Project

Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

Navigation
Downloads

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.57

Motif logo

logo of logo of logo of logo of logo of logo of

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.6 orthopedia homeobox
PHOX2B
ENSG00000109132.5 paired like homeobox 2B
LHX1
ENSG00000132130.7 LIM homeobox 1
LMX1A
ENSG00000162761.10 LIM homeobox transcription factor 1 alpha
LHX5
ENSG00000089116.3 LIM homeobox 5
HOXC4
ENSG00000198353.6 homeobox C4
HOXC4
ENSG00000273266.1 homeobox C4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXC4hg19_v2_chr12_+_54447637_544476610.422.1e-02Click!
OTPhg19_v2_chr5_-_76935513_769355130.365.3e-02Click!
LHX1hg19_v2_chr17_+_35294075_352941020.301.1e-01Click!
PHOX2Bhg19_v2_chr4_-_41750922_417509870.242.1e-01Click!
LMX1Ahg19_v2_chr1_-_165325939_165325958,
hg19_v2_chr1_-_165325449_165325478		0.242.1e-01Click!
LHX5hg19_v2_chr12_-_113909877_1139098770.029.2e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_141747950 2.13 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_-_121986923 1.72 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr19_+_50016610 1.71 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_50016411 1.61 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_+_130339710 1.58 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr3_-_164796269 1.23 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr17_+_1674982 0.85 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr4_-_39033963 0.78 ENST00000381938.3
TMEM156
transmembrane protein 156
chr20_-_33735070 0.75 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chrX_-_18690210 0.75 ENST00000379984.3
RS1
retinoschisin 1
chr4_-_120243545 0.74 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr1_+_117544366 0.70 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr10_-_118928543 0.69 ENST00000419373.2
RP11-501J20.2
RP11-501J20.2
chr12_+_26348582 0.68 ENST00000535504.1
SSPN
sarcospan
chrX_+_43515467 0.65 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr11_-_327537 0.64 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr12_+_26348246 0.63 ENST00000422622.2
SSPN
sarcospan
chr9_-_28670283 0.61 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr6_+_114178512 0.58 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr7_+_134528635 0.55 ENST00000445569.2
CALD1
caldesmon 1
chr1_+_62439037 0.52 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr9_-_99540328 0.51 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr7_-_111032971 0.49 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr17_-_9694614 0.46 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr1_-_201140673 0.45 ENST00000367333.2
TMEM9
transmembrane protein 9
chr1_-_190446759 0.45 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr15_+_75970672 0.44 ENST00000435356.1
AC105020.1
Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
chr2_+_90077680 0.44 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr6_+_26402465 0.43 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr2_-_89327228 0.42 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr12_+_26348429 0.40 ENST00000242729.2
SSPN
sarcospan
chr17_+_74463650 0.39 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr12_+_59989918 0.38 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr6_+_26402517 0.38 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chrX_-_21676442 0.37 ENST00000379499.2
KLHL34
kelch-like family member 34
chr4_+_86525299 0.36 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr19_-_36304201 0.35 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr4_+_183370146 0.34 ENST00000510504.1
TENM3
teneurin transmembrane protein 3
chr3_-_141719195 0.34 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr9_+_125133315 0.33 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr20_-_29978383 0.32 ENST00000339144.3
ENST00000376321.3
DEFB119
defensin, beta 119
chrX_-_100872911 0.32 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr1_+_160370344 0.30 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr15_-_20193370 0.28 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr15_+_64680003 0.28 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr13_-_61989655 0.27 ENST00000409204.4
PCDH20
protocadherin 20
chr10_-_50396407 0.27 ENST00000374153.2
ENST00000374151.3
C10orf128
chromosome 10 open reading frame 128
chr20_-_56265680 0.27 ENST00000414037.1
PMEPA1
prostate transmembrane protein, androgen induced 1
chr7_-_44580861 0.26 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr12_+_8309630 0.26 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr10_-_75415825 0.26 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr5_+_81575281 0.26 ENST00000380167.4
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr17_+_12569306 0.26 ENST00000425538.1
MYOCD
myocardin
chr10_-_4285923 0.26 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr6_+_26440700 0.26 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr18_-_47018769 0.26 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr20_+_30697298 0.26 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr3_-_157221380 0.25 ENST00000468233.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_-_116833500 0.25 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr7_+_5465382 0.25 ENST00000609130.1
RP11-1275H24.2
RP11-1275H24.2
chr1_-_211307404 0.24 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr21_+_33671160 0.24 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr4_+_155484155 0.23 ENST00000509493.1
FGB
fibrinogen beta chain
chr2_-_25391468 0.23 ENST00000395826.2
POMC
proopiomelanocortin
chr3_-_20053741 0.22 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr16_+_12059091 0.22 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr5_-_126409159 0.22 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr2_-_25391425 0.21 ENST00000264708.3
ENST00000449220.1
POMC
proopiomelanocortin
chr2_+_234826016 0.21 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr7_+_141811539 0.21 ENST00000550469.2
ENST00000477922.3
RP11-1220K2.2
Putative inactive maltase-glucoamylase-like protein LOC93432
chr14_-_67878917 0.20 ENST00000216446.4
PLEK2
pleckstrin 2
chr4_-_76944621 0.20 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr7_-_107642348 0.20 ENST00000393561.1
LAMB1
laminin, beta 1
chr12_-_10978957 0.20 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr2_+_90211643 0.20 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr19_-_44388116 0.20 ENST00000587539.1
ZNF404
zinc finger protein 404
chr19_-_51920952 0.19 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
SIGLEC10
sialic acid binding Ig-like lectin 10
chr3_-_157221357 0.19 ENST00000494677.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr6_+_29079668 0.19 ENST00000377169.1
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr6_+_47749718 0.19 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
OPN5
opsin 5
chr2_+_90273679 0.18 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr12_-_10022735 0.18 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr7_-_101272576 0.18 ENST00000223167.4
MYL10
myosin, light chain 10, regulatory
chr6_-_41039567 0.17 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr7_-_22862406 0.17 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr12_-_22063787 0.16 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr18_-_47018869 0.16 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr12_-_12674032 0.16 ENST00000298573.4
DUSP16
dual specificity phosphatase 16
chr11_+_114168085 0.15 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr15_-_55489097 0.15 ENST00000260443.4
RSL24D1
ribosomal L24 domain containing 1
chr19_+_29456034 0.15 ENST00000589921.1
LINC00906
long intergenic non-protein coding RNA 906
chr17_-_39093672 0.15 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr4_+_5527117 0.15 ENST00000505296.1
C4orf6
chromosome 4 open reading frame 6
chr4_+_5526883 0.15 ENST00000195455.2
C4orf6
chromosome 4 open reading frame 6
chr14_+_103851712 0.15 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr8_-_7673238 0.15 ENST00000335021.2
DEFB107A
defensin, beta 107A
chr4_+_155484103 0.14 ENST00000302068.4
FGB
fibrinogen beta chain
chr15_-_75748115 0.14 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr17_-_4938712 0.14 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr10_-_105845674 0.14 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr13_-_38172863 0.14 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr5_+_95066823 0.14 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr14_+_22465771 0.13 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr8_+_7353368 0.13 ENST00000355602.2
DEFB107B
defensin, beta 107B
chr6_+_42584847 0.13 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr5_+_126984710 0.13 ENST00000379445.3
CTXN3
cortexin 3
chrY_-_6740649 0.13 ENST00000383036.1
ENST00000383037.4
AMELY
amelogenin, Y-linked
chr12_-_117318788 0.13 ENST00000550505.1
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr3_+_185431080 0.13 ENST00000296270.1
C3orf65
chromosome 3 open reading frame 65
chr9_-_116065551 0.13 ENST00000297894.5
RNF183
ring finger protein 183
chr2_-_25391507 0.13 ENST00000380794.1
POMC
proopiomelanocortin
chr18_-_47018897 0.13 ENST00000418495.1
RPL17
ribosomal protein L17
chr10_+_94451574 0.12 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr5_-_125930929 0.12 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr14_+_102276192 0.12 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr6_-_32157947 0.12 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr4_+_169418255 0.12 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr9_-_21351377 0.12 ENST00000380210.1
IFNA6
interferon, alpha 6
chr13_-_81801115 0.12 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr1_+_10509971 0.12 ENST00000320498.4
CORT
cortistatin
chr2_-_25391772 0.12 ENST00000405623.1
POMC
proopiomelanocortin
chr17_-_72772462 0.12 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr11_+_89764274 0.12 ENST00000448984.1
ENST00000432771.1
TRIM49C
tripartite motif containing 49C
chr1_-_231005310 0.11 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr9_-_77567743 0.11 ENST00000376854.5
C9orf40
chromosome 9 open reading frame 40
chr6_-_66417107 0.11 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr4_+_119809984 0.11 ENST00000307142.4
ENST00000448416.2
ENST00000429713.2
SYNPO2
synaptopodin 2
chr1_-_67266939 0.11 ENST00000304526.2
INSL5
insulin-like 5
chr7_-_150020750 0.11 ENST00000539352.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr5_-_20575959 0.11 ENST00000507958.1
CDH18
cadherin 18, type 2
chr5_+_140593509 0.11 ENST00000341948.4
PCDHB13
protocadherin beta 13
chr9_+_95997205 0.10 ENST00000411624.1
WNK2
WNK lysine deficient protein kinase 2
chr1_+_15668240 0.10 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr11_+_5710919 0.10 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr11_-_89541743 0.10 ENST00000329758.1
TRIM49
tripartite motif containing 49
chr8_-_110986918 0.10 ENST00000297404.1
KCNV1
potassium channel, subfamily V, member 1
chr7_-_22862448 0.10 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr16_-_66584059 0.10 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr4_+_95128748 0.10 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chrX_+_107288239 0.09 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr4_+_183164574 0.09 ENST00000511685.1
TENM3
teneurin transmembrane protein 3
chr14_+_72052983 0.09 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr7_-_150020578 0.09 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr2_+_166095898 0.09 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr6_-_136788001 0.09 ENST00000544465.1
MAP7
microtubule-associated protein 7
chr7_-_87342564 0.09 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr21_-_15583165 0.09 ENST00000536861.1
LIPI
lipase, member I
chr2_+_68961934 0.09 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr13_-_36050819 0.09 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr12_+_10124001 0.09 ENST00000396507.3
ENST00000304361.4
ENST00000434319.2
CLEC12A
C-type lectin domain family 12, member A
chr9_-_44402427 0.09 ENST00000540551.1
BX088651.1
LOC100126582 protein; Uncharacterized protein
chr17_-_38821373 0.09 ENST00000394052.3
KRT222
keratin 222
chr15_+_94899183 0.09 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr17_+_20978854 0.09 ENST00000456235.1
AC087393.1
AC087393.1
chr7_+_138915102 0.08 ENST00000486663.1
UBN2
ubinuclein 2
chr8_-_62602327 0.08 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr11_-_128894053 0.08 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr6_+_125304502 0.08 ENST00000519799.1
ENST00000368414.2
ENST00000359704.2
RNF217
ring finger protein 217
chr11_+_2405833 0.08 ENST00000527343.1
ENST00000464784.2
CD81
CD81 molecule
chr15_-_37393406 0.08 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr12_+_26164645 0.08 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr6_-_133035185 0.08 ENST00000367928.4
VNN1
vanin 1
chr14_+_50234309 0.08 ENST00000298307.5
KLHDC2
kelch domain containing 2
chr2_+_68961905 0.08 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr21_+_17909594 0.08 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr6_-_144385698 0.08 ENST00000444202.1
ENST00000437412.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr12_-_118797475 0.08 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr6_+_26365443 0.08 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr3_-_149095652 0.07 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr9_+_34652164 0.07 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr12_-_25150373 0.07 ENST00000549828.1
C12orf77
chromosome 12 open reading frame 77
chr1_+_225600404 0.07 ENST00000366845.2
AC092811.1
AC092811.1
chr15_+_84115868 0.07 ENST00000427482.2
SH3GL3
SH3-domain GRB2-like 3
chr12_-_7655329 0.07 ENST00000541972.1
CD163
CD163 molecule
chr10_-_95242044 0.07 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr16_-_66583701 0.07 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
TK2
thymidine kinase 2, mitochondrial
chr10_-_95241951 0.07 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr7_+_150020363 0.07 ENST00000359623.4
ENST00000493307.1
LRRC61
leucine rich repeat containing 61
chr19_-_19887185 0.07 ENST00000590092.1
ENST00000589910.1
ENST00000589508.1
ENST00000586645.1
ENST00000586816.1
ENST00000588223.1
ENST00000586885.1
LINC00663
long intergenic non-protein coding RNA 663
chr14_-_106552755 0.07 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr1_+_168250194 0.07 ENST00000367821.3
TBX19
T-box 19
chr3_-_151034734 0.07 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr1_-_168464875 0.06 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr17_-_39203519 0.06 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr12_+_8662057 0.06 ENST00000382064.2
CLEC4D
C-type lectin domain family 4, member D
chr6_-_7313381 0.06 ENST00000489567.1
ENST00000479365.1
ENST00000462112.1
ENST00000397511.2
ENST00000534851.1
ENST00000474597.1
ENST00000244763.4
SSR1
signal sequence receptor, alpha
chr8_+_104384616 0.06 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr16_+_28565230 0.06 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr3_+_12329397 0.06 ENST00000397015.2
PPARG
peroxisome proliferator-activated receptor gamma
chr4_+_169418195 0.06 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr9_+_125132803 0.06 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_-_51027838 0.06 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr8_-_29605625 0.06 ENST00000506121.3
LINC00589
long intergenic non-protein coding RNA 589
chr1_-_114414316 0.05 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chrX_+_47696275 0.05 ENST00000376954.1
ENST00000338637.7
ZNF81
zinc finger protein 81
chr1_+_81771806 0.05 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr14_-_106668095 0.05 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr8_-_52721975 0.05 ENST00000356297.4
ENST00000543296.1
PXDNL
peroxidasin homolog (Drosophila)-like
chr20_+_55904815 0.05 ENST00000371263.3
ENST00000345868.4
ENST00000371260.4
ENST00000418127.1
SPO11
SPO11 meiotic protein covalently bound to DSB
chr3_+_157154578 0.05 ENST00000295927.3
PTX3
pentraxin 3, long

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.2 0.7 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 1.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 0.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 0.8 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 0.4 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 1.6 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.3 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.3 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222)
0.1 0.7 GO:2000852 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 0.5 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.1 0.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.2 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 0.4 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 2.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.2 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.1 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.0 0.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.9 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.7 GO:0009642 response to light intensity(GO:0009642)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.0 0.6 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.6 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.0 0.2 GO:0010819 regulation of T cell chemotaxis(GO:0010819) positive regulation of cAMP-mediated signaling(GO:0043950) regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.3 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.1 GO:0042138 meiotic DNA double-strand break processing(GO:0000706) meiotic DNA double-strand break formation(GO:0042138) double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.0 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.1 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.0 GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation(GO:2001186)
0.0 0.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.0 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.3 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.1 0.2 GO:0005607 laminin-2 complex(GO:0005607)
0.1 0.8 GO:0043203 axon hillock(GO:0043203)
0.0 1.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.5 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.0 GO:1990357 terminal web(GO:1990357)
0.0 0.0 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0019770 IgG receptor activity(GO:0019770)
0.4 1.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.9 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 0.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.4 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.3 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.2 GO:0004797 thymidine kinase activity(GO:0004797)
0.1 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.2 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.3 GO:0015266 protein channel activity(GO:0015266)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.0 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions