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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NR1D1

Z-value: 0.42

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Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
ENSG00000126368.5 nuclear receptor subfamily 1 group D member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg19_v2_chr17_-_38256973_382569900.048.3e-01Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_20915409 1.86 ENST00000375071.3
cytidine deaminase
chr2_+_127656486 0.81 ENST00000568484.1
ENST00000450035.1
Protein LOC339760
chr1_-_111991850 0.73 ENST00000411751.2
WD repeat domain 77
chr1_-_6557156 0.64 ENST00000537245.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr14_-_94595993 0.58 ENST00000238609.3
interferon, alpha-inducible protein 27-like 2
chr16_+_71392616 0.56 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
calbindin 2
chr2_-_89442621 0.56 ENST00000492167.1
immunoglobulin kappa variable 3-20
chr14_-_50999190 0.55 ENST00000557390.1
mitogen-activated protein kinase kinase kinase kinase 5
chr16_+_77225071 0.55 ENST00000439557.2
ENST00000545553.1
MON1 secretory trafficking family member B
chr10_-_43762329 0.51 ENST00000395810.1
RasGEF domain family, member 1A
chr1_-_26232951 0.50 ENST00000426559.2
ENST00000455785.2
stathmin 1
chr14_+_24540046 0.50 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
copine VI (neuronal)
chr1_-_26232522 0.50 ENST00000399728.1
stathmin 1
chr1_-_111991908 0.49 ENST00000235090.5
WD repeat domain 77
chr3_-_182703688 0.49 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCN1, defective in cullin neddylation 1, domain containing 1
chr4_+_169842707 0.49 ENST00000503290.1
palladin, cytoskeletal associated protein
chr1_-_11865982 0.45 ENST00000418034.1
methylenetetrahydrofolate reductase (NAD(P)H)
chr9_-_136242909 0.43 ENST00000371991.3
ENST00000545297.1
surfeit 4
chr15_+_26360970 0.42 ENST00000556159.1
ENST00000557523.1
long intergenic non-protein coding RNA 929
chr5_-_43313574 0.42 ENST00000325110.6
ENST00000433297.2
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr4_+_1873100 0.40 ENST00000508803.1
Wolf-Hirschhorn syndrome candidate 1
chr1_+_110210644 0.40 ENST00000369831.2
ENST00000442650.1
ENST00000369827.3
ENST00000460717.3
ENST00000241337.4
ENST00000467579.3
ENST00000414179.2
ENST00000369829.2
glutathione S-transferase mu 2 (muscle)
chr17_-_36347030 0.38 ENST00000518551.1
TBC1 domain family, member 3
chr19_-_19932501 0.36 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
zinc finger protein 506
CTC-559E9.4
chr22_-_37880543 0.36 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_+_24540731 0.34 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
copine VI (neuronal)
chr19_-_42927251 0.34 ENST00000597001.1
lipase, hormone-sensitive
chr14_-_50999307 0.31 ENST00000013125.4
mitogen-activated protein kinase kinase kinase kinase 5
chr19_-_51220176 0.30 ENST00000359082.3
ENST00000293441.1
SH3 and multiple ankyrin repeat domains 1
chr2_+_220306745 0.29 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
SPEG complex locus
chr19_-_14629224 0.28 ENST00000254322.2
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_-_11865351 0.28 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
methylenetetrahydrofolate reductase (NAD(P)H)
chr8_+_11561660 0.27 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA binding protein 4
chrX_+_54947229 0.27 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
trophinin
chr6_+_31543334 0.26 ENST00000449264.2
tumor necrosis factor
chr1_+_2398876 0.26 ENST00000449969.1
phospholipase C, eta 2
chr3_-_52002403 0.26 ENST00000490063.1
ENST00000468324.1
ENST00000497653.1
ENST00000484633.1
poly(rC) binding protein 4
chr22_-_47882857 0.26 ENST00000405369.3
Novel protein; Uncharacterized protein
chr1_+_168250194 0.25 ENST00000367821.3
T-box 19
chr1_-_11866034 0.24 ENST00000376590.3
methylenetetrahydrofolate reductase (NAD(P)H)
chr17_-_79139817 0.24 ENST00000326724.4
apoptosis-associated tyrosine kinase
chr1_-_38218577 0.21 ENST00000540011.1
EPH receptor A10
chr1_-_26233423 0.21 ENST00000357865.2
stathmin 1
chr1_+_44398943 0.20 ENST00000372359.5
ENST00000414809.3
artemin
chr17_-_3599492 0.20 ENST00000435558.1
ENST00000345901.3
purinergic receptor P2X, ligand-gated ion channel, 5
chr2_-_73053126 0.20 ENST00000272427.6
ENST00000410104.1
exocyst complex component 6B
chr1_-_41131326 0.20 ENST00000372684.3
regulating synaptic membrane exocytosis 3
chr17_-_3599327 0.20 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
purinergic receptor P2X, ligand-gated ion channel, 5
chr2_+_90153696 0.19 ENST00000417279.2
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr19_+_21324863 0.19 ENST00000598331.1
zinc finger protein 431
chr16_+_67233007 0.18 ENST00000360833.1
ENST00000393997.2
engulfment and cell motility 3
chr16_+_67233412 0.18 ENST00000477898.1
engulfment and cell motility 3
chr17_+_39411636 0.18 ENST00000394008.1
keratin associated protein 9-9
chr10_+_11047259 0.18 ENST00000379261.4
ENST00000416382.2
CUGBP, Elav-like family member 2
chr10_-_103880209 0.18 ENST00000425280.1
LIM domain binding 1
chr1_+_161719552 0.18 ENST00000367943.4
dual specificity phosphatase 12
chr2_-_89513402 0.17 ENST00000498435.1
immunoglobulin kappa variable 1-27
chr7_+_45039783 0.16 ENST00000258781.6
ENST00000541586.1
ENST00000544363.1
cerebral cavernous malformation 2
chr22_+_37415700 0.16 ENST00000397129.1
mercaptopyruvate sulfurtransferase
chr7_-_44229022 0.16 ENST00000403799.3
glucokinase (hexokinase 4)
chr19_+_21203481 0.15 ENST00000595401.1
zinc finger protein 430
chr1_+_203764742 0.15 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
zinc finger CCCH-type containing 11A
chr6_+_167525277 0.15 ENST00000400926.2
chemokine (C-C motif) receptor 6
chr1_-_226374373 0.14 ENST00000366812.5
acyl-CoA binding domain containing 3
chr17_-_76128488 0.14 ENST00000322914.3
transmembrane channel-like 6
chr12_-_110883346 0.14 ENST00000547365.1
actin related protein 2/3 complex, subunit 3, 21kDa
chr14_+_100789669 0.14 ENST00000361529.3
ENST00000557052.1
solute carrier family 25, member 47
chr22_+_37415728 0.14 ENST00000404802.3
mercaptopyruvate sulfurtransferase
chr10_+_90346519 0.13 ENST00000371939.3
lipase, family member J
chr16_+_30006615 0.13 ENST00000563197.1
INO80 complex subunit E
chr3_+_171758344 0.13 ENST00000336824.4
ENST00000423424.1
fibronectin type III domain containing 3B
chr4_-_147043058 0.13 ENST00000512063.1
ENST00000507726.1
long intergenic non-protein coding RNA 1095
chr19_-_43702231 0.13 ENST00000597374.1
ENST00000599371.1
pregnancy specific beta-1-glycoprotein 4
chrX_+_68725084 0.12 ENST00000252338.4
family with sequence similarity 155, member B
chr7_-_128695147 0.12 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
transportin 3
chr22_+_37415776 0.12 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
mercaptopyruvate sulfurtransferase
chr9_+_136243264 0.11 ENST00000371955.1
chromosome 9 open reading frame 96
chr15_+_65903680 0.11 ENST00000537259.1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr19_+_21203426 0.11 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
zinc finger protein 430
chr14_+_74815116 0.11 ENST00000256362.4
vertebrae development associated
chr19_-_12833361 0.11 ENST00000592287.1
transportin 2
chr7_-_128694927 0.11 ENST00000471166.1
ENST00000265388.5
transportin 3
chr17_+_39394250 0.10 ENST00000254072.6
keratin associated protein 9-8
chr6_+_99282570 0.10 ENST00000328345.5
POU class 3 homeobox 2
chr1_-_11007927 0.10 ENST00000468348.1
chromosome 1 open reading frame 127
chr19_+_22235279 0.09 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
zinc finger protein 257
chr11_-_64013663 0.09 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_-_23433144 0.09 ENST00000418100.1
ENST00000597537.1
ENST00000597037.1
zinc finger protein 724, pseudogene
chr9_-_136242956 0.09 ENST00000371989.3
ENST00000485435.2
surfeit 4
chr9_+_136243117 0.09 ENST00000426926.2
ENST00000371957.3
chromosome 9 open reading frame 96
chr17_+_39405939 0.09 ENST00000334109.2
keratin associated protein 9-4
chr11_+_125365110 0.08 ENST00000527818.1
AP000708.1
chrX_+_24167828 0.08 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
zinc finger protein, X-linked
chr4_+_88529681 0.08 ENST00000399271.1
dentin sialophosphoprotein
chr6_+_63921351 0.08 ENST00000370659.1
FK506 binding protein 1C
chr2_-_103353277 0.08 ENST00000258436.5
major facilitator superfamily domain containing 9
chr22_+_27017921 0.07 ENST00000354760.3
crystallin, beta A4
chr3_-_48723268 0.07 ENST00000439518.1
ENST00000416649.2
ENST00000341520.4
ENST00000294129.2
NCK interacting protein with SH3 domain
chr17_-_38256973 0.07 ENST00000246672.3
nuclear receptor subfamily 1, group D, member 1
chr6_+_76458909 0.06 ENST00000369981.3
ENST00000369985.4
myosin VI
chr2_-_64371546 0.06 ENST00000358912.4
pellino E3 ubiquitin protein ligase 1
chr7_-_142630820 0.06 ENST00000442623.1
ENST00000265310.1
transient receptor potential cation channel, subfamily V, member 5
chrX_+_24167746 0.06 ENST00000428571.1
ENST00000539115.1
zinc finger protein, X-linked
chr7_+_114562616 0.06 ENST00000448022.1
MyoD family inhibitor domain containing
chrX_+_130192318 0.05 ENST00000370922.1
Rho GTPase activating protein 36
chr15_-_81282133 0.05 ENST00000261758.4
mesoderm development candidate 2
chr16_+_1832902 0.05 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
nucleotide binding protein 2
chr9_-_35112376 0.05 ENST00000488109.2
family with sequence similarity 214, member B
chr10_-_105156198 0.04 ENST00000369815.1
ENST00000309579.3
ENST00000337003.4
up-regulated during skeletal muscle growth 5 homolog (mouse)
chr7_+_62809239 0.04 ENST00000456890.1
AC006455.1
chr6_+_76458990 0.04 ENST00000369977.3
myosin VI
chr1_+_159796534 0.04 ENST00000289707.5
SLAM family member 8
chr2_+_103353367 0.04 ENST00000454536.1
ENST00000409528.1
ENST00000409173.1
transmembrane protein 182
chr4_-_21699380 0.03 ENST00000382148.3
Kv channel interacting protein 4
chr19_-_52035044 0.03 ENST00000359982.4
ENST00000436458.1
ENST00000425629.3
ENST00000391797.3
ENST00000343300.4
sialic acid binding Ig-like lectin 6
chr9_+_91150016 0.02 ENST00000375854.3
ENST00000375855.3
nucleoredoxin-like 2
chr9_+_139221880 0.02 ENST00000392945.3
ENST00000440944.1
G-protein signaling modulator 1
chr9_-_37592561 0.02 ENST00000544379.1
ENST00000377773.5
ENST00000401811.3
ENST00000321301.6
translocase of outer mitochondrial membrane 5 homolog (yeast)
chr1_+_197382957 0.02 ENST00000367397.1
crumbs homolog 1 (Drosophila)
chr17_-_74528128 0.02 ENST00000590175.1
cytoglobin
chr12_-_7125770 0.01 ENST00000261407.4
lysophosphatidylcholine acyltransferase 3
chr1_-_168513229 0.01 ENST00000367819.2
chemokine (C motif) ligand 2
chr13_+_113623509 0.01 ENST00000535094.2
MCF.2 cell line derived transforming sequence-like
chr12_-_123755639 0.01 ENST00000535979.1
cyclin-dependent kinase 2 associated protein 1
chr19_-_12833164 0.01 ENST00000356861.5
transportin 2
chr14_+_50999744 0.01 ENST00000441560.2
atlastin GTPase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0019858 cytosine metabolic process(GO:0019858)
0.3 0.3 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.2 1.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.2 1.2 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.2 1.0 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.2 0.5 GO:0019085 early viral transcription(GO:0019085)
0.1 0.3 GO:0050894 determination of affect(GO:0050894)
0.1 0.3 GO:0003285 septum secundum development(GO:0003285)
0.1 0.4 GO:0009440 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.1 0.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.4 GO:0070458 cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.2 GO:0097021 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.2 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.2 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.5 GO:0045116 protein neddylation(GO:0045116)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.6 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.4 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.4 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071748 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.1 1.2 GO:0034709 methylosome(GO:0034709)
0.0 1.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.4 GO:0005921 gap junction(GO:0005921)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 1.0 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.3 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.4 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.1 0.3 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.2 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.0 0.4 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.1 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.4 GO:0043295 glutathione binding(GO:0043295)
0.0 0.2 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0019957 C-C chemokine binding(GO:0019957)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis