ISMARA results: OTP_PHOX2B_LHX1_LMX1A_LHX5

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.57

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol	Gene ID	Gene Info
OTP Ensembl NCBI GeneCards UniProt NextProt	ENSG00000171540.6	orthopedia homeobox
PHOX2B Ensembl NCBI GeneCards UniProt NextProt	ENSG00000109132.5	paired like homeobox 2B
LHX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000132130.7	LIM homeobox 1
LMX1A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000162761.10	LIM homeobox transcription factor 1 alpha
LHX5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000089116.3	LIM homeobox 5
HOXC4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000198353.6	homeobox C4
HOXC4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000273266.1	homeobox C4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC4	hg19_v2_chr12_+_54447637_54447661	0.42	2.1e-02	Click!
OTP	hg19_v2_chr5_-_76935513_76935513	0.36	5.3e-02	Click!
LHX1	hg19_v2_chr17_+_35294075_35294102	0.30	1.1e-01	Click!
PHOX2B	hg19_v2_chr4_-_41750922_41750987	0.24	2.1e-01	Click!
LMX1A	hg19_v2_chr1_-_165325939_165325958, hg19_v2_chr1_-_165325449_165325478	0.24	2.1e-01	Click!
LHX5	hg19_v2_chr12_-_113909877_113909877	0.02	9.2e-01	Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_141747950 Show fit	2.13	ENST00000497579.1	TFDP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor Dp-2 (E2F dimerization partner 2)
chr11_-_121986923 Show fit	1.72	ENST00000560104.1	BLID Ensembl NCBI GeneCards UniProt NextProt Show fit	BH3-like motif containing, cell death inducer
chr19_+_50016610 Show fit	1.71	ENST00000596975.1	FCGRT Ensembl NCBI GeneCards UniProt NextProt Show fit	Fc fragment of IgG, receptor, transporter, alpha
chr19_+_50016411 Show fit	1.61	ENST00000426395.3 ENST00000600273.1 ENST00000599988.1	FCGRT Ensembl NCBI GeneCards UniProt NextProt Show fit	Fc fragment of IgG, receptor, transporter, alpha
chr6_+_130339710 Show fit	1.58	ENST00000526087.1 ENST00000533560.1 ENST00000361794.2	L3MBTL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	l(3)mbt-like 3 (Drosophila)
chr3_-_164796269 Show fit	1.23	ENST00000264382.3	SI Ensembl NCBI GeneCards UniProt NextProt Show fit	sucrase-isomaltase (alpha-glucosidase)
chr17_+_1674982 Show fit	0.85	ENST00000572048.1 ENST00000573763.1	SERPINF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr4_-_39033963 Show fit	0.78	ENST00000381938.3	TMEM156 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 156
chr20_-_33735070 Show fit	0.75	ENST00000374491.3 ENST00000542871.1 ENST00000374492.3	EDEM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ER degradation enhancer, mannosidase alpha-like 2
chrX_-_18690210 Show fit	0.75	ENST00000379984.3	RS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	retinoschisin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.3	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	2.1	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1	1.6	GO:0043249	erythrocyte maturation(GO:0043249)
0.2	1.2	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.9	GO:0072643	interferon-gamma secretion(GO:0072643)
0.2	0.8	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.2	0.7	GO:0036511	trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1	0.7	GO:2000852	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0	0.7	GO:0009642	response to light intensity(GO:0009642)
0.0	0.6	GO:0042420	dopamine catabolic process(GO:0042420)

Showing 1 to 10 of 53 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.0	1.7	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.8	GO:0043203	axon hillock(GO:0043203)
0.0	0.7	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	0.6	GO:0001674	female germ cell nucleus(GO:0001674)
0.2	0.5	GO:0042720	mitochondrial inner membrane peptidase complex(GO:0042720)
0.0	0.5	GO:0030478	actin cap(GO:0030478)
0.0	0.4	GO:0005577	fibrinogen complex(GO:0005577)
0.1	0.3	GO:0060187	cell pole(GO:0060187)
0.0	0.3	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.3	GO:0019770	IgG receptor activity(GO:0019770)
0.4	1.2	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.1	0.9	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.8	GO:0005504	fatty acid binding(GO:0005504)
0.1	0.7	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1	0.7	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.7	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	0.6	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.5	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.5	GO:0035035	histone acetyltransferase binding(GO:0035035)

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	PID E2F PATHWAY	E2F transcription factor network
0.0	0.7	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	0.7	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.7	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.6	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.6	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.5	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.4	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.4	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.4	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions

Showing 1 to 10 of 11 entries

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.57

Motif logo

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Activity-expression correlation:

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: