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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for POU2F2_POU3F1
Z-value: 1.16
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F1 | hg19_v2_chr1_-_38512450_38512474 | 0.20 | 3.0e-01 | Click! |
| POU2F2 | hg19_v2_chr19_-_42636543_42636607 | 0.06 | 7.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_107078851 Show fit | 4.03 |
ENST00000390628.2
|
immunoglobulin heavy variable 1-58 |
|
| chr3_+_63638339 Show fit | 3.64 |
ENST00000343837.3
ENST00000469440.1 |
sentan, cilia apical structure protein |
|
| chr1_-_149858227 Show fit | 3.50 |
ENST00000369155.2
|
histone cluster 2, H2be |
|
| chr9_-_75567962 Show fit | 3.27 |
ENST00000297785.3
ENST00000376939.1 |
aldehyde dehydrogenase 1 family, member A1 |
|
| chr6_+_26124373 Show fit | 3.06 |
ENST00000377791.2
ENST00000602637.1 |
histone cluster 1, H2ac |
|
| chr1_-_183622442 Show fit | 2.68 |
ENST00000308641.4
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) |
|
| chr6_+_26217159 Show fit | 2.66 |
ENST00000303910.2
|
histone cluster 1, H2ae |
|
| chr6_+_27833034 Show fit | 2.52 |
ENST00000357320.2
|
histone cluster 1, H2al |
|
| chr19_-_44124019 Show fit | 2.47 |
ENST00000300811.3
|
zinc finger protein 428 |
|
| chr5_+_36608422 Show fit | 2.26 |
ENST00000381918.3
|
solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 7.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.4 | 7.5 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 6.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.5 | 5.8 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.0 | 4.5 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.1 | 3.8 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.8 | 3.3 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 0.9 | 2.6 | GO:0070668 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668) |
| 0.3 | 2.3 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 7.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 5.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 3.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 2.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 2.6 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.0 | 2.1 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 1.2 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 1.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.0 | GO:0033269 | internode region of axon(GO:0033269) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 7.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.5 | 5.8 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 1.0 | 5.0 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.3 | 4.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 2.8 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 2.7 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 0.3 | 2.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.5 | 1.9 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.0 | 1.8 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 3.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 3.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 28.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 4.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 3.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 2.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 2.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.7 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 1.6 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 1.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 1.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |