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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PITX2

Z-value: 0.50

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111558135_111558198,
hg19_v2_chr4_-_111563076_111563172,
hg19_v2_chr4_-_111544254_111544270		-0.431.7e-02Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_36429763 2.97 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr9_+_34458771 2.88 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr11_-_5248294 2.49 ENST00000335295.4
HBB
hemoglobin, beta
chr6_-_111804905 1.27 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr16_-_5116025 1.13 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
C16orf89
chromosome 16 open reading frame 89
chr19_-_49843539 1.01 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4
CTC-301O7.4
chr3_+_119421849 0.98 ENST00000273390.5
ENST00000463700.1
MAATS1
MYCBP-associated, testis expressed 1
chr12_-_90049878 0.95 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr12_-_90049828 0.93 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr14_+_75988768 0.89 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr10_-_61900762 0.86 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_-_75017734 0.85 ENST00000532525.1
ARRB1
arrestin, beta 1
chr8_-_27462822 0.81 ENST00000522098.1
CLU
clusterin
chr1_-_165414414 0.65 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr8_-_10512569 0.62 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr1_+_201979645 0.56 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr14_+_75988851 0.56 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr17_-_4643114 0.49 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr17_+_4643337 0.48 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr11_-_119217365 0.47 ENST00000360167.4
ENST00000555262.1
ENST00000449574.2
ENST00000445041.2
MFRP
C1QTNF5
membrane frizzled-related protein
C1q and tumor necrosis factor related protein 5
chr13_+_73632897 0.47 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr17_+_4643300 0.46 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr10_-_49482907 0.45 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr19_-_51893827 0.45 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr5_+_64920543 0.45 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chrM_+_9207 0.44 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr6_-_53013620 0.40 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr1_+_22303503 0.37 ENST00000337107.6
CELA3B
chymotrypsin-like elastase family, member 3B
chr11_-_96076334 0.37 ENST00000524717.1
MAML2
mastermind-like 2 (Drosophila)
chr19_+_2476116 0.36 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr16_+_28722684 0.35 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr3_-_191000172 0.35 ENST00000427544.2
UTS2B
urotensin 2B
chr15_+_41221536 0.32 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chr19_-_19314162 0.32 ENST00000420605.3
ENST00000544883.1
ENST00000538165.2
ENST00000331552.7
NR2C2AP
nuclear receptor 2C2-associated protein
chr17_-_10633535 0.30 ENST00000341871.3
TMEM220
transmembrane protein 220
chr12_-_323689 0.25 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr7_-_122339162 0.25 ENST00000340112.2
RNF133
ring finger protein 133
chr16_-_68014732 0.24 ENST00000268793.4
DPEP3
dipeptidase 3
chr1_-_31230650 0.22 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr3_-_50388522 0.22 ENST00000232501.3
NPRL2
nitrogen permease regulator-like 2 (S. cerevisiae)
chr21_-_34915147 0.15 ENST00000381831.3
ENST00000381839.3
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr12_+_40787194 0.15 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr7_+_73868439 0.14 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr10_+_18240834 0.13 ENST00000377371.3
ENST00000539911.1
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr11_+_61522844 0.12 ENST00000265460.5
MYRF
myelin regulatory factor
chr9_+_12693336 0.12 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chrX_+_15767971 0.11 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr4_-_68620053 0.09 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr13_-_95131923 0.09 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chrX_-_48931648 0.08 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr18_-_3880051 0.07 ENST00000584874.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr7_+_73868220 0.07 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chr7_-_128415844 0.07 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr10_+_18240814 0.06 ENST00000377374.4
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr17_-_40021656 0.04 ENST00000319121.3
KLHL11
kelch-like family member 11
chr4_+_146560245 0.03 ENST00000541599.1
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr4_-_76912070 0.01 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1
chr10_+_18240753 0.01 ENST00000377369.2
SLC39A12
solute carrier family 39 (zinc transporter), member 12

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0030185 nitric oxide transport(GO:0030185)
0.2 1.9 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.2 0.9 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.8 GO:0061517 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 0.4 GO:0060018 astrocyte fate commitment(GO:0060018)
0.1 0.3 GO:0072554 blood vessel lumenization(GO:0072554)
0.1 0.8 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 3.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.4 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.6 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 1.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.6 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.0 GO:0003341 cilium movement(GO:0003341)
0.0 0.5 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.4 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.2 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 1.0 GO:0001534 radial spoke(GO:0001534)
0.3 2.9 GO:0036157 outer dynein arm(GO:0036157)
0.2 1.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.8 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 0.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0030492 hemoglobin binding(GO:0030492)
0.3 0.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 2.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.8 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 3.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters