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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PROX1

Z-value: 0.71

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Transcription factors associated with PROX1

Gene Symbol Gene ID Gene Info
PROX1
ENSG00000117707.11 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PROX1hg19_v2_chr1_+_214161272_2141613220.261.6e-01Click!

Activity profile of PROX1 motif

Sorted Z-values of PROX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrY_+_22918021 5.23 ENST00000288666.5
RPS4Y2
ribosomal protein S4, Y-linked 2
chr20_-_7921090 2.50 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_35992270 1.32 ENST00000394602.2
ENST00000355574.2
SLC26A8
solute carrier family 26 (anion exchanger), member 8
chr5_-_156569850 1.03 ENST00000524219.1
HAVCR2
hepatitis A virus cellular receptor 2
chr17_+_42081914 0.88 ENST00000293404.3
ENST00000589767.1
NAGS
N-acetylglutamate synthase
chr10_-_121296045 0.81 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr5_-_157002775 0.79 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr15_-_91537723 0.78 ENST00000394249.3
ENST00000559811.1
ENST00000442656.2
ENST00000557905.1
ENST00000361919.3
PRC1
protein regulator of cytokinesis 1
chr20_+_30028322 0.74 ENST00000376309.3
DEFB123
defensin, beta 123
chr1_-_202311088 0.73 ENST00000367274.4
UBE2T
ubiquitin-conjugating enzyme E2T (putative)
chr18_+_2571510 0.73 ENST00000261597.4
ENST00000575515.1
NDC80
NDC80 kinetochore complex component
chr7_+_48128316 0.72 ENST00000341253.4
UPP1
uridine phosphorylase 1
chr7_+_48128194 0.71 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
UPP1
uridine phosphorylase 1
chr9_+_132096166 0.67 ENST00000436710.1
RP11-65J3.1
RP11-65J3.1
chr2_+_128403439 0.61 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr2_+_128403720 0.60 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr10_+_14920843 0.57 ENST00000433779.1
ENST00000378325.3
ENST00000354919.6
ENST00000313519.5
ENST00000420416.1
SUV39H2
suppressor of variegation 3-9 homolog 2 (Drosophila)
chr15_-_101835110 0.53 ENST00000560496.1
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr16_+_50300427 0.53 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
ADCY7
adenylate cyclase 7
chr9_+_34990219 0.52 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr10_+_16478942 0.52 ENST00000535784.2
ENST00000423462.2
ENST00000378000.1
PTER
phosphotriesterase related
chr1_+_82266053 0.51 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr18_-_2571437 0.47 ENST00000574676.1
ENST00000574538.1
ENST00000319888.6
METTL4
methyltransferase like 4
chr17_+_26646121 0.46 ENST00000226230.6
TMEM97
transmembrane protein 97
chr2_+_97001491 0.46 ENST00000240423.4
ENST00000427946.1
ENST00000435975.1
ENST00000456906.1
ENST00000455200.1
NCAPH
non-SMC condensin I complex, subunit H
chr1_-_23342340 0.44 ENST00000566855.1
C1orf234
chromosome 1 open reading frame 234
chr3_-_11888246 0.44 ENST00000455809.1
ENST00000444133.2
ENST00000273037.5
TAMM41
TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)
chr7_-_143105941 0.42 ENST00000275815.3
EPHA1
EPH receptor A1
chr6_-_4079334 0.42 ENST00000492651.1
ENST00000498677.1
ENST00000274673.3
FAM217A
family with sequence similarity 217, member A
chr15_-_31453157 0.41 ENST00000559177.1
ENST00000558445.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr6_-_8102279 0.40 ENST00000488226.2
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr2_+_89999259 0.39 ENST00000558026.1
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr14_-_35183755 0.39 ENST00000555765.1
CFL2
cofilin 2 (muscle)
chr9_+_93564191 0.39 ENST00000375747.1
SYK
spleen tyrosine kinase
chr1_+_70876891 0.38 ENST00000411986.2
CTH
cystathionase (cystathionine gamma-lyase)
chr18_-_21166841 0.38 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr4_-_140477353 0.36 ENST00000406354.1
ENST00000506866.2
SETD7
SET domain containing (lysine methyltransferase) 7
chr9_+_75136717 0.35 ENST00000297784.5
TMC1
transmembrane channel-like 1
chr12_-_122240792 0.35 ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
ENST00000541657.1
AC084018.1
RHOF
AC084018.1
ras homolog family member F (in filopodia)
chr19_-_45909585 0.34 ENST00000593226.1
ENST00000418234.2
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr1_-_173176452 0.34 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr16_+_28722684 0.34 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr1_-_111061797 0.34 ENST00000369771.2
KCNA10
potassium voltage-gated channel, shaker-related subfamily, member 10
chr2_-_89247338 0.34 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr11_-_61062762 0.33 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr1_+_70876926 0.33 ENST00000370938.3
ENST00000346806.2
CTH
cystathionase (cystathionine gamma-lyase)
chr5_-_157002749 0.32 ENST00000517905.1
ENST00000430702.2
ENST00000394020.1
ADAM19
ADAM metallopeptidase domain 19
chr9_+_125133315 0.31 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_+_128886532 0.31 ENST00000444616.1
ENST00000388795.5
C4orf29
chromosome 4 open reading frame 29
chr15_-_31453359 0.31 ENST00000542188.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr18_+_33767473 0.31 ENST00000261326.5
MOCOS
molybdenum cofactor sulfurase
chr3_+_186915274 0.30 ENST00000312295.4
RTP1
receptor (chemosensory) transporter protein 1
chr19_+_35773242 0.30 ENST00000222304.3
HAMP
hepcidin antimicrobial peptide
chr16_+_28722809 0.30 ENST00000566866.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr10_-_92681033 0.30 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr16_-_22012419 0.29 ENST00000537222.2
ENST00000424898.2
ENST00000286143.6
PDZD9
PDZ domain containing 9
chr1_-_94050668 0.29 ENST00000539242.1
BCAR3
breast cancer anti-estrogen resistance 3
chr19_-_46234119 0.28 ENST00000317683.3
FBXO46
F-box protein 46
chr19_-_40732594 0.28 ENST00000430325.2
ENST00000433940.1
CNTD2
cyclin N-terminal domain containing 2
chr11_-_46408107 0.28 ENST00000433765.2
CHRM4
cholinergic receptor, muscarinic 4
chr15_-_76304731 0.28 ENST00000394907.3
NRG4
neuregulin 4
chr1_-_225616515 0.28 ENST00000338179.2
ENST00000425080.1
LBR
lamin B receptor
chr11_+_60609537 0.28 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr6_-_32634425 0.27 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr21_-_26979786 0.27 ENST00000419219.1
ENST00000352957.4
ENST00000307301.7
MRPL39
mitochondrial ribosomal protein L39
chr1_+_35544968 0.27 ENST00000359858.4
ENST00000373330.1
ZMYM1
zinc finger, MYM-type 1
chr15_-_74726283 0.27 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr14_+_24563262 0.26 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr1_+_165864800 0.25 ENST00000469256.2
UCK2
uridine-cytidine kinase 2
chr10_-_96122682 0.25 ENST00000371361.3
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr5_-_127418573 0.25 ENST00000508353.1
ENST00000508878.1
ENST00000501652.1
ENST00000514409.1
CTC-228N24.3
CTC-228N24.3
chr11_+_28131821 0.25 ENST00000379199.2
ENST00000303459.6
METTL15
methyltransferase like 15
chr1_+_165864821 0.25 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr17_+_41994576 0.24 ENST00000588043.2
FAM215A
family with sequence similarity 215, member A (non-protein coding)
chr17_+_73629500 0.23 ENST00000375215.3
SMIM5
small integral membrane protein 5
chr14_+_22458631 0.23 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr3_-_122283424 0.23 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr11_-_64739358 0.23 ENST00000301896.5
ENST00000530444.1
C11orf85
chromosome 11 open reading frame 85
chr2_-_54087066 0.23 ENST00000394705.2
ENST00000352846.3
ENST00000406625.2
GPR75
GPR75-ASB3
ASB3
G protein-coupled receptor 75
GPR75-ASB3 readthrough
Ankyrin repeat and SOCS box protein 3
chr5_+_131892603 0.22 ENST00000378823.3
ENST00000265335.6
RAD50
RAD50 homolog (S. cerevisiae)
chr12_-_11091862 0.22 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr10_+_54074033 0.22 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr11_-_57298187 0.22 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr10_+_30722866 0.22 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr3_-_47950745 0.21 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr6_-_107235287 0.21 ENST00000436659.1
ENST00000428750.1
ENST00000427903.1
RP1-60O19.1
RP1-60O19.1
chr16_+_57279248 0.21 ENST00000562023.1
ENST00000563234.1
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr3_+_12525931 0.20 ENST00000446004.1
ENST00000314571.7
ENST00000454502.2
ENST00000383797.5
ENST00000402228.3
ENST00000284995.6
ENST00000444864.1
TSEN2
TSEN2 tRNA splicing endonuclease subunit
chr19_+_15752088 0.19 ENST00000585846.1
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr1_+_241695670 0.19 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr17_-_7307358 0.19 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr4_-_159592996 0.18 ENST00000508457.1
C4orf46
chromosome 4 open reading frame 46
chr9_-_130890662 0.18 ENST00000277462.5
ENST00000338961.6
PTGES2
prostaglandin E synthase 2
chr16_+_4845379 0.18 ENST00000588606.1
ENST00000586005.1
SMIM22
small integral membrane protein 22
chr16_+_23194033 0.18 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chr9_+_125132803 0.18 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr5_+_145826867 0.18 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr19_+_45754505 0.18 ENST00000262891.4
ENST00000300843.4
MARK4
MAP/microtubule affinity-regulating kinase 4
chr17_-_48546324 0.17 ENST00000508540.1
CHAD
chondroadherin
chr13_-_36788718 0.17 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr22_+_24990746 0.17 ENST00000456869.1
ENST00000411974.1
GGT1
gamma-glutamyltransferase 1
chr12_+_20522179 0.17 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr2_+_232826211 0.17 ENST00000325385.7
ENST00000360410.4
DIS3L2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
chr11_-_64739542 0.17 ENST00000536065.1
C11orf85
chromosome 11 open reading frame 85
chr8_-_41166953 0.16 ENST00000220772.3
SFRP1
secreted frizzled-related protein 1
chr3_+_138067314 0.16 ENST00000423968.2
MRAS
muscle RAS oncogene homolog
chr20_+_17949724 0.16 ENST00000377704.4
MGME1
mitochondrial genome maintenance exonuclease 1
chr18_+_60190226 0.15 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr11_+_1860200 0.15 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr3_-_196014520 0.15 ENST00000441879.1
ENST00000292823.2
ENST00000411591.1
ENST00000431016.1
ENST00000443555.1
PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr19_-_16582815 0.15 ENST00000455140.2
ENST00000248070.6
ENST00000594975.1
EPS15L1
epidermal growth factor receptor pathway substrate 15-like 1
chr3_+_137906353 0.15 ENST00000461822.1
ENST00000485396.1
ENST00000471453.1
ENST00000470821.1
ENST00000471709.1
ENST00000538260.1
ENST00000393058.3
ENST00000463485.1
ARMC8
armadillo repeat containing 8
chr6_-_42690312 0.15 ENST00000230381.5
PRPH2
peripherin 2 (retinal degeneration, slow)
chr5_+_154320623 0.15 ENST00000523037.1
ENST00000265229.8
ENST00000439747.3
ENST00000522038.1
MRPL22
mitochondrial ribosomal protein L22
chr13_+_49822041 0.15 ENST00000538056.1
ENST00000251108.6
ENST00000444959.1
ENST00000429346.1
CDADC1
cytidine and dCMP deaminase domain containing 1
chr19_+_6361754 0.15 ENST00000597326.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr6_+_117198400 0.14 ENST00000332958.2
RFX6
regulatory factor X, 6
chr16_+_57279004 0.14 ENST00000219204.3
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr22_-_39640756 0.14 ENST00000331163.6
PDGFB
platelet-derived growth factor beta polypeptide
chr1_+_241695424 0.14 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_-_109399682 0.14 ENST00000369995.3
ENST00000370001.3
AKNAD1
AKNA domain containing 1
chr14_+_45605157 0.13 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr16_+_12070567 0.13 ENST00000566228.1
SNX29
sorting nexin 29
chr2_+_232826394 0.13 ENST00000409401.3
ENST00000441279.1
DIS3L2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
chr11_+_46740730 0.13 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr12_-_52946923 0.13 ENST00000267119.5
KRT71
keratin 71
chr16_-_10674528 0.13 ENST00000359543.3
EMP2
epithelial membrane protein 2
chr1_+_10459111 0.13 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD
phosphogluconate dehydrogenase
chr12_-_43945724 0.12 ENST00000389420.3
ENST00000553158.1
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr1_-_76398077 0.12 ENST00000284142.6
ASB17
ankyrin repeat and SOCS box containing 17
chr2_+_28718921 0.12 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
PLB1
phospholipase B1
chr1_-_204380919 0.12 ENST00000367188.4
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr1_+_207669573 0.12 ENST00000400960.2
ENST00000534202.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr9_-_86571628 0.12 ENST00000376344.3
C9orf64
chromosome 9 open reading frame 64
chr6_+_29141311 0.12 ENST00000377167.2
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr5_-_132113083 0.11 ENST00000296873.7
SEPT8
septin 8
chr11_+_73882144 0.11 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr9_+_131266963 0.11 ENST00000309971.4
ENST00000372770.4
GLE1
GLE1 RNA export mediator
chr8_+_145064215 0.11 ENST00000313269.5
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr7_-_12443501 0.11 ENST00000275358.3
VWDE
von Willebrand factor D and EGF domains
chr17_-_36904437 0.11 ENST00000585100.1
ENST00000360797.2
ENST00000578109.1
ENST00000579882.1
PCGF2
polycomb group ring finger 2
chr5_-_132113036 0.11 ENST00000378706.1
SEPT8
septin 8
chr8_-_87755878 0.10 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr18_+_29769978 0.10 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr11_-_4719072 0.10 ENST00000396950.3
ENST00000532598.1
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chr10_-_69455873 0.10 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr22_-_45559540 0.10 ENST00000432502.1
CTA-217C2.1
CTA-217C2.1
chr2_+_163175394 0.09 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr12_+_54402790 0.09 ENST00000040584.4
HOXC8
homeobox C8
chr12_+_10331605 0.09 ENST00000298530.3
TMEM52B
transmembrane protein 52B
chr6_-_107235331 0.09 ENST00000433965.1
ENST00000430094.1
RP1-60O19.1
RP1-60O19.1
chr11_+_73882311 0.09 ENST00000398427.4
ENST00000544401.1
PPME1
protein phosphatase methylesterase 1
chr22_-_50050986 0.09 ENST00000405854.1
C22orf34
chromosome 22 open reading frame 34
chr19_+_58281014 0.09 ENST00000391702.3
ENST00000598885.1
ENST00000598183.1
ENST00000396154.2
ENST00000599802.1
ENST00000396150.4
ZNF586
zinc finger protein 586
chr22_+_26138108 0.09 ENST00000536101.1
ENST00000335473.7
ENST00000407587.2
MYO18B
myosin XVIIIB
chr21_-_40033618 0.09 ENST00000417133.2
ENST00000398910.1
ENST00000442448.1
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chrX_+_16668278 0.09 ENST00000380200.3
S100G
S100 calcium binding protein G
chr12_-_66524482 0.08 ENST00000446587.2
ENST00000266604.2
LLPH
LLP homolog, long-term synaptic facilitation (Aplysia)
chr19_+_917287 0.08 ENST00000592648.1
ENST00000234371.5
KISS1R
KISS1 receptor
chr8_-_143696833 0.08 ENST00000356613.2
ARC
activity-regulated cytoskeleton-associated protein
chr4_+_128886424 0.08 ENST00000398965.1
C4orf29
chromosome 4 open reading frame 29
chr6_+_28227063 0.08 ENST00000343684.3
NKAPL
NFKB activating protein-like
chr3_-_33138624 0.08 ENST00000445488.2
ENST00000307377.8
ENST00000440656.1
ENST00000436768.1
ENST00000307363.5
GLB1
galactosidase, beta 1
chr5_+_64859066 0.08 ENST00000261308.5
ENST00000535264.1
ENST00000538977.1
PPWD1
peptidylprolyl isomerase domain and WD repeat containing 1
chr14_-_50559361 0.08 ENST00000305273.1
C14orf183
chromosome 14 open reading frame 183
chr22_-_45559642 0.08 ENST00000426282.2
CTA-217C2.1
CTA-217C2.1
chr2_+_101869262 0.08 ENST00000289382.3
CNOT11
CCR4-NOT transcription complex, subunit 11
chr15_+_38746307 0.08 ENST00000397609.2
ENST00000491535.1
FAM98B
family with sequence similarity 98, member B
chr14_+_45605127 0.08 ENST00000556036.1
ENST00000267430.5
FANCM
Fanconi anemia, complementation group M
chr17_+_16593539 0.08 ENST00000340621.5
ENST00000399273.1
ENST00000443444.2
ENST00000360524.8
ENST00000456009.1
CCDC144A
coiled-coil domain containing 144A
chr4_-_170947485 0.07 ENST00000504999.1
MFAP3L
microfibrillar-associated protein 3-like
chr2_-_89310012 0.07 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr4_-_128887069 0.07 ENST00000541133.1
ENST00000296468.3
ENST00000513559.1
MFSD8
major facilitator superfamily domain containing 8
chr6_+_34725263 0.07 ENST00000374018.1
ENST00000374017.3
SNRPC
small nuclear ribonucleoprotein polypeptide C
chr22_-_32058166 0.07 ENST00000435900.1
ENST00000336566.4
PISD
phosphatidylserine decarboxylase
chr4_+_4861385 0.07 ENST00000382723.4
MSX1
msh homeobox 1
chr1_-_207226313 0.07 ENST00000367084.1
YOD1
YOD1 deubiquitinase
chr1_-_15850676 0.07 ENST00000440484.1
ENST00000333868.5
CASP9
caspase 9, apoptosis-related cysteine peptidase
chr11_+_92085262 0.07 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3
FAT atypical cadherin 3
chr15_-_41047421 0.07 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
RMDN3
regulator of microtubule dynamics 3
chr1_+_161719552 0.07 ENST00000367943.4
DUSP12
dual specificity phosphatase 12
chr19_-_15529790 0.07 ENST00000596195.1
ENST00000595067.1
ENST00000595465.2
ENST00000397410.5
ENST00000600247.1
AKAP8L
A kinase (PRKA) anchor protein 8-like
chr3_-_112218205 0.07 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr19_-_19754404 0.06 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GMIP
GEM interacting protein
chr1_+_150980989 0.06 ENST00000368935.1
PRUNE
prune exopolyphosphatase
chr6_+_168196210 0.06 ENST00000597278.1
AL009178.1
Uncharacterized protein; cDNA FLJ43200 fis, clone FEBRA2007793
chrX_-_53461305 0.06 ENST00000168216.6
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr12_+_113229452 0.06 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr12_+_113229543 0.06 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr3_-_197025447 0.06 ENST00000346964.2
ENST00000357674.4
ENST00000314062.3
ENST00000448528.2
ENST00000419553.1
DLG1
discs, large homolog 1 (Drosophila)
chr19_+_6361440 0.06 ENST00000245816.4
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr15_+_81489213 0.06 ENST00000559383.1
ENST00000394660.2
IL16
interleukin 16
chr3_+_126113734 0.06 ENST00000352312.1
ENST00000393425.1
CCDC37
coiled-coil domain containing 37
chr1_+_203830703 0.06 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chrY_-_20935572 0.06 ENST00000382852.1
ENST00000344884.4
ENST00000304790.3
HSFY2
heat shock transcription factor, Y linked 2
chr18_+_32073253 0.06 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA
dystrobrevin, alpha
chr7_+_128864848 0.06 ENST00000325006.3
ENST00000446544.2
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_6640108 0.05 ENST00000377674.4
ENST00000488936.1
ZBTB48
zinc finger and BTB domain containing 48
chr5_-_132113063 0.05 ENST00000378719.2
SEPT8
septin 8
chr12_+_98987369 0.05 ENST00000401722.3
ENST00000188376.5
ENST00000228318.3
ENST00000551917.1
ENST00000548046.1
ENST00000552981.1
ENST00000551265.1
ENST00000550695.1
ENST00000547534.1
ENST00000549338.1
ENST00000548847.1
SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of PROX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0006218 uridine catabolic process(GO:0006218)
0.3 1.0 GO:0002519 natural killer cell tolerance induction(GO:0002519) regulation of tolerance induction dependent upon immune response(GO:0002652) negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.3 2.5 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 0.7 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.2 0.7 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.1 0.4 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1 0.5 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.3 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 1.3 GO:0019532 oxalate transport(GO:0019532)
0.1 0.3 GO:1990641 cellular response to bile acid(GO:1903413) response to iron ion starvation(GO:1990641)
0.1 0.9 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.4 GO:0032672 regulation of interleukin-3 production(GO:0032672)
0.1 0.6 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 0.7 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 1.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 0.4 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.6 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.1 0.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.2 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.0 0.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:0019520 pentose-phosphate shunt, oxidative branch(GO:0009051) aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.0 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.4 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.0 0.8 GO:0000022 mitotic spindle elongation(GO:0000022)
0.0 0.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.7 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:1905176 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0 0.2 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.0 0.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.2 GO:1901569 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.0 0.3 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.2 GO:0071321 cellular response to cGMP(GO:0071321)
0.0 0.3 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.1 GO:1900738 cytolysis in other organism involved in symbiotic interaction(GO:0051801) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.4 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.5 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)
0.0 0.2 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 1.0 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.1 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.0 0.1 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0 0.1 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.0 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.1 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.1 GO:1903912 negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.1 GO:0070836 caveola assembly(GO:0070836)
0.0 0.3 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0035841 new growing cell tip(GO:0035841)
0.1 0.7 GO:0031262 condensed nuclear chromosome outer kinetochore(GO:0000942) Ndc80 complex(GO:0031262)
0.1 0.5 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.2 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 5.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.8 GO:0070938 contractile ring(GO:0070938)
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0009368 endopeptidase Clp complex(GO:0009368)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 2.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.0 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.3 1.4 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.2 0.9 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.4 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.6 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.1 0.3 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.3 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.2 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 0.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 0.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.2 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 5.2 GO:0019843 rRNA binding(GO:0019843)
0.1 0.3 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 0.5 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 0.2 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.5 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.5 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0 1.4 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.4 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.0 0.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.2 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.6 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.0 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.0 GO:0033149 FFAT motif binding(GO:0033149)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.9 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.7 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions