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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for NR5A2
Z-value: 1.37
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Transcription factors associated with NR5A2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR5A2 | hg19_v2_chr1_+_199996702_199996732 | -0.11 | 5.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR5A2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.3 | 4.9 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 4.7 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.8 | 4.2 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.0 | 3.9 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.2 | 2.9 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.1 | 2.9 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.4 | 2.8 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.1 | 2.8 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.3 | 2.7 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 6.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 5.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 4.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 4.0 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 3.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.2 | 2.9 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 2.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.2 | 2.6 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 2.2 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.2 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 3.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 3.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 3.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 3.3 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 3.2 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 3.0 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.2 | 3.0 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 2.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.2 | 2.8 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 2.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.1 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.8 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 1.4 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 4.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 3.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 3.1 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 2.8 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 2.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.4 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 2.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 1.9 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |