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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PKNOX2

Z-value: 0.64

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
PKNOX2
ENSG00000165495.11 PBX/knotted 1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PKNOX2hg19_v2_chr11_+_125034586_1250346040.057.9e-01Click!

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_149365827 3.89 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr16_+_2880296 3.50 ENST00000571723.1
ZG16B
zymogen granule protein 16B
chr16_+_2880157 3.48 ENST00000382280.3
ZG16B
zymogen granule protein 16B
chr16_+_2880369 3.45 ENST00000572863.1
ZG16B
zymogen granule protein 16B
chr16_+_2880254 3.41 ENST00000570670.1
ZG16B
zymogen granule protein 16B
chr2_-_73460334 1.97 ENST00000258083.2
PRADC1
protease-associated domain containing 1
chr11_+_6411670 1.95 ENST00000530395.1
ENST00000527275.1
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr11_+_6411636 1.86 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr14_-_54421190 1.81 ENST00000417573.1
BMP4
bone morphogenetic protein 4
chr5_-_139283982 1.38 ENST00000340391.3
NRG2
neuregulin 2
chr10_+_94608245 1.21 ENST00000443748.2
ENST00000260762.6
EXOC6
exocyst complex component 6
chr18_+_3449330 1.05 ENST00000549253.1
TGIF1
TGFB-induced factor homeobox 1
chr18_-_54305658 0.97 ENST00000586262.1
ENST00000217515.6
TXNL1
thioredoxin-like 1
chr21_-_34185944 0.96 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr6_+_138188551 0.95 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr2_-_202316260 0.89 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr7_-_137028534 0.88 ENST00000348225.2
PTN
pleiotrophin
chr17_+_68071458 0.86 ENST00000589377.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071389 0.86 ENST00000283936.1
ENST00000392671.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_-_137028498 0.82 ENST00000393083.2
PTN
pleiotrophin
chr4_+_166300084 0.81 ENST00000402744.4
CPE
carboxypeptidase E
chr4_+_3076388 0.80 ENST00000355072.5
HTT
huntingtin
chr1_+_170904612 0.77 ENST00000367759.4
ENST00000367758.3
MROH9
maestro heat-like repeat family member 9
chr15_+_57668695 0.77 ENST00000281282.5
CGNL1
cingulin-like 1
chr6_-_87804815 0.72 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr22_+_17082732 0.72 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1
transmembrane phosphatase with tensin homology pseudogene 1
chr6_+_29910301 0.71 ENST00000376809.5
ENST00000376802.2
HLA-A
major histocompatibility complex, class I, A
chr16_+_57481382 0.70 ENST00000564655.1
ENST00000567072.1
ENST00000567933.1
ENST00000563166.1
COQ9
coenzyme Q9
chr1_+_110577229 0.66 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr8_+_57124245 0.58 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
CHCHD7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr16_+_57481349 0.57 ENST00000262507.6
ENST00000565964.1
COQ9
coenzyme Q9
chr3_+_140981456 0.56 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr5_-_94620239 0.53 ENST00000515393.1
MCTP1
multiple C2 domains, transmembrane 1
chr5_+_125758813 0.53 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr14_-_21492113 0.52 ENST00000554094.1
NDRG2
NDRG family member 2
chr3_+_32147997 0.51 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr5_+_125758865 0.50 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr18_+_54318566 0.47 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr16_-_57481278 0.45 ENST00000567751.1
ENST00000568940.1
ENST00000563341.1
ENST00000565961.1
ENST00000569370.1
ENST00000567518.1
ENST00000565786.1
ENST00000394391.4
CIAPIN1
cytokine induced apoptosis inhibitor 1
chr14_-_21994525 0.45 ENST00000538754.1
SALL2
spalt-like transcription factor 2
chr4_-_157892167 0.44 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr1_-_54872059 0.43 ENST00000371320.3
SSBP3
single stranded DNA binding protein 3
chr3_+_185080908 0.43 ENST00000265026.3
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr16_-_30457048 0.42 ENST00000500504.2
ENST00000542752.1
SEPHS2
selenophosphate synthetase 2
chr13_+_33160553 0.41 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr15_-_37392086 0.41 ENST00000561208.1
MEIS2
Meis homeobox 2
chr2_-_74779744 0.39 ENST00000409249.1
LOXL3
lysyl oxidase-like 3
chr2_+_219524473 0.39 ENST00000439945.1
ENST00000431802.1
BCS1L
BC1 (ubiquinol-cytochrome c reductase) synthesis-like
chr19_+_41281416 0.38 ENST00000597140.1
MIA
melanoma inhibitory activity
chr4_-_157892498 0.38 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr19_+_41281060 0.37 ENST00000594436.1
ENST00000597784.1
MIA
melanoma inhibitory activity
chr17_-_26220366 0.37 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chrX_-_39923656 0.37 ENST00000413905.1
BCOR
BCL6 corepressor
chr5_-_81046904 0.36 ENST00000515395.1
SSBP2
single-stranded DNA binding protein 2
chr1_-_35658736 0.36 ENST00000357214.5
SFPQ
splicing factor proline/glutamine-rich
chr22_-_31885514 0.35 ENST00000397525.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr11_-_71810258 0.35 ENST00000544594.1
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chrX_+_16804544 0.35 ENST00000380122.5
ENST00000398155.4
TXLNG
taxilin gamma
chr19_+_41281282 0.34 ENST00000263369.3
MIA
melanoma inhibitory activity
chr2_-_219524193 0.34 ENST00000450560.1
ENST00000449707.1
ENST00000432460.1
ENST00000411696.2
ZNF142
zinc finger protein 142
chr6_+_111195973 0.33 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1
adenosylmethionine decarboxylase 1
chr5_-_81046841 0.33 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
SSBP2
single-stranded DNA binding protein 2
chr6_-_116575226 0.32 ENST00000420283.1
TSPYL4
TSPY-like 4
chr3_-_3221358 0.30 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN
cereblon
chr3_-_52719810 0.30 ENST00000424867.1
ENST00000394830.3
ENST00000431678.1
ENST00000450271.1
PBRM1
polybromo 1
chr1_-_179112189 0.30 ENST00000512653.1
ENST00000344730.3
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr2_-_74780176 0.30 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr6_-_149867122 0.29 ENST00000253329.2
PPIL4
peptidylprolyl isomerase (cyclophilin)-like 4
chr20_+_43514320 0.29 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr6_-_32140886 0.29 ENST00000395496.1
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr15_-_61521495 0.28 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr3_-_33481835 0.27 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr2_+_128848881 0.27 ENST00000259253.6
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr15_+_33010175 0.27 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr19_+_7733929 0.27 ENST00000221515.2
RETN
resistin
chr1_+_161736072 0.26 ENST00000367942.3
ATF6
activating transcription factor 6
chr4_-_46391805 0.26 ENST00000540012.1
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr4_-_157892055 0.25 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr19_+_36142147 0.25 ENST00000590618.1
COX6B1
cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
chr16_+_50776021 0.25 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr5_-_81046922 0.25 ENST00000514493.1
ENST00000320672.4
SSBP2
single-stranded DNA binding protein 2
chr1_+_154966058 0.24 ENST00000392487.1
LENEP
lens epithelial protein
chr17_-_35969409 0.24 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG
synergin, gamma
chr12_+_113495492 0.24 ENST00000257600.3
DTX1
deltex homolog 1 (Drosophila)
chr6_+_42123141 0.24 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr6_+_17600576 0.22 ENST00000259963.3
FAM8A1
family with sequence similarity 8, member A1
chr19_-_39735646 0.22 ENST00000413851.2
IFNL3
interferon, lambda 3
chr2_+_128848740 0.21 ENST00000375990.3
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr18_+_3449821 0.21 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr7_-_100253993 0.21 ENST00000461605.1
ENST00000160382.5
ACTL6B
actin-like 6B
chr20_-_3065362 0.21 ENST00000380293.3
AVP
arginine vasopressin
chr5_+_118407053 0.20 ENST00000311085.8
ENST00000539542.1
DMXL1
Dmx-like 1
chr20_-_61847586 0.20 ENST00000370339.3
YTHDF1
YTH domain family, member 1
chr16_+_88636789 0.20 ENST00000301011.5
ENST00000452588.2
ZC3H18
zinc finger CCCH-type containing 18
chr8_-_37594944 0.19 ENST00000330539.1
RP11-863K10.7
Uncharacterized protein
chr7_-_156803329 0.18 ENST00000252971.6
MNX1
motor neuron and pancreas homeobox 1
chr10_+_49514698 0.18 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
MAPK8
mitogen-activated protein kinase 8
chr2_-_61765315 0.16 ENST00000406957.1
ENST00000401558.2
XPO1
exportin 1 (CRM1 homolog, yeast)
chr10_+_51565188 0.16 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4
nuclear receptor coactivator 4
chr6_+_37225540 0.15 ENST00000373491.3
TBC1D22B
TBC1 domain family, member 22B
chr11_-_842509 0.15 ENST00000322028.4
POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr17_-_4046257 0.15 ENST00000381638.2
ZZEF1
zinc finger, ZZ-type with EF-hand domain 1
chr21_-_34185989 0.14 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr6_-_84418860 0.13 ENST00000521743.1
SNAP91
synaptosomal-associated protein, 91kDa
chr8_-_99837856 0.13 ENST00000518165.1
ENST00000419617.2
STK3
serine/threonine kinase 3
chr3_-_127541194 0.13 ENST00000453507.2
MGLL
monoglyceride lipase
chr18_+_54318616 0.12 ENST00000254442.3
WDR7
WD repeat domain 7
chr6_-_84418841 0.12 ENST00000369694.2
ENST00000195649.6
SNAP91
synaptosomal-associated protein, 91kDa
chr22_+_50946645 0.12 ENST00000420993.2
ENST00000395698.3
ENST00000395701.3
ENST00000523045.1
ENST00000299821.11
NCAPH2
non-SMC condensin II complex, subunit H2
chrX_-_71792477 0.11 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr17_-_42452063 0.11 ENST00000588098.1
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr9_-_79307096 0.10 ENST00000376717.2
ENST00000223609.6
ENST00000443509.2
PRUNE2
prune homolog 2 (Drosophila)
chr19_-_6424783 0.10 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr11_+_12132117 0.09 ENST00000256194.4
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr15_+_68346501 0.09 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr3_+_52828805 0.09 ENST00000416872.2
ENST00000449956.2
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr12_+_69201923 0.08 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr3_-_127541679 0.07 ENST00000265052.5
MGLL
monoglyceride lipase
chr12_+_49621658 0.07 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr11_-_132813566 0.07 ENST00000331898.7
OPCML
opioid binding protein/cell adhesion molecule-like
chr11_-_59383617 0.06 ENST00000263847.1
OSBP
oxysterol binding protein
chr3_+_52719936 0.06 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr8_+_133787586 0.06 ENST00000395379.1
ENST00000395386.2
ENST00000337920.4
PHF20L1
PHD finger protein 20-like 1
chr6_+_150070831 0.06 ENST00000367380.5
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr18_+_3449695 0.05 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr5_-_58882219 0.04 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_52405564 0.04 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
MOCS2
molybdenum cofactor synthesis 2
chr11_-_64013288 0.04 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_145549203 0.03 ENST00000355594.4
ENST00000544626.1
ANKRD35
ankyrin repeat domain 35
chr5_+_78985673 0.02 ENST00000446378.2
CMYA5
cardiomyopathy associated 5
chr4_+_140222609 0.02 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr17_-_40337470 0.01 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr5_-_132073111 0.00 ENST00000403231.1
KIF3A
kinesin family member 3A
chr5_-_127873896 0.00 ENST00000502468.1
FBN2
fibrillin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0071893 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.6 1.7 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.5 3.8 GO:0023021 termination of signal transduction(GO:0023021)
0.4 1.2 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
0.3 0.9 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.3 0.8 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.2 0.7 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 0.8 GO:0030070 insulin processing(GO:0030070)
0.2 0.5 GO:0097359 UDP-glucosylation(GO:0097359)
0.1 13.8 GO:0001895 retina homeostasis(GO:0001895)
0.1 0.4 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.4 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.3 GO:2000196 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.1 0.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.7 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.2 GO:0002125 maternal aggressive behavior(GO:0002125)
0.1 0.4 GO:0060620 regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.1 0.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 0.3 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.1 1.3 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 0.4 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.4 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.1 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 1.7 GO:0010107 potassium ion import(GO:0010107)
0.0 0.5 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0071301 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0 0.7 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.3 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.5 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.2 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) ribosomal small subunit export from nucleus(GO:0000056)
0.0 1.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.7 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.2 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 3.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 GO:0042599 lamellar body(GO:0042599)
0.1 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.2 GO:0043291 RAVE complex(GO:0043291)
0.1 0.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.0 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0044754 autolysosome(GO:0044754)
0.0 21.5 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.3 3.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 0.5 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 0.4 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 1.8 GO:0070700 co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700)
0.1 0.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.8 GO:0034452 dynactin binding(GO:0034452)
0.0 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.7 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 1.3 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 1.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 11.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 3.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.1 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 0.1 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.0 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 2.1 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.1 PID BMP PATHWAY BMP receptor signaling
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 3.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors