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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for PITX1
Z-value: 1.40
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Transcription factors associated with PITX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX1 | hg19_v2_chr5_-_134369973_134369988 | 0.43 | 1.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51487282 Show fit | 8.18 |
ENST00000595820.1
ENST00000597707.1 ENST00000336317.4 |
kallikrein-related peptidase 7 |
|
| chr1_+_151030234 Show fit | 4.49 |
ENST00000368921.3
|
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
|
| chr1_-_153348067 Show fit | 4.05 |
ENST00000368737.3
|
S100 calcium binding protein A12 |
|
| chr2_+_234104079 Show fit | 4.00 |
ENST00000417661.1
|
inositol polyphosphate-5-phosphatase, 145kDa |
|
| chr19_-_55653259 Show fit | 3.62 |
ENST00000593194.1
|
troponin T type 1 (skeletal, slow) |
|
| chr6_+_151662815 Show fit | 3.17 |
ENST00000359755.5
|
A kinase (PRKA) anchor protein 12 |
|
| chr1_-_113478603 Show fit | 2.95 |
ENST00000443580.1
|
solute carrier family 16 (monocarboxylate transporter), member 1 |
|
| chr22_+_30792846 Show fit | 2.87 |
ENST00000312932.9
ENST00000428195.1 |
SEC14-like 2 (S. cerevisiae) |
|
| chr19_-_15343773 Show fit | 2.65 |
ENST00000435261.1
ENST00000594042.1 |
epoxide hydrolase 3 |
|
| chr9_+_139847347 Show fit | 2.57 |
ENST00000371632.3
|
lipocalin 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 8.2 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.3 | 6.4 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
| 0.7 | 6.0 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.6 | 5.7 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.1 | 4.2 | GO:0050832 | defense response to fungus(GO:0050832) |
| 1.3 | 4.0 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.3 | 4.0 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.3 | 3.9 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.1 | 3.7 | GO:0007566 | embryo implantation(GO:0007566) |
| 0.6 | 3.5 | GO:0035803 | egg coat formation(GO:0035803) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 8.7 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 8.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 7.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 6.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 6.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 4.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 4.1 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 4.1 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.0 | 3.5 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 3.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 9.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 6.0 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.6 | 5.8 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 5.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 5.4 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.2 | 4.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 4.1 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 4.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.7 | 3.9 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 5.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 5.2 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 4.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 4.0 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 3.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.4 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.8 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 6.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 5.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 5.2 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 4.7 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 4.1 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 3.8 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 3.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.2 | 3.0 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 3.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |