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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for OTX1
Z-value: 0.75
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Transcription factors associated with OTX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OTX1 | hg19_v2_chr2_+_63277927_63277938 | 0.57 | 9.3e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of OTX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.6 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.1 | 4.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 3.2 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.7 | 2.1 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.3 | 1.9 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 1.8 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 1.8 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.1 | 1.7 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.3 | 1.4 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.1 | 1.4 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 3.4 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.3 | 1.4 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 1.4 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 1.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.8 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 0.8 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 0.8 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.7 | GO:1902911 | protein kinase complex(GO:1902911) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.9 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.3 | 2.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.1 | 2.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.5 | 2.1 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.1 | 1.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 1.9 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.4 | 1.8 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.0 | 1.8 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.3 | 1.7 | GO:0004999 | vasoactive intestinal polypeptide receptor activity(GO:0004999) |
| 0.1 | 1.7 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.8 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 1.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.3 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 2.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.7 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 1.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.7 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.4 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.4 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |