ISMARA results: PAX6

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PAX6

Z-value: 0.72

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Transcription factors associated with PAX6

Gene Symbol	Gene ID	Gene Info
PAX6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000007372.16	paired box 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PAX6	hg19_v2_chr11_-_31839488_31839515	0.32	8.9e-02	Click!

Activity profile of PAX6 motif

Sorted Z-values of PAX6 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_58343319 Show fit	1.92	ENST00000395074.2	LPXN Ensembl NCBI GeneCards UniProt NextProt Show fit	leupaxin
chr7_-_97501706 Show fit	1.72	ENST00000455086.1 ENST00000453600.1	ASNS Ensembl NCBI GeneCards UniProt NextProt Show fit	asparagine synthetase (glutamine-hydrolyzing)
chr19_-_36019123 Show fit	1.68	ENST00000588674.1 ENST00000452271.2 ENST00000518157.1	SBSN Ensembl NCBI GeneCards UniProt NextProt Show fit	suprabasin
chr12_-_47473425 Show fit	1.48	ENST00000550413.1	AMIGO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	adhesion molecule with Ig-like domain 2
chr13_+_96085847 Show fit	1.47	ENST00000376873.3	CLDN10 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 10
chr7_-_97501733 Show fit	1.43	ENST00000444334.1 ENST00000422745.1 ENST00000394308.3 ENST00000451771.1 ENST00000175506.4	ASNS Ensembl NCBI GeneCards UniProt NextProt Show fit	asparagine synthetase (glutamine-hydrolyzing)
chr12_-_2986107 Show fit	1.42	ENST00000359843.3 ENST00000342628.2 ENST00000361953.3	FOXM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	forkhead box M1
chr18_-_21242774 Show fit	1.38	ENST00000322980.9	ANKRD29 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin repeat domain 29
chr11_-_28129656 Show fit	1.35	ENST00000263181.6	KIF18A Ensembl NCBI GeneCards UniProt NextProt Show fit	kinesin family member 18A
chr7_-_76255444 Show fit	1.26	ENST00000454397.1	POMZP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	POM121 and ZP3 fusion

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.2	GO:0070982	L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
0.0	2.5	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1	2.2	GO:1904776	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.2	1.9	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.5	1.8	GO:0090362	positive regulation of platelet-derived growth factor production(GO:0090362)
0.2	1.6	GO:1904849	positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.2	1.6	GO:0015820	leucine transport(GO:0015820) proline transmembrane transport(GO:0035524)
0.1	1.6	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
0.0	1.5	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1	1.4	GO:2000781	positive regulation of double-strand break repair(GO:2000781)

Showing 1 to 10 of 94 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	GO:0008091	spectrin(GO:0008091)
0.0	1.9	GO:0002102	podosome(GO:0002102)
0.5	1.6	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.1	1.3	GO:0005828	kinetochore microtubule(GO:0005828)
0.2	1.2	GO:0031905	early endosome lumen(GO:0031905)
0.1	1.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.2	1.0	GO:0031262	Ndc80 complex(GO:0031262)
0.1	0.8	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.1	0.8	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.8	GO:0005922	connexon complex(GO:0005922)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.2	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.0	2.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	2.2	GO:0042731	PH domain binding(GO:0042731)
0.0	2.0	GO:0001618	virus receptor activity(GO:0001618)
0.5	1.6	GO:0005298	proline:sodium symporter activity(GO:0005298)
0.1	1.6	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.3	1.3	GO:0015616	DNA translocase activity(GO:0015616)
0.1	1.3	GO:0032190	acrosin binding(GO:0032190)
0.1	1.3	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	1.3	GO:0051010	microtubule plus-end binding(GO:0051010)

Showing 1 to 10 of 64 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.6	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	1.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	1.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.8	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.7	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.6	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	1.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	1.6	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	1.6	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	1.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.3	REACTOME KINESINS	Genes involved in Kinesins
0.0	1.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	1.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	1.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	1.0	REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	Genes involved in Glucagon signaling in metabolic regulation

Showing 1 to 10 of 28 entries

Results for PAX6

Z-value: 0.72

Motif logo

Transcription factors associated with PAX6

Activity-expression correlation:

Activity profile of PAX6 motif

Sorted Z-values of PAX6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: