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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PAX6

Z-value: 0.72

Motif logo

Transcription factors associated with PAX6

Gene Symbol Gene ID Gene Info
ENSG00000007372.16 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX6hg19_v2_chr11_-_31839488_318395150.328.9e-02Click!

Activity profile of PAX6 motif

Sorted Z-values of PAX6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_58343319 1.92 ENST00000395074.2
leupaxin
chr7_-_97501706 1.72 ENST00000455086.1
ENST00000453600.1
asparagine synthetase (glutamine-hydrolyzing)
chr19_-_36019123 1.68 ENST00000588674.1
ENST00000452271.2
ENST00000518157.1
suprabasin
chr12_-_47473425 1.48 ENST00000550413.1
adhesion molecule with Ig-like domain 2
chr13_+_96085847 1.47 ENST00000376873.3
claudin 10
chr7_-_97501733 1.43 ENST00000444334.1
ENST00000422745.1
ENST00000394308.3
ENST00000451771.1
ENST00000175506.4
asparagine synthetase (glutamine-hydrolyzing)
chr12_-_2986107 1.42 ENST00000359843.3
ENST00000342628.2
ENST00000361953.3
forkhead box M1
chr18_-_21242774 1.38 ENST00000322980.9
ankyrin repeat domain 29
chr11_-_28129656 1.35 ENST00000263181.6
kinesin family member 18A
chr7_-_76255444 1.26 ENST00000454397.1
POM121 and ZP3 fusion
chr11_+_86667117 1.23 ENST00000531827.1
RP11-736K20.6
chr11_-_87908600 1.19 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38, member RAS oncogene family
chr12_-_85306594 1.18 ENST00000266682.5
solute carrier family 6 (neutral amino acid transporter), member 15
chr6_-_131291572 1.14 ENST00000529208.1
erythrocyte membrane protein band 4.1-like 2
chr12_-_47473707 1.11 ENST00000429635.1
adhesion molecule with Ig-like domain 2
chr6_-_131321863 1.11 ENST00000528282.1
erythrocyte membrane protein band 4.1-like 2
chr1_+_163291732 1.04 ENST00000271452.3
NUF2, NDC80 kinetochore complex component
chr1_-_185597619 1.01 ENST00000608417.1
ENST00000436955.1
GS1-204I12.1
chr7_-_80551671 0.96 ENST00000419255.2
ENST00000544525.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr18_-_21242833 0.93 ENST00000586087.1
ENST00000592179.1
ankyrin repeat domain 29
chr18_+_61445007 0.93 ENST00000447428.1
ENST00000546027.1
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr18_+_61420169 0.92 ENST00000425392.1
ENST00000336429.2
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr8_+_66955648 0.89 ENST00000522619.1
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr2_-_161056762 0.87 ENST00000428609.2
ENST00000409967.2
integrin, beta 6
chrX_-_65259914 0.86 ENST00000374737.4
ENST00000455586.2
V-set and immunoglobulin domain containing 4
chr21_+_39628852 0.85 ENST00000398938.2
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_47473369 0.84 ENST00000546455.1
PC-esterase domain containing 1B
chr4_+_123747979 0.84 ENST00000608478.1
fibroblast growth factor 2 (basic)
chr10_-_75226166 0.82 ENST00000544628.1
protein phosphatase 3, catalytic subunit, beta isozyme
chr4_+_123747834 0.79 ENST00000264498.3
fibroblast growth factor 2 (basic)
chr8_-_95487331 0.77 ENST00000336148.5
RAD54 homolog B (S. cerevisiae)
chr2_-_161056802 0.75 ENST00000283249.2
ENST00000409872.1
integrin, beta 6
chr4_-_68749745 0.74 ENST00000283916.6
transmembrane protease, serine 11D
chr6_+_25652501 0.74 ENST00000334979.6
secretagogin, EF-hand calcium binding protein
chr5_-_114938090 0.73 ENST00000427199.2
toll-like receptor adaptor molecule 2
chr1_+_203651937 0.69 ENST00000341360.2
ATPase, Ca++ transporting, plasma membrane 4
chr2_-_85645545 0.67 ENST00000409275.1
capping protein (actin filament), gelsolin-like
chr4_-_68749699 0.66 ENST00000545541.1
transmembrane protease, serine 11D
chr1_+_73771844 0.66 ENST00000440762.1
ENST00000444827.1
ENST00000415686.1
ENST00000411903.1
RP4-598G3.1
chr11_+_118175132 0.65 ENST00000361763.4
CD3e molecule, epsilon (CD3-TCR complex)
chr4_+_115519577 0.64 ENST00000310836.6
UDP glycosyltransferase 8
chr2_+_29320571 0.63 ENST00000401605.1
ENST00000401617.2
CAP-GLY domain containing linker protein family, member 4
chr2_+_196521458 0.63 ENST00000409086.3
solute carrier family 39 (zinc transporter), member 10
chr12_+_56915776 0.62 ENST00000550726.1
ENST00000542360.1
RNA binding motif, single stranded interacting protein 2
chr4_+_70916119 0.60 ENST00000246896.3
ENST00000511674.1
histatin 1
chr12_-_10007448 0.59 ENST00000538152.1
C-type lectin domain family 2, member B
chr14_+_57671888 0.59 ENST00000391612.1
AL391152.1
chr8_-_79470728 0.59 ENST00000522807.1
ENST00000519242.1
ENST00000522302.1
RP11-594N15.2
chr12_+_56915713 0.59 ENST00000262031.5
ENST00000552247.2
RNA binding motif, single stranded interacting protein 2
chr4_-_174320687 0.59 ENST00000296506.3
stimulator of chondrogenesis 1
chr8_+_59323823 0.58 ENST00000399598.2
UBX domain protein 2B
chr11_+_844406 0.58 ENST00000397404.1
tetraspanin 4
chr17_+_58499844 0.57 ENST00000269127.4
chromosome 17 open reading frame 64
chr2_+_132160448 0.56 ENST00000437751.1
long intergenic non-protein coding RNA 1120
chr2_+_220363579 0.56 ENST00000313597.5
ENST00000373917.3
ENST00000358215.3
ENST00000373908.1
ENST00000455657.1
ENST00000435316.1
ENST00000341142.3
GDP-mannose pyrophosphorylase A
chr8_-_95487272 0.56 ENST00000297592.5
RAD54 homolog B (S. cerevisiae)
chr19_-_50370509 0.55 ENST00000596014.1
polynucleotide kinase 3'-phosphatase
chr2_+_98986400 0.55 ENST00000272602.2
cyclic nucleotide gated channel alpha 3
chr2_+_196521845 0.55 ENST00000359634.5
ENST00000412905.1
solute carrier family 39 (zinc transporter), member 10
chr1_+_84609944 0.52 ENST00000370685.3
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_104597286 0.51 ENST00000369887.3
cytochrome P450, family 17, subfamily A, polypeptide 1
chr11_-_117748138 0.50 ENST00000527717.1
FXYD domain containing ion transport regulator 6
chr19_+_41222998 0.50 ENST00000263370.2
inositol-trisphosphate 3-kinase C
chr7_+_45067265 0.48 ENST00000474617.1
cerebral cavernous malformation 2
chr2_-_163008903 0.47 ENST00000418842.2
ENST00000375497.3
glucagon
chr2_-_85625857 0.47 ENST00000453973.1
capping protein (actin filament), gelsolin-like
chr13_+_25875662 0.47 ENST00000381736.3
ENST00000463407.1
ENST00000381718.3
nucleoporin like 1
chr14_+_24867992 0.45 ENST00000382554.3
NYN domain and retroviral integrase containing
chr10_+_35894338 0.45 ENST00000321660.1
gap junction protein, delta 4, 40.1kDa
chr5_+_3596168 0.44 ENST00000302006.3
iroquois homeobox 1
chr1_+_207925391 0.44 ENST00000358170.2
ENST00000354848.1
ENST00000322918.5
ENST00000367042.1
ENST00000367041.1
ENST00000357714.1
ENST00000322875.4
ENST00000367047.1
ENST00000441839.2
ENST00000361067.1
ENST00000360212.2
ENST00000480003.1
CD46 molecule, complement regulatory protein
chr13_-_24007815 0.44 ENST00000382298.3
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr6_-_10412600 0.44 ENST00000379608.3
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr12_-_85306562 0.43 ENST00000551612.1
ENST00000450363.3
ENST00000552192.1
solute carrier family 6 (neutral amino acid transporter), member 15
chr8_+_67104323 0.42 ENST00000518412.1
ENST00000518035.1
ENST00000517725.1
long intergenic non-protein coding RNA 967
chr21_+_39628655 0.42 ENST00000398925.1
ENST00000398928.1
ENST00000328656.4
ENST00000443341.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_-_119379719 0.42 ENST00000493094.1
popeye domain containing 2
chr11_-_117747607 0.42 ENST00000540359.1
ENST00000539526.1
FXYD domain containing ion transport regulator 6
chr22_-_36220420 0.41 ENST00000473487.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr12_-_70093190 0.41 ENST00000330891.5
bestrophin 3
chr3_-_196910721 0.41 ENST00000443183.1
discs, large homolog 1 (Drosophila)
chr11_+_116700600 0.40 ENST00000227667.3
apolipoprotein C-III
chr11_+_116700614 0.40 ENST00000375345.1
apolipoprotein C-III
chr1_+_147374915 0.40 ENST00000240986.4
gap junction protein, alpha 8, 50kDa
chr21_-_40032581 0.39 ENST00000398919.2
v-ets avian erythroblastosis virus E26 oncogene homolog
chr11_-_117747434 0.39 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD domain containing ion transport regulator 6
chr12_+_113354341 0.38 ENST00000553152.1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr16_-_71264558 0.37 ENST00000448089.2
ENST00000393550.2
ENST00000448691.1
ENST00000393567.2
ENST00000321489.5
ENST00000539973.1
ENST00000288168.10
ENST00000545267.1
ENST00000541601.1
ENST00000538248.1
HYDIN, axonemal central pair apparatus protein
chrX_-_138914394 0.36 ENST00000327569.3
ENST00000361648.2
ENST00000370543.1
ENST00000359686.2
ATPase, class VI, type 11C
chr1_-_232598163 0.36 ENST00000308942.4
signal-induced proliferation-associated 1 like 2
chr17_+_36283971 0.35 ENST00000327454.6
ENST00000378174.5
TBC1 domain family, member 3F
chr1_+_77333117 0.35 ENST00000477717.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr5_+_147691979 0.35 ENST00000274565.4
serine peptidase inhibitor, Kazal type 7 (putative)
chr10_-_118764862 0.35 ENST00000260777.10
KIAA1598
chr12_+_10460549 0.34 ENST00000543420.1
ENST00000543777.1
killer cell lectin-like receptor subfamily D, member 1
chr11_-_11374904 0.34 ENST00000528848.2
casein kinase 2, alpha 3 polypeptide
chr11_+_28129795 0.33 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
methyltransferase like 15
chr8_-_13372253 0.33 ENST00000316609.5
deleted in liver cancer 1
chr1_-_89458287 0.33 ENST00000370485.2
cysteine conjugate-beta lyase 2
chr2_+_192110199 0.33 ENST00000304164.4
myosin IB
chr6_+_42896865 0.33 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr11_+_4788500 0.32 ENST00000380390.1
matrix metallopeptidase 26
chr19_-_22806764 0.31 ENST00000598042.1
AC011516.2
chr8_+_49984894 0.31 ENST00000522267.1
ENST00000399653.4
ENST00000303202.8
chromosome 8 open reading frame 22
chr19_-_41222775 0.31 ENST00000324464.3
ENST00000450541.1
ENST00000594720.1
aarF domain containing kinase 4
chr20_-_44144249 0.31 ENST00000217428.6
serine peptidase inhibitor, Kunitz type, 3
chr10_-_118765081 0.30 ENST00000392903.2
ENST00000355371.4
KIAA1598
chr1_-_110933663 0.30 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
solute carrier family 16, member 4
chr12_+_69080734 0.30 ENST00000378905.2
nucleoporin 107kDa
chr12_-_69080590 0.30 ENST00000433116.2
ENST00000500695.2
RP11-637A17.2
chr7_+_142919130 0.30 ENST00000408947.3
taste receptor, type 2, member 40
chr2_+_192109911 0.30 ENST00000418908.1
ENST00000339514.4
ENST00000392318.3
myosin IB
chr17_-_9694614 0.30 ENST00000330255.5
ENST00000571134.1
dehydrogenase/reductase (SDR family) member 7C
chrX_-_53461288 0.29 ENST00000375298.4
ENST00000375304.5
hydroxysteroid (17-beta) dehydrogenase 10
chr1_-_23504176 0.29 ENST00000302291.4
leucine zipper protein 1
chr4_+_71063641 0.29 ENST00000514097.1
odontogenic, ameloblast asssociated
chr2_+_238877424 0.29 ENST00000434655.1
ubiquitin-conjugating enzyme E2F (putative)
chr1_-_110933611 0.29 ENST00000472422.2
ENST00000437429.2
solute carrier family 16, member 4
chr2_-_86116093 0.29 ENST00000377332.3
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr11_+_33563821 0.28 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549-like
chr11_+_57105991 0.28 ENST00000263314.2
purinergic receptor P2X, ligand-gated ion channel, 3
chr9_+_93589734 0.27 ENST00000375746.1
spleen tyrosine kinase
chr3_-_195310802 0.27 ENST00000421243.1
ENST00000453131.1
apolipoprotein D
chr12_+_10460417 0.27 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
killer cell lectin-like receptor subfamily D, member 1
chr8_+_22428457 0.26 ENST00000517962.1
sorbin and SH3 domain containing 3
chr17_+_57297807 0.26 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
glycerophosphodiester phosphodiesterase domain containing 1
chr7_+_65552756 0.26 ENST00000450043.1
AC068533.7
chr12_+_18414446 0.26 ENST00000433979.1
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr4_-_10686373 0.26 ENST00000442825.2
cytokine-dependent hematopoietic cell linker
chr14_+_88471468 0.25 ENST00000267549.3
G protein-coupled receptor 65
chr11_-_3078838 0.25 ENST00000397111.5
cysteinyl-tRNA synthetase
chr1_-_201368653 0.25 ENST00000367313.3
ladinin 1
chr16_-_47493041 0.25 ENST00000565940.2
integrin alpha FG-GAP repeat containing 1
chrX_-_53461305 0.25 ENST00000168216.6
hydroxysteroid (17-beta) dehydrogenase 10
chr13_+_25875785 0.25 ENST00000381747.3
nucleoporin like 1
chr17_-_39023462 0.25 ENST00000251643.4
keratin 12
chr14_+_29241910 0.25 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
chromosome 14 open reading frame 23
chr6_+_167704798 0.25 ENST00000230256.3
unc-93 homolog A (C. elegans)
chr3_-_195997410 0.25 ENST00000419333.1
phosphate cytidylyltransferase 1, choline, alpha
chr1_-_201368707 0.24 ENST00000391967.2
ladinin 1
chr5_+_152870734 0.24 ENST00000521843.2
glutamate receptor, ionotropic, AMPA 1
chr17_-_77023683 0.24 ENST00000581579.1
C1QTNF1 antisense RNA 1
chr10_+_118350468 0.24 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
pancreatic lipase-related protein 1
chr17_-_39216344 0.24 ENST00000391418.2
keratin associated protein 2-3
chr7_+_76109827 0.24 ENST00000446820.2
deltex homolog 2 (Drosophila)
chr12_-_56352368 0.24 ENST00000549404.1
premelanosome protein
chr9_-_95166884 0.24 ENST00000375561.5
osteoglycin
chr7_-_30726065 0.24 ENST00000341843.4
corticotropin releasing hormone receptor 2
chr7_+_138943265 0.24 ENST00000483726.1
ubinuclein 2
chr11_+_60223312 0.24 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
membrane-spanning 4-domains, subfamily A, member 1
chr15_+_52155001 0.24 ENST00000544199.1
tropomodulin 3 (ubiquitous)
chrY_+_25130410 0.23 ENST00000331070.3
ENST00000382585.1
basic charge, Y-linked, 2
chrY_+_26764151 0.23 ENST00000382392.1
basic charge, Y-linked, 2B
chrY_-_27198251 0.23 ENST00000382287.1
basic charge, Y-linked, 2C
chr11_-_18813353 0.23 ENST00000358540.2
ENST00000396171.4
ENST00000396167.2
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr16_-_87350970 0.23 ENST00000567970.1
chromosome 16 open reading frame 95
chr5_-_156593273 0.23 ENST00000302938.4
family with sequence similarity 71, member B
chr6_-_64029879 0.23 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
lengsin, lens protein with glutamine synthetase domain
chr3_-_111852128 0.22 ENST00000308910.4
germinal center-associated, signaling and motility
chr6_-_137494775 0.21 ENST00000349184.4
ENST00000296980.2
ENST00000339602.3
interleukin 22 receptor, alpha 2
chr7_-_91808845 0.21 ENST00000343318.5
leucine-rich repeats and death domain containing 1
chr12_-_121476959 0.21 ENST00000339275.5
2'-5'-oligoadenylate synthetase-like
chr10_+_12110963 0.20 ENST00000263035.4
ENST00000437298.1
dehydrogenase E1 and transketolase domain containing 1
chr7_-_87342564 0.20 ENST00000265724.3
ENST00000416177.1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr14_+_24099318 0.20 ENST00000432832.2
dehydrogenase/reductase (SDR family) member 2
chr14_+_22782867 0.20 ENST00000390467.3
T cell receptor alpha variable 40
chr1_-_211666259 0.20 ENST00000367002.4
retinal degeneration 3
chr10_+_90354503 0.19 ENST00000531458.1
lipase, family member J
chr1_-_55089191 0.19 ENST00000302250.2
ENST00000371304.2
family with sequence similarity 151, member A
chr10_+_118350522 0.19 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
pancreatic lipase-related protein 1
chr15_-_65282274 0.19 ENST00000204566.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr21_-_35014027 0.19 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
crystallin, zeta (quinone reductase)-like 1
chr12_+_83080659 0.19 ENST00000321196.3
transmembrane and tetratricopeptide repeat containing 2
chr11_+_60223225 0.19 ENST00000524807.1
ENST00000345732.4
membrane-spanning 4-domains, subfamily A, member 1
chr9_-_128246769 0.19 ENST00000444226.1
mitogen-activated protein kinase associated protein 1
chr11_-_57298187 0.19 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr8_-_62602327 0.19 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
aspartate beta-hydroxylase
chr11_-_18813110 0.19 ENST00000396168.1
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr12_-_70093065 0.19 ENST00000553096.1
bestrophin 3
chr12_-_70093235 0.18 ENST00000266661.4
bestrophin 3
chr1_-_204183071 0.18 ENST00000308302.3
golgi transport 1A
chr7_-_229557 0.18 ENST00000514988.1
Uncharacterized protein
chr14_+_61995722 0.18 ENST00000556347.1
RP11-47I22.4
chrX_-_130423240 0.18 ENST00000370910.1
ENST00000370901.4
immunoglobulin superfamily, member 1
chrX_-_92928557 0.17 ENST00000373079.3
ENST00000475430.2
nucleosome assembly protein 1-like 3
chr20_+_48807351 0.17 ENST00000303004.3
CCAAT/enhancer binding protein (C/EBP), beta
chr5_+_119799927 0.17 ENST00000407149.2
ENST00000379551.2
proline rich 16
chr5_-_141338627 0.16 ENST00000231484.3
protocadherin 12
chr4_-_10686475 0.16 ENST00000226951.6
cytokine-dependent hematopoietic cell linker
chr10_+_102222798 0.16 ENST00000343737.5
wingless-type MMTV integration site family, member 8B
chr9_+_131549483 0.16 ENST00000372648.5
ENST00000539497.1
TBC1 domain family, member 13
chr9_-_5185629 0.16 ENST00000381641.3
insulin-like 6
chr11_-_102401469 0.15 ENST00000260227.4
matrix metallopeptidase 7 (matrilysin, uterine)
chr17_-_3819751 0.15 ENST00000225538.3
purinergic receptor P2X, ligand-gated ion channel, 1
chr16_+_84682108 0.15 ENST00000564996.1
ENST00000258157.5
ENST00000567410.1
kelch-like family member 36
chr1_+_207818460 0.14 ENST00000508064.2
complement component (3b/4b) receptor 1-like
chr19_+_55105085 0.14 ENST00000251372.3
ENST00000453777.1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr4_-_65275162 0.14 ENST00000381210.3
ENST00000507440.1
trans-2,3-enoyl-CoA reductase-like
chr19_+_35820064 0.14 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22 molecule
chr4_+_87928140 0.13 ENST00000307808.6
AF4/FMR2 family, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0070982 L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
0.5 1.8 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.3 0.8 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.2 0.7 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.2 1.9 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 1.6 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.2 0.7 GO:2000283 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.2 1.3 GO:0035803 egg coat formation(GO:0035803)
0.2 1.6 GO:0015820 leucine transport(GO:0015820) proline transmembrane transport(GO:0035524)
0.2 1.2 GO:1903232 melanosome assembly(GO:1903232)
0.2 1.0 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 2.2 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 1.6 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 0.6 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 0.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.6 GO:0098502 DNA dephosphorylation(GO:0098502)
0.1 0.4 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.1 1.4 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.1 0.4 GO:0003409 optic cup structural organization(GO:0003409)
0.1 0.4 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.1 0.8 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.3 GO:0021503 neural fold bending(GO:0021503)
0.1 0.3 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 1.3 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.4 GO:0002442 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.1 0.3 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.1 0.4 GO:0002027 regulation of heart rate(GO:0002027)
0.1 0.6 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.5 GO:0097338 response to clozapine(GO:0097338)
0.1 0.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 1.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.4 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.4 GO:0014901 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.1 0.3 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1 0.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 1.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.4 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.2 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.3 GO:1902572 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.3 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 1.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309) regulation of SA node cell action potential(GO:0098907)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.4 GO:0015074 DNA integration(GO:0015074)
0.0 0.4 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.3 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.4 GO:0043382 positive regulation of memory T cell differentiation(GO:0043382)
0.0 1.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 2.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.0 0.3 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.5 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.2 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.1 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.5 GO:0006702 androgen biosynthetic process(GO:0006702)
0.0 0.2 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.9 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.1 GO:0019230 proprioception(GO:0019230)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.3 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 0.1 GO:0032661 release of cytoplasmic sequestered NF-kappaB(GO:0008588) regulation of interleukin-18 production(GO:0032661)
0.0 0.6 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.6 GO:0032026 response to magnesium ion(GO:0032026)
0.0 1.4 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.6 GO:0050776 regulation of immune response(GO:0050776)
0.0 1.3 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.2 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664)
0.0 0.1 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) chromatin silencing at telomere(GO:0006348) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:1903421 regulation of synaptic vesicle recycling(GO:1903421)
0.0 0.2 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.2 1.2 GO:0031905 early endosome lumen(GO:0031905)
0.2 1.0 GO:0031262 Ndc80 complex(GO:0031262)
0.1 2.2 GO:0008091 spectrin(GO:0008091)
0.1 0.4 GO:1990716 axonemal central apparatus(GO:1990716)
0.1 0.8 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 1.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.5 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 0.4 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 1.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.4 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.3 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0043219 lateral loop(GO:0043219)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.4 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.5 1.6 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.3 1.3 GO:0015616 DNA translocase activity(GO:0015616)
0.3 1.2 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.2 0.7 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.2 2.2 GO:0042731 PH domain binding(GO:0042731)
0.2 0.8 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.6 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) polynucleotide phosphatase activity(GO:0098518)
0.1 1.3 GO:0032190 acrosin binding(GO:0032190)
0.1 0.6 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.6 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 0.8 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 0.3 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.1 1.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.6 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.3 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 0.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 1.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.6 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.2 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.0 1.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.4 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.3 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0034711 inhibin binding(GO:0034711)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.5 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0005243 gap junction channel activity(GO:0005243)
0.0 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0 2.0 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.3 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.6 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.6 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.8 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 3.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.5 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.0 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.6 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase