Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for PLAGL1
Z-value: 2.16
Motif logo
Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144385698_144385742 | 0.18 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 26.7 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.6 | 14.5 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 1.6 | 14.3 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 2.2 | 13.5 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.1 | 12.3 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.4 | 11.7 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 11.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.6 | 11.0 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.7 | 10.9 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.5 | 10.7 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 88.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 35.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.9 | 21.4 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 19.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.2 | 15.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.4 | 14.2 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 13.9 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 1.9 | 13.5 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 13.4 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 12.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 98.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 22.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 19.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 19.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 15.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 15.1 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 1.0 | 14.7 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.9 | 13.2 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.2 | 13.1 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 13.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 65.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 42.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 39.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 25.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 20.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 17.7 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.3 | 17.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 16.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 10.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 10.7 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 19.3 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.1 | 18.8 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 17.7 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.2 | 14.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.6 | 14.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 13.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.2 | 13.6 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 11.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 11.2 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |