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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for PATZ1_KLF4
Z-value: 1.94
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Transcription factors associated with PATZ1_KLF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PATZ1 | hg19_v2_chr22_-_31741757_31741770 | -0.73 | 3.9e-06 | Click! |
| KLF4 | hg19_v2_chr9_-_110251836_110251927 | 0.26 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PATZ1_KLF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 48.2 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 1.6 | 46.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 7.7 | 46.2 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 2.0 | 43.5 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.4 | 41.0 | GO:0070268 | cornification(GO:0070268) |
| 3.8 | 34.0 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.7 | 32.7 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.6 | 30.8 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 1.3 | 30.3 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
| 1.2 | 30.1 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 107.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 67.5 | GO:0005925 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055) |
| 0.5 | 58.0 | GO:0032432 | actin filament bundle(GO:0032432) |
| 6.6 | 46.2 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.6 | 44.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.7 | 42.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 41.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 39.2 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 1.6 | 39.1 | GO:0005861 | troponin complex(GO:0005861) |
| 1.4 | 35.4 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 195.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.5 | 161.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 91.5 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.3 | 71.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.6 | 53.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 11.5 | 46.0 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 3.1 | 43.0 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.4 | 36.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 34.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 32.5 | GO:0051015 | actin filament binding(GO:0051015) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 120.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.0 | 76.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.0 | 65.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.9 | 54.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.5 | 48.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 45.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.8 | 45.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 43.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.5 | 35.0 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 1.1 | 34.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 87.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.5 | 53.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.0 | 45.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.2 | 45.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.8 | 37.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.1 | 36.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 1.5 | 36.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 32.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.1 | 30.8 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.8 | 27.8 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |