC1
cysteine-rich hydrophobic domain 1
chr21_-_31538971 0.30 ENST00000286808.3
CLDN17
claudin 17
chr17_+_59489112 0.30 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr1_+_101003687 0.30 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr2_-_216946500 0.30 ENST00000265322.7
PECR
peroxisomal trans-2-enoyl-CoA reductase
chr20_+_11008408 0.30 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr20_+_52105495 0.30 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr6_-_9933500 0.30 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr15_+_41913690 0.30 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr11_-_102496063 0.29 ENST00000260228.2
MMP20
matrix metallopeptidase 20
chr12_+_20963632 0.29 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr13_+_108922228 0.29 ENST00000542136.1
TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr5_+_69321074 0.29 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
SERF1B
small EDRK-rich factor 1B (centromeric)
chr16_-_28621312 0.29 ENST00000314752.7
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr1_-_227505289 0.29 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr1_+_44679113 0.29 ENST00000361745.6
ENST00000446292.1
ENST00000440641.1
ENST00000436069.1
ENST00000437511.1
DMAP1
DNA methyltransferase 1 associated protein 1
chr3_+_120626919 0.29 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr4_-_105416039 0.28 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr17_+_39261584 0.28 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chrX_+_68835911 0.28 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr14_-_69261310 0.28 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr11_-_26593649 0.28 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr7_+_141478242 0.27 ENST00000247881.2
TAS2R4
taste receptor, type 2, member 4
chr6_-_33160231 0.27 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr8_-_72274095 0.27 ENST00000303824.7
EYA1
eyes absent homolog 1 (Drosophila)
chr8_+_121137333 0.27 ENST00000309791.4
ENST00000297848.3
ENST00000247781.3
COL14A1
collagen, type XIV, alpha 1
chr17_-_72527605 0.27 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr4_-_74486347 0.27 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr21_+_17443434 0.27 ENST00000400178.2
LINC00478
long intergenic non-protein coding RNA 478
chr1_+_40713573 0.27 ENST00000372766.3
TMCO2
transmembrane and coiled-coil domains 2
chr19_+_50016610 0.26 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_-_114790179 0.26 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_160279207 0.26 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr11_+_20620946 0.26 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr6_+_5261225 0.26 ENST00000324331.6
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr10_-_62332357 0.26 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_+_107110488 0.25 ENST00000304402.4
GPR22
G protein-coupled receptor 22
chr2_+_179184955 0.25 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr10_+_111765562 0.25 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr2_+_234959376 0.25 ENST00000425558.1
SPP2
secreted phosphoprotein 2, 24kDa
chr6_-_32908792 0.25 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr9_-_136933134 0.25 ENST00000303407.7
BRD3
bromodomain containing 3
chr10_-_1779663 0.25 ENST00000381312.1
ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chr5_-_35195338 0.25 ENST00000509839.1
PRLR
prolactin receptor
chr7_+_73442102 0.24 ENST00000445912.1
ENST00000252034.7
ELN
elastin
chr3_+_157154578 0.24 ENST00000295927.3
PTX3
pentraxin 3, long
chr18_-_53069419 0.24 ENST00000570177.2
TCF4
transcription factor 4
chr7_-_92855762 0.24 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr11_+_15136462 0.24 ENST00000379556.3
ENST00000424273.1
INSC
inscuteable homolog (Drosophila)
chr14_-_98444461 0.24 ENST00000499006.2
C14orf64
chromosome 14 open reading frame 64
chr13_-_36788718 0.23 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr9_-_124989804 0.23 ENST00000373755.2
ENST00000373754.2
LHX6
LIM homeobox 6
chr13_-_88323218 0.23 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500HG
MIR4500 host gene (non-protein coding)
chr7_+_114055052 0.23 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2
forkhead box P2
chr3_-_72149553 0.23 ENST00000468646.2
ENST00000464271.1
LINC00877
long intergenic non-protein coding RNA 877
chr11_-_26593677 0.23 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr5_+_133562095 0.23 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr3_-_27763803 0.23 ENST00000449599.1
EOMES
eomesodermin
chr6_+_12717892 0.22 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr7_+_97361388 0.22 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr2_+_183943464 0.22 ENST00000354221.4
DUSP19
dual specificity phosphatase 19
chr3_-_112360116 0.22 ENST00000206423.3
ENST00000439685.2
CCDC80
coiled-coil domain containing 80
chr4_+_89206076 0.22 ENST00000500009.2
RP11-10L7.1
RP11-10L7.1
chr5_-_159827033 0.22 ENST00000523213.1
C5orf54
chromosome 5 open reading frame 54

Network of associatons between targets according to the STRING database.

First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0048392 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.3 0.9 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.3 2.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 2.6 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.3 1.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2 0.7 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.2 0.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 1.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 0.6 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.2 0.2 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.2 2.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 0.9 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.2 1.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 1.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.4 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 0.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.5 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.2 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.1 0.3 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.1 2.1 GO:0072189 ureter development(GO:0072189)
0.1 0.2 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.3 GO:0061743 motor learning(GO:0061743)
0.1 0.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.4 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.1 0.2 GO:2000979 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.6 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.1 1.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 0.9 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 1.7 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.4 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.6 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.2 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.8 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 0.7 GO:0045176 apical protein localization(GO:0045176)
0.1 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.6 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 1.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 1.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 0.4 GO:0021764 amygdala development(GO:0021764)
0.1 0.3 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.3 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.7 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.2 GO:1904640 response to methionine(GO:1904640)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 2.6 GO:0016486 peptide hormone processing(GO:0016486)
0.1 2.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.2 GO:0015692 lead ion transport(GO:0015692)
0.0 0.2 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.4 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.2 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.4 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:0007113 endomitotic cell cycle(GO:0007113)
0.0 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.5 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.1 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.1 GO:1904247 regulation of polynucleotide adenylyltransferase activity(GO:1904245) positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.0 0.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.1 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.0 0.1 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.8 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 1.8 GO:0007595 lactation(GO:0007595)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.1 GO:0086097 renin-angiotensin regulation of aldosterone production(GO:0002018) phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 1.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.0 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:0070162 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
0.0 0.1 GO:0010748 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.5 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0060849 radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 0.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.0 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.3 GO:0031647 regulation of protein stability(GO:0031647)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.0 0.6 GO:0007628 adult walking behavior(GO:0007628)
0.0 0.1 GO:0006196 AMP catabolic process(GO:0006196)
0.0 0.7 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.3 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.5 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.7 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.1 GO:0003150 membranous septum morphogenesis(GO:0003149) muscular septum morphogenesis(GO:0003150)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.5 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.7 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.0 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.0 0.1 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.3 3.4 GO:0071953 elastic fiber(GO:0071953)
0.2 1.1 GO:0036021 endolysosome lumen(GO:0036021)
0.1 0.5 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.8 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 0.3 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 2.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.5 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 3.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.9 GO:0032982 myosin filament(GO:0032982)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 2.1 GO:0000792 heterochromatin(GO:0000792)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.7 GO:0031904 endosome lumen(GO:0031904)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 3.2 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 1.0 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.0 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 2.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.1 GO:0043209 myelin sheath(GO:0043209)
0.0 0.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.5 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 1.7 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.2 0.9 GO:0061714 folic acid receptor activity(GO:0061714)
0.2 1.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 0.5 GO:0005148 prolactin receptor binding(GO:0005148)
0.2 0.6 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.3 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.3 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 0.8 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.4 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 1.1 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.0 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.2 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.2 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.5 GO:0045545 syndecan binding(GO:0045545)
0.0 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 2.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.6 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.2 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 1.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.2 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 1.1 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.2 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 1.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0004951 cholecystokinin receptor activity(GO:0004951)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.5 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 3.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.7 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation