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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PBX2

Z-value: 0.43

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.7 PBX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_321579920.818.1e-08Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_31440377 2.04 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr14_-_55658252 2.01 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr14_-_55658323 1.91 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr2_+_234104079 1.65 ENST00000417661.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr2_-_190044480 1.50 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr12_-_28124903 1.30 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr12_-_28125638 1.07 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr15_+_67418047 0.83 ENST00000540846.2
SMAD3
SMAD family member 3
chr11_-_2162162 0.69 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr4_-_100065419 0.63 ENST00000504125.1
ENST00000505590.1
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr7_+_134528635 0.63 ENST00000445569.2
CALD1
caldesmon 1
chr2_+_234601512 0.59 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr11_+_69455855 0.55 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr4_+_37962018 0.51 ENST00000504686.1
PTTG2
pituitary tumor-transforming 2
chr2_+_204732666 0.48 ENST00000295854.6
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr11_+_62432777 0.47 ENST00000532971.1
METTL12
methyltransferase like 12
chrX_+_46696372 0.46 ENST00000218340.3
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr2_+_33661382 0.41 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_29151794 0.37 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr1_+_207038699 0.33 ENST00000367098.1
IL20
interleukin 20
chr2_+_20646824 0.32 ENST00000272233.4
RHOB
ras homolog family member B
chr1_+_101702417 0.32 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr2_-_99917639 0.31 ENST00000308528.4
LYG1
lysozyme G-like 1
chr9_-_128246769 0.30 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr5_+_54320078 0.30 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr2_+_204732487 0.29 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr3_+_188889737 0.28 ENST00000345063.3
TPRG1
tumor protein p63 regulated 1
chr14_+_27342334 0.24 ENST00000548170.1
ENST00000552926.1
RP11-384J4.1
RP11-384J4.1
chr14_+_64854958 0.22 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr1_+_62417957 0.20 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chrX_+_119737806 0.20 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr10_-_45474237 0.19 ENST00000448778.1
ENST00000298295.3
C10orf10
chromosome 10 open reading frame 10
chr11_-_104769141 0.19 ENST00000508062.1
ENST00000422698.2
CASP12
caspase 12 (gene/pseudogene)
chr2_+_113033164 0.16 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr3_+_159943362 0.14 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr16_+_1128781 0.14 ENST00000293897.4
ENST00000562758.1
SSTR5
somatostatin receptor 5
chr3_-_129158850 0.12 ENST00000503197.1
ENST00000249910.1
ENST00000429544.2
ENST00000507208.1
MBD4
methyl-CpG binding domain protein 4
chr4_-_100065440 0.11 ENST00000508393.1
ENST00000265512.7
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr10_+_124320195 0.11 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr11_-_111794446 0.11 ENST00000527950.1
CRYAB
crystallin, alpha B
chr3_-_129158676 0.11 ENST00000393278.2
MBD4
methyl-CpG binding domain protein 4
chr18_-_72920372 0.08 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr10_+_124320156 0.08 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1
deleted in malignant brain tumors 1
chr2_+_234602305 0.07 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_44396000 0.04 ENST00000409895.4
ENST00000409432.3
ENST00000282412.4
ENST00000378551.2
ENST00000345249.4
PPM1B
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr2_+_27255806 0.02 ENST00000238788.9
ENST00000404032.3
TMEM214
transmembrane protein 214
chr3_-_52864680 0.01 ENST00000406595.1
ENST00000485816.1
ENST00000434759.3
ENST00000346281.5
ENST00000266041.4
ITIH4
inter-alpha-trypsin inhibitor heavy chain family, member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.9 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.5 1.6 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.5 1.5 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 0.8 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.3 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.1 0.5 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 2.4 GO:0002076 osteoblast development(GO:0002076)
0.1 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.7 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.5 GO:0070141 response to UV-A(GO:0070141)
0.0 0.7 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.3 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.3 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.2 GO:0045008 depyrimidination(GO:0045008)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0005588 collagen type V trimer(GO:0005588)
0.2 3.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.5 GO:1990075 periciliary membrane compartment(GO:1990075)
0.1 0.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.6 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.8 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2 0.7 GO:0005503 all-trans retinal binding(GO:0005503)
0.2 0.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.3 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.1 2.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.2 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 2.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 4.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID AURORA A PATHWAY Aurora A signaling
0.1 2.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.3 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway