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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for PITX3
Z-value: 0.99
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Transcription factors associated with PITX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX3 | hg19_v2_chr10_-_104001231_104001274 | -0.04 | 8.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrY_+_2709527 Show fit | 2.35 |
ENST00000250784.8
|
ribosomal protein S4, Y-linked 1 |
|
| chr17_-_38859996 Show fit | 1.81 |
ENST00000264651.2
|
keratin 24 |
|
| chr7_+_36429424 Show fit | 1.62 |
ENST00000396068.2
|
anillin, actin binding protein |
|
| chr4_-_120988229 Show fit | 1.41 |
ENST00000296509.6
|
MAD2 mitotic arrest deficient-like 1 (yeast) |
|
| chr11_-_102668879 Show fit | 1.36 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr8_-_27695552 Show fit | 1.23 |
ENST00000522944.1
ENST00000301905.4 |
PDZ binding kinase |
|
| chr20_+_25388293 Show fit | 1.22 |
ENST00000262460.4
ENST00000429262.2 |
GINS complex subunit 1 (Psf1 homolog) |
|
| chr10_+_115674530 Show fit | 1.21 |
ENST00000451472.1
|
CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein |
|
| chr22_-_42336209 Show fit | 1.21 |
ENST00000472374.2
|
centromere protein M |
|
| chr7_+_36429409 Show fit | 1.20 |
ENST00000265748.2
|
anillin, actin binding protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | GO:0070268 | cornification(GO:0070268) |
| 0.4 | 3.1 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.9 | 2.8 | GO:1904172 | regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172) |
| 0.1 | 2.7 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.0 | 2.7 | GO:0043486 | histone exchange(GO:0043486) |
| 0.0 | 2.7 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.2 | 2.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.3 | 2.5 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.2 | 2.5 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.0 | 2.2 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 4.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 3.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.6 | 2.8 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 2.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.1 | 2.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 2.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.2 | 2.0 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 1.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 1.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.9 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.3 | 2.5 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.1 | 2.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 2.2 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.0 | 1.9 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 1.8 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 1.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.6 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 1.6 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 1.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 4.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 3.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 1.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 5.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 4.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 2.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 2.7 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 2.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 1.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 1.5 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.1 | 1.5 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |