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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PRDM14

Z-value: 0.26

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.3 PR/SET domain 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_709835620.038.6e-01Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_55866997 0.60 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr4_-_103266626 0.33 ENST00000356736.4
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr19_+_49838653 0.21 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr2_-_69098566 0.21 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr2_+_101437487 0.18 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chrX_+_15525426 0.18 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr12_-_49351228 0.17 ENST00000541959.1
ENST00000447318.2
ARF3
ADP-ribosylation factor 3
chr9_+_132099158 0.17 ENST00000444125.1
RP11-65J3.1
RP11-65J3.1
chr17_+_41924511 0.15 ENST00000377203.4
ENST00000539718.1
ENST00000588884.1
ENST00000293396.8
ENST00000586233.1
CD300LG
CD300 molecule-like family member g
chr2_-_228244013 0.15 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chrX_+_41193407 0.14 ENST00000457138.2
ENST00000441189.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr12_+_56325812 0.14 ENST00000394147.1
ENST00000551156.1
ENST00000553783.1
ENST00000557080.1
ENST00000432422.3
ENST00000556001.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr14_+_89290965 0.13 ENST00000345383.5
ENST00000536576.1
ENST00000346301.4
ENST00000338104.6
ENST00000354441.6
ENST00000380656.2
ENST00000556651.1
ENST00000554686.1
TTC8
tetratricopeptide repeat domain 8
chr12_-_49351148 0.12 ENST00000398092.4
ENST00000539611.1
RP11-302B13.5
ARF3
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr6_-_46048116 0.11 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr12_-_49351303 0.11 ENST00000256682.4
ARF3
ADP-ribosylation factor 3
chr7_-_139763521 0.11 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr1_+_36621529 0.10 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr7_+_150211918 0.10 ENST00000313543.4
GIMAP7
GTPase, IMAP family member 7
chr10_+_12171721 0.10 ENST00000379020.4
ENST00000379017.3
SEC61A2
Sec61 alpha 2 subunit (S. cerevisiae)
chr19_-_53757941 0.10 ENST00000594517.1
ENST00000601413.1
ENST00000594681.1
ZNF677
zinc finger protein 677
chr10_+_12171636 0.10 ENST00000379051.1
ENST00000379033.3
ENST00000441368.1
ENST00000298428.9
ENST00000304267.8
SEC61A2
Sec61 alpha 2 subunit (S. cerevisiae)
chr19_+_3572758 0.10 ENST00000416526.1
HMG20B
high mobility group 20B
chr17_-_46692287 0.10 ENST00000239144.4
HOXB8
homeobox B8
chr22_-_29457832 0.10 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr9_+_132597722 0.09 ENST00000372429.3
ENST00000315480.4
ENST00000358355.1
USP20
ubiquitin specific peptidase 20
chr2_-_192711968 0.09 ENST00000304141.4
SDPR
serum deprivation response
chr7_-_30066233 0.09 ENST00000222803.5
FKBP14
FK506 binding protein 14, 22 kDa
chr5_+_32710736 0.08 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr17_+_39994032 0.08 ENST00000293303.4
ENST00000438813.1
KLHL10
kelch-like family member 10
chrX_+_119292467 0.08 ENST00000371388.3
RHOXF2
Rhox homeobox family, member 2
chr11_-_65625014 0.07 ENST00000534784.1
CFL1
cofilin 1 (non-muscle)
chr7_-_124405681 0.07 ENST00000303921.2
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr11_+_15136462 0.07 ENST00000379556.3
ENST00000424273.1
INSC
inscuteable homolog (Drosophila)
chr3_-_155394152 0.07 ENST00000494598.1
PLCH1
phospholipase C, eta 1
chr4_+_4861385 0.07 ENST00000382723.4
MSX1
msh homeobox 1
chr5_-_16936340 0.07 ENST00000507288.1
ENST00000513610.1
MYO10
myosin X
chr19_+_39109735 0.07 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3, subunit K
chr17_-_46691990 0.07 ENST00000576562.1
HOXB8
homeobox B8
chr17_+_36873677 0.06 ENST00000471200.1
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr15_+_63188009 0.06 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr17_+_75450075 0.06 ENST00000592951.1
SEPT9
septin 9
chr5_+_32711419 0.06 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr6_+_72926145 0.06 ENST00000425662.2
ENST00000453976.2
RIMS1
regulating synaptic membrane exocytosis 1
chr5_-_108063949 0.06 ENST00000606054.1
LINC01023
long intergenic non-protein coding RNA 1023
chr2_-_208030647 0.06 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_-_27216729 0.06 ENST00000431781.2
ENST00000374135.4
GPN2
GPN-loop GTPase 2
chr11_-_65624415 0.05 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr20_-_48770174 0.05 ENST00000341698.2
TMEM189-UBE2V1
TMEM189-UBE2V1 readthrough
chr4_-_10458982 0.05 ENST00000326756.3
ZNF518B
zinc finger protein 518B
chr11_+_85566422 0.04 ENST00000342404.3
CCDC83
coiled-coil domain containing 83
chr3_-_47517302 0.04 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr6_-_109777128 0.04 ENST00000358807.3
ENST00000358577.3
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr18_+_57567180 0.04 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr17_-_17485731 0.03 ENST00000395783.1
PEMT
phosphatidylethanolamine N-methyltransferase
chr3_-_143567262 0.03 ENST00000474151.1
ENST00000316549.6
SLC9A9
solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
chr17_-_19651654 0.03 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_+_47653178 0.03 ENST00000328741.5
NXPH3
neurexophilin 3
chr2_-_145277882 0.03 ENST00000465070.1
ENST00000444559.1
ZEB2
zinc finger E-box binding homeobox 2
chr7_-_44580861 0.03 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr11_-_46615498 0.03 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr15_+_69850521 0.02 ENST00000558781.1
RP11-279F6.1
RP11-279F6.1
chr1_-_155006224 0.02 ENST00000368424.3
DCST2
DC-STAMP domain containing 2
chr12_+_3600356 0.02 ENST00000382622.3
PRMT8
protein arginine methyltransferase 8
chr1_+_155006300 0.02 ENST00000295542.1
ENST00000392480.1
ENST00000423025.2
ENST00000368419.2
DCST1
DC-STAMP domain containing 1
chr1_+_156052354 0.02 ENST00000368301.2
LMNA
lamin A/C
chr1_+_50571949 0.02 ENST00000357083.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr3_+_10289707 0.02 ENST00000287652.4
TATDN2
TatD DNase domain containing 2
chr1_+_65730385 0.02 ENST00000263441.7
ENST00000395325.3
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr20_-_3154162 0.02 ENST00000360342.3
LZTS3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr4_+_81187753 0.02 ENST00000312465.7
ENST00000456523.3
FGF5
fibroblast growth factor 5
chr17_-_19651668 0.01 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr11_+_62475130 0.01 ENST00000294117.5
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr8_-_102216925 0.01 ENST00000517844.1
ZNF706
zinc finger protein 706
chr1_-_116383322 0.01 ENST00000429731.1
NHLH2
nescient helix loop helix 2
chr8_+_110346546 0.00 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
ENY2
enhancer of yellow 2 homolog (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.3 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.1 GO:0048808 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.1 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 0.1 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.1 GO:2000771 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.1 GO:0050893 sensory processing(GO:0050893)
0.0 0.0 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034464 BBSome(GO:0034464)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.0 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.0 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters