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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1
Z-value: 0.64
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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000214513.3 | notochord homeobox | |
| ENSG00000119614.2 | visual system homeobox 2 | |
| ENSG00000115844.6 | distal-less homeobox 2 | |
| ENSG00000006377.9 | distal-less homeobox 6 | |
| ENSG00000163623.5 | NK6 homeobox 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DLX2 | hg19_v2_chr2_-_172967621_172967637 | 0.54 | 2.2e-03 | Click! |
| DLX6 | hg19_v2_chr7_+_96634850_96634874, hg19_v2_chr7_+_96635277_96635301 | -0.29 | 1.2e-01 | Click! |
| NKX6-1 | hg19_v2_chr4_-_85418103_85418103 | 0.15 | 4.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_36050881 Show fit | 4.03 |
ENST00000537702.1
|
neurobeachin |
|
| chr17_-_39203519 Show fit | 3.46 |
ENST00000542137.1
ENST00000391419.3 |
keratin associated protein 2-1 |
|
| chr6_-_87804815 Show fit | 2.99 |
ENST00000369582.2
|
glycoprotein hormones, alpha polypeptide |
|
| chr7_-_25268104 Show fit | 2.49 |
ENST00000222674.2
|
neuropeptide VF precursor |
|
| chr1_-_183622442 Show fit | 2.09 |
ENST00000308641.4
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) |
|
| chr8_-_10512569 Show fit | 1.92 |
ENST00000382483.3
|
retinitis pigmentosa 1-like 1 |
|
| chr20_-_7921090 Show fit | 1.61 |
ENST00000378789.3
|
hydroxyacid oxidase (glycolate oxidase) 1 |
|
| chr4_-_138453606 Show fit | 1.57 |
ENST00000412923.2
ENST00000344876.4 ENST00000507846.1 ENST00000510305.1 |
protocadherin 18 |
|
| chr2_-_68052694 Show fit | 1.48 |
ENST00000457448.1
|
AC010987.6 |
|
| chr6_-_76203345 Show fit | 1.47 |
ENST00000393004.2
|
filamin A interacting protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.3 | 2.6 | GO:0032277 | negative regulation of gonadotropin secretion(GO:0032277) |
| 0.1 | 2.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 2.5 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.3 | 2.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.2 | 2.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 2.1 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 1.9 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.0 | 1.8 | GO:0007595 | lactation(GO:0007595) |
| 0.1 | 1.7 | GO:0006068 | ethanol catabolic process(GO:0006068) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.3 | 3.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 3.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.2 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 3.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 2.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 2.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 2.1 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 1.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.4 | 1.1 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 0.2 | 1.7 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294) |
| 0.5 | 1.6 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
| 0.0 | 1.3 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 1.2 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.0 | 1.2 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 1.2 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 1.1 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 1.1 | GO:0001637 | G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950) |
| 0.1 | 1.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 2.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.1 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.1 | 1.7 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.2 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 1.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 1.1 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.6 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |