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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for POU5F1_POU2F3
Z-value: 0.98
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F3 | hg19_v2_chr11_+_120107344_120107351 | -0.59 | 6.1e-04 | Click! |
| POU5F1 | hg19_v2_chr6_-_31138439_31138475 | 0.40 | 2.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153044083 Show fit | 6.33 |
ENST00000341611.2
|
small proline-rich protein 2B |
|
| chr1_-_153029980 Show fit | 6.08 |
ENST00000392653.2
|
small proline-rich protein 2A |
|
| chr1_-_153066998 Show fit | 5.25 |
ENST00000368750.3
|
small proline-rich protein 2E |
|
| chr1_-_153013588 Show fit | 4.66 |
ENST00000360379.3
|
small proline-rich protein 2D |
|
| chr2_-_113594279 Show fit | 4.35 |
ENST00000416750.1
ENST00000418817.1 ENST00000263341.2 |
interleukin 1, beta |
|
| chr9_+_132099158 Show fit | 3.75 |
ENST00000444125.1
|
RP11-65J3.1 |
|
| chr19_-_50143452 Show fit | 3.43 |
ENST00000246792.3
|
related RAS viral (r-ras) oncogene homolog |
|
| chr1_+_17575584 Show fit | 2.71 |
ENST00000375460.3
|
peptidyl arginine deiminase, type III |
|
| chr20_+_361890 Show fit | 2.62 |
ENST00000449710.1
ENST00000422053.2 |
tribbles pseudokinase 3 |
|
| chr17_+_62461569 Show fit | 2.61 |
ENST00000603557.1
ENST00000605096.1 |
mast cell immunoglobulin-like receptor 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.3 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 14.0 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.0 | 7.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 6.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 6.1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 5.8 | GO:0031640 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.2 | 5.0 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.1 | 4.8 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
| 1.4 | 4.3 | GO:0060559 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 0.1 | 4.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 16.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 8.9 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 4.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 2.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 2.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 2.4 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.6 | 2.3 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.9 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 17.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.3 | 6.1 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.2 | 5.4 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.3 | 5.2 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.3 | 5.2 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.0 | 5.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 3.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.5 | 3.7 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.1 | 3.7 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.7 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 4.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 3.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.3 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.7 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.5 | 5.6 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 4.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 4.5 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 4.4 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 3.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 3.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 3.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 3.0 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |