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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for POU6F1

Z-value: 0.54

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
ENSG00000184271.11 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg19_v2_chr12_-_51611477_516116120.251.8e-01Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_151646800 2.02 ENST00000354675.6
A kinase (PRKA) anchor protein 12
chr1_-_153123345 1.12 ENST00000368748.4
small proline-rich protein 2G
chr1_-_197115818 0.87 ENST00000367409.4
ENST00000294732.7
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr9_+_128509624 0.87 ENST00000342287.5
ENST00000373487.4
pre-B-cell leukemia homeobox 3
chr1_-_47655686 0.80 ENST00000294338.2
PDZK1 interacting protein 1
chr7_-_83824169 0.78 ENST00000265362.4
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr12_-_30887948 0.78 ENST00000433722.2
caprin family member 2
chr6_-_110501200 0.77 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WAS protein family, member 1
chr2_+_115219171 0.72 ENST00000409163.1
dipeptidyl-peptidase 10 (non-functional)
chr2_+_191045562 0.72 ENST00000340623.4
chromosome 2 open reading frame 88
chr8_+_118147498 0.71 ENST00000519688.1
ENST00000456015.2
solute carrier family 30 (zinc transporter), member 8
chr8_+_39792474 0.71 ENST00000502986.2
indoleamine 2,3-dioxygenase 2
chr2_+_128403720 0.67 ENST00000272644.3
G protein-coupled receptor 17
chr13_+_107029084 0.67 ENST00000444865.1
long intergenic non-protein coding RNA 460
chr2_+_128403439 0.67 ENST00000544369.1
G protein-coupled receptor 17
chr2_+_191045656 0.66 ENST00000443551.2
chromosome 2 open reading frame 88
chr16_+_15744078 0.60 ENST00000396354.1
ENST00000570727.1
nudE neurodevelopment protein 1
chr3_+_46395219 0.57 ENST00000445132.2
ENST00000292301.4
chemokine (C-C motif) receptor 2
chr12_+_15699286 0.57 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
protein tyrosine phosphatase, receptor type, O
chr4_+_130692778 0.55 ENST00000513875.1
ENST00000508724.1
RP11-422J15.1
chr7_+_80267973 0.54 ENST00000394788.3
ENST00000447544.2
CD36 molecule (thrombospondin receptor)
chr16_-_58718611 0.49 ENST00000564100.1
ENST00000570101.1
solute carrier family 38, member 7
chr20_-_50419055 0.49 ENST00000217086.4
spalt-like transcription factor 4
chr8_-_10512569 0.48 ENST00000382483.3
retinitis pigmentosa 1-like 1
chr6_+_26183958 0.47 ENST00000356530.3
histone cluster 1, H2be
chr7_-_38407770 0.47 ENST00000390348.2
T cell receptor gamma variable 1 (non-functional)
chr11_-_107729887 0.47 ENST00000525815.1
solute carrier family 35, member F2
chr4_+_106631966 0.45 ENST00000360505.5
ENST00000510865.1
ENST00000509336.1
glutathione S-transferase, C-terminal domain containing
chr6_+_29274403 0.45 ENST00000377160.2
olfactory receptor, family 14, subfamily J, member 1
chr12_+_102514019 0.44 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARP1 binding protein
chr11_-_2323089 0.41 ENST00000456145.2
chromosome 11 open reading frame 21
chr12_+_102513950 0.36 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARP1 binding protein
chr7_+_141490017 0.35 ENST00000247883.4
taste receptor, type 2, member 5
chr6_+_25754927 0.34 ENST00000377905.4
ENST00000439485.2
solute carrier family 17, member 4
chr22_-_32767017 0.34 ENST00000400234.1
RFPL3 antisense
chr19_+_52076425 0.33 ENST00000436511.2
zinc finger protein 175
chr4_+_110749143 0.33 ENST00000317735.4
retinal pigment epithelium-derived rhodopsin homolog
chr11_+_49050504 0.33 ENST00000332682.7
tripartite motif containing 49B
chr2_+_202937972 0.32 ENST00000541917.1
ENST00000295844.3
uncharacterized protein KIAA2012
chr16_-_87350970 0.31 ENST00000567970.1
chromosome 16 open reading frame 95
chr9_-_131644306 0.31 ENST00000302586.3
cysteine conjugate-beta lyase, cytoplasmic
chr2_+_11679963 0.31 ENST00000263834.5
growth regulation by estrogen in breast cancer 1
chr16_-_87351022 0.30 ENST00000253461.4
chromosome 16 open reading frame 95
chr5_+_115177178 0.30 ENST00000316788.7
adaptor-related protein complex 3, sigma 1 subunit
chrX_+_43515467 0.29 ENST00000338702.3
ENST00000542639.1
monoamine oxidase A
chr1_+_225140372 0.28 ENST00000366848.1
ENST00000439375.2
dynein, axonemal, heavy chain 14
chr15_-_31283618 0.27 ENST00000563714.1
myotubularin related protein 10
chr9_-_131644202 0.27 ENST00000320665.6
ENST00000436267.2
cysteine conjugate-beta lyase, cytoplasmic
chr2_-_166060571 0.26 ENST00000360093.3
sodium channel, voltage-gated, type III, alpha subunit
chr1_+_225117350 0.26 ENST00000413949.2
ENST00000430092.1
ENST00000366850.3
ENST00000400952.3
ENST00000366849.1
dynein, axonemal, heavy chain 14
chr2_-_166060552 0.26 ENST00000283254.7
ENST00000453007.1
sodium channel, voltage-gated, type III, alpha subunit
chr1_+_171107241 0.25 ENST00000236166.3
flavin containing monooxygenase 6 pseudogene
chr13_+_58206655 0.21 ENST00000377918.3
protocadherin 17
chr13_+_30510003 0.21 ENST00000400540.1
long intergenic non-protein coding RNA 544
chr22_-_22307199 0.20 ENST00000397495.4
ENST00000263212.5
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr1_-_106161540 0.19 ENST00000420901.1
ENST00000610126.1
ENST00000435253.2
RP11-251P6.1
chr3_-_108248169 0.19 ENST00000273353.3
myosin, heavy chain 15
chr4_+_78829479 0.19 ENST00000504901.1
mitochondrial ribosomal protein L1
chr17_-_40337470 0.18 ENST00000293330.1
hypocretin (orexin) neuropeptide precursor
chr11_-_4414880 0.18 ENST00000254436.7
ENST00000543625.1
tripartite motif containing 21
chr13_+_98612446 0.17 ENST00000496368.1
ENST00000421861.2
ENST00000357602.3
importin 5
chr1_+_176432298 0.17 ENST00000367661.3
ENST00000367662.3
pappalysin 2
chr12_+_10460417 0.17 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
killer cell lectin-like receptor subfamily D, member 1
chr1_+_113010056 0.16 ENST00000369686.5
wingless-type MMTV integration site family, member 2B
chr12_-_7596735 0.16 ENST00000416109.2
ENST00000396630.1
ENST00000313599.3
CD163 molecule-like 1
chr3_+_77088989 0.15 ENST00000461745.1
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr13_-_52027134 0.14 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
integrator complex subunit 6
chr15_-_85259360 0.14 ENST00000559729.1
SEC11 homolog A (S. cerevisiae)
chr9_+_131644398 0.13 ENST00000372599.3
leucine rich repeat containing 8 family, member A
chr1_-_243326612 0.13 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
centrosomal protein 170kDa
chr9_-_13165457 0.13 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
multiple PDZ domain protein
chr11_+_85339623 0.12 ENST00000358867.6
ENST00000534341.1
ENST00000393375.1
ENST00000531274.1
transmembrane protein 126B
chr19_-_3786253 0.12 ENST00000585778.1
megakaryocyte-associated tyrosine kinase
chr9_+_131644388 0.12 ENST00000372600.4
leucine rich repeat containing 8 family, member A
chr19_-_3786354 0.11 ENST00000395040.2
ENST00000310132.6
megakaryocyte-associated tyrosine kinase
chr6_-_47009996 0.10 ENST00000371243.2
G protein-coupled receptor 110
chr6_-_138539627 0.10 ENST00000527246.2
prostate and breast cancer overexpressed 1
chr2_-_99917639 0.10 ENST00000308528.4
lysozyme G-like 1
chr18_+_61554932 0.10 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr12_-_95397442 0.10 ENST00000547157.1
ENST00000547986.1
ENST00000327772.2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr11_+_2323349 0.10 ENST00000381121.3
tetraspanin 32
chr4_+_113970772 0.10 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr13_+_107028897 0.10 ENST00000439790.1
ENST00000435024.1
long intergenic non-protein coding RNA 460
chr15_+_80351977 0.09 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
zinc finger, AN1-type domain 6
chr17_-_39165366 0.09 ENST00000391588.1
keratin associated protein 3-1
chr11_-_65149422 0.09 ENST00000526432.1
ENST00000527174.1
solute carrier family 25, member 45
chr4_-_120222076 0.08 ENST00000504110.1
chromosome 4 open reading frame 3
chr1_-_89641680 0.08 ENST00000294671.2
guanylate binding protein 7
chrX_+_119737806 0.08 ENST00000371317.5
malignant T cell amplified sequence 1
chr4_-_130692631 0.08 ENST00000500092.2
ENST00000509105.1
RP11-519M16.1
chr12_-_108954933 0.07 ENST00000431469.2
ENST00000546815.1
squamous cell carcinoma antigen recognized by T cells 3
chr10_-_43904235 0.07 ENST00000356053.3
heterogeneous nuclear ribonucleoprotein F
chr15_-_85259294 0.07 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
SEC11 homolog A (S. cerevisiae)
chr15_+_80351910 0.07 ENST00000261749.6
ENST00000561060.1
zinc finger, AN1-type domain 6
chr10_+_97803151 0.07 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
cyclin J
chr15_-_85259330 0.07 ENST00000560266.1
SEC11 homolog A (S. cerevisiae)
chr1_-_21377383 0.07 ENST00000374935.3
eukaryotic translation initiation factor 4 gamma, 3
chr7_+_148287657 0.07 ENST00000307003.2
chromosome 7 open reading frame 33
chrX_-_100129128 0.06 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NADPH oxidase 1
chr15_-_85259384 0.06 ENST00000455959.3
SEC11 homolog A (S. cerevisiae)
chr12_+_54892550 0.05 ENST00000545638.2
NCK-associated protein 1-like
chr11_+_2323236 0.05 ENST00000182290.4
tetraspanin 32
chr12_-_108955070 0.05 ENST00000228284.3
ENST00000546611.1
squamous cell carcinoma antigen recognized by T cells 3
chr2_-_202562716 0.04 ENST00000428900.2
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr11_-_65381643 0.04 ENST00000309100.3
ENST00000529839.1
ENST00000526293.1
mitogen-activated protein kinase kinase kinase 11
chr17_-_39677971 0.04 ENST00000393976.2
keratin 15
chr4_+_123161120 0.04 ENST00000446180.1
KIAA1109
chr4_-_169401628 0.04 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr6_+_42123141 0.03 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr13_+_49551020 0.03 ENST00000541916.1
fibronectin type III domain containing 3A
chr2_-_202563414 0.03 ENST00000409474.3
ENST00000315506.7
ENST00000359962.5
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr2_+_207220463 0.03 ENST00000598562.1
Uncharacterized protein
chr8_-_146176199 0.02 ENST00000532351.1
ENST00000276816.4
ENST00000394909.2
zinc finger protein 16
chr4_-_76912070 0.02 ENST00000395711.4
ENST00000356260.5
SDA1 domain containing 1
chr2_-_202562774 0.01 ENST00000396886.3
ENST00000409143.1
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr18_+_9475001 0.00 ENST00000019317.4
ralA binding protein 1
chr18_+_52495426 0.00 ENST00000262094.5
RAB27B, member RAS oncogene family
chr1_-_153538292 0.00 ENST00000497140.1
ENST00000368708.3
S100 calcium binding protein A2

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 0.6 GO:2000439 negative regulation of eosinophil activation(GO:1902567) positive regulation of monocyte extravasation(GO:2000439)
0.2 0.6 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 0.5 GO:0089709 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.2 0.8 GO:0048880 sensory system development(GO:0048880)
0.1 2.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.9 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.5 GO:0070543 response to linoleic acid(GO:0070543)
0.1 1.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 0.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.7 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 0.7 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 0.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.2 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.0 0.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.6 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309) regulation of SA node cell action potential(GO:0098907)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.3 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.2 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.2 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.2 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.8 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.2 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0 0.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.4 GO:0007635 chemosensory behavior(GO:0007635)
0.0 0.1 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.3 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 2.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.5 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.1 0.5 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 1.3 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.5 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.0 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle