ISMARA results: NRF1

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NRF1

Z-value: 3.03

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Transcription factors associated with NRF1

Gene Symbol	Gene ID	Gene Info
NRF1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000106459.10	nuclear respiratory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NRF1	hg19_v2_chr7_+_129251531_129251601	0.79	2.3e-07	Click!

Activity profile of NRF1 motif

Sorted Z-values of NRF1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_7044657 Show fit	16.95	ENST00000310085.4	CCDC96 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 96
chr9_+_124922171 Show fit	16.77	ENST00000373764.3 ENST00000536616.1	MORN5 Ensembl NCBI GeneCards UniProt NextProt Show fit	MORN repeat containing 5
chr17_+_260097 Show fit	16.30	ENST00000360127.6 ENST00000571106.1 ENST00000491373.1	C17orf97 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 17 open reading frame 97
chr2_-_99757977 Show fit	16.29	ENST00000355053.4	TSGA10 Ensembl NCBI GeneCards UniProt NextProt Show fit	testis specific, 10
chr2_-_99757876 Show fit	11.46	ENST00000539964.1 ENST00000393482.3	TSGA10 Ensembl NCBI GeneCards UniProt NextProt Show fit	testis specific, 10
chr3_+_49449636 Show fit	9.80	ENST00000273590.3	TCTA Ensembl NCBI GeneCards UniProt NextProt Show fit	T-cell leukemia translocation altered
chr20_-_35580104 Show fit	9.66	ENST00000373694.5	SAMHD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SAM domain and HD domain 1
chr5_+_10441970 Show fit	9.32	ENST00000274134.4	ROPN1L Ensembl NCBI GeneCards UniProt NextProt Show fit	rhophilin associated tail protein 1-like
chr20_-_35580240 Show fit	8.96	ENST00000262878.4	SAMHD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SAM domain and HD domain 1
chr17_-_6735035 Show fit	8.21	ENST00000338694.2	TEKT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	tektin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	36.7	GO:0042073	intraciliary transport(GO:0042073)
3.7	18.6	GO:0006203	dGTP catabolic process(GO:0006203)
1.0	16.8	GO:0060294	cilium movement involved in cell motility(GO:0060294)
0.2	15.3	GO:0007368	determination of left/right symmetry(GO:0007368)
0.2	13.9	GO:0042733	embryonic digit morphogenesis(GO:0042733)
0.0	13.8	GO:0048232	spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.0	12.4	GO:0043687	post-translational protein modification(GO:0043687)
0.5	12.1	GO:0003341	cilium movement(GO:0003341)
0.8	11.1	GO:0006108	malate metabolic process(GO:0006108)
1.6	9.8	GO:0072675	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)

Showing 1 to 10 of 499 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	62.5	GO:0031514	motile cilium(GO:0031514)
0.3	29.6	GO:0036064	ciliary basal body(GO:0036064)
0.3	17.3	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
1.6	14.0	GO:0036157	outer dynein arm(GO:0036157)
0.7	13.2	GO:0036038	MKS complex(GO:0036038)
0.0	10.9	GO:0005929	cilium(GO:0005929)
0.5	10.4	GO:0097225	sperm midpiece(GO:0097225)
0.2	10.2	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
2.2	8.9	GO:0016939	kinesin II complex(GO:0016939)
0.1	8.7	GO:0045171	intercellular bridge(GO:0045171)

Showing 1 to 10 of 214 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	18.5	GO:0032554	purine deoxyribonucleotide binding(GO:0032554)
0.4	16.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.7	14.8	GO:0045504	dynein heavy chain binding(GO:0045504)
1.3	12.1	GO:0008158	hedgehog receptor activity(GO:0008158)
1.6	11.1	GO:0030060	L-malate dehydrogenase activity(GO:0030060)
0.0	9.4	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.7	8.8	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	8.7	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.4	8.5	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6	7.6	GO:0019826	oxygen sensor activity(GO:0019826)

Showing 1 to 10 of 301 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.3	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.2	10.3	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	9.0	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	8.3	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.2	7.6	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.3	6.0	PID ALK2 PATHWAY	ALK2 signaling events
0.1	5.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	4.3	PID E2F PATHWAY	E2F transcription factor network
0.1	4.1	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	3.5	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway

Showing 1 to 10 of 46 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.2	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	9.4	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.5	8.5	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.2	7.4	REACTOME KINESINS	Genes involved in Kinesins
0.0	6.3	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	5.2	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.2	5.1	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
0.2	4.7	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	4.6	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2	3.9	REACTOME POL SWITCHING	Genes involved in Polymerase switching

Showing 1 to 10 of 72 entries

Results for NRF1

Z-value: 3.03

Motif logo

Transcription factors associated with NRF1

Activity-expression correlation:

Activity profile of NRF1 motif

Sorted Z-values of NRF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: