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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for POU4F2

Z-value: 0.47

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU class 4 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg19_v2_chr4_+_147560042_147560046-0.281.3e-01Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_89746173 0.91 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr1_-_182641367 0.88 ENST00000508450.1
RGS8
regulator of G-protein signaling 8
chr4_+_169013666 0.86 ENST00000359299.3
ANXA10
annexin A10
chr4_-_47983519 0.73 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
CNGA1
cyclic nucleotide gated channel alpha 1
chr4_+_159443090 0.73 ENST00000343542.5
ENST00000470033.1
RXFP1
relaxin/insulin-like family peptide receptor 1
chr13_-_36050819 0.70 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr11_-_107729887 0.70 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr21_-_31859755 0.68 ENST00000334055.3
KRTAP19-2
keratin associated protein 19-2
chr5_+_154393260 0.66 ENST00000435029.4
KIF4B
kinesin family member 4B
chr3_+_63428752 0.61 ENST00000295894.5
SYNPR
synaptoporin
chr3_+_121774202 0.60 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr7_-_25268104 0.53 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr11_+_118175132 0.50 ENST00000361763.4
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr21_-_32185570 0.49 ENST00000329621.4
KRTAP8-1
keratin associated protein 8-1
chr21_-_31864275 0.49 ENST00000334063.4
KRTAP19-3
keratin associated protein 19-3
chr6_-_109777128 0.48 ENST00000358807.3
ENST00000358577.3
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr14_+_42077552 0.47 ENST00000554120.1
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr4_+_144354644 0.45 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr6_-_25874440 0.42 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr2_+_191792376 0.41 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr20_+_48909240 0.41 ENST00000371639.3
RP11-290F20.1
RP11-290F20.1
chr4_+_169418255 0.40 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr8_-_49833978 0.39 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr12_-_30887948 0.37 ENST00000433722.2
CAPRIN2
caprin family member 2
chr8_-_49834299 0.36 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr2_-_158300556 0.35 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr9_+_125133315 0.32 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr17_-_79623597 0.31 ENST00000574024.1
ENST00000331056.5
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr18_+_32455201 0.30 ENST00000590831.2
DTNA
dystrobrevin, alpha
chr14_+_22356029 0.29 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr4_-_138453606 0.27 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr20_-_50419055 0.27 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr4_-_10686373 0.26 ENST00000442825.2
CLNK
cytokine-dependent hematopoietic cell linker
chr2_-_70780572 0.24 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr5_-_140998481 0.24 ENST00000518047.1
DIAPH1
diaphanous-related formin 1
chr16_-_20416053 0.23 ENST00000302451.4
PDILT
protein disulfide isomerase-like, testis expressed
chr8_+_22857048 0.23 ENST00000251822.6
RHOBTB2
Rho-related BTB domain containing 2
chr5_-_140998616 0.22 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
DIAPH1
diaphanous-related formin 1
chr3_-_51909600 0.22 ENST00000446461.1
IQCF5
IQ motif containing F5
chr11_-_125550764 0.22 ENST00000527795.1
ACRV1
acrosomal vesicle protein 1
chr20_+_56136136 0.21 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr4_-_10686475 0.21 ENST00000226951.6
CLNK
cytokine-dependent hematopoietic cell linker
chr1_+_50574585 0.21 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr17_-_33390667 0.21 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr12_-_7596735 0.20 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
CD163L1
CD163 molecule-like 1
chr7_-_81399329 0.19 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_+_130339710 0.19 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr14_+_55221541 0.19 ENST00000555192.1
SAMD4A
sterile alpha motif domain containing 4A
chr8_-_131399110 0.19 ENST00000521426.1
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr9_+_125132803 0.19 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_-_41481135 0.18 ENST00000528697.1
ENST00000530763.1
LRRC4C
leucine rich repeat containing 4C
chr9_+_77230499 0.17 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr6_+_12717892 0.16 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr4_+_169418195 0.16 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr5_+_66300446 0.16 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr8_+_50824233 0.16 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr1_+_40506392 0.16 ENST00000414893.1
ENST00000414281.1
ENST00000420216.1
ENST00000372792.2
ENST00000372798.1
ENST00000340450.3
ENST00000372805.3
ENST00000435719.1
ENST00000427843.1
ENST00000417287.1
ENST00000424977.1
ENST00000446031.1
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr14_+_23727694 0.16 ENST00000399905.1
ENST00000470456.1
C14orf164
chromosome 14 open reading frame 164
chr3_-_58613323 0.16 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr16_+_89228757 0.16 ENST00000565008.1
LINC00304
long intergenic non-protein coding RNA 304
chr11_+_31531291 0.15 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr1_-_204183071 0.14 ENST00000308302.3
GOLT1A
golgi transport 1A
chr8_+_7738726 0.13 ENST00000314357.3
DEFB103A
defensin, beta 103A
chr14_+_32030582 0.13 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr17_-_7832753 0.13 ENST00000303790.2
KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr8_-_7287870 0.11 ENST00000318124.3
DEFB103B
defensin, beta 103B
chr3_+_159557637 0.10 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr4_+_159442878 0.10 ENST00000307765.5
ENST00000423548.1
RXFP1
relaxin/insulin-like family peptide receptor 1
chr19_-_10446449 0.10 ENST00000592439.1
ICAM3
intercellular adhesion molecule 3
chr13_+_46039037 0.10 ENST00000349995.5
COG3
component of oligomeric golgi complex 3
chr1_-_182640988 0.10 ENST00000367556.1
RGS8
regulator of G-protein signaling 8
chr1_-_182641037 0.09 ENST00000483095.2
RGS8
regulator of G-protein signaling 8
chr19_-_7698599 0.09 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr1_-_193028426 0.09 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr12_-_118797475 0.09 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr1_-_47655686 0.09 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr1_-_193028632 0.09 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr11_-_125550726 0.08 ENST00000315608.3
ENST00000530048.1
ACRV1
acrosomal vesicle protein 1
chr19_-_7697857 0.08 ENST00000598935.1
PCP2
Purkinje cell protein 2
chrX_-_18690210 0.07 ENST00000379984.3
RS1
retinoschisin 1
chr10_-_99205607 0.07 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr4_-_169401628 0.07 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr6_-_139308777 0.07 ENST00000529597.1
ENST00000415951.2
ENST00000367663.4
ENST00000409812.2
REPS1
RALBP1 associated Eps domain containing 1
chrX_-_106146547 0.07 ENST00000276173.4
ENST00000411805.1
RIPPLY1
ripply transcriptional repressor 1
chr1_-_193028621 0.06 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chrX_+_139791917 0.06 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chrX_+_68835911 0.06 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr9_-_14308004 0.06 ENST00000493697.1
NFIB
nuclear factor I/B
chr6_+_118869452 0.06 ENST00000357525.5
PLN
phospholamban
chr4_-_123542224 0.05 ENST00000264497.3
IL21
interleukin 21
chr6_+_10521574 0.05 ENST00000495262.1
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr1_-_44482979 0.05 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_+_95372289 0.05 ENST00000371447.3
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chrX_-_133931164 0.05 ENST00000370790.1
ENST00000298090.6
FAM122B
family with sequence similarity 122B
chr1_+_193028552 0.04 ENST00000400968.2
ENST00000432079.1
TROVE2
TROVE domain family, member 2
chr4_+_78432907 0.03 ENST00000286758.4
CXCL13
chemokine (C-X-C motif) ligand 13
chr6_-_138820624 0.02 ENST00000343505.5
NHSL1
NHS-like 1
chr5_-_87516448 0.02 ENST00000511218.1
TMEM161B
transmembrane protein 161B
chr10_+_18549645 0.02 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr17_-_64225508 0.02 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_+_73498898 0.02 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr14_-_51027838 0.01 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr5_-_58295712 0.01 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_159443024 0.01 ENST00000448688.2
RXFP1
relaxin/insulin-like family peptide receptor 1
chr10_+_99205959 0.01 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr4_+_141264597 0.00 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr3_+_115342349 0.00 ENST00000393780.3
GAP43
growth associated protein 43

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.7 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2 0.6 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.2 0.5 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.5 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 0.4 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.1 0.5 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 1.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.4 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 1.0 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.2 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.1 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.0 0.1 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.2 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.2 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.4 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.2 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.7 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.4 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.5 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.4 GO:0030553 cGMP binding(GO:0030553)
0.0 0.4 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.6 GO:0015026 coreceptor activity(GO:0015026)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.5 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR