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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for POU3F2
Z-value: 1.62
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Transcription factors associated with POU3F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F2 | hg19_v2_chr6_+_99282570_99282591 | -0.63 | 1.8e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_63638339 Show fit | 12.19 |
ENST00000343837.3
ENST00000469440.1 |
sentan, cilia apical structure protein |
|
| chr2_+_228735763 Show fit | 11.30 |
ENST00000373666.2
|
dynein assembly factor with WDR repeat domains 1 |
|
| chr3_-_19975665 Show fit | 10.78 |
ENST00000295824.9
ENST00000389256.4 |
EF-hand domain family, member B |
|
| chr13_+_43355732 Show fit | 10.78 |
ENST00000313851.1
|
family with sequence similarity 216, member B |
|
| chr3_-_197686847 Show fit | 9.10 |
ENST00000265239.6
|
IQ motif containing G |
|
| chr4_-_16077741 Show fit | 8.01 |
ENST00000447510.2
ENST00000540805.1 ENST00000539194.1 |
prominin 1 |
|
| chr9_+_124922171 Show fit | 7.70 |
ENST00000373764.3
ENST00000536616.1 |
MORN repeat containing 5 |
|
| chr7_-_16921601 Show fit | 7.45 |
ENST00000402239.3
ENST00000310398.2 ENST00000414935.1 |
anterior gradient 3 |
|
| chr6_-_32557610 Show fit | 7.25 |
ENST00000360004.5
|
major histocompatibility complex, class II, DR beta 1 |
|
| chr1_+_111888890 Show fit | 7.19 |
ENST00000369738.4
|
primary cilia formation |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 36.7 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.3 | 21.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 4.6 | 13.9 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 1.3 | 12.9 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.1 | 12.1 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.1 | 11.7 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.6 | 9.2 | GO:0042737 | drug catabolic process(GO:0042737) |
| 2.0 | 8.0 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 1.5 | 7.7 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.1 | 7.7 | GO:0042073 | intraciliary transport(GO:0042073) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 32.6 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 1.0 | 21.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 2.5 | 17.3 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 16.9 | GO:0005929 | cilium(GO:0005929) |
| 0.1 | 16.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 14.0 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 13.0 | GO:0005814 | centriole(GO:0005814) |
| 0.5 | 8.4 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.3 | 8.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 6.8 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.5 | GO:0042805 | actinin binding(GO:0042805) |
| 0.6 | 14.0 | GO:0070330 | aromatase activity(GO:0070330) |
| 3.5 | 13.9 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.4 | 13.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.3 | 13.0 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 11.5 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 9.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.6 | 8.0 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 1.0 | 7.9 | GO:0032554 | purine deoxyribonucleotide binding(GO:0032554) |
| 0.3 | 7.9 | GO:0002162 | dystroglycan binding(GO:0002162) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 4.2 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 4.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 4.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 3.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 3.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 3.0 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 2.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 20.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.8 | 18.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.2 | 16.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.6 | 11.1 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.2 | 7.9 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 5.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.6 | 5.1 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.1 | 5.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 5.0 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 4.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |